Fluoride: A review of pre-clinical and clinical studies

Aasenden, 1974, Effects of fluoride supplementation from birth on human deciduous and permanent teeth, Arch. Oral Biol., 19, 321, 10.1016/0003-9969(74)90194-0 Agalakova, 2012, Fluoride induces oxidative stress and ATP depletion in the rat erythrocytes in vitro, Environ. Toxicol. Pharmacol., 34, 334, 10.1016/j.etap.2012.05.006 Ahn, 1995, Interactive effects of fluoride and aluminum uptake and accumulation in bones of rabbits administered both agents in their drinking water, J. Toxicol. Environ. Health, 44, 337, 10.1080/15287399509531963 Al-Hiyasat, 2000, Reproductive toxic effects of ingestion of sodium fluoride in female rats, Fluoride, 33, 79 Arianejad, 2015, Levels of some heavy metals in raw cow’s milk from selected milk production sites in Iran: is there any health concern?, Health Promot. Perspect., 5, 176, 10.15171/hpp.2015.021 Basha, 2012, Combined influence of intermittent exercise and temperature stress on the modulation of fluoride toxicity, Biol. Trace Elem. Res., 148, 69, 10.1007/s12011-012-9338-4 Bhatnagar, 2002, Neurotoxicity of fluoride: neurodegeneration in hippocampus of female mice, Indian J. Exp. Biol., 40, 546 Boink, 1994, The mechanism of fluoride-induced hypocalcaemia, Hum. Exp. Toxicol., 13, 149, 10.1177/096032719401300302 Boivin, 1989, Skeletal fluorosis: histomorphometric analysis of bone changes and bone fluoride content in 29 patients, Bone, 10, 89, 10.1016/8756-3282(89)90004-5 Bouaziz, 2005, Toxic effects of fluoride by maternal ingestion on kidney function of adult mice and their suckling pups, Fluoride, 38, 23 Bouaziz, 2006, Effects of sodium fluoride on hepatic toxicity in adult mice and their suckling pups, Pestic. Biochem. Phys., 86, 124, 10.1016/j.pestbp.2006.02.004 Bouaziz, 2007, Oxidative stress induced by fluoride in adult mice and their suckling pups, Exp. Toxicol. Pathol., 58, 339, 10.1016/j.etp.2006.11.004 Boulton, 1995, Fluoride accumulation and toxicity in laboratory populations of wild small mammals and white mice, J. Appl. Toxicol., 15, 423, 10.1002/jat.2550150602 Bucher, 1991, Results and conclusions of the national toxicology program's rodent carcinogenicity studies with sodium fluoride, Int. J. Cancer, 48, 733, 10.1002/ijc.2910480517 Burmaoglu, 2017, Design of potent fluoro-substituted chalcones as antimicrobial agents, J. Enzyme Inhib. Med. Chem., 32, 490, 10.1080/14756366.2016.1265517 Buttner, 1961, Effects of some trace elements on fluoride retention and dental caries, Arch. Oral Biol., 6, 40, 10.1016/0003-9969(61)90018-8 Camargo, 1992, The relative sensitivity of competing hydropsychid species to fluoride toxicity in the Cache la Poudre River (Colorado), Arch. Environ. Con. Toxicol., 22, 107, 10.1007/BF00213308 Cardenas-Gonzalez, 2015, Sub-chronic exposure to fluoride impacts the response to a subsequent nephrotoxic treatment with gentamycin, J. Appl. Toxicol., 36, 309, 10.1002/jat.3186 Chattopadhyay, 2011, Fluoride-induced histopathology and synthesis of stress protein in liver and kidney of mice, Arch. Toxicol., 85, 327, 10.1007/s00204-010-0588-7 Chauhan, 2013, Effects of fluoride and ethanol administration on lipid peroxidation systems in rat brain, Indian J. Exp. Biol., 51, 249 Chiba, 2002, The influence of fluoride ingestion on urinary aluminum excretion in humans, Tohoku J. Exp. Med., 196, 139, 10.1620/tjem.196.139 Chinoy, 1999, Effects of protein supplementation and deficiency on fluoride-induced toxicity in reproductive organs of male mice, Fluoride, 32, 204 Chinoy, 