From clinical evidence to molecular mechanisms underlying neuroprotection afforded by estrogens
Tài liệu tham khảo
Garcia-Segura, 2001, Neuroprotection by estradiol, Prog Neurobiol, 63, 29, 10.1016/S0301-0082(00)00025-3
Wise, 2003, Estrogens: protective or risk factors in brain function?, Prog Neurobiol, 69, 181, 10.1016/S0301-0082(03)00035-2
Maggi, 2004, Estrogens in the nervous system: mechanisms and nonreproductive functions, Annu Rev Physiol, 66, 291, 10.1146/annurev.physiol.66.032802.154945
Levin, 2002, Cellular functions of plasma membrane estrogen receptors, Steroids, 67, 471, 10.1016/S0039-128X(01)00179-9
Toran-Allerand, 2004, Estrogen and the brain: beyond ER-α and ER-β, Exp Gerontol, 39, 1579, 10.1016/j.exger.2004.05.006
Bedard, 1977, Estrogens and the extrapyramidal system, Lancet, 2, 1367, 10.1016/S0140-6736(77)90429-9
Cyr, 2002, Estrogenic modulation of brain activity: implications for schizophrenia and Parkinson's disease, J Psychiatry Neurosci, 27, 12
Currie, 2004, Postmenopausal estrogen use affects risk for Parkinson disease, Arch Neurol, 61, 886, 10.1001/archneur.61.6.886
Paganini-Hill, 1996, Estrogen replacement therapy and risk of Alzheimer disease, Arch Intern Med, 156, 2213, 10.1001/archinte.156.19.2213
Henderson, 1997, Estrogen replacement therapy for the prevention and treatment of Alzheimer's disease, CNS Drugs, 8, 343, 10.2165/00023210-199708050-00001
Brinton, 2004, Impact of estrogen therapy on Alzheimer's disease: a fork in the road?, CNS Drugs, 18, 405, 10.2165/00023210-200418070-00001
Henderson, 1994, Estrogen replacement therapy in older women, Arch Neurol, 51, 896, 10.1001/archneur.1994.00540210068014
Resnick, 1998, Effects of estrogen replacement therapy on PET cerebral blood flow and neuropsychological performance, Horm Behav, 34, 171, 10.1006/hbeh.1998.1476
Costa, 1999, Estrogen replacement therapy and cognitive decline in memory-impaired post-menopausal women, Biol Psychiatry, 46, 182, 10.1016/S0006-3223(98)00355-2
Resnick, 2001, Effects of hormone replacement therapy on cognitive and brain aging, Ann N Y Acad Sci, 949, 203, 10.1111/j.1749-6632.2001.tb04023.x
Zec, 2002, The effects of estrogen replacement therapy on neuropsychological functioning in postmenopausal women with and without dementia: a critical and theoretical review, Neuropsychol Rev, 12, 65, 10.1023/A:1016880127635
Sherwin, 2003, Estrogen and cognitive functioning in women, Endocr Rev, 24, 133, 10.1210/er.2001-0016
Barrett-Connor, 1993, Estrogen replacement therapy and cognitive function in older women, J Am Med Assoc, 269, 2637, 10.1001/jama.269.20.2637
Mulnard, 2000, Estrogen replacement therapy for treatment of mild to moderate Alzheimer disease: a randomized controlled trial. Alzheimer's Disease Cooperative Study, J Am Med Assoc, 283, 1007, 10.1001/jama.283.8.1007
Mulnard, 2004, Estrogen replacement therapy, Alzheimer's disease, and mild cognitive impairment, Curr Neurol Neurosci Rep, 4G, 368, 10.1007/s11910-004-0083-8
Gibbs, 2003, Estrogen and cognition: applying preclinical findings to clinical perspectives, J Neurosci Res, 74, 637, 10.1002/jnr.10811
Paganini-Hill, 1995, Estrogen replacement therapy and stroke, Prog Cardiovasc Dis, 38, 223, 10.1016/S0033-0620(95)80014-X
Schmidt, 1996, Estrogen replacement therapy in older women: a neuropsychological and brain MRI study, J Am Geriatr Soc, 44, 1307, 10.1111/j.1532-5415.1996.tb01400.x
Paganini-Hill, 1988, Postmenopausal oestrogen treatment and stroke: a prospective study, Br Med J, 297, 519, 10.1136/bmj.297.6647.519
Falkeborn, 1993, Hormone replacement therapy and the risk of stoke, Arch Intern Med, 153, 1201, 10.1001/archinte.153.10.1201
Longstreth, 1994, Subarachnoid hemorrhage and hormonal factors in women, Ann Intern Med, 121, 168, 10.7326/0003-4819-121-3-199408010-00002
Hurn, 2003, Estrogen and stroke: a balanced analysis, Stroke, 34, 338, 10.1161/01.STR.0000054051.88378.25
Medina, 2003, The action of ovarian hormones in cardiovascular disease, J Biol Res, 36, 325
Petitti, 1996, Stroke in users of low-dose oral contraceptives, N Engl J Med, 335, 8, 10.1056/NEJM199607043350102
Viscoli, 2001, A clinical trial of estrogen-replacement therapy after ischemic stroke, N Engl J Med, 345, 1243, 10.1056/NEJMoa010534
Hulley, 1998, Randomized trial of estrogen plus progestin for secondary prevention of coronary heart disease in postmenopausal women, J Am Med Assoc, 280, 605, 10.1001/jama.280.7.605
Cherry, 2002, Oestrogen therapy for prevention of reinfarction in postmenopausal women: a randomised placebo controlled trial, Lancet, 360, 2001, 10.1016/S0140-6736(02)12001-0
Hafner, 2003, Gender differences in schizophrenia, Psychoneuroendocrinology, 28, 17, 10.1016/S0306-4530(02)00125-7
