Flowers for Algernon: steroid dysgenesis, epigenetics and brain disorders

Pharmacological Reports - Tập 64 Số 6 - Trang 1285-1290 - 2012
Bryan K. Sanders1
1College of Letters and Science (Alumnus), University of California, Durant Hall, MC 2920, Berkeley, CA 94720, USA

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Aiello, 2011, Sexual differentiation and the neuroendocrine hypothesis of autism, Anat Rec (Hoboken), 294, 1663, 10.1002/ar.21251

Bambini-Junior, 2011, Animal model of autism induced by prenatal exposure to valproate: behavioral changes and liver parameters, Brain Res, 1408, 8, 10.1016/j.brainres.2011.06.015

Baron-Cohen, 2002, The extreme male brain theory of autism, Trends Cogn Sci, 6, 248, 10.1016/S1364-6613(02)01904-6

Baum, 2009, New evidence that an epigenetic mechanism mediates testosterone-dependent brain masculinization, Endocrinology, 150, 3980, 10.1210/en.2009-0664

Bejerot, 2012, The extreme male brain revisited: gender coherence in adults with autism spectrum disorder, Br J Psychiatry, 201, 116, 10.1192/bjp.bp.111.097899

Bellemare, 2005, Characterization of 17α-hydroxysteroid dehydrogenase activity (17α-HSD) and its involvement in the biosynthesis of epitestosterone, BMC Biochem, 6, 12, 10.1186/1471-2091-6-12

Bicíková, 1993, Inhibition of steroid 17α-hydroxylase and C17,20-lyase in the human testis by epitestosterone, J Steroid Biochem Mol Biol, 46, 515, 10.1016/0960-0760(93)90106-7

Bicíková, 1992, Epitestosterone – a potent competitive inhibitor of C21-steroid side chain cleavage in the testis, J Steroid Biochem Mol Biol, 43, 721, 10.1016/0960-0760(92)90298-W

Bicíková, 1997, Inhibition of rat renal and testicular 11β-hydroxysteroid dehydrogenase by some antihypertensive drugs, diuretics, and epitestosterone, Horm Metab Res, 29, 465, 10.1055/s-2007-979079

Bicíková, 2000, The effect of epitestosterone on estrogen biosynthesis in vitro, Horm Metab Res, 32, 125, 10.1055/s-2007-978605

Corbier, 1992, The neonatal testosterone surge: a comparative study, Arch Int Physiol Biochim Biophys, 100, 127, 10.3109/13813459209035274

Dalló, 1977, Effect of two brain serotonin depletors on the sexual behavior of male rats, Pol J Pharmacol Pharm, 29, 247

de Larminat, 1979, Effect of in vivo administration of 5α reductase inhibitors on epididymal function, Acta Physiol Lat Am, 29, 1

Death, 2005, Valproate is an anti-androgen and anti-progestin, Steroids, 70, 946, 10.1016/j.steroids.2005.07.003

Dhagat, 2008, Inhibition of 3(17)α-hydroxysteroid dehydrogenase (AKR1C21) by aldose reductase inhibitors, Bioorg Med Chem, 16, 3245, 10.1016/j.bmc.2007.12.016

Dörner, 1987, Sexual differentiation of gonadotrophin secretion, sexual orientation and gender role behavior, J Steroid Biochem, 27, 1081, 10.1016/0022-4731(87)90193-2

Dufour-Rainfray, 2010, Behavior and serotonergic disorders in rats exposed prenatally to valproate: amodel for autism, Neurosci Lett, 470, 55, 10.1016/j.neulet.2009.12.054

Ehrenkranz, 1976, Effects of sex steroids on serotonin uptake in blood platelets, Acta Endocrinol (Copenh), 83, 420, 10.1530/acta.0.0830420

Ellis, 1972, Inhibition of rat testicular androgen synthesis in vitro by melatonin and serotonin, Endocrinology, 90, 17, 10.1210/endo-90-1-17

Ellis, 1969, The direct action of melatonin and serotonin on testicular androgen production in vitro, J Reprod Fertil, 18, 159

Engel, 1979, Effects of gonadectomy and hormone replacement on brain monoamine synthesis in male rats, Pharmacol Biochem Behav, 10, 149, 10.1016/0091-3057(79)90181-3

Epitestosterone, PubChem Compound Summary (CID.10204), http://pubchem. ncbi. nlm. nih. gov/summary/summary.cgi?.cid=10204

Fratta, 1977, Homosexual mounting behavior induced in male rats and rabbits by a tryptophanfree diet, Life Sci, 21, 379, 10.1016/0024-3205(77)90518-5

Gawienowski, 1973, Alteration of sexual behavior and sex accessory glands by pchlorophenylalanine and testosterone, Life Sci I, 12, 307, 10.1016/0024-3205(73)90414-1

Giulian, 1973, Effects of gonadal steroids upon brain 5-hydroxytryptamine levels in the neonatal rat, Endocrinology, 93, 1329, 10.1210/endo-93-6-1329

Griffin, 1999, Selective serotonin reuptake inhibitors directly alter activity of neurosteroidogenic enzymes, Proc Natl Acad Sci USA, 96, 13512, 10.1073/pnas.96.23.13512