2001, Beneficial effects of some vitamins and calcium on fluoride and aluminium toxicity on gastrocnemius muscle and liver of male mice, Fluoride, 34, 21 Chinoy, 1994, In vitro fluoride toxicity in human spermatozoa, Reprod. Toxicol., 8, 155, 10.1016/0890-6238(94)90022-1 Chinoy, 1989, Effects of fluoride on the histoarchitecture of reproductive organs of the male mouse, Reprod. Toxicol., 3, 261, 10.1016/0890-6238(89)90020-8 Chinoy, 2004, Beneficial effects of some antidotes in fluoride and arsenic induced toxicity in kidney of mice, Fluoride, 37, 151 Chinoy, 2004, Biochemical effects of sodium fluoride and arsenic trioxide toxicity and their reversal in the brain of mice, Fluoride, 37, 80 Chinoy, 1998, Amelioration of fluoride toxicity by vitamins E and D in reproductive functions of male mice, Fluoride, 31, 203 Chinoy, 1994, Transient and reversible fluoride toxicity in some soft tissues of female mice, Fluoride, 27, 205 Chinoy, 1997, Fluoride toxicity on rat testis and cauda epididymal tissue components and its reversal, Fluoride, 30, 41 Chinoy, 2005, Fluoride and aluminium induced toxicity in mice epididymis and its mitigation by vitamin C, Fluoride, 38, 115 Chinoy, 2005, Fluoride and aluminium induced toxicity in mice testis with giant cells and its reversal by vitamin C, Fluoride, 38, 109 Chong, 2011, A review of the uses of fluoride and outcomes of dental caries control in Singapore, Singapore Dent. J., 32, 14, 10.1016/S0377-5291(12)70011-1 Chouhan, 2008, Effects of fluoride on the tissue oxidative stress and apoptosis in rats: biochemical assays supported by IR spectroscopy data, Toxicology, 254, 61, 10.1016/j.tox.2008.09.008 Chu, 2008, Uses of sodium fluoride varnish in dental practice, Ann. R. Australas. Coll. Dent. Surg., 19, 58 Cittanova, 1996, Fluoride ion toxicity in human kidney collecting ducts cells, Anesthesiology, 84, 428, 10.1097/00000542-199602000-00022 Collins, 1995, Developmental toxicity of sodium fluoride in rats, Food Chem. Toxicol., 33, 951, 10.1016/0278-6915(95)00066-B Connett, 2014 Csábia, 2016, Synthesis and in vitro evaluation of the antitumor potential and chemo-sensitizing activity of fluorinated ecdysteroid derivatives, MedChemComm, 7, 2197 Darmani, 2001, Effects of sodium fluoride in drinking water on fertility in female mice, Fluoride, 34, 242 Daston, 1985, Toxicity of sodium fluoride to the postnatally developing rat kidney, Environ. Res., 37, 461, 10.1016/0013-9351(85)90128-8 Davis, 1970, Acute toxicity of oxygen difluoride, 329 Dijkman, 1990, Remineralization of human enamel in situ after 3 months: the effect of not brushing versus the effect of an F dentifrice and an F-free dentifrice, Caries Res., 24, 263, 10.1159/000261280 Duckworth, 1991, Effect of mouthrinsing after toothbrushing with a fluoride dentifrice on human salivary fluoride levels, Caries Res., 25, 287, 10.1159/000261378 Dugar, 1996, Metabolism and structure activity data based drug design: discovery of (2)SCH 53079 an analog of the potent cholesterol absorption inhibitor (2)SCH 48461, Bioorg. Med. Chem. Lett., 6, 1271, 10.1016/0960-894X(96)00214-4 Dunipace, 1995, Effect of aging on animal response to chronic fluoride exposure, J. Den. Res., 74, 358, 10.1177/00220345950740011201 Eanes, 1965, Small-angle X-ray diffraction analysis of the effect of fluoride on human bone apatite, Arch. Oral Biol., 10, 161, 10.1016/0003-9969(65)90068-3 Ekambaram, 2001, Calcium preventing locomotor behavioral and dental toxicities of fluoride by decreasing serum fluoride level in rats, Environ. Toxicol. Phar., 