Fli-1, một yếu tố chức năng trong bệnh lupus tự miễn

Wang-Dong Xu1, Min Zhang2, Yi Zhao1, Yi Liu1
1Department of Rheumatology and Immunology, West China Hospital, Sichuan University, Chengdu, