Four-Hydroxynonenal, a Product of Lipid Peroxidation, is Increased in the Brain in Alzheimer’s Disease

Blanc, 1997, 4-Hydroxynonenal, an aldehydic product of lipid peroxidation, impairs signal transduction associated with muscarinic acetylcholine and metabotropic glutamate receptors, J. Neurochem., 69, 570, 10.1046/j.1471-4159.1997.69020570.x

Bruce-Keller, A. D.; Li, Y.-J.; Lovell, M. A.; Kraemer, P. J.; Gary, D. S.; Brown, R. R.; Markesbery, W. R.; Mattson, M. P. 4-Hydroxynonenal, a product of lipid peroxidation, damages cholinergic neurons and impairs visuospatial memory in rats. J. Neuropathol. Exp. Neurol. In press; 1998.

Ehmann, 1986, Brain trace elements in Alzheimer’s disease, Neurotoxicology, 7, 197

Esterbauer, 1991, Chemistry and biochemistry of 4-hydroxynonenal, malondialdehyde and related aldehydes, Free Radic. Biol. Med., 11, 81, 10.1016/0891-5849(91)90192-6

Francis, 1994, Neurotransmitters and neuropeptides, 247

Geula, 1994, Cholinergic systems and related neuropathological predilection patterns in Alzheimer disease, 263

Good, 1992, Selective accumulation of aluminum and iron in the neurofibrillary tangles of Alzheimer’s disease, Ann. Neurol., 31, 286, 10.1002/ana.410310310

Good, 1996, Evidence for neuronal oxidative damage in Alzheimer’s disease, Am. J. Pathol., 149, 21

Hensley, 1995, Brain regional correspondence between Alzheimer’s disease histopathology and biomarkers of protein oxidation, J. Neurochem., 65, 2146, 10.1046/j.1471-4159.1995.65052146.x

Keller, 1997, Impairment of glucose and glutamate transport and induction of mitochondrial oxidative stress and dysfunction in synaptosomes by amyloid β-peptide, J. Neurochem., 69, 273, 10.1046/j.1471-4159.1997.69010273.x

Khachaturian, 1985, Diagnosis of Alzheimer’s disease, Arch. Neurol., 42, 1097, 10.1001/archneur.1985.04060100083029

Kruman, 1997, Evidence that 4-hydroxynonenal mediates oxidative stress-induced neuronal apoptosis, J. Neurosci., 17, 5089, 10.1523/JNEUROSCI.17-13-05089.1997

Lowry, 1951, Protein measurement with the Folin phenol reagent, J. Biol. Chem., 193, 263, 10.1016/S0021-9258(19)52451-6

Lovell, 1995, Elevated thiobarbituric acid-reactive substances and antioxidant enzyme activity in the brain in Alzheimer’s disease, Neurology, 45, 1594, 10.1212/WNL.45.8.1594

Lovell, 1997, Elevated 4-hydroxynonenal in ventricular fluid in Alzheimer’s disease, Neurobiol. Aging, 18, 457, 10.1016/S0197-4580(97)00108-5

Lovell, M. A.; Markesbery, W. R. Four-hydroxynonenal selectively impairs choline acetyltransferase in cell cultures. Submitted, 1998.

Mark, 1997, A role for 4-hydroxynonenal, an aldehydic product of lipid peroxidation, in disruption of ion homeostasis and neuronal death induced by amyloid β-peptide, J. Neurochem., 68, 255, 10.1046/j.1471-4159.1997.68010255.x

Mark, 1997, Amyloid β-peptide impairs glucose transport in hippocampal and cortical neurons, J. Neurosci., 17, 1046, 10.1523/JNEUROSCI.17-03-01046.1997

Markesbery, 1997, The oxidative stress hypothesis in Alzheimer’s disease, Free Radic. Biol. Med., 23, 134, 10.1016/S0891-5849(96)00629-6

McKhann, 1984, Clinical diagnosis of Alzheimer’s disease, Neurology, 34, 939, 10.1212/WNL.34.7.939

Mecocci, 1994, Oxidative damage to mitochondrial DNA is increased in Alzheimer’s disease, Ann. Neurol., 36, 747, 10.1002/ana.410360510

Mirra, 1991, The Consortium to Establish a Registry for Alzheimer’s Disease (CERAD). II. Standardization of the neuropathologic assessment of Alzheimer’s disease, Neurology, 41, 479, 10.1212/WNL.41.4.479

Montine, 1997, Immunohistochemical detection of 4-hydroxy-2-nonenal adducts in Alzheimer’s disease is associated with inheritance of APOE4, Am. J. Pathol., 150, 437

Montine, 1996, 4-Hydroxy-2-nonenal is cytotoxic and cross links cytoskeletal proteins in P19 neuroglial cultures, Am. J. Pathol., 148, 89

Prasad, 1998, Regional membrane phospholipid alterations in Alzheimer’s disease, Neurochem. Res., 23, 81, 10.1023/A:1022457605436

Samudralwar, 1995, Elemental imbalances in the olfactory pathway in Alzheimer’s disease, J. Neurol. Sci., 130, 139, 10.1016/0022-510X(95)00018-W

Sayre, L. M.; Zelasko, D. A.; Harris, P. L. R.; Perry, G.; Salomon, R. G.; Smith, M. A. 4-hydroxynonenal-derived advanced lipid peroxidation end products are increased in Alzheimer’s disease. J. Neurochem. 2092–2097; 1997.

Smith, 1991, Excess brain protein oxidation and enzyme dysfunction in normal aging and Alzheimer’s disease, Proc. Natl. Acad. Sci. USA, 88, 10540, 10.1073/pnas.88.23.10540

Smith, 1994, Advanced Maillard reaction end products are associated with Alzheimer disease pathology, Proc. Natl. Acad. Sci. USA, 91, 5710, 10.1073/pnas.91.12.5710

Smith, 1995, Radical AGEing in Alzheimer’s disease, Trends Neurosci., 18, 172, 10.1016/0166-2236(95)93897-7

Smith, 1996, Oxidative damage in Alzheimer’s, Nature, 382, 120, 10.1038/382120b0

Svennerholm, 1994, Membrane lipids, selectively diminished in Alzheimer brains, suggest synapse loss as a primary event in early-onset form (type I) and demyelination in late-onset form (type II), J. Neurochem., 62, 1039, 10.1046/j.1471-4159.1994.62031039.x

Thompson, 1988, Regional brain trace-element studies in Alzheimer’s disease, Neurotoxicology, 9, 1

Uchida, 1993, Covalent attachment of 4-hydroxynonenal to glyceraldehyde-e-phosphate dehydrogenase, J. Biol. Chem., 268, 6388, 10.1016/S0021-9258(18)53264-6

Wenstrup, D.; Ehmann, W.; Markesbery, W. Trace element imbalances in isolated subcellular fractions of Alzheimer’s disease brains. Brain Res. 533:135–131; 1990.

Yan, 1994, Glycated tau protein in Alzheimer disease, Proc. Natl. Acad. Sci. USA, 91, 7787, 10.1073/pnas.91.16.7787

Yoshino, 1986, Fluorometric liquid chromatographic determination of aliphatic aldehydes arising from lipid peroxides, Chem. Pharm. Bull., 34, 1694, 10.1248/cpb.34.1694