Free radicals and antioxidants – quo vadis?

Trends in Pharmacological Sciences - Tập 32 Số 3 - Trang 125-130 - 2011
Barry Halliwell1
1Department of Biochemistry, National University of Singapore, 8 Medical Drive, Singapore 117597

Tóm tắt

Từ khóa


Tài liệu tham khảo

Halliwell, B. and Gutteridge, J.M.C. (2007) Free Radicals in Biology and Medicine (4th edn), Oxford University Press

Halliwell, 2006, Reactive species and antioxidants. Redox biology is a fundamental theme of aerobic life, Plant Physiol., 141, 312, 10.1104/pp.106.077073

Janssen-Heininger, 2008, Redox-based regulation of signal transduction: principles, pitfalls and promises, Free Radic. Biol. Med., 45, 1, 10.1016/j.freeradbiomed.2008.03.011

Lambeth, 2007, Nox enzymes, ROS, and chronic disease: an example of antagonistic pleiotropy, Free Radic. Biol. Med., 43, 332, 10.1016/j.freeradbiomed.2007.03.027

Huang, 2001, Genetic modification of prenatal lethality and dilated cardiomyopathy in Mn superoxide dismutase mutant mice, Free Radic. Biol. Med., 31, 1101, 10.1016/S0891-5849(01)00694-3

Kim, 2010, Enhanced expression of mitochondrial superoxide dismutase leads to prolonged in vivo cell cycle progression and up-regulation of mitochondrial thioredoxin, Free Radic. Biol. Med., 48, 1501, 10.1016/j.freeradbiomed.2010.02.028

Stowe, 2009, Mitochondrial reactive oxygen species production in excitable cells: modulators of mitochondrial and cell function, Antioxid. Redox Signal., 11, 1373, 10.1089/ars.2008.2331

Imlay, 2008, Cellular defenses against superoxide and hydrogen peroxide, Annu. Rev. Biochem., 77, 755, 10.1146/annurev.biochem.77.061606.161055

Hultqvist, 2009, The protective role of ROS in autoimmune disease, Trends Immunol., 30, 201, 10.1016/j.it.2009.03.004

Halliwell, 2006, Phagocyte-derived reactive species: salvation or suicide?, Trends Biochem. Sci., 31, 509, 10.1016/j.tibs.2006.07.005

Morgenstern, 1997, Absence of respiratory burst in X-linked chronic granulomatous disease mice leads to abnormalities in both host defense and inflammatory response to Aspergillus fumigatus, J. Exp. Med., 185, 207, 10.1084/jem.185.2.207

Finch, 2007

Woo, 2010, Inactivation of peroxiredoxin I by phosphorylation allows localized H2O2 accumulation for cell signaling, Cell, 140, 517, 10.1016/j.cell.2010.01.009

Ristow, 2009, Antioxidants prevent health-promoting effects of physical exercise in humans, Proc. Natl. Acad. Sci. U.S.A., 106, 8665, 10.1073/pnas.0903485106

Tang, 2002, Oxidant species trigger late preconditioning against myocardial stunning in conscious rabbits, Am. J. Physiol. Heart Circ. Physiol., 282, H281, 10.1152/ajpheart.2002.282.1.H281

Pagliaro, 2010, Cardioprotective pathways during reperfusion: focus on redox signaling and other modalities of cell signaling, Antioxid. Redox Signal.

Palomero, 2010, Redox regulation in skeletal muscle during contractile activity and aging, J. Anim. Sci., 88, 1307, 10.2527/jas.2009-2436

Halliwell, 2008, Are polyphenols antioxidants or pro-oxidants? What do we learn from cell culture and in vivo studies?, Arch. Biochem. Biophys., 476, 107, 10.1016/j.abb.2008.01.028

Jang, 2010, Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration, FASEB J., 24, 1376, 10.1096/fj.09-146308

Juntilla, 2009, AKT1 and AKT2 maintain hematopoietic stem cell function by regulating reactive oxygen species, Blood, 115, 4030, 10.1182/blood-2009-09-241000

