Flumequine in the Goat: Pharmacokinetics after Intravenous and Intramuscular Administration
Tóm tắt
The pharmacokinetics of flumequine, administered intravenously and intramuscularly at a single dose of 20 mg/kg, was investigated in healthy goats. After intravenous injection, flumequine distributed rapidly (t½α = 0.87±0.15 h) but was eliminated slowly (t½β = 7.12±1.27 h); mean clearance (Cl) and volume of distribution (V½αdss) were 0.32±0.03 (L/(h.kg) and 1.22±029 (L/kg), respectively. After intramuscular administration, the peakserum concentration (Cmax = 7.40±0.5 μg/ml) was reached in about 1.5 h (Tmax) and bioavailability was about 93%. Estimated flumequine serum levels following repeated intramuscular administration of the aqueous suspension used in the study (7.23±0.7 μg/ml and 4.82±0.47 μg/ml at intervals of 8 and 12 h, respectively) indicated that to maintain serum levels above MIC values for susceptible bacteria a dosage regimen of 20 mg/kg every 12 h is necessary by the intramuscular route.
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