Frailty Consensus: A Call to Action

Journal of the American Medical Directors Association - Tập 14 Số 6 - Trang 392-397 - 2013
John E. Morley1, Bruno Vellas2, Gabor Abellán van Kan2, Stefan D. Anker3, Jürgen M. Bauer4, Roberto Bernabei5, Matteo Cesari2, Wm. Cameron Chumlea6, Wolfram Doehner7, Jonathan P Evans8, Linda P. Fried9, Jack M. Guralnik10, Paul R. Katz11, Theodore K. Malmstrom1, Roger McCarter12, Luis Miguel Gutiérrez‐Robledo13, K Rockwood14, Stephan von Haehling15, Maurits Vandewoude16, Jeremy Walston17
1Division of Geriatric Medicine, Saint Louis University School of Medicine, St Louis, MO
2INSERM UMR 1027, Univerisité de Toulouse III Paul Sabatier, Toulouse, France
3Applied Cachexia Research, Department of Cardiology, Charité Medical School, Berlin, Germany
4Geriatrics Centre, Carl von Ossietzky University, Oldenberg, Germany; Institute for Biomedicine of Ageing, Friedrich-Alexander University, Erlangen-Nuremberg, Germany
5Department of Geriatrics, Neurosciences and Orthopaedics, Catholic University of Sacred Heart, Rome, Italy
6Department of Community Health, Lifespan Health Research Center, Wright State University, Boonshoft School of Medicine, Dayton, OH
7Centre for Stroke Research Berlin, Charité-Universitätsmedizin Berlin, Germany
8President, American Medical Directors Association (AMDA)
9Joseph L. Mailman School of Public Health and College of Physicians and Surgeons, Columbia University, New York, NY
10Department of Epidemiology & Public Health, School of Medicine, University of Maryland, Baltimore, MD
11Baycrest Health Science Center and University of Toronto, Toronto, Ontario, Canada
12Biobehavioral Health, The Pennsylvania State University, University Park, PA.
13Instituto Nacional de Geriatria, Institutos Nacionales de Salud de Mexico, Mexico City, Mexico
14Geriatric Medicine, Dalhousie University, Halifax, Nova Scotia, Canada
15Applied Cachexia Research, Department of Cardiology, Charite Universitätsmedizin Berlin, Germany.
16Department of Geriatrics, ZNA St. Elizabeth Hospital, University of Antwerp, Antwerp, Belgium.
17Division of Geriatric Medicine and Gerontology, Johns Hopkins University, Baltimore, Md

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Walston, 2006, Research agenda for frailty in older adults: Toward a better understanding of physiology and etiology: Summary from the American Geriatrics Society/National Institute on Aging Research Conference on Frailty in Older Adults, J Am Geriatr Soc, 54, 991, 10.1111/j.1532-5415.2006.00745.x

Cerreta, 2012, Drug policy for an aging population—the European Medicines Agency's geriatric medicines strategy, N Engl J Med, 367, 1972, 10.1056/NEJMp1209034

Available at: http://ec.europa.eu/economy_finance/publications/european_economy/2012/pdf/ee-2012-2_en.pdf. Accessed April 22, 2013.

Rockwood, 2011, Frailty defined by deficit accumulation and geriatric medicine defined by frailty, Clin Geriatr Med, 27, 17, 10.1016/j.cger.2010.08.008

Fried, 2004, Untangling the concepts of disability, frailty, and comorbidity: Implications for improved targeting and care, J Gerontol A Biol Sci Med Sci, 59, 255, 10.1093/gerona/59.3.M255

Sourial, 2012, Contribution of frailty markers in explaining differences among individuals in five samples of older persons, J Gerontol A Biol Sci Med Sci, 67, 1197, 10.1093/gerona/gls084

Collard, 2012, Prevalence of frailty in community-dwelling older persons: A systematic review, J Am Geriatr Soc, 60, 1487, 10.1111/j.1532-5415.2012.04054.x

Rodríguez-Mañas, 2013, Searching for an operational definition of frailty: A Delphi method based consensus statement. The Frailty Operative Definition-Consensus Conference Project, J Gerontol A Biol Sci Med Sci, 68, 62, 10.1093/gerona/gls119

Rockwood, 2005, What would make a definition of frailty successful?, Age Ageing, 34, 432, 10.1093/ageing/afi146

