Fractional Photothermolysis: A New Concept for Cutaneous Remodeling Using Microscopic Patterns of Thermal Injury

Lasers in Surgery and Medicine - Tập 34 Số 5 - Trang 426-438 - 2004
Dieter Manstein1, G. Scott Herron2, R. K. Sink2, Heather Tanner2, R. R. Anderson1
1Wellman Laboratories of Photomedicine, Department of Dermatology, Harvard Medical School, Boston, Massachusetts 02114
2Reliant Technologies, Palo Alto, California 94306

Tóm tắt

AbstractBackground and ObjectivesWe introduce and clinically examine a new concept of skin treatment called fractional photothermolysis (FP), achieved by applying an array of microscopic treatment zones (MTZ) of thermal injury to the skin.Study Design/Materials and MethodsTwo prototype devices emitting at 1.5 μm wavelength provided a pattern of micro‐exposures with variable MTZ density. Effects of different MTZ densities were tested on the forearms of 15 subjects. Clinical effects and histology were assessed up to 3 months after exposure. Treatment of photoaged skin on the periorbital area in an additional 30 subjects receiving four treatments over a period of 2–3 weeks was also tested. Tissue shrinkage and clinical effects were assessed up to 3 months after treatment.ResultsPattern densities with spacing of 250 μm or more were well tolerated. Typical MTZ had a diameter of 100 μm and penetrated 300 μm into the skin. Reepithelialization was complete within 1 day. Clinical effects were assessed over a 3‐month period. Histology at 3 months revealed enhanced undulating rete ridges and increased mucin deposition within the superficial dermis. Periorbital treatments were well tolerated with minimal erythema and edema. Linear shrinkage of 2.1% was measured 3 months after the last treatment. The wrinkle score improved 18% (P<0.001) 3 months after the last treatment.ConclusionsFP is a new concept for skin restoration treatment. Safety and efficacy were demonstrated with a prototype device. Further clinical studies are necessary to refine the optimum parameters and to explore further dermatological applications. Lasers Surg. Med. 34:426–438, 2004. © 2004 Wiley‐Liss, Inc.

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Lasers in Surgery and Medicine

Tập 34 Số 5

426-438

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