Formulation of the respiratory syncytial virus fusion protein with a polymer-based combination adjuvant promotes transient and local innate immune responses and leads to improved adaptive immunity

Vaccine - Tập 34 - Trang 5114-5124 - 2016
Indranil Sarkar1,2, Ravendra Garg1, Sylvia van Drunen Littel-van den Hurk1,2
1VIDO-InterVac, University of Saskatchewan, Saskatoon S7N 5E3, Canada
2Microbiology and Immunology, University of Saskatchewan, Saskatoon S7N 5E5, Canada

Tài liệu tham khảo

Nair, 2011, An evaluation of the emerging interventions against Respiratory Syncytial Virus (RSV)-associated acute lower respiratory infections in children, BMC Public Health, 11, S30, 10.1186/1471-2458-11-S3-S30 Nair, 2010, Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis, Lancet, 375, 1545, 10.1016/S0140-6736(10)60206-1 Empey, 2010, Pharmacologic advances in the treatment and prevention of respiratory syncytial virus, Clin Infect Dis, 50, 1258, 10.1086/651603 Makidon, 2012, Nanoemulsion mucosal adjuvant uniquely activates cytokine production by nasal ciliated epithelium and induces dendritic cell trafficking, Eur J Immunol, 42, 2073, 10.1002/eji.201142346 Hall, 2010, Probing local innate immune responses after mucosal immunisation, J Immune Based Ther Vaccines, 8, 5, 10.1186/1476-8518-8-5 Heritage, 1997, Comparison of murine nasal-associated lymphoid tissue and Peyer’s patches, Am J Respir Crit Care Med, 156, 1256, 10.1164/ajrccm.156.4.97-03017 Asanuma, 1997, Isolation and characterization of mouse nasal-associated lymphoid tissue, J Immunol Methods, 202, 123, 10.1016/S0022-1759(96)00243-8 Kiyono, 2004, NALT- versus Peyer’s-patch-mediated mucosal immunity, Nat Rev Immunol, 4, 699, 10.1038/nri1439 Bienenstock, 2005, Bronchus- and nasal-associated lymphoid tissues, Immunol Rev, 206, 22, 10.1111/j.0105-2896.2005.00299.x Pashine, 2005, Targeting the innate immune response with improved vaccine adjuvants, Nat Med, 11, 10.1038/nm1210 Garg, 2014, Induction of mucosal immunity and protection by intranasal immunization with a respiratory syncytial virus subunit vaccine formulation, J Gen Virol, 95, 301, 10.1099/vir.0.058461-0 Garg, 2015, The respiratory syncytial virus fusion protein formulated with a novel combination adjuvant induces balanced immune responses in lambs with maternal antibodies, Vaccine, 33, 1338, 10.1016/j.vaccine.2015.01.041 Garg, 2014, Vaccination with the RSV fusion protein formulated with a combination adjuvant induces long-lasting protective immunity, J Gen Virol, 95, 1043, 10.1099/vir.0.062570-0 Garlapati, 2012, Enhanced immune responses and protection by vaccination with respiratory syncytial virus fusion protein formulated with CpG oligodeoxynucleotide and innate defense regulator peptide in polyphosphazene microparticles, Vaccine, 30, 5206, 10.1016/j.vaccine.2012.06.011 Shrivastava, 2015, Blunted inflammatory and mucosal IgA responses to pneumonia virus of mice in C57BL/6 neonates are correlated to reduced protective immunity upon re-infection as elderly mice, Virology, 485, 233, 10.1016/j.virol.2015.07.019 Watkiss, 2013, Innate and adaptive immune response to pneumonia virus of mice in a resistant and a susceptible mouse strain, Viruses, 5, 295, 10.3390/v5010295 Mapletoft, 2008, Intranasal immunization of mice with a formalin-inactivated bovine respiratory syncytial virus vaccine co-formulated with CpG oligodeoxynucleotides and polyphosphazenes results in enhanced protection, J Gen Virol, 89, 250, 10.1099/vir.0.83300-0 Rot, 2004, Chemokines in innate and adaptive host defense: basic chemokinese grammar for immune cells, Annu Rev Immunol, 22, 891, 10.1146/annurev.immunol.22.012703.104543 Deshmane, 2009, Monocyte chemoattractant protein-1 (MCP-1): an overview, J Interferon Cytokine Res, 29, 313, 10.1089/jir.2008.0027 Foti, 1999, Upon dendritic cell (DC) activation chemokines and chemokine receptor expression are rapidly regulated for recruitment and maintenance of DC at the inflammatory site, Int Immunol, 11, 979, 10.1093/intimm/11.6.979 Morel, 2011, Adjuvant System AS03 