Folate receptor-targeted RNAi nanoparticles for silencing STAT3 in tumor-associated macrophages and tumor cells

Jing Chen1, Yushun Dou1, Yue Tang1, Xinru Zhang1
1Department of Pharmacy, China Pharmaceutical University, Nanjing, PR China

Tài liệu tham khảo

Tsai, 2014, Tumor microenvironment: a new treatment target for Cancer, ISRN Biochem, 2014, 1, 10.1155/2014/351959 Conde, 2016, RNAi nanomaterials targeting immune cells as an anti-tumor therapy: the missing link in cancer treatment?, Mater Today, 19, 29, 10.1016/j.mattod.2015.07.005 Mantovani, 2015, The interaction of anticancer therapies with tumor-associated macrophages, J Exp Med, 212, 435, 10.1084/jem.20150295 Chanmee, 2014, Tumor-associated macrophages as major players in the tumor microenvironment, Cancers (Basel), 6, 1670, 10.3390/cancers6031670 Ngambenjawong, 2017, Progress in tumor-associated macrophage (TAM)-targeted therapeutics, Adv Drug Deliv Rev, 114, 206, 10.1016/j.addr.2017.04.010 Tang, 2013, Anti-tumour strategies aiming to target tumour-associated macrophages, Immunology, 138, 93, 10.1111/imm.12023 Qian Y., Qiao S., Dai Y., Xu G., Dai B., Lu L., et al. A Molecular-Targeted Immunotherapeutic Strategy for Melanoma via Dual-Targeting Nanoparticles Delivering Small Interfering RNA to Tumor-Associated Macrophages. ACS Nano 2017:acsnano.7b05465. Doi:https://doi.org/10.1021/acsnano.7b05465. He, 2017, A dual macrophage targeting Nanovector for delivery of oligodeoxynucleotides to overcome cancer-associated immunosuppression, ACS Appl Mater Interfaces, 9, 42566, 10.1021/acsami.7b13594 Yu, 2009, STATs in cancer inflammation and immunity: a leading role for STAT3, Nat Rev Cancer, 9, 798, 10.1038/nrc2734 Kortylewski M., Kujawski M., Wang T., Wei S., Zhang S., Pilon-Thomas S., et al. Inhibiting Stat3 signaling in the hematopoietic system elicits multicomponent antitumor immunity. Nat Med 2005;11(12):1314–21. Doi:https://doi.org/10.1038/nm1325. Chan KS., Sano S., Kiguchi K., Anders J., Komazawa N., Takeda J., et al. Disruption of Stat3 reveals a critical role in both the initiation and the promotion stages of epithelial carcinogenesis. J Clin Invest 2004;114(5):720–8. Doi:10.1172/JCI200421032. Sun, 2017, Resveratrol inhibits lung cancer growth by suppressing M2-like polarization of tumor associated macrophages, Cell Immunol, 311, 86, 10.1016/j.cellimm.2016.11.002 Harada, 2014, The role of STAT3 in non-small cell lung cancer, Cancers (Basel), 6, 708, 10.3390/cancers6020708 Sun, 2017, Resveratrol inhibits lung cancer growth by suppressing M2-like polarization of tumor associated macrophages, Cell Immunol, 311, 86, 10.1016/j.cellimm.2016.11.002 Low, 2008, Discovery and development of folic-acid-based receptor targeting for imaging and therapy of cancer and inflammatory diseases, Acc Chem Res, 41, 120, 10.1021/ar7000815 Pei, 2016, Drug delivery to macrophages: challenges and opportunities, J Control Release, 240, 202, 10.1016/j.jconrel.2015.12.014 Dai, 2015, Self-assembled targeted folate-conjugated eight-arm-polyethylene glycol–betulinic acid nanoparticles for co-delivery of anticancer drugs, J Mater Chem B, 3, 3754, 10.1039/C5TB00042D Turk, 2004, Folate-conjugated liposomes preferentially target macrophages associated with ovarian carcinoma, Cancer Lett, 213, 165, 10.1016/j.canlet.2003.12.028 Li, 2014, Carboxymethyl chitosan-folic acid-conjugated Fe3O4@SiO2 as a safe and targeting antitumor nanovehicle in vitro, Nanoscale Res Lett, 9, 146, 10.1186/1556-276X-9-146 Zhang X., Goncalves R., Mosser DM. The Isolation and Characterization of Murine Macrophages. Current Protocols in Immunology, vol. CHAPTER, Hoboken, NJ, USA: John Wiley & Sons, Inc.; 2008, p. Unit-14. Ying, 2013, Investigation of macrophage polarization using bone marrow derived macrophages, J Vis Exp, 76, 1 Yang, 2010, Folic acid-conjugated chitosan nanoparticles enhanced Protoporphyrin IX accumulation in colorectal Cancer cells - bioconjugate chemistry (ACS publications), Bioconjug Chem, 21, 679, 10.1021/bc9004798 Esfandiarpour-Boroujeni, 2016, Modeling and optimization of degree of folate grafted on chitosan and carboxymethyl-chitosan, Prog Biomater, 5, 1, 10.1007/s40204-015-0044-0 Li, 2015, Preparation and testing of Quaternized chitosan nanoparticles as gene delivery vehicles, Appl Biochem Biotechnol, 175, 3244, 10.1007/s12010-015-1483-8 Hong D., Kurzrock R., Kim Y., Woessner R., Younes A., Nemunaitis J., et al. AZD9150, a Next-Generation Antisense Oligonucleotide Inhibitor of STAT3 with Early Evidence of Clinical Activity in Lymphoma and Lung Cancer 2017;7(314). Doi:https://doi.org/10.1126/scitranslmed.aac5272.AZD9150. Komohara, 2012, Importance of direct macrophage - tumor cell interaction on progression of human glioma, Cancer Sci, 103, 2165, 10.1111/cas.12015 De Beule N., De Veirman K., Maes K., De Bruyne E., Menu E., Breckpot K., et al. Tumour-associated macrophage-mediated survival of myeloma cells through STAT3 activation. J Pathol 2017;241(4):534–46. Doi:https://doi.org/10.1002/path.4860. Veremeyko, 2013, IL-4/IL-13-dependent and independent expression of miR-124 and its contribution to M2 phenotype of monocytic cells in normal conditions and during allergic inflammation, PLoS One, 8, 10.1371/journal.pone.0081774 Alshamsan A., Haddadi A., Hamdy S., Samuel J., El-Kadi AOS., Uludaǧ H., et al. STAT3 silencing in dendritic cells by siRNA polyplexes encapsulated in PLGA nanoparticles for the modulation of anticancer immune response. Mol Pharm 2010;7(5):1643–54. Doi:https://doi.org/10.1021/mp100067u. Nicolas, 2017, Testicular activin and follistatin levels are elevated during the course of experimental autoimmune epididymo-orchitis in mice, Sci Rep, 7, 1 Tariq, 2017, Macrophage polarization: anti-cancer strategies to target tumor-associated macrophage in breast cancer, J Cell Biochem, 118, 2484, 10.1002/jcb.25895