Dueñas, 1996, Interaction of insulin-like grow factor-1 and estradiol signalling pathways on hypothalamic neuronal differentiation, Neuroscience, 74, 531, 10.1016/0306-4522(96)00142-X
Arimatsu, 1986, Estrogen treatment enhances survival of cultured fetal rat amygdala neurons in a defined medium, Brain Res, 391, 151, 10.1016/0165-3806(86)90017-9
Brinton, 1997, 17β-Estradiol enhances the outgrowth and survival of neocortical neurons in culture, Neurochem Res, 22, 1339, 10.1023/A:1022015005508
Wang, 2003, Estrogen receptor (ER) beta knockout mice reveal a role for ERbeta in migration of cortical neurons in the developing brain, Proc Natl Acad Sci USA, 100, 703, 10.1073/pnas.242735799
Beyer, 1999, Estrogen and the developing mammalian brain, Anat Embryol, 199, 379, 10.1007/s004290050236
Sudo, 1997, β-Estradiol protects hippocampal CA1 neurons against transient forebrain ischemia in gerbil, Neurosci Res, 29, 345, 10.1016/S0168-0102(97)00106-5
Audesirk, 2003, Beta-estradiol influences differentiation of hippocampal neurons in vitro through an estrogen receptor-mediated process, Neuroscience, 121, 927, 10.1016/S0306-4522(03)00294-X
Huang, 2004, Estradiol acutely attenuates glutamate-induced calcium overload in primarily cultured rat hippocampal neurons through a membrane receptor-dependent mechanism, Brain Res, 1026, 254, 10.1016/j.brainres.2004.08.038
Sawada, 1998, Estradiol protects mesencephalic dopaminergic neurons from oxidative stress-induced neuronal death, J Neurosci Res, 54, 707, 10.1002/(SICI)1097-4547(19981201)54:5<707::AID-JNR16>3.0.CO;2-T
Singer, 1996, Estrogen protects primary cortical neurons from glutamate toxicity, Neurosci Lett, 212, 13, 10.1016/0304-3940(96)12760-9
Zaulyanov, 1999, Glutamate receptor requirement for neuronal cell death from anoxia-reoxygenation: an in vitro model for assessment of the neuroprotective effects of estrogens, Cell Mol Neurobiol, 19, 705, 10.1023/A:1006948921855
Sribnick, 2004, 17β-Estradiol attenuates glutamate-induced apoptosis and preserves electrophysiologic function in primary cortical neurons, J Neurosci Res, 76, 688, 10.1002/jnr.20124
Regan, 1997, Estrogens attenuate neuronal injury due to haemoglobin, chemical hypoxia, and excitatory amino acids in murine cortical cultures, Brain Res, 764, 133, 10.1016/S0006-8993(97)00437-X
Weaver, 1997, 17β-Estradiol protects against NMDA-induced excitotoxicity by direct inhibition of NMDA receptors, Brain Res, 761, 338, 10.1016/S0006-8993(97)00449-6
Brooke, 1997, Endocrine modulation of the neurotoxicity of gp120: implications for AIDS-related dementia complex, Proc Natl Acad Sci USA, 94, 9457, 10.1073/pnas.94.17.9457
Howard, 2001, Mechanisms of estrogenic protection against gp120-induced neurotoxicity, Exp Neurol, 168, 385, 10.1006/exnr.2000.7619
Singer, 1998, Modulation of Bcl-2 expression: a potential component of estrogen protection in NT2 neurons, Neuroreport, 9, 2565, 10.1097/00001756-199808030-00025
Bonnefont, 1998, Estrogen protects neuronal cells from the cytotoxicity induced by acetylcholinesterase–amyloid complexes, FEBS Lett, 441, 220, 10.1016/S0014-5793(98)01552-X
Moosmann, 1999, The antioxidant neuroprotective effects of estrogens and phenolic compounds are independent from their estrogenic properties, Proc Natl Acad Sci USA, 96, 8867, 10.1073/pnas.96.16.8867
Gelinas, 2002, Neuroprotective effect of estradiol and phytoestrogens on MPP+-induced cytotoxicity in neuronal PC12 cells, J Neurosci Res, 70, 90, 10.1002/jnr.10315
Gelinas, 2004, Alpha and beta estradiol protect neuronal but not native PC12 cells from paraquat-induced oxidative stress, Neurotoxicol Res, 6, 141, 10.1007/BF03033216
Goodman, 1996, Estrogens attenuate and corticosterone exacerbates excitotoxicity, oxidative injury, and amyloid beta-peptide toxicity in hippocampal neurons, J Neurochem, 66, 1836, 10.1046/j.1471-4159.1996.66051836.x
Hosoda, 2001, Estrogen protects neuronal cells from amyloid beta-induced apoptotic cell death, Neuroreport, 12, 1965, 10.1097/00001756-200107030-00038
Marin, 2003, Estradiol prevents amyloid-beta peptide-induced cell death in a cholinergic cell line via modulation of a classical estrogen receptor, Neuroscience, 121, 917, 10.1016/S0306-4522(03)00464-0
Celsi, 2003, Overexpression of superoxide dismutase 1 protects against beta-amyloid peptide toxicity: effect of estrogen and copper chelators, Neurochem Int, 44, 25, 10.1016/S0197-0186(03)00101-3
Zhang, 2004, Estrogen and androgen protection of human neurons against intracellular amyloid beta1–42 toxicity through heat shock protein 70, J Neurosci, 24, 5315, 10.1523/JNEUROSCI.0913-04.2004
Guerra, 2004, Plasma membrane oestrogen receptor mediates neuroprotection against β-amyloid toxicity through activation of Raf-1/MEK/ERK cascade in septal-derived cholinergic SN56 cells, J Neurochem, 91, 99, 10.1111/j.1471-4159.2004.02695.x