9, 141, 10.1016/S1382-6689(00)00063-6 Ekambaram, 2002, Modulation of fluoride toxicity in rats by calcium carbonate and by withdrawal of fluoride exposure, Pharmacol. Toxicol., 90, 53, 10.1034/j.1600-0773.2002.900201.x El-lethey, 2010, Neurobehavioral toxicity produced by sodium fluoride in drinking water of laboratory rats, J. Am. Sci., 6, 54 Elbetieha, 2000, Fertility effects of sodium fluoride in male mice, Fluoride, 33, 128 Emilson, 1976, Effect of a fluoride-containing chlorhexidine gel on bacteria in human plaque, Eur. J. Oral Sci., 84, 56, 10.1111/j.1600-0722.1976.tb00462.x Ersan, 2010, Histopathological effects of chronic fluorosis on the liver of mice (Swiss albino), Turk. J. Med. Sci., 40, 619 Fejerskov, 1987, Combined effect of systemic and topical fluoride treatments on human deciduous teeth–case studies, Caries Res., 21, 452, 10.1159/000261051 Fernandes, 2011, Alkaline phosphatase activity in plasma and liver of rats submitted to chronic exposure to fluoride, Braz. Arch. Biol. Technol., 54, 1187, 10.1590/S1516-89132011000600014 Flora, 2009, Co-exposure to arsenic and fluoride on oxidative stress, glutathione linked enzymes, biogenic amines and DNA damage in mouse brain, J. Neurol. Sci., 285, 198, 10.1016/j.jns.2009.07.001 Fried, 1980, 10,10-Difluoro-13-dehydroprostacyclin: a chemically and metabolically stabilized potent prostacyclin, J. Med. Chem., 23, 235 Gabovic, 1969, Effect of F in drinking water on physiological aging (From the data of a gerontological health experiment), Gigiena Naselen. Mest. Kiev., 5 Garrido-Acosta, 2016, Anticonvulsant and toxicological evaluation of parafluorinated/chlorinated derivatives of 3-hydroxy-3-ethyl-3-phenylpropionamide, Bio. Med. Res. Int., 1 Geddes, 1982, The effect of 0.2 per cent (48 mM) NaF rinses daily on human plaque acidogenicity in situ (Stephan curve) and fluoride content, Arch. Oral Biol., 27, 765, 10.1016/0003-9969(82)90027-9 Ghosh, 2002, Testicular toxicity in sodium fluoride treated rats: association with oxidative stress, Reprod. Toxicol., 16, 385, 10.1016/S0890-6238(02)00038-2 Goshman, 1985, Clinical toxicology of commercial products, 5th By R.E. Gosselin, R.P. Smith, and H.C. Hodge. Williams and Wilkins, 428 East Preston Street, Baltimore, MD 21202. 1984. 1987+ix pp. 26×17.5cm. ISBN 0-683-03632-7. $95.00, J. Pharm. Sci., 74, 1139, 10.1002/jps.2600741037 Government of India, 2009 Gray, 1973, A morphological study of the influence of fluoride on rat molar teeth, Arch. Oral Biol., 18, 1451, 10.1016/0003-9969(73)90121-0 Guan, 1998, Influence of chronic fluorosis on membrane lipids in rat brain, Neurotoxicol. Teratol., 20, 537, 10.1016/S0892-0362(97)00136-0 Guner, 2016, Dental fluorosis and catalase immunoreactivity of the brain tissues in rats exposed to high fluoride pre- and postnatally, Biol. Trace Elem. Res., 174, 150, 10.1007/s12011-016-0695-2 Guo, 2008, A preliminary investigation of the IQs of 7–13year old children from an area with coal burning-related fluoride poisoning, Fluoride, 41, 125 Gupta, 2007, The toxic effects of sodium fluoride on the reproductive system of male rats, Toxicol. Ind. Health, 23, 507, 10.1177/0748233708089041 He, 2006, DNA damage, apoptosis and cell cycle changes induced by fluoride in rat oral mucosal cells and hepatocytes, World J. Gastroenterol., 12, 1144, 10.3748/wjg.v12.i7.1144 Horowitz, 1971, The effect on human dental caries of weekly oral rinsing with a sodium fluoride mouthwash: a final report, Arch. Oral Biol., 16, 609, 10.1016/0003-9969(71)90064-1 Inkielewicz, 2006, Lipid