Fried, 2001, Cardiovascular Health Study Collaborative Research Group. Frailty in older adults: Evidence for a phenotype, J Gerontol A Biol Sci Med Sci, 56, M146, 10.1093/gerona/56.3.M146

Bandeen-Roche, 2006, Phenotype of frailty: Characterization in the women's health and aging studies, J Gerontol A Biol Sci Med Sci, 61, 262, 10.1093/gerona/61.3.262

Ensrud, 2008, Comparison of 2 frailty indexes for prediction of falls, disability, fractures, and death in older women, Arch Intern Med, 168, 382, 10.1001/archinternmed.2007.113

Kiely, 2009, Validation and comparison of two frailty indexes: The MOBILIZE Boston Study, J Am Geriatr Soc, 57, 1532, 10.1111/j.1532-5415.2009.02394.x

Rockwood, 2007, How should we grade frailty in nursing home patients?, J Am Med Dir Assoc, 8, 595, 10.1016/j.jamda.2007.07.012

Rockwood, 2006, Long-term risks of death and institutionalization of elderly people in relation to deficit accumulation at age 70, J Am Geriatr Soc, 54, 975, 10.1111/j.1532-5415.2006.00738.x

Abellan van Kan, 2008, Frailty: Toward a clinical definition, J Am Med Dir Assoc, 9, 71, 10.1016/j.jamda.2007.11.005

Abellan van Kan, 2008, The I.A.N.A. Task Force on Frailty assessment of older people in clinical practice, J Nutr Health Aging, 12, 29, 10.1007/BF02982161

Romero-Ortuno, 2011, The Frailty Instrument of the Survey of Health, Ageing and Retirement in Europe (SHARE-FI) predicts mortality beyond age, comorbidities, disability, self-rated health, education and depression, Eur Geriatr Med, 2, 323, 10.1016/j.eurger.2011.08.005

Romero-Ortuno, 2010, A frailty instrument for primary care: Findings from the Survey of Health, Ageing and Retirement in Europe (SHARE), BMC Geriatr, 10, 57, 10.1186/1471-2318-10-57

Min, 2006, Higher vulnerable elders survey scores predict death and functional decline in vulnerable older people, J Am Geriatr Soc, 54, 507, 10.1111/j.1532-5415.2005.00615.x

Min, 2009, The vulnerable elders-13 survey predicts 5-year functional decline and mortality outcomes in older ambulatory care patients, J Am Geriatr Soc, 57, 2070, 10.1111/j.1532-5415.2009.02497.x

Biganzoli, 2013, Evaluation of the cardiovascular health study (CHS) instrument and the Vulnerable Elders Survey-13 (VES-13) in elderly cancer patients. Are we still missing the right screening tool?, Ann Oncol, 24, 494, 10.1093/annonc/mds331

Gobbens, 2010, The Tilberg Frailty Indicator: Psychometric properties, J Am Med Dir Assoc, 11, 344, 10.1016/j.jamda.2009.11.003

Gobbens, 2010, Determinants of frailty, J Am Med Dir Assoc, 11, 356, 10.1016/j.jamda.2009.11.008

Peters, 2012, Measurement properties of the Groningen Frailty Indicator in home-dwelling and institutionalized elderly people, J Am Med Dir Assoc, 13, 546, 10.1016/j.jamda.2012.04.007

Hoogendijk, 2012, Investigating measurement properties of the Groningen Frailty Indicator: A more systematic approach is needed, J Am Med Dir Assoc, 13, 757, 10.1016/j.jamda.2012.06.008

Morley, 2011, Sarcopenia with limited mobility: An international consensus, J Am Med Dir Assoc, 12, 403, 10.1016/j.jamda.2011.04.014

Fielding, 2011, Sarcopenia: An undiagnosed condition in older adults. Current consensus definition: Prevalence, etiology, and consequences. International Working Group on Sarcopenia, J Am Med Dir Assoc, 12, 249, 10.1016/j.jamda.2011.01.003

Muscaritoli, 2010, Consensus definition of sarcopenia, cachexia and pre-cachexia: Joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting disease” and “nutrition in Geriatrics.”, Clin Nutr, 29, 154, 10.1016/j.clnu.2009.12.004