Barranco-Medina, 2009, The oligomeric conformation of peroxiredoxins links redox state to function, FEBS Lett., 583, 1809, 10.1016/j.febslet.2009.05.029

Kaspar, 2009, Nrf2:INrf2 (Keap1) signaling in oxidative stress, Free Radic. Biol. Med., 47, 1304, 10.1016/j.freeradbiomed.2009.07.035

Leiser, 2010, Nrf2 signaling, a mechanism for cellular stress resistance in long-lived mice, Mol. Cell Biol., 30, 871, 10.1128/MCB.01145-09

Gems, 2009, Antioxidant defense and aging in C.elegans: is the oxidative damage theory of aging wrong?, Cell Cycle, 8, 1681, 10.4161/cc.8.11.8595

Pérez, 2009, Is the oxidative stress theory of aging dead?, Biochim. Biophys. Acta, 1790, 1005, 10.1016/j.bbagen.2009.06.003

Jang, 2009, The mitochondrial theory of aging: insight from transgenic and knockout mouse models, Exp. Gerontol., 44, 256, 10.1016/j.exger.2008.12.006

Halliwell, 2006, Oxidative stress and neurodegeneration; where are we now?, J. Neurochem., 97, 1634, 10.1111/j.1471-4159.2006.03907.x

Halliwell, 2009, The wanderings of a free radical, Free Radic. Biol. Med., 46, 531, 10.1016/j.freeradbiomed.2008.11.008

Halliwell, 2005, Health promotion by flavonoids, tocopherols, tocotrienols, and other phenols: direct or indirect effects? Antioxidant or not?, Am. J. Clin. Nutr., 81, 276S, 10.1093/ajcn/81.1.268S

Møller, 2002, Oxidative DNA damage in human white blood cells in dietary antioxidant intervention studies, Am. J. Clin. Nutr., 76, 303, 10.1093/ajcn/76.2.303

Loke, 2008, Pure dietary flavonoids quercetin and (−)-epicatechin augment nitric oxide products and reduce endothelin-1 acutely in healthy men, Am. J. Clin. Nutr., 88, 1018, 10.1093/ajcn/88.4.1018

Rytter, 2010, Biomarkers of oxidative stress in overweight men are not influenced by a combination of antioxidants, Free Radic. Res., 44, 522, 10.3109/10715761003647101

Meagher, 2001, Effects of vitamin E on lipid peroxidation in healthy persons, JAMA, 285, 1178, 10.1001/jama.285.9.1178

Jacob, 2003, Moderate antioxidant supplementation has no effect on biomarkers of oxidant damage in healthy men with low fruit and vegetable intakes, J. Nutr., 133, 740, 10.1093/jn/133.3.740

Bjelakovic, 2008, Systematic review: primary and secondary prevention of gastrointestinal cancers with antioxidant supplements, Aliment. Pharmacol. Ther., 28, 689, 10.1111/j.1365-2036.2008.03785.x

Xu, 2010, An international trial of antioxidants in the prevention of preeclampsia (INTAPP), Am. J. Obstet. Gynecol., 202, 10.1016/j.ajog.2010.01.050

Seet, 2010, Markers of oxidative damage are not elevated in otherwise healthy individuals with the metabolic syndrome, Diabetes Care, 33, 1140, 10.2337/dc09-2124

Mas, 2010, The omega-3 fatty acids EPA and DHA decrease plasma F2-isoprostanes: results from two placebo-controlled interventions, Free Radic. Res., 44, 983, 10.3109/10715762.2010.492830

Lehr, 1999, Do vitamin E supplements in diets for laboratory animals jeopardize findings in animal models of disease?, Free Radic. Biol. Med., 26, 472, 10.1016/S0891-5849(98)00219-6

Loke, 2010, Specific dietary polyphenols attenuate atherosclerosis in apolipoprotein E knockout mice by alleviating inflammation and endothelial dysfunction, Arterioscler. Thromb. Vasc. Biol., 30, 749, 10.1161/ATVBAHA.109.199687

Halliwell, 2001, Role of free radicals in the neurodegenerative diseases. Therapeutic implications for antioxidant treatment, Drugs & Aging, 18, 685, 10.2165/00002512-200118090-00004

Halliwell, 2007, Oxidative stress and cancer: have we moved forward?, Biochem. J., 401, 1, 10.1042/BJ20061131

Butterfield, 2010, Oxidative stress in Alzheimer disease: synergy between the Butterfield and Markesbery laboratories, Neuromolecular Med.