Fader, 1998, Estrogen improves performance of reinforced T-maze alternation and prevents the amnestic effects of scopolamine administered systemically or intrahippocampally, Neurobiol Learn Mem, 69, 225, 10.1006/nlme.1998.3820
Daniel, 1999, Effects of ovarian hormones and environment on radial maze and water maze performance of female rats, Physiol Behav, 66, 11, 10.1016/S0031-9384(98)00272-8
Markowska, 1999, Sex dimorphism in the rate of age-related decline in spatial memory: relevance to alterations in the estrous cycle, J Neurosci, 19, 8122, 10.1523/JNEUROSCI.19-18-08122.1999
Frick, 2000, Reference memory, anxiety and estrous cyclicity in C57BL/6NIA mice are affected by age and sex, Neuroscience, 95, 293, 10.1016/S0306-4522(99)00418-2
Gibbs, 2000, Long-term treatment with estrogen and progesterone enhances acquisition of a spatial memory task by ovariectomized aged rats, Neurobiol Aging, 21, 107, 10.1016/S0197-4580(00)00103-2
Simpkins, 1997, Role of estrogen replacement therapy in memory enhancement and the prevention of neuronal loss associated with Alzheimer's disease, Am J Med, 103, 19S, 10.1016/S0002-9343(97)00260-X
Bimonte, 1999, Estradiol facilitates performance as working memory load increases, Psychoneuroendocrinology, 24, 161, 10.1016/S0306-4530(98)00068-7
Fader, 1999, Estrogen improves working memory but not reference memory and prevents amnestic effects of scopolamine of a radial-arm maze, Pharmacol Biochem Behav, 62, 711, 10.1016/S0091-3057(98)00219-6
Simpkins, 1997, Estrogens may reduce mortality and ischemic damage caused by middle cerebral artery occlusion in the female rat, J Neurosurg, 87, 724, 10.3171/jns.1997.87.5.0724
Alkayed, 1998, Gender-linked brain injury in experimental stroke, Stroke, 29, 159, 10.1161/01.STR.29.1.159
Dubal, 1998, Estradiol protects against ischemic injury, J Cereb Blood Flow Metab, 18, 1253, 10.1097/00004647-199811000-00012
Rusa, 1999, 17β-Estradiol reduces stroke injury in estrogen-deficient female animals, Stroke, 30, 1665, 10.1161/01.STR.30.8.1665
Toung, 1998, Estrogen-mediated neuroprotection after experimental stroke in male rats, Stroke, 29, 1666, 10.1161/01.STR.29.8.1666
Wang, 1999, Estrogen provides neuroprotection in transient forebrain ischemia through perfusion-independent mechanisms in rats, Stroke, 30, 630, 10.1161/01.STR.30.3.630
Bagetta, 2004, Estradiol reduces cytochrome c translocation and minimizes hippocampal damage caused by transient global ischemia in rat, Neurosci Lett, 368, 87, 10.1016/j.neulet.2004.06.062
Horsburgh, 2002, Estrogen is neuroprotective via an apolipoprotein E-dependent mechanism in a mouse model of global ischemia, J Cereb Blood Flow Metab, 22, 1189, 10.1097/00004647-200210000-00006
Chen, 1998, The effects of 17β-estradiol on ischemia-induced neuronal damage in the gerbil hippocampus, Neuroscience, 87, 817, 10.1016/S0306-4522(98)00198-5
Dluzen, 1996, Estrogen alters MPTP-induced neurotoxicity in female mice: effects on striatal dopamine concentrations and release, J Neurochem, 66, 658, 10.1046/j.1471-4159.1996.66020658.x
Callier, 2000, Stereospecific prevention by 17β-estradiol of MPTP-induced dopamine depletion in mice, Synapse, 37, 245, 10.1002/1098-2396(20000915)37:4<245::AID-SYN1>3.0.CO;2-5
Ramirez, 2003, Repeated estradiol treatment prevents MPTP-induced dopamine depletion in male mice, Neuroendocrinology, 77, 223, 10.1159/000070277
Gomez-Mancilla, 1992, Effect of estrogen and progesterone on l-dopa induced dyskinesia in MPTP-treated monkeys, Neurosci Lett, 135, 129, 10.1016/0304-3940(92)90152-W
Miller, 1998, The impact of gender on striatal dopaminergic neurotoxicity, Ann N Y Acad Sci, 844, 153, 10.1111/j.1749-6632.1998.tb08230.x
Leranth, 2000, Estrogen is essential for maintaining nigrostriatal dopamine neurons in primates: implications for Parkinson's disease and memory, J Neurosci, 20, 8604, 10.1523/JNEUROSCI.20-23-08604.2000
Azcoitia, 1998, Estradiol prevents kainic acid-induced neuronal loss in the rat dentate gyrus, Neuroreport, 9, 3075, 10.1097/00001756-199809140-00029
Picazo, 2003, Neuroprotective and neurotoxic effects of estrogens, Brain Res, 990, 20, 10.1016/S0006-8993(03)03380-8
Corasaniti, 2002, Neuronal apoptosis induced by HIV-1 gp120 in the neocortex of rat is prevented by systemic administration of 17β-estradiol, Br J Pharmacol, 135, 229P
Green, 2000, Neuroprotective effects of estrogens: potential mechanisms of action, Int J Dev Neurosci, 18, 347, 10.1016/S0736-5748(00)00017-4
Wise, 2001, Estrogens: trophic and protective factors in the adult brain, Front Neuroendocrinol, 22, 33, 10.1006/frne.2000.0207
Wise, 2002, Estrogens and neuroprotection, Trends Endocrinol Metab, 13, 229, 10.1016/S1043-2760(02)00611-2
Ogawa, 1997, Behavioral effects of estrogen receptor gene disruption in male mice, Proc Natl Acad Sci USA, 94, 1476, 10.1073/pnas.94.4.1476