Cruz-Jentoft, 2010, Sarcopenia: European consensus on definition and diagnosis: Report of the European Working Group on Sarcopenia in Older People, Age Ageing, 39, 412, 10.1093/ageing/afq034

Von Haehling, 2012, From muscle wasting to sarcopenia and myopenia: Update 2012, J Cachexia Sarcopenia Muscle, 3, 213, 10.1007/s13539-012-0089-z

Morley, 2009, Developing novel therapeutic approaches to frailty, Curr Pharm Des, 15, 3384, 10.2174/138161209789105045

Lacas, 2012, Frailty in primary care: A review of its conceptualization and implications for practice, BMC Med, 10, 4, 10.1186/1741-7015-10-4

Pialoux, 2012, Screening tools for frailty in primary health care: A systematic review, Geriatr Gerontol Int, 12, 189, 10.1111/j.1447-0594.2011.00797.x

Sternberg, 2011, The identification of frailty: A systematic literature review, J Am Geriatr Soc, 59, 2129, 10.1111/j.1532-5415.2011.03597.x

Hubbard, 2011, Frailty in older women, Maturitas, 69, 203, 10.1016/j.maturitas.2011.04.006

Pijpers, 2012, The frailty dilemma. Review of the predictive accuracy of major frailty scores, Eur J Intern Med, 23, 118, 10.1016/j.ejim.2011.09.003

Morley, 2011, Frailty: Diagnosis and management, J Nutr Health Aging, 15, 667, 10.1007/s12603-011-0338-4

Shamliyan, 2012, Association of frailty with survival: A systematic literature review, Ageing Res Rev

Tinetti, 2012, Designing health care for the most common chronic condition—multimorbidity, JAMA, 307, 2493, 10.1001/jama.2012.5265

Rockwood, 2005, A global clinical measure of fitness and frailty in elderly people, CMAJ, 173, 489, 10.1503/cmaj.050051

Royal College of Physicians. Acute Care Toolkit 3: Acute Medical Care for Frail Older people. March 2012. Available at: http://www.rcplondon.ac.uk/sites/default/files/acute-care-toolkit-3.pdf. Accessed December 20, 2012.

Rolland, 2011, Frailty in older population: A brief position paper from the French society of geriatrics and gerontology, Geriatr Psychol Neuropsychiatr Vieil, 9, 387

Hyde, 2010, Low free testosterone predicts frailty in older men: The Health in Men study, J Clin Endocrinol Metab, 95, 3165, 10.1210/jc.2009-2754

Lopez, 2012, Validation of the frail scale in a cohort of older Australian women, J Am Geriatr Soc, 60, 171, 10.1111/j.1532-5415.2011.03746.x

Morley, 2012, A simple frailty questionnaire (FRAIL) predicts outcomes in middle aged African Americans, J Nutr Health Aging, 16, 601, 10.1007/s12603-012-0084-2

Woo, 2012, Comparison of frailty indicators based on clinical phenotype and the multiple deficit approach in predicting mortality and physical limitation, J Am Geriatr Soc, 60, 1478, 10.1111/j.1532-5415.2012.04074.x

Subra, 2012, The integration of frailty into clinical practice: Preliminary results from the Gérontopôle, J Nutr Health Aging, 16, 714, 10.1007/s12603-012-0391-7

Singh, 2012, Effects of high-intensity progressive resistance training and targeted multidisciplinary treatment of frailty on mortality and nursing home admissions after hip fracture: A randomized controlled trial, J Am Med Dir Assoc, 13, 24, 10.1016/j.jamda.2011.08.005

Yamada, 2012, Community-based exercise program is cost-effective by preventing care and disability in Japanese frail older adults, J Am Med Dir Assoc, 13, 507, 10.1016/j.jamda.2012.04.001

Theou, 2011, The effectiveness of exercise interventions for the management of frailty: A systematic review, J Aging Res, 2011, 569194

Gillespie, 2012, Interventions for preventing falls in older people living in the community, Cochrane Database Syst Rev, CD007146

Landi, 2010, The anorexia of aging: Is it a geriatric syndrome?, J Am Med Dir Assoc, 11, 153, 10.1016/j.jamda.2009.09.003

Morley, 2011, Undernutrition: A major problem in nursing homes, J Am Med Dir Assoc, 12, 243, 10.1016/j.jamda.2011.02.013