peroxidation and antioxidant enzyme activity in rats exposed to fluoride and ethanol, Fluoride, 39, 53 Inkovaara, 1975, Prophylactic fluoride treatment and aged bones, Br. Med. J., 3, 73, 10.1136/bmj.3.5975.73 Izquierdo-Vega, 2008, Decreased in vitro fertility in male rats exposed to fluoride-induced oxidative stress damage and mitochondrial transmembrane potential loss, Toxicol. Appl. Pharm., 230, 352, 10.1016/j.taap.2008.03.008 Jacks, 2005, Controls on the genesis of some high-fluoride ground waters in India, Appl. Geochem., 20, 221, 10.1016/j.apgeochem.2004.07.002 Jacksa, 2005, Controls on the genesis of some high-fluoride ground waters in India, Appl.Geochem., 20, 221, 10.1016/j.apgeochem.2004.07.002 Jagan, 2015, Effectiveness of sodium fluoride mouthrinses on the prevention of dental caries: a systematic review, J. Indian Assoc. Public Health Dent., 13, 110, 10.4103/2319-5932.159042 Jowsey, 1972, Effect of combined therapy with sodium fluoride, vitamin D and calcium in osteoporosis, Am. J. Med., 53, 43, 10.1016/0002-9343(72)90114-3 Kakei, 2016, Fluoride exposure may accelerate the osteoporotic change in postmenopausal women: animal model of fluoride-induced osteoporosis, Adv. Tech. Biol. Med., 4, 1 Kessabi, 1980, Acute kidney toxicity of sodium fluoride in the rat, Toxicol. Lett., 5, 169, 10.1016/0378-4274(80)90168-X Khan, 2014, Biochemical changes in sodium fluoride induced kidney of swiss albino mice and it’s amelioration by ascorbic acid, Int. J. Adv. Pharm. Biol. Chem., 3, 948 Khandare, 2000, Beneficial effect of tamarind ingestion on fluoride toxicity in dogs, Fluoride, 33, 33 Khandare, 2011, Magnesium hydroxide for protection against fluoride toxicity in rabbits, Fluoride, 44, 21 Khandare, 2015, Synergistic effects of strontium and fluoride on nutritional status in guinea pigs (Cavia porcellus), Fluoride, 48, 283 Kim, 2015, Effect of sodium fluoride on male mouse fertility, Andrology, 3, 544, 10.1111/andr.12006 Klimek, 1985, Effect of a preventive program based on professional tooth cleaning and fluoride application on caries and gingivitis, Community Dent. Oral. Epidemiol., 13, 295, 10.1111/j.1600-0528.1985.tb00459.x Kumar, 1995, Effects of chronic fluoride toxicity on the morphology of ductus epididymis and the maturation of spermatozoa of rabbit, Int. J. Exp. Pathol., 76, 1 Kumar, 2010, Effect of duration of fluoride exposure on the reproductive system in male rabbits, J. Hum. Reprod. Sci., 3, 148, 10.4103/0974-1208.74159 Lee, 2015, Anti-inflammatory effects of bamboo salt and sodium fluoride in human gingival fibroblasts–an in vitro study, Kaohsiung J. Med. Sci., 31, 303, 10.1016/j.kjms.2015.03.005 Li, 2012, Fluoride enhances the activity of fungicides that destabilize cell membrane, Bioorg. Med. Chem. Lett., 22, 3317, 10.1016/j.bmcl.2012.03.006 Long, 2002, Chronic fluoride toxicity decreases the number of nicotinic acetylcholine receptors in rat brain, Neurotoxicol. Teratol., 24, 751, 10.1016/S0892-0362(02)00273-8 Lu, 1985, The effect of a fluoride dentifrice containing an anticalculus agent on dental caries in children, ASDC J. Dent. Child., 52, 449 Lu, 2000, Effect of high-fluoride water on intelligence in children, Fluoride, 33, 74 Machalinska, 2002, Morphological effects of sodium fluoride on hematopoietic organs in mice, Fluoride, 35, 231 Maithani, 1998, Anomalous fluoride in groundwater from western part of sirohi district, Rajasthan and its crippling effects on human health, Curr. Sci., 74, 773 Manocha, 1975, Cytochemical response of kidney, liver and nervous system