Ogawa, 1999, Survival of reproductive behaviours in estrogen receptor beta gene-deficient (βERKO) male and female mice, Proc Natl Acad Sci USA, 96, 12887, 10.1073/pnas.96.22.12887
Rissman, 1997, Estrogen receptors are essential for female sexual receptivity, Endocrinology, 138, 507, 10.1210/en.138.1.507
Singer, 1999, The mitogen-activated protein kinase pathway mediates estrogen neuroprotection after glutamate toxicity in primary cortical neurons, J Neurosci, 196, 2455, 10.1523/JNEUROSCI.19-07-02455.1999
Azcoita, 1999, Neuroprotective effects of estradiol in the adult rat hippocampus: interaction with insulin-like growth factor-I signalling, J Neurosci Res, 58, 815, 10.1002/(SICI)1097-4547(19991215)58:6<815::AID-JNR8>3.0.CO;2-R
Gollapudi, 1999, Stable transfection of PC12 cells with estrogen receptor (ERalpha): protective effects of estrogen on cell survival after serum deprivation, J Neurosci Res, 56, 99, 10.1002/(SICI)1097-4547(19990401)56:1<99::AID-JNR13>3.0.CO;2-G
Dubal, 2001, Estrogen receptor alpha, not beta, is a critical link in estradiol-mediated protection against brain injury, Proc Natl Acad Sci USA, 98, 1952, 10.1073/pnas.041483198
D’Astous, 2004, Effect of estrogen receptor agonists treatment in MPTP mice: evidence of neuroprotection by an ERα agonist, Neuropharmacology, 47, 1180, 10.1016/j.neuropharm.2004.08.020
Wang, 2001, Morphological abnormalities in the brains of estrogen receptor beta knockout mice, Proc Natl Acad Sci USA, 98, 2792, 10.1073/pnas.041617498
Zhao, 2004, Estrogen receptor subtypes alpha and beta contribute to neuroprotection and increased Bcl-2 expression in primary hippocampal neurons, Brain Res, 1010, 22, 10.1016/j.brainres.2004.02.066
Garcia-Segura, 1998, Estradiol upregulates Bcl-2 expression in adult brain neurons, Neuroreport, 9, 593, 10.1097/00001756-199803090-00006
Pike, 1999, Estrogen modulates neuronal Bcl-XL expression and beta-amyloid-induced apoptosis: relevance to Alzheimer's disease, J Neurochem, 72, 1552, 10.1046/j.1471-4159.1999.721552.x
Garnier, 1997, Identification of estrogen-responsive genes in neuroblastoma SK-ER3 cells, J Neurosci, 17, 4591, 10.1523/JNEUROSCI.17-12-04591.1997
Vegeto, 1999, Estrogen and progesterone induction of survival of monoblastoid cells undergoing TNF-α-induced apoptosis, FASEB J, 13, 793, 10.1096/fasebj.13.8.793
Nilsen, 2003, Mechanism of estrogen-mediated neuroprotection: regulation of mitochondrial calcium and Bcl-2 expression, Proc Natl Acad Sci USA, 100, 2842, 10.1073/pnas.0438041100
Dubal, 1999, Estradiol modulates Bcl-2 in cerebral ischemia: a potential role for estrogen receptor, J Neurosci, 19, 6385, 10.1523/JNEUROSCI.19-15-06385.1999
Alkayed, 2001, Estrogen and Bcl-2: gene induction and effect of transgene in experimental stroke, J Neurosci, 21, 7543, 10.1523/JNEUROSCI.21-19-07543.2001
Desagher, 2000, Mitochondria as the central control point of apoptosis, Trends Cell Biol, 10, 369, 10.1016/S0962-8924(00)01803-1
Reed, 2002, Apoptosis-based therapy, Nat Rev Drug Discov, 1, 111, 10.1038/nrd726
Dispersyn, 1999, Bcl-2 protects against FCCP-induced apoptosis and mitochondrial membrane potential depolarization in PC12 cells, Biochim Biophys Acta, 1428, 357, 10.1016/S0304-4165(99)00073-2
Kim, 2001, MPP(+) downregulates mitochondrially encoded gene transcripts and their activities in dopaminergic neuronal cells: protective role of Bcl-2, Biochem Biophys Res Commun, 286, 659, 10.1006/bbrc.2001.5446
Howard, 2002, Neuroprotective effects of bcl-2 overexpression in hippocampal cultures: interactions with pathways of oxidative damage, J Neurochem, 83, 914, 10.1046/j.1471-4159.2002.01198.x
Chen, 1997, Bcl-2 promotes regeneration of severed axons in mammalian CNS, Nature, 385, 434, 10.1038/385434a0
Holm, 1999, Factors intrinsic to the neuron can induce and maintain its ability to promote axonal outgrowth: a role for Bcl-2?, Trends Neurosci, 22, 269, 10.1016/S0166-2236(98)01352-6
Bogdanov, 1999, Oxidative stress is attenuated in mice overexpressing Bcl-2, Neurosci Lett, 262, 33, 10.1016/S0304-3940(99)00047-6
Finkbeiner, 2000, CREB couples neurotrophin signals to survival messages, Neuron, 25, 11, 10.1016/S0896-6273(00)80866-1
Pugazhenthi, 2000, Akt/protein kinase B up-regulates Bcl-2 expression through cAMP-response element-binding protein, J Biol Chem, 275, 10761, 10.1074/jbc.275.15.10761
Singh, 2001, Ovarian hormones elicit phosphorylation of Akt and extracellular-signal regulated kinase in explants of the cerebral cortex, Endocrine, 14, 407, 10.1385/ENDO:14:3:407
Wilson, 2001, Estradiol enhances Akt activation in cortical explant cultures following neuronal injury, Mol Brain Res, 102, 48, 10.1016/S0169-328X(02)00181-X
