Flow-Mediated Vasodilation and Plasma Fibronectin Levels in Preeclampsia

Hypertension - Tập 36 Số 3 - Trang 400-404 - 2000
Atsushi Yoshida1, Shinji Nakao1, Mitsunao Kobayashi1, Hisaaki Kobayashi1
1From the Department of Perinatal and Maternal Medicine, National Defense Medical College, Suzuka, Japan.

Tóm tắt

Abstract —To clarify the vascular endothelial function in pregnant women with hypertensive disorders, we assessed the flow-mediated vasodilation in the radial artery and compared it with plasma fibronectin levels. We determined flow-mediated vasodilation by measuring the change in radial artery diameter during hyperemia in 58 normal pregnant women, 22 preeclamptic pregnant women, and 15 pregnant women with chronic hypertension. In 41 of the 95 pregnant women, we measured the plasma fibronectin levels. Flow-mediated vasodilation in preeclamptic women was significantly less than that in normal pregnant women ( P <0.001). In chronic hypertensive women, flow-mediated vasodilation was significantly less than that in normal pregnant women ( P <0.001) but more than that in preeclamptic women ( P <0.001). Flow-mediated vasodilation showed significant negative correlation with plasma fibronectin levels ( P <0.001, r =0.73). Our results indicate that the endothelial function can be noninvasively assessed in pregnant women with hypertensive disorders by measuring the flow-mediated vasodilation of the radial artery with high-resolution ultrasound.

Từ khóa


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Hypertension

Tập 36 Số 3

400-404

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