to fluoride ions in drinking water, Histochem. J., 7, 343, 10.1007/BF01007019 Markitziu, 1991, Modulatory effect of fluoride and irradiation on rat molar rate of wear, Bull. Group Int. Sci. Stomatol. Odontal., 34, 139 Maurer, 1990, Two-year carcinogenicity study of sodium fluoride in rats, J. Natl. Cancer Inst., 82, 1118, 10.1093/jnci/82.13.1118 Maurer, 1993, Confounded carcinogenicity study of sodium fluoride in CD-1 mice, Regul. Toxicol. Pharmacol., 18, 154, 10.1006/rtph.1993.1050 Mccann, 1957, The effects of fluoride ingestion on the composition and solubility of mineralized tissues of the rat, J. Den. Res., 36, 391, 10.1177/00220345570360031101 Mittal, 2006, Effects of individual and combined exposure to sodium arsenite and sodium fluoride on tissue oxidative stress, arsenic and fluoride levels in male mice, Chem. Biol. Interact., 162, 128, 10.1016/j.cbi.2006.05.018 Muhler, 1951, Effects of stannous fluoride in food and in drinking water on caries prevention in rats on high sucrose and coarse corn diets, J. Nutr., 44, 413, 10.1093/jn/44.3.413 Muhler, 1955, Effect of pH and state of oxidation of different fluorides in the drinking water on dental caries and fluoride storage in the rat, J. Den. Res., 34, 68, 10.1177/00220345550340011701 Mullenix, 1995, Neurotoxicity of sodium fluoride in rats, Neurotoxicol. Teratol., 17, 169, 10.1016/0892-0362(94)00070-T Mumtaz, 2015, Global fluoride occurrence, available technologies for fluoride removal and electrolytic defluoridation: a review, Crit. Rev. Env. Sci. Technol., 45, 2357, 10.1080/10643389.2015.1025638 Muray, 1986 Nabavi, 2012, Protective effects of curcumin against sodium fluoride-induced toxicity in rat kidneys, Biol. Trace Elem. Res., 145, 369, 10.1007/s12011-011-9194-7 Ohmi, 2005, The effect of fluoridation and its discontinuation on fluoride profiles in the alveolar bone of rat, Calcif. Tissue Int., 77, 226, 10.1007/s00223-004-1304-5 Pant, 2010, Evaluation of in vitro anti-genotoxic potential of melatonin against arsenic and fluoride in human blood cultures, Ecotoxicol. Environ. Saf., 73, 1333, 10.1016/j.ecoenv.2010.05.004 Park, 2001, Metabolism of fluorine-containing drugs, Annu. Rev. Pharmacol. Toxicol., 41, 443, 10.1146/annurev.pharmtox.41.1.443 Paul, 1998, Effects of sodium fluoride on locomotor behavior and a few biochemical parameters in rats, Environ. Toxicol. Phar., 6, 187, 10.1016/S1382-6689(98)00033-7 Peterson, 2004, Challenges to improvement of oral health in the 21st century–the approach of the WHO Global Oral Health Programme, Int. Dent. J., 54, 329, 10.1111/j.1875-595X.2004.tb00009.x Pieta, 2013, Influence of vitamin E on liver morphology and activity of carbohydrate enzymes of rats exposed to sodium fluoride, Fluoride, 46, 142 Pillai, 1988, Effect of subacute dosage of fluoride on male mice, Toxiocol. Lett., 44, 21, 10.1016/0378-4274(88)90125-7 Posner, 1963, X-ray diffraction analysis of the effect of fluoride on human bone apatit, Arch. Oral Biol., 8, 549, 10.1016/0003-9969(63)90071-2 Pyke, 1992, Effect of fluoride on magnesium deficiency in the Guinea pig, J. Nutr., 92, 311, 10.1093/jn/92.3.311 Qujeq, 2002, Effects of sodium fluoride on total serum protein levels and transaminase activity in rats, Biomed. Pharmacother., 56, 169, 10.1016/S0753-3322(02)00172-5 Raghunath, 2016, In silico prediction of microRNAs on fluoride induced sperm toxicity in mice, Food Chem. Toxicol., 98, 34, 10.1016/j.fct.2016.03.005 Ramseyer, 1957, Effect of sodium fluoride administration on body changes in old rats, J. Gerontol., 12, 