Choi, 2004, 17β-Estradiol prevents focal cerebral ischemic damages via activation of Akt and CREB in association with reduced PTEN phosphorylation in rats, Fundam Clin Pharmacol, 18, 547, 10.1111/j.1472-8206.2004.00284.x
Zhang, 2001, Estrogen protects against beta-amyloid-induced neurotoxicity in rat hippocampal neurons by activation of Akt, Neuroreport, 12, 1919, 10.1097/00001756-200107030-00030
Honda, 2000, Phosphatidylinositol 3-kinase mediates neuroprotection by estrogen in cultured cortical neurons, J Neurosci Res, 60, 321, 10.1002/(SICI)1097-4547(20000501)60:3<321::AID-JNR6>3.0.CO;2-T
Honda, 2001, Nongenomic antiapoptotic signal transduction by estrogen in cultured cortical neurons, J Neurosci Res, 64, 466, 10.1002/jnr.1098
Simoncini, 2000, Interaction of oestrogen receptor with the regulatory subunit of phosphatidylinositol-3-OH kinase, Nature, 407, 538, 10.1038/35035131
Cardona-Gomez, 2003, Interactions of estrogen and insulin-like growth factor-I in the brain: molecular mechanisms and functional implications, J Steroid Biochem Mol Biol, 83, 211, 10.1016/S0960-0760(02)00261-3
Jover, 2002, Estrogen protects against global ischemia-induced neuronal death and prevents activation of apoptotic signalling cascades in the hippocampal CA1, J Neurosci, 22, 2115, 10.1523/JNEUROSCI.22-06-02115.2002
Rau, 2003, Estradiol attenuates programmed cell death after stroke-like injury, J Neurosci, 23, 11420, 10.1523/JNEUROSCI.23-36-11420.2003
Guo, 1998, Par-4 is a mediator of neuronal degeneration associated with the pathogenesis of Alzheimer disease, Nat Med, 4, 957, 10.1038/nm0898-957
Chan, 1999, Prostate apoptosis response-4 mediates trophic factor withdrawal-induced apoptosis of hippocampal neurons: actions prior to mitochondrial dysfunction and caspase activation, J Neurochem, 73, 502, 10.1046/j.1471-4159.1999.0730502.x
Duan, 1999, Prostate apoptosis response-4 production in synaptic compartments following apoptotic and excitotoxic insults: evidence for a pivotal role in mitochondrial dysfunction and neuronal degeneration, J Neurochem, 72, 2312, 10.1046/j.1471-4159.1999.0722312.x
Miranda, 1993, Neuronal colocalization of mRNAs for neurotrophins and their receptors in the developing central nervous system suggests a potential for autocrine interactions, Proc Natl Acad Sci USA, 90, 6439, 10.1073/pnas.90.14.6439
Toran-Allerand, 1999, Novel mechanisms of estrogen action in the brain: new players in an old story, Front Neuroendocrinol, 20, 97, 10.1006/frne.1999.0177
Gibbs, 1994, Effects of estrogen replacement on the relative levels of choline acetyltransferase, trkA, and nerve growth factor messenger RNAs in the basal forebrain and hippocampal formation of adult rats, Exp Neurol, 129, 70, 10.1006/exnr.1994.1148
Sohrabji, 1994, Reciprocal regulation of estrogen and NGF receptors by their ligands in PC12 cells, J Neurobiol, 25, 974, 10.1002/neu.480250807
Sohrabji, 1994, Estrogen differentially regulates estrogen and nerve growth factor receptor mRNAs in adult sensory neurons, J Neurosci, 14, 459, 10.1523/JNEUROSCI.14-02-00459.1994
McMillan, 1996, The effects of ovariectomy and estrogen replacement on trkA and choline acetyltransferase mRNA expression in the basal forebrain of the adult female Sprague–Dawley rat, J Neurosci, 16, 1860, 10.1523/JNEUROSCI.16-05-01860.1996
Murphy, 1998, Brain-derived neurotrophic factor mediates estradiol-induced dendritic spine formation in hippocampal neurons, Proc Natl Acad Sci USA, 95, 11412, 10.1073/pnas.95.19.11412
Jezierski, 2000, Region- and peptide-specific regulation of the neurotrophins by estrogen, Mol Brain Res, 85, 77, 10.1016/S0169-328X(00)00244-8
Scharfman, 2005, Similarities between actions of estrogen and BDNF in the hippocampus: coincidence or clue?, Trends Neurosci, 28, 79, 10.1016/j.tins.2004.12.005
Gibbs, 1999, Treatment with estrogen and progesterone affects relative levels of brain-derived neurotrophic factor mRNA and protein in different regions of the adult rat brain, Brain Res, 844, 20, 10.1016/S0006-8993(99)01880-6
Ivanova, 2001, Estrogen stimulates brain-derived neurotrophic factor expression in embryonic mouse midbrain neurons through a membrane-mediated and calcium-dependent mechanism, J Neurosci Res, 66, 221, 10.1002/jnr.1214
Sohrabji, 1995, Identification of a putative estrogen response element in the gene encoding brain-derived neurotrophic factor, Proc Natl Acad Sci USA, 92, 11110, 10.1073/pnas.92.24.11110
Toran-Allerand, 1996, Mechanisms of estrogen action during neural development: mediation by interactions with the neurotrophins and their receptors?, J Steroid Biochem Mol Biol, 56, 169, 10.1016/0960-0760(95)00234-0
Singh, 1999, Estrogen-induced activation of mitogen-activated protein kinase in cerebral cortical explants: convergence of estrogen and neurotrophin signalling pathways, J Neurosci, 19, 1179, 10.1523/JNEUROSCI.19-04-01179.1999