containing alpha-tocopherol modulates innate immune response and leads to improved adaptive immunity, Vaccine, 29, 2461, 10.1016/j.vaccine.2011.01.011 Zimmermann, 2003, Chemokines in asthma: cooperative interaction between chemokines and IL-13, J Allergy Clin Immunol, 111, 227, 10.1067/mai.2003.139 Esche, 2005, Chemokines: key players in innate and adaptive immunity, J Invest Dermatol, 125, 615, 10.1111/j.0022-202X.2005.23841.x Randolph, 2008, Antigen presentation by monocytes and monocyte-derived cells, Curr Opin Immunol, 20, 52, 10.1016/j.coi.2007.10.010 Wesa, 2001, IL-1 beta induces dendritic cells to produce IL-12, Int Immunol, 13, 1053, 10.1093/intimm/13.8.1053 Ghimire, 2015, The mechanisms of action of vaccines containing aluminum adjuvants: an in vitro vs in vivo paradigm, Springerplus, 4, 181, 10.1186/s40064-015-0972-0 Pabst, 2015, Mucosal vaccination by the intranasal route. Nose-associated lymphoid tissue (NALT)-Structure, function and species differences, Vaccine, 33, 4406, 10.1016/j.vaccine.2015.07.022 Shikina, 2004, IgA class switch occurs in the organized nasopharynx- and gut-associated lymphoid tissue, but not in the diffuse lamina propria of airways and gut, J Immunol, 172, 6259, 10.4049/jimmunol.172.10.6259 Asanuma, 1998, IgA antibody-forming cell responses in the nasal-associated lymphoid tissue of mice vaccinated by intranasal, intravenous and/or subcutaneous administration, Vaccine, 16, 1257, 10.1016/S0264-410X(98)00048-6 Brandtzaeg, 2010, Function of mucosa-associated lymphoid tissue in antibody formation, Immunol Invest, 39, 303, 10.3109/08820131003680369 Shimoda, 2001, Isotype-specific selection of high affinity memory B cells in nasal-associated lymphoid tissue, J Exp Med, 194, 1597, 10.1084/jem.194.11.1597 Yanagita, 1999, Nasopharyngeal-associated lymphoreticular tissue (NALT) immunity: fimbriae-specific Th1 and Th2 cell-regulated IgA responses for the inhibition of bacterial attachment to epithelial cells and subsequent inflammatory cytokine production, J Immunol, 162, 3559, 10.4049/jimmunol.162.6.3559 Salem, 2009, The TLR3 agonist poly(I:C) targets CD8+ T cells and augments their antigen-specific responses upon their adoptive transfer into naive recipient mice, Vaccine, 27, 549, 10.1016/j.vaccine.2008.11.013 Hilchie, 2013, Immune modulation by multifaceted cationic host defense (antimicrobial) peptides, Nat Chem Biol, 9, 761, 10.1038/nchembio.1393 Awate, 2012, Activation of adjuvant core response genes by the novel adjuvant PCEP, Mol Immunol, 51, 292, 10.1016/j.molimm.2012.03.026 Csencsits, 1999, Nasal-associated lymphoid tissue: phenotypic and functional evidence for the primary role of peripheral node addressin in naive lymphocyte adhesion to high endothelial venules in a mucosal site, J Immunol, 163, 1382, 10.4049/jimmunol.163.3.1382 Tecchio, 2014, Neutrophil-derived cytokines: facts beyond expression, Front Immunol, 5, 508, 10.3389/fimmu.2014.00508 Mantovani, 2011, Neutrophils in the activation and regulation of innate and adaptive immunity, Nat Rev Immunol, 11, 519, 10.1038/nri3024 Gartlan, 2016, Sterile inflammation induced by Carbopol elicits robust adaptive immune responses in the absence of pathogen-associated molecular patterns, Vaccine, 34, 2188, 10.1016/j.vaccine.2016.03.025 Wegmann, 2012, Polyethyleneimine is a potent mucosal adjuvant for viral glycoprotein antigens, Nat Biotechnol, 30, 883, 10.1038/nbt.2344 Lambrecht, 2009, Mechanism of action of clinically approved adjuvants, Curr Opin Immunol, 21, 23, 10.1016/j.coi.2009.01.004 Calabro, 2011, Vaccine adjuvants alum and MF59 induce rapid recruitment of neutrophils and monocytes that participate in antigen transport to draining lymph nodes, Vaccine, 29, 1812, 10.1016/j.vaccine.2010.12.090 Kool, 2008, Alum adjuvant boosts adaptive immunity by inducing uric acid and activating inflammatory dendritic cells, J Exp Med, 205, 869, 10.1084/jem.20071087 Pulendran, 2006, Translating innate immunity into immunological memory: implications for vaccine development, Cell, 124, 849, 10.1016/j.cell.2006.02.019