Morley, 2007, Weight loss in older persons: New therapeutic approaches, Curr Pharm Des, 13, 3637, 10.2174/138161207782794149

Milne, 2009, Protein and energy supplementation in elderly people at risk from malnutrition, Cochrane Database Syst Rev, CD003288

van Wetering, 2010, Efficacy and costs of nutritional rehabilitation in muscle-wasted patients with chronic obstructive pulmonary disease in a community-based setting: A prespecified subgroup analysis of the INTERCOM trial, J Am Med Dir Assoc, 11, 179, 10.1016/j.jamda.2009.12.083

Neelemat, 2011, Post-discharge nutritional support in malnourished elderly individuals improves functional limitations, J Am Med Dir Assoc, 12, 295, 10.1016/j.jamda.2010.12.005

Morley, 2010, Nutritional recommendations for the management of sarcopenia, J Am Med Dir Assoc, 11, 391, 10.1016/j.jamda.2010.04.014

Tieland, 2012, Protein supplementation improves physical performance in frail elderly people: A randomized, double-blind, placebo-controlled trial, J Am Med Dir Assoc, 13, 720, 10.1016/j.jamda.2012.07.005

Volpi, 2012, Is the optimal level of protein intake for older adults greater than the recommended dietary allowance?, J Gerontol A Biol Sci Med Sci

Paddon-Jones, 2013, Perspective: Exercise and protein supplementation in frail elders, J Am Med Dir Assoc, 14, 73, 10.1016/j.jamda.2012.09.028

Malafarina, 2013, Effectiveness of nutritional supplementation on muscle mass in treatment of sarcopenia in old age: A systematic review, J Am Med Dir Assoc, 14, 10, 10.1016/j.jamda.2012.08.001

Tieland, 2012, Protein supplementation increases muscle mass gain during prolonged resistance-type exercise training in frail elderly people: A randomized, double-blind, placebo-controlled trial, J Am Med Dir Assoc, 13, 713, 10.1016/j.jamda.2012.05.020

Morley, 2012, Do frail older persons need more protein?, J Am Med Dir Assoc, 13, 667, 10.1016/j.jamda.2012.07.014

Cawood, 2012, Systematic review and meta-analysis of the effects of high protein oral nutritional supplements, Ageing Res Rev, 11, 278, 10.1016/j.arr.2011.12.008

Waters, 2013, Long-term maintenance of weight loss after lifestyle intervention in frail, obese older adults, J Nutr Health Aging, 17, 3, 10.1007/s12603-012-0421-5

Murad, 2011, Clinical review: The effect of vitamin D on falls: A systematic review and meta-analysis, J Clin Endocrinol Metab, 96, 2997, 10.1210/jc.2011-1193

Bischoff-Ferrari, 2012, A pooled analysis of vitamin D dose requirements for fracture prevention, N Engl J Med, 567, 40, 10.1056/NEJMoa1109617

Rejnmark, 2012, Vitamin D with calcium reduces mortality: Patient level pooled analysis of 70,528 patients from eight major vitamin D trials, J Clin Endocrinol Metab, 97, 2670, 10.1210/jc.2011-3328

Muir, 2011, Effect of vitamin D supplementation on muscle strength, gait and balance in older adults: A systematic review and meta-analysis, J Am Geriatr Soc, 59, 2291, 10.1111/j.1532-5415.2011.03733.x

Rolland, 2011, Current and future pharmacologic treatment of sarcopenia, Clin Geriatr Med, 27, 423, 10.1016/j.cger.2011.03.008

Sukuma, 2010, Molecular mechanisms in aging and current strategies to counteract sarcopenia, Curr Aging Sci, 3, 90, 10.2174/1874609811003020090

Gnjidic, 2012, Polypharmacy cutoff and outcomes: Five or more medicines were used to identify community-dwelling older men at risk of different adverse outcomes, J Clin Epidemiol, 65, 989, 10.1016/j.jclinepi.2012.02.018

Flaherty, 2000, Polypharmacy and hospitalization among older home care patients, J Gerontol A Biol Sci Med Sci, 55, M554, 10.1093/gerona/55.10.M554

Rockwood, 1997, Medical management of frailty: Confessions of a gnostic, CMAJ, 157, 1081