Jezierski, 2003, Estrogen enhances retrograde transport of brain-derived neurotrophic factor in the rodent forebrain, Endocrinology, 144, 5022, 10.1210/en.2003-0724
Gibbs, 1992, Effects of estrogen and fimbria/fornix transection on p75NGFR and ChAT expression in the medial septum and diagonal band of Broca, Exp Neurol, 116, 23, 10.1016/0014-4886(92)90173-N
Toran-Allerand, 1992, Estrogen receptors colocalize with low affinity nerve growth factor receptors in cholinergic neurons of the basal forebrain, Proc Natl Acad Sci USA, 89, 4668, 10.1073/pnas.89.10.4668
Gollapudi, 1999, Estrogen and NGF synergistically protect terminally differentiated ERα-transfected PC12 cells from apoptosis, J Neurosci Res, 56, 471, 10.1002/(SICI)1097-4547(19990601)56:5<471::AID-JNR3>3.0.CO;2-1
Toran-Allerand, 1988, Estrogen and insulin synergism in neurite growth enhancement in vitro: mediation of steroid effects by interactions with growth factors?, Brain Res, 469, 87, 10.1016/0165-3806(88)90172-1
Quesada, 2004, Estrogen interacts with the IGF-1 system to protect nigrostriatal dopamine and maintain motoric behaviour after 6-hydroxydopamine lesions, J Neurosci Res, 75, 107, 10.1002/jnr.10833
Fernandez-Galaz, 1997, Role of astroglia and insulin-like growth factor-I in gonadal hormone dependent synaptic plasticity, Brain Res Bull, 44, 525, 10.1016/S0361-9230(97)00238-4
Fernandez-Galaz, 1999, Phasic synaptic remodeling in the rat arcuate nucleus during the estrous cycle depends on insulin like growth factor-I receptor activation, J Neurosci Res, 55, 286, 10.1002/(SICI)1097-4547(19990201)55:3<286::AID-JNR3>3.0.CO;2-4
Cardona-Gómez, 2000, Insulin-like growth factor I receptors and estrogen receptors colocalize in female rat brain, Neuroscience, 99, 751, 10.1016/S0306-4522(00)00228-1
Cardona-Gomez, 2001, Interactions of estrogens and insulin-like growth factor-I in the brain: implications for neuroprotection, Brain Res Rev, 37, 320, 10.1016/S0165-0173(01)00137-0
Cheng, 1998, Bidirectional regulation of p38 kinase and c-Jun N-terminal protein kinase by insulin-like growth factor-I, J Biol Chem, 273, 14560, 10.1074/jbc.273.23.14560
Fernandez, 1999, Neuroprotective actions of peripherally administered insulin-like growth factor I in the injured olivo-cerebellar pathway, Eur J Neurosci, 11, 2019, 10.1046/j.1460-9568.1999.00623.x
Heck, 1999, Insulin-like growth factor-1-mediated neuroprotection against oxidative stress is associated with activation of nuclear factor kB, J Biol Chem, 274, 9828, 10.1074/jbc.274.14.9828
Shyamala, 1992, Activation of kappa B-specific proteins by estradiol, Proc Natl Acad Sci USA, 89, 10628, 10.1073/pnas.89.22.10628
Cerillo, 1998, The oestrogen receptor regulates NFkappaB and AP-1 activity in a cell-specific manner, J Steroid Biochem Mol Biol, 67, 79, 10.1016/S0960-0760(98)00078-8
Wen, 2004, Estrogen attenuates nuclear factor-kappa B activation induced by transient cerebral ischemia, Brain Res, 1008, 147, 10.1016/j.brainres.2004.02.019
Liao, 2002, Estrogen attenuates tumor necrosis factor-α expression to provide ischemic neuroprotection in female rats, Neurosci Lett, 330, 159, 10.1016/S0304-3940(02)00754-1
Ito, 2001, Estrogen treatment down-regulates TNF-alpha production and reduces the severity of experimental autoimmune encephalomyelitis cytokine knockout mice, J Immunol, 167, 542, 10.4049/jimmunol.167.1.542
Matejuk, 2001, 17Beta-estradiol inhibits cytokine, chemokine, and chemokine receptor mRNA expression in the central nervous system of female mice with experimental autoimmune encephalomyelitis, J Neurosci Res, 65, 529, 10.1002/jnr.1183
Rothwell, 1995, Cytokines in neurodegeneration and repair, Int J Dev Neurosci, 13, 179, 10.1016/0736-5748(95)00018-C
Rothwell, 1999, Cytokines—killers in the brain?, J Physiol, 514, 3, 10.1111/j.1469-7793.1999.003af.x
Plata-Salaman, 1992, Interleukin-1β depresses calcium currents in CA1 hippocampal neurons at pathophysiological concentrations, Brain Res Bull, 29, 221, 10.1016/0361-9230(92)90029-W
Zeise, 1992, Interleukin-1β increases synaptic inhibition in rat hippocampal pyramidal neurons in vitro, Regul Pept, 39, 1, 10.1016/0167-0115(92)90002-C
Miller, 1994, Interleukin-1 modulates GABAergic and glutamatergic function in brain, Ann N Y Acad Sci, 739, 292, 10.1111/j.1749-6632.1994.tb19831.x
Murray, 1997, Interleukin-1β inhibits glutamate release in hippocampus of young, but not aged, rats, Neurobiol Aging, 18, 343, 10.1016/S0197-4580(97)80317-X
Coogan, 1997, Inhibition of NMDA receptor-mediated synaptic transmission in the rat dentate gyrus in vitro by IL-1 beta, Neuroreport, 8, 2107, 10.1097/00001756-199707070-00004