14, 10.1093/geronj/12.1.14 Ranjan, 2009, Oxidative stress indices in erythrocytes, liver and kidneys of fluoride-exposed rabbits, Fluoride, 42, 88 Ranjan, 2009, Tamarindus indica L. and Moringa oleifera M. extract administration ameliorates fluoride toxicity in rabbits, Indian J. Exp. Biol., 47, 900 Reen, 1962, The cariostatic effect of dietary phosphate in the rat in the presence or absence of fluoride in the drinking water, Arch. Oral Biol., 7, 587, 10.1016/0003-9969(62)90065-1 Rozier, 2010, Evidence based clinical recommendations on the prescription of dietary fluoride supplements for caries prevention, J. Am. Dent. Assoc., 141, 1480, 10.14219/jada.archive.2010.0111 Ruiz-Payan, 2005, Determination of fluoride in drinking water and in urine of adolescents living in three countries in Northern Chihuahua Mexico using a fluoride ion selective electrode, Microchem. J., 81, 19, 10.1016/j.microc.2005.01.017 Safe Drinking Water Committee: National Research Council (US), 1977, vol. 1 Saville, 1967, Water fluoridation: effect on bone fragility and skeletal calcium content in the rat, J. Nutr., 91, 353, 10.1093/jn/91.3_Suppl.353 Schuld, 2011, Another fluoride drug bites the dust Schwarz, 1990, Alimentary intake of fluorides of artificially fed infants and effect on enamel tissue, Z. Gesamte Hyg., 36, 646 Sengupta, 1971, Iodine and fluoride content of foodstuffs, Indian J. Nutr. Diet., 8, 66 Shanthakumari, 2004, Effect of fluoride intoxication on lipid peroxidation and antioxidant status in experimental rats, Toxiocology, 204, 219, 10.1016/j.tox.2004.06.058 Shashi, 2000, Histopathology of fluoride-induced hepatotoxicity in rabbits, Fluoride, 34, 34 Shashi, 2002, Toxic effects of fluoride on rabbit kidney, Fluoride, 35, 38 Shashi, 2003, Histopathological investigation of fluoride-induced neurotoxicity in rabbits, Fluoride, 36, 95 Shashi, 2003, In vivo studies concerning toxic effects of sodium fluoride on hepatic function in rabbits, Fluoride, 36, 30 Shi, 2016, Effects of fluoride on the expression of p38MAPK signaling pathway-related genes and proteins in spleen lymphocytes of mice, Biol. Trace Elem. Res., 173, 333, 10.1007/s12011-016-0656-9 Shivarajashankara, 2003, Lipid peroxidation and antioxidant systems in the blood of young rats subjected to chronic fluoride toxicity, Indian J. Exp. Biol., 41, 857 Shivarajashankara, 2001, Effect of fluoride intoxication on lipid peroxidation and antioxidant systems in rats, Fluoride, 34, 108 Shivarajashankara, 2001, Oxidative stress in children with endemic skeletal fluorosis, Fluoride, 34, 103 Shivarajashankara, 2002, Brain lipid peroxidation and antioxidant systems of young rats in chronic fluoride intoxication, Fluoride, 35, 197 Shivashankara, 2000, A clinical and biochemical study of chronic fluoride toxicity in children of Kheru Thandu of Gulbarga district Karnataka, India, Fluoride, 33, 66 Singh, 2007, Fluoride in drinking water and human urine in southern Haryana, India, J. Hazard. Mater., 144, 147, 10.1016/j.jhazmat.2006.10.010 Slack, 1956, The effect of topical application of stannous fluoride on the incidence of dental caries in 6-year-oId children, Brit. Dent. J., 101, 7 Sondhi, 1995, Intestinal effects of sodium fluoride in swiss albino mice, Fluoride, 28, 21 Stefanidis, 1993, Structure reactivity correlations for reactions of substituted phenolate anions with acetate and formate esters, J. Am. Chem. Soc., 115, 1650, 10.1021/ja00058a006 Stepanenko, 1968, Experimental study of the anticarious effect of different reagents containing F for the