Four-year clinical evaluation of quinacrine pellets for non-surgical female sterilization
Tóm tắt
The aim of this study was to evaluate the efficacy, safety and acceptability of two monthly transcervical applications of quinacrine 252 mg and ibuprofen 55.5 mg as pellets for non-surgical female sterilization. From August 1992 through October 1996, a prospective clinical study was conducted on 200 normal women seeking surgical sterilization voluntarily in the Family Planning Clinic of the Department of Obstetrics and Gynecology, Regency Hospital, Wonosobo, Central Java, Indonesia. Quinacrine 252 mg and ibuprofen 55.5 mg were inserted transcervically, as pellets, using a Copper T IUD insertor in the proliferative phase of two consecutive menstrual cycles. The women were followed up 6, 12, 24 and 48 months after insertion. There were no major complications during the insertion procedures, and side-effects which occurred during the us e of the methods were transient. Cumulative life-table continuation rate per 100 women at four years was 0.91±0.02 (SE). The pregnancy fail ure rate was 0.04 or 4.3%. The results of this study indicate that intrauterine insertion of quinacrine pellets is a safe, acceptable and effective method of non-surgical female sterilization.
Tài liệu tham khảo
Zipper J, Cole LP, Goldsmith A, Wheeler R, Rivera M. Quinacrine hydrochloride pellets: preliminary data on a nonsurgical method of female sterilization. Int J Gynaecol Obstet. 1980;18:275-9.
Kessel E, Mumford SD. Potential demand for voluntary female sterilization in the 1980s: The compelling need for a nonsurgical method. Fertil Steril. 1982;37:725-33.
Kessel E. Prospects for nonsurgical female sterilization. Int J Gynaecol Obstet. 1989;29:1-4.
Kessel E, Zipper J, Mumford SD. Introduction. The quinacrine pellet method for nonsurgical female sterilization, a collection of background materials. Center for Research on Population and Security, Research Triangle Park, North Carolina, USA. 1990:1-11.
Klitsch M. Sterilization without surgery, Int Fam Perspect. 1982;8:101-4.
Kang XP, Wan HZ, Wang P, Wang SX, Chow LP. Effectiveness of phenol atebrine-paste (PAP) instillation for nonsurgical female sterilization. Int J Gynaecol Obstet. 1990;33:49-57.
Bhatt R, Waszak CS. Four year follow-up insertion of quinacrine hydrochloride pellets as a means of nonsurgical female sterilization. Fertil Steril. 1985;44:49-57.
Zipper J, Medel R, Goldsmith A, Edelman D, Pastene L, Rivera M. The clinical efficacy of the repeated transcervical instillation of quinacrine for female sterilization. Int J Gynaecol Obstet. 1976;14:499-502.
Laufe LE, Cole LP. Nonsurgical female sterilization. Int J Gynaecol Obstet. 1980;18:333-9.
Mehtaji S, Jadwani K, Goyal V. Chemical sterilization with quinacrine. In: Pachauri S, ed. Fourth Transaction of Scientific Papers of the India FRP Contributors Conference, India Fertility Research Programme. 1977:167-70.
Zipper J, Stacchetti E, Medel M. Human fertility control by transvaginal chemical sterilization: clinical use of quinacrine on the fallopian tube. Fertil Steril. 1970;21:581-9.
Zipper J, Stacchetti E, Medel M. Transvaginal chemical sterilization: clinical use of quinacrine plus potentiating adjuvants. Contraception. 1975;12:11-21.
Mathews DE, Farewell VT. Kaplan-Meier Actuarial Survival Curves. In: Using and Understanding Medical Statistics. Basel, New York: Karger; 1985:67-75.
Zipper J, Rivera M, Cole LP, Brown E, Wheeler RG. Efficacy of two insertions of 100 minute releasing quinacrine hydrochloride pellets for nonsurgical female sterilization. Adv Contracept. 1987;3:255-61.
Suhadi A, Soejoenoes A. One year experience using quinacrine pellets for nonsurgical female sterilization. Indonesian J Obstet Gynecol. 1996;20(1):39-43.
Zipper J, Edelman D, Cole LP, Rivera M. Overview of quinacrine pellets for nonsurgical female sterilization. In: Zatuchni GI, Shelton JD, Goldsmith A, Sciarra JJ, eds. Female Transcervical Sterilization. Philadelphia: Harper and Row; 1983:172.
Hieu DT, Tan TT, Tan DN, Nguyet PT, Vinh DQ. 31781 cases of nonsurgical female sterilization with quinacrine pellets in Vietnam. Lancet. 1983;342:213-17.
Sokal DC, Zipper J, King T. Quinacrine: Clinical Experience. Background paper for theWorld Health Organization Consultation on the development of new technologies for female sterilization. Geneva: WHO; 1994:25-7.
Sokal DC, Zipper J, King T. Transcervical quinacrine sterilization: clinical experience. Int J Gynecol Obstet. 1995;51(Suppl):556-69.
Mullick BC, Kessel E, Mumford SD. A potential single insertion protocol for quinacrine pellet non-surgical female sterilization. Adv Contracept. 1995;11:239-44.
Zipper J, Prager R, Medel M. Biologic changes induced by unilateral intrauterine instillation of quinacrine in the rat and their reversal by either estradiol or progesterone. Fertil Steril. 1973;24:48-52.
Kessel E. 100 000 quinacrine sterilizations. Adv Contracept. 1996;12:69-76.
Central Bureau of Statistics (CBS) [Indonesia] and State Ministry of Population/National Family Planning Coordinating Board (NFPCB) and Ministry of Health (MOH) and Macro International Inc. (MI). Indonesian Demographic and Health Survey 1994. Calverton, Maryland: CBS and MI; 1995:73.
Central Bureau of Statistics (CBS) [Indonesia] and State Ministry of Population/National Family Planning Coordinating Board (NFPCB) and Ministry of Health (MOH) and Macro International Inc. (MI). Indonesian Demographic and Health Survey 1994. Calverton, Maryland: CBS and MI; 1995:211.
Mullick B, Mumford SD, Kessel E. Studies of quinacrine and of tetracycline for nonsurgical female sterilization. Adv Contracept. 1987;3:245-254.
El Kady AA, Nagib HS, Kessel E. Efficacy and safety of repeated transcervical quinacrine pellet insertions for female sterilization. Fertil Steril. 1993;59:301-304.
Merchant RN, Doctor VM, Thaku SS et al. Clinico pathological study of fallopian tube after transcervical insertion of quinacrine hydrochloride pellets. Adv Contracept. 1986;2:79-90.
Bashir A. Quinacrine nonsurgical female sterilization. Adv Contracept Deliv Syst. 1993;9:37-42.
Bashir A, Muhammad M, Muhammad AC, Muhammad YC. Non-surgical female sterilization: 3 years experience with quinacrine. Seminar on Quinacrine for Non-surgical Female Sterilization, Karachi, 1994.