Viviani, 2003, Interleukin-1β enhances NMDA receptor-mediated intracellular calcium increase through activation of the Src family of kinases, J Neurosci, 23, 8692, 10.1523/JNEUROSCI.23-25-08692.2003
Vegeto, 2003, Estrogen receptor-α mediates the brain antiinflammatory activity of estradiol, Proc Natl Acad Sci USA, 100, 9614, 10.1073/pnas.1531957100
Santizo, 2000, Effects of estrogen on leukocytes adhesion after transient forebrain ischemia, Stroke, 31, 2231, 10.1161/01.STR.31.9.2231
Bruce-Keller, 2000, Antiinflammatory effects of estrogen on microglial activation, Endocrinology, 141, 3646, 10.1210/en.141.10.3646
Vegeto, 2001, Estrogen prevents the lipopolysaccharide-induced inflammatory response in microglia, J Neurosci, 21, 1809, 10.1523/JNEUROSCI.21-06-01809.2001
Hurn, 2000, Estrogen as a neuroprotectant in stroke, J Cereb Blood Flow Metab, 20, 631, 10.1097/00004647-200004000-00001
Mendelsohn, 2002, Protective effects of estrogen on the cardiovascular system, Am J Cardiol, 89, 12E, 10.1016/S0002-9149(02)02405-0
Santizo, 1999, Estrogen reduces leukocyte adhesion in the cerebral circulation of female rats, J Cereb Blood Flow Metab, 19, 1061, 10.1097/00004647-199910000-00001
Hurn, 1995, Postischemic cerebral blood flow recovery in the female: effect of 17beta-estradiol, J Cereb Blood Flow Metab, 15, 666, 10.1038/jcbfm.1995.82
Pelligrino, 1998, Cerebral vasodilating capacity during forebrain ischemia: effects of chronic estrogen depletion and repletion and the role of neuronal nitric oxide synthase, Neuroreport, 9, 3285, 10.1097/00001756-199810050-00026
Alkayed, 2000, Neuroprotective effects of female gonadal steroids in reproductively senescent female rats, Stroke, 31, 161, 10.1161/01.STR.31.1.161
Fukada, 2000, Ovariectomy exacerbates and estrogen replacement attenuates phytothrombotic focal ischemic brain injury in rats, Stroke, 31, 155, 10.1161/01.STR.31.1.155
Dubal, 2001, Neuroprotective effects of estradiol in middle-aged female rats, Endocrinology, 142, 43, 10.1210/en.142.1.43
McNeill, 1999, Chronic estrogen treatment increases levels of endothelial nitric oxide synthase protein in rat cerebral microvessels, Stroke, 30, 2186, 10.1161/01.STR.30.10.2186
Kim, 1999, Nongenomic stimulation of nitric oxide release by estrogen is mediated by estrogen receptor α localized in caveolae, Biochem Biophys Res Commun, 263, 257, 10.1006/bbrc.1999.1348
Chen, 1999, Estrogen receptor α mediates the nongenomic activation of endothelial nitric oxide synthase by estrogen, J Clin Invest, 103, 401, 10.1172/JCI5347
Simoncini, 2002, Nongenomic mechanisms of endothelial nitric oxide synthase activation by the selective estrogen receptor modulator raloxifene, Circulation, 105, 1368, 10.1161/hc1102.105267
Bucci, 2002, 17β-Oestradiol-induced vasorelaxation in vitro is mediated by eNOS through hsp90 and akt/pkb dependent mechanism, Br J Pharmacol, 135, 1695, 10.1038/sj.bjp.0704641
Chambliss, 2002, Estrogen modulation of endothelial nitric oxide synthase, Endocr Rev, 23, 665, 10.1210/er.2001-0045
Samdani, 1997, Nitric oxide synthase in models of focal ischemia, Stroke, 28, 1283, 10.1161/01.STR.28.6.1283
Prorock, 2003, Vascular protection by estrogen in ischemia–reperfusion injury requires endothelial nitric oxide synthase, Am J Physiol Heart Circ Physiol, 284, 133, 10.1152/ajpheart.00957.2001
Endres, 2004, Targeting eNOS for stroke protection, Trends Neurosci, 27, 283, 10.1016/j.tins.2004.03.009
Weiner, 1994, Induction of calcium-dependent nitric oxide synthases by sex hormones, Proc Natl Acad Sci USA, 91, 5212, 10.1073/pnas.91.11.5212
Grohe, 2004, 17Beta-estradiol regulates nNOS and eNOS activity in the hippocampus, Neuroreport, 15, 89, 10.1097/00001756-200401190-00018
Xia, 2004, Estrogen induces nitric oxide production via activation of constitutive nitric oxide synthases in human neuroblastoma cells, Endocrinology, 145, 4550, 10.1210/en.2004-0327
Wen, 2004, nNOS is involved in estrogen mediated neuroprotection in neuroblastoma cells, Neuroreport, 15, 1515, 10.1097/01.wnr.0000131674.92694.96
Lee, 2003, 17Beta-estradiol activates ICI 182,780-sensitive estrogen receptors and cyclic GMP-dependent thioredoxin expression for neuroprotection, FASEB J, 17, 947, 10.1096/fj.02-0807fje
Behl, 1997, Neuroprotection against oxidative stress by estrogens: structure–activity relationship, Mol Pharmacol, 51, 535, 10.1124/mol.51.4.535
Culmsee, 1999, Neuroprotection by estrogens in a mouse model of focal cerebral ischemia and in cultured neurons: evidence for a receptor-independent antioxidative mechanism, J Cereb Blood Flow Metab, 19, 1263, 10.1097/00004647-199911000-00011
Biewenga, 2005, Estradiol and raloxifene protect cultured SN4741 neurons against oxidative stress, Neurosci Lett, 373, 179, 10.1016/j.neulet.2004.09.067
