From correlation to causation: The missing point in the study of functional foods and gut microbiota

Al-Asmakh, 2015, Use of germ-free animal models in microbiota-related research, Journal of Microbiology and Biotechnology, 25, 1583, 10.4014/jmb.1501.01039 Anhê, 2019, Treatment with camu camu (Myrciaria dubia) prevents obesity by altering the gut microbiota and increasing energy expenditure in diet-induced obese mice, Gut, 68, 453, 10.1136/gutjnl-2017-315565 Chang, 2015, Ganoderma lucidum reduces obesity in mice by modulating the composition of the gut microbiota, Nature Communications, 6, 7489, 10.1038/ncomms8489 Chen, 2019, A forward chemical genetic screen reveals gut microbiota metabolites that modulate host physiology, Cell, 177, 1217, 10.1016/j.cell.2019.03.036 Hu, 2019, Fucoidan from Acaudina molpadioides improves insulin resistance by altering gut microbiota dysfunction, Journal of Functional Foods, 57, 59, 10.1016/j.jff.2019.03.033 Paul, 2017, Impact of genistein on the gut microbiome of humanized mice and its role in breast tumor inhibition, PLOS ONE, 12, e0189756, 10.1371/journal.pone.0189756 Shang, 2017, Dietary fucoidan improves metabolic syndrome in association with increased Akkermansia population in the gut microbiota of high-fat diet-fed mice, Journal of Functional Foods, 28, 138, 10.1016/j.jff.2016.11.002 Sharon, 2019, Human gut microbiota from autism spectrum disorder promote behavioral symptoms in mice, Cell, 177, 1600, 10.1016/j.cell.2019.05.004 Sommer, 2013, The gut microbiota—masters of host development and physiology, Nature Reviews Microbiology, 11, 227, 10.1038/nrmicro2974 Sun, 2019, An insoluble polysaccharide from the sclerotium of Poria cocos improves hyperglycemia, hyperlipidemia and hepatic steatosis in ob/ob mice via modulation of gut microbiota, Chinese Journal of Natural Medicines, 17, 3, 10.1016/S1875-5364(19)30003-2 Uzbay, 2019, Germ-free animal experiments in the gut microbiota studies, Current Opinion in Pharmacology, 49, 6, 10.1016/j.coph.2019.03.016 Wostmann, 1981, The germfree animal in nutritional studies, Annual Review of Nutrition, 1, 257, 10.1146/annurev.nu.01.070181.001353 Wu, 2019, Gut commensal Parabacteroides goldsteinii plays a predominant role in the anti-obesity effects of polysaccharides isolated from Hirsutella sinensis, Gut, 68, 248, 10.1136/gutjnl-2017-315458 Xiao, 2016, Chitosan lowers body weight through intestinal microbiota and reduces IL-17 expression via mTOR signaling, Journal of Functional Foods, 22, 166, 10.1016/j.jff.2016.01.009