fluoridation of drinking water, Stomatologija, 5, 22 Sun, 2011, Fluoride-induced apoptosis and gene expression profiling in mice sperm in vivo, Arch. Toxicol., 85, 1441, 10.1007/s00204-011-0672-7 Susheela, 1993, Fluoride toxicity: a biochemical and scanning electron microscopic study of enamel surface of rabbit teeth, Arch. Toxicol., 67, 573, 10.1007/BF01969271 Susheela, 1988, Chronic fluoride toxicity: a scanning electron microscopic study of duodenal mucosa, J. Toxicol.: Clin. Toxicol., 26, 467 Susheela, 1996, Circulating testosterone levels in skeletal fluorosis patients, J. Toxicol. Clin. Toxicol., 34, 183, 10.3109/15563659609013768 Susheela, 1991, A study of the effect of high concentrations of fluoride on the reproductive organs of male rabbits, using light and scanning electron microscopy, J. Reprod. Fertil., 92, 353, 10.1530/jrf.0.0920353 Susheela, 1980, Fluoride poisoning and the effect on collagen biosynthesis of osseus and non-osseus tissues of rabbit, Toxicol. Eur. Res., 3, 99 Susheela, 1980, Chemical profile of blood in fluoride toxicity III. plasma fibrinogen levels in rabbits, Toxicol. Eur. Res., 3, 105 Susheela, 1993, Prevention and control of fluorosis in India, vol. 1 Takagi, 1982, Acute sodium fluoride toxicity in the rat kidney, Bull. Tokyo Med. Dent. Univ., 29, 123 Taylor, 1961, Toxic effects of fluoride on the rat kidney: I. Acute injury from single large doses, Toxicol. Appl. Pharm., 3, 278, 10.1016/0041-008X(61)90067-9 Trivedi, 2007, Amelioration by black tea of sodium fluoride-induced changes in protein content of cerebral hemisphere, cerebellum and medulla oblongata in brain region of mice, Acta Pol. Pharm., 64, 221 Tsunoda, 2005, Changes in fluoride levels in the liver, kidney and brain and in neurotransmitters of mice after subacute administration of fluoride, Fluoride, 38, 284 Vani, 2000, Effects of fluoride accumulation on some enzymes of brain and gastrocnemius muscle of mice, Fluoride, 33, 17 Vasant, 2014, Antidotal activity of Averrhoa carambola (Star fruit) on fluoride induced toxicity in rats, Interdiscip. Toxicol., 7, 103, 10.2478/intox-2014-0014 Vieira, 2005, Assessment of teeth as biomarkers for skeletal fluoride exposure, Osteoporosis Int., 16, 1576, 10.1007/s00198-005-1870-z World Health Organization, 2004, Fluoride in drinking-water Wang, 2000, Effect of long term fluoride exposure on lipid composition in rat liver, Toxicology, 146, 161, 10.1016/S0300-483X(00)00167-0 Weber, 1969, Fluoride toxicity in the mouse, J. Nutr., 97, 90, 10.1093/jn/97.1.90 Wei, 2016, Chronic fluoride exposure-induced testicular toxicity is associated with inflammatory, Chemosphere, 153, 419, 10.1016/j.chemosphere.2016.03.045 Whitford, 1979, Acute fluoride toxicity: influence of metabolic alkalosis, Toxicol. Appl. Pharm., 50, 31, 10.1016/0041-008X(79)90489-7 Willinger, 1995, The effect of sodium fluoride at prophylactic and toxic doses on renal structure and function in the isolated perfused rat kidney, Toxicology, 95, 55, 10.1016/0300-483X(94)02875-U Wolinsky, 1972, Effects of fluoride on metabolism and mechanical properties of rat bone, Am. J. Physiol., 223, 46, 10.1152/ajplegacy.1972.223.1.46 Xiang, 2003, Effect of fluoride in drinking water on children’s intelligence, Fluoride, 36, 84 Yadav, 2007, Determination of exposure and probable ingestion of fluoride through tea, toothpaste, tobacco and pan masala, J. Hazard. Mater., 142, 77, 10.1016/j.jhazmat.2006.07.051 Yazdi, 2011, Effects of fluoride on psychomotor performance and memory of potroom workers, Fluoride, 44, 158