Gridley, 1997, Low concentrations of estradiol reduce β-amyloid (25–35)-induced toxicity, lipid peroxidation and glucose utilization in human SK-N-SH neuroblastoma cells, Brain Res, 778, 158, 10.1016/S0006-8993(97)01056-1
Keller, 1997, 17β-Estradiol attenuates oxidative impairment of synaptic Na+/K+-ATPase activity, glucose transport, and glutamate transport induced by amyloid beta-peptide and iron, J Neurosci Res, 50, 522, 10.1002/(SICI)1097-4547(19971115)50:4<522::AID-JNR3>3.0.CO;2-G
Sagara, 1998, Induction of reactive oxygen species in neurons by haloperidol, J Neurochem, 71, 1002, 10.1046/j.1471-4159.1998.71031002.x
Roth, 1999, Phytoestrogen kaempferol (3,4,5,7-tetrahydroxyflavone) protects PC12 and T47D cells from beta-amyloid-induced toxicity, J Neurosci Res, 57, 399, 10.1002/(SICI)1097-4547(19990801)57:3<399::AID-JNR12>3.0.CO;2-W
Ramirez, 1996, Membrane sex-steroid receptors in the brain, Front Neuroendocrinol, 17, 402, 10.1006/frne.1996.0011
Toran-Allerand, 2002, RE-X: a novel, plasma membrane-associated, putative estrogen receptor that is regulated during development after ischemic brain injury, J Neurosci, 22, 8391, 10.1523/JNEUROSCI.22-19-08391.2002
Bicknell, 1998, Sex-steroid actions on neurotransmission, Curr Opin Neurol, 11, 667, 10.1097/00019052-199812000-00010
Moss, 1999, Estrogen: mechanisms for a rapid action in CA1 hippocampal neurons, Steroids, 64, 14, 10.1016/S0039-128X(98)00092-0
Qiu, 2003, Rapid signaling of estrogen in hypothalamic neurons involves a novel G-protein-coupled estrogen receptor that activates protein kinase C, J Neurosci, 23, 9529, 10.1523/JNEUROSCI.23-29-09529.2003
Kajta, 2001, Effects of 17beta estradiol and estriol on NMDA-induced toxicity and apoptosis in primary cultures of rat cortical neurons, J Physiol Pharmacol, 52, 437
Kajta, 2004, Effects of estrone on N-methyl-d-aspartic acid- and staurosporine-induced changes in caspase-3-like protease activity and lactate dehydrogenase-release: time- and tissue-dependent effects in neuronal primary cultures, Neuroscience, 123, 515, 10.1016/j.neuroscience.2003.09.005
Weiland, 1992, Glutamic acid decarboxylase messenger ribonucleic acid is regulated by estradiol and progesterone in the hippocampus, Endocrinology, 131, 2697, 10.1210/en.131.6.2697
Woolley, 1997, Estradiol increases the sensitivity of hippocampal CA1 pyramidal cells to NMDA receptor-mediated synaptic input: correlation with dendritic spine density, J Neurosci, 17, 1848, 10.1523/JNEUROSCI.17-05-01848.1997
Saldanha, 2004, Presynaptic N-methyl-d-aspartate receptor expression is increased by estrogen in an aromatase-rich area of the songbird hippocampus, J Comp Neurol, 469, 522, 10.1002/cne.11035
Joëls, 1995, Effects of estradiol and progesterone on voltage-gated calcium and potassium conductances in rat CA1 hippocampal neurons, J Neurosci, 15, 4289, 10.1523/JNEUROSCI.15-06-04289.1995
Chen, 1999, Premarin regulates intracellular calcium concentrations in cultured rat hippocampal neurons, Soc Neurosci Abstr, 25, 2118
Nilsen, 2002, Dual action of estrogen on glutamate-induced calcium signalling: mechanisms requiring interaction between estrogen receptors and src/mitogen activated protein kinase pathway, Brain Res, 930, 216, 10.1016/S0006-8993(02)02254-0
Ba, 2004, The role of Ca2+ channel modulation in the neuroprotective actions of estrogen in β-amyloid protein and 1-methyl-4-phenyl-1,2,3,6-tretrahydropyridine (MPTP) cytotoxic model, Neurochem Int, 45, 31, 10.1016/j.neuint.2003.12.013
Zheng, 1999, Rapid inhibition of rat brain mitochondrial proton FoF1-ATPase activity by estrogens: comparison with Na+, K+-ATPase of porcine cortex, Eur J Pharmacol, 368, 95, 10.1016/S0014-2999(99)00012-6
Dicko, 1999, Effect of estradiol and tamoxifen on brain membranes: investigation by infrared and fluorescence spectroscopy, Brain Res Bull, 49, 401, 10.1016/S0361-9230(99)00066-0
Whiting, 2000, Steroid hormone-induced effects on membrane fluidity and their potential roles in non-genomic mechanisms, Life Sci, 67, 743, 10.1016/S0024-3205(00)00669-X
Ardelt, 2005, Estradiol regulates angiopoietin-1 mRNA expression through estrogen receptor-alpha in a rodent experimental stroke model, Stroke, 36, 337, 10.1161/01.STR.0000153795.38388.72
Srivastava, 1996, Apolipoprotein E gene expression in various tissues of mouse and regulation by estrogen, Biochem Mol Biol Int, 38, 91
Stone, 1997, Astrocytes and microglia respond to estrogen with increased apoE mRNA in vivo and in vitro, Exp Neurol, 143, 313, 10.1006/exnr.1996.6360
Struble, 2003, Regionally specific modulation of brain apolipoprotein E in the mouse during the estrous cycle and by exogenous 17beta estradiol, Exp Neurol, 183, 638, 10.1016/S0014-4886(03)00215-2
Levin-Allerhand, 2001, Brain region-specific up-regulation of mouse apolipoprotein E by pharmacological estrogen treatments, J Neurochem, 79, 796, 10.1046/j.1471-4159.2001.00627.x