Cochemé, 2010, Can antioxidants be effective therapeutics?, Curr. Opin. Investig. Drugs, 11, 426

Day, 2009, Catalase and glutathione peroxidase mimics, Biochem. Pharmacol., 77, 285, 10.1016/j.bcp.2008.09.029

Batiníc-Haberle, 2010, Superoxide dismutase mimics: chemistry, pharmacology and therapeutic potential, Antioxid. Redox Signal., 13, 877, 10.1089/ars.2009.2876

Wanagat, 2010, Mitochondrial oxidative stress and mammalian healthspan, Mech. Ageing Dev., 131, 527, 10.1016/j.mad.2010.06.002

Anisimov, 2008, Mitochondria-targeted plastoquinone derivatives as tools to interrupt execution of the ageing program. 5. SkQ1 prolongs lifespan and prevents development of traits of senescence, Biochemistry (Mosc.), 73, 1329, 10.1134/S0006297908120055

Doughan, 2007, Mitochondrial redox cycling of mitoquinone leads to superoxide production and cellular apoptosis, Antioxid. Redox Signal., 9, 1825, 10.1089/ars.2007.1693

Halliwell, 2000, The gastrointestinal tract: a major site of antioxidant action?, Free Radic. Res., 33, 819, 10.1080/10715760000301341

Gorelik, 2008, The stomach as a ‘bioreactor’: when red meat meets red wine, J. Agric. Food Chem., 56, 5002, 10.1021/jf703700d

American Type Culture Collection Standards Development Organization Workgroup ASN-0002 (2010) Cell line misidentification: the beginning of the end. Nat. Rev. Cancer 10, 441–448

Long, 2010, Instability of, and generation of hydrogen peroxide by, phenolic compounds in cell culture media, Arch. Biochem. Biophys., 501, 162, 10.1016/j.abb.2010.06.012

Harman, 2009, About ‘origin and evolution of the free radical theory of aging: a brief personal history, 1954–2009’, Biogerontology, 10, 783, 10.1007/s10522-009-9253-z

Dai, 2009, Overexpression of catalase targeted to mitochondria attenuates murine cardiac aging, Circulation, 119, 2789, 10.1161/CIRCULATIONAHA.108.822403

Gruber, 2008, The mitochondrial free radical theory of ageing – where do we stand?, Front. Biosci., 13, 6554, 10.2741/3174

Rattan, 2009, Hormesis can and does work in humans, Dose Response, 8, 58, 10.2203/dose-response.09-041.Rattan

Pun, 2010, Ageing in nematodes: do antioxidants extend lifespan in Caenorhabditis elegans?, Biogerontology, 11, 17, 10.1007/s10522-009-9223-5

Lapointe, 2009, Reversal of the mitochondrial phenotype and slow development of oxidative biomarkers of aging in long-lived Mclk1+/− mice, J. Biol. Chem., 284, 20364, 10.1074/jbc.M109.006569

Dröge, 2007, Oxidative stress and aberrant signaling in aging and cognitive decline, Aging Cell, 6, 361, 10.1111/j.1474-9726.2007.00294.x

Bergeron, 2010, HO radicals induce an unexpected high proportion of tandem base lesions refractory to repair by DNA glycosylases, Proc. Natl. Acad. Sci. U.S.A., 107, 5528, 10.1073/pnas.1000193107

Johansson, 2010, An ECVAG trial on assessment of oxidative damage to DNA measured by the comet assay, Mutagenesis., 25, 125, 10.1093/mutage/gep055

Zainol, 2009, Introducing a true internal standard for the Comet assay to minimize intra- and inter-experiment variability in measures of DNA damage and repair, Nucleic Acids Res., 37, e150, 10.1093/nar/gkp826