Bronskill, 2012, Exploring variation in rates of polypharmacy across long term care homes, J Am Med Dir Assoc, 13, 309.e15, 10.1016/j.jamda.2011.07.001

Gokce Kutsal, 2009, Polypharmacy in the elderly: A multicenter study, J Am Med Dir Assoc, 10, 486, 10.1016/j.jamda.2009.03.018

Kojima, 2012, Reducing cost by reducing polypharmacy: The polypharmacy outcomes project, J Am Med Dir Assoc, 13, 818.e11, 10.1016/j.jamda.2012.07.019

Fitzgerald, 2010, An analysis of the interactions between individual comorbidities and their treatments—implications for guidelines and polypharmacy, J Am Med Dir Assoc, 11, 475, 10.1016/j.jamda.2010.05.008

Tamura, 2011, Physician intervention for medication reduction in a nursing home: The polypharmacy outcomes project, J Am Med Dir Assoc, 12, 326, 10.1016/j.jamda.2010.08.013

Morley, 2009, Polypharmacy in the nursing home, J Am Med Dir Assoc, 10, 289, 10.1016/j.jamda.2009.03.011

Merle, 2006, Predicting and preventing adverse drug reactions in the very old, Drugs Aging, 22, 375, 10.2165/00002512-200522050-00003

Resnick, 2012, 2012 Beers Criteria, J Am Geriatr Soc, 60, 612, 10.1111/j.1532-5415.2012.03921.x

Gallagher, 2008, STOPP (Screening Tool of Older Person's Prescription) and START (Screening Tool to Alert doctors to Right Treatment). Consensus validation, Int J Clin Pharmacol Ther, 46, 72, 10.5414/CPP46072

Pyszka, 2010, Identification of inappropriate prescribing in geriatrics at a Veterans Affairs hospital using STOPP/START screening tools, Consult Pharm, 25, 365, 10.4140/TCP.n.2010.365

Theou, 2012, Should frailty status always be considered when treating the elderly patient?, Aging Health, 8, 261, 10.2217/ahe.12.8

Espinoza, 2005, Frailty in older adults: Insights and interventions, Cleve Clin J Med, 72, 1105, 10.3949/ccjm.72.12.1105

Vellas, 2012, Implementing frailty into clinical practice: We cannot wait, J Nutr Health Aging, 16, 599, 10.1007/s12603-012-0096-y

Ogawa, 2011, [The validity of the “Kihon Checklist” as an index of frailty and its biomarkers and inflammatory markers in elderly people.], Nihon Ronen Igakkai Zasshi, 48, 545, 10.3143/geriatrics.48.545

Tomata, 2011, [Validation of the Kihon Checklist for predicting the risk of 1-year incident long term care insurance certification: The Ohsaki Cohort 2006 Study.], Nihon Koshu Eisei Zasshi, 58, 3

Fukutomi, 2012, Importance of cognitive assessment as part of the “Kihon Checklist” developed by the Japanese Ministry of Health, Labor and Welfare for prediction of frailty at a 2-year follow up, Geriatr Gerontol Int

Afilalo, 2011, Frailty in patients with cardiovascular disease: Why, when and how to measure, Curr Cardiovasc Risk Rep, 5, 467, 10.1007/s12170-011-0186-0

Ruiz, 2012, Management of elderly and frail elderly patients: The importance of comprehensive geriatrics assessment and the need for guidelines, Am J Med Sci

Shilpak, 2004, The presence of frailty in elderly persons with chronic renal insufficiency, Am J Kidney Dis, 43, 861, 10.1053/j.ajkd.2003.12.049

Desquilbet, 2007, HIV-1 infection is associated with an earlier occurrence of a phenotype related to frailty, J Gerontol A Biol Sci Med Sci, 62, 1279, 10.1093/gerona/62.11.1279

Sinclair, 2012, Diabetes mellitus in older people: Position statement on behalf of the International Association of Gerontology and Geriatrics (IAGG), the European Diabetes Working Party for Older People (EDWPOP), and the International Task Force of Experts in Diabetes, J Am Med Dir Assoc, 13, 497, 10.1016/j.jamda.2012.04.012

Partridge, 2012, Frailty in the older surgical patient: A review, Age Ageing, 41, 142, 10.1093/ageing/afr182