Gustafsson, 1976, Sex-specific occurrence of androgen receptors in rat brain, J Biol Chem, 251, 4047, 10.1016/S0021-9258(17)33353-7

Havlíková, 2002, Sex- and age-related changes in epitestosterone in relation to pregnenolone sulfate and testosterone in normal subjects, J Clin Endocrinol Metab, 87, 2225, 10.1210/jcem.87.5.8499

Henley, 2010, Exogenous androgen during development alters adult partner preference and mating behavior in gonadally intact male rats, Horm Behav, 57, 488, 10.1016/j.yhbeh.2010.02.007

Kataoka, 2011, Autism-like behaviours with transient histone hyperacetylation in mice treated prenatally with valproic acid, Int J Neuropsychopharmacol, 1

Kendall, 1982, The influence of sex hormones on antidepressant-induced alterations in neurotransmitter receptor binding, J Neurosci, 2, 354, 10.1523/JNEUROSCI.02-03-00354.1982

Kim, 2011, The critical period of valproate exposure to induce autistic symptoms in Sprague-Dawley rats, Toxicol Lett, 201, 137, 10.1016/j.toxlet.2010.12.018

Kinson, 1973, The effects of melatonin and serotonin on blood flow fraction and testosterone metabolism in selected organs of the male rat, Can J Physiol Pharmacol, 51, 313, 10.1139/y73-047

Kołomańska, 2011, Neonatal serotonin (5-HT) depletion does not disrupt prepulse inhibition of the startle response in rats, Pharmacol Rep, 63, 1077, 10.1016/S1734-1140(11)70626-0

Langer, 1986, Antidepressant-binding sites in brain and platelets, Ciba Found Symp, 123, 3

Langer, 1987, Association of [3H]-imipramine and [3H]-paroxetine binding with the 5HT transporter in brain and platelets: relevance to studies in depression, J Recept Res, 7, 499, 10.3109/10799898709054999

Lapcík, 1995, Plasma levels of epitestosterone from prepuberty to adult life, J Steroid Biochem Mol Biol, 55, 405, 10.1016/0960-0760(95)00181-6

Maciag, 2006, Neonatal citalopram exposure produces lasting changes in behavior which are reversed by adult imipramine treatment, Eur J Pharmacol, 532, 265, 10.1016/j.ejphar.2005.12.081

McCarthy, 2009, New tricks by an old dogma: mechanisms of the organizational/activational hypothesis of steroid-mediated sexual differentiation of brain and behavior, Horm Behav, 55, 655, 10.1016/j.yhbeh.2009.02.012

Piechal, 2012, Neonatal serotonin (5-HT) depletion does not affect spatial learning and memory in rats, Pharmacol Rep, 64, 266, 10.1016/S1734-1140(12)70764-8

Przegaliński, 1987, Effect of repeated administration of antidepressant drugs on the serum and brain concentration of testosterone and its metabolites, Pol J Pharmacol Pharm, 39, 683

Ruta, 2011, Increased serum androstenedione in adults with autism spectrum conditions, Psychoneuroendocrinology, 36, 1154, 10.1016/j.psyneuen.2011.02.007

Sanders, 2007, Sex, drugs and sports: prostaglandins, epitestosterone and sexual development, Med Hypotheses, 69, 829, 10.1016/j.mehy.2006.12.058

Schantz, 2001, Cognitive effects of endocrinedisrupting chemicals in animals, Environ Health Perspect, 109, 1197, 10.1289/ehp.011091197

Simpson, 2011, Perinatal antidepressant exposure alters cortical network function in rodents, Proc Natl Acad Sci USA, 108, 18465, 10.1073/pnas.1109353108

Stárka, 2003, Epitestosterone, J Steroid Biochem Mol Biol, 87, 27, 10.1016/S0960-0760(03)00383-2

Stárka, 1993, Epitestosterone – a hormone or not, Endocr Regul, 27, 43

Terranova, 1990, Serotonin enhances oestradiol production by hamster preovulatory follicles in vitro: effects of experimentally induced atresia, J Endocrinol, 125, 433, 10.1677/joe.0.1250433

Testosterone PubChem Compound Summary (CID 6013) http://pubchem.ncbi.nlm.nih.gov/summary/summary.cgi?cid=6013

Toran-Allerand, 2005, 17α-Estradiol: a brain-active estrogen?, Endocrinology, 146, 3843, 10.1210/en.2004-1616

Veenstra-Vanderweele, 2012, Autism gene variant causes hyperserotonemia, serotonin receptor hypersensitivity, social impairment and repetitive behavior, Proc Natl Acad Sci USA, 109, 5469, 10.1073/pnas.1112345109

Vlassis, 1973, Effect of serotonin on placental aromatization, Acta Endocrinol Suppl (Copenh), 173, 78, 10.1530/acta.0.072S078

Ugrumov, 1996, Androgen-dependent sex differences in the hypothalamic serotoninergic system, Eur J Endocrinol, 134, 232, 10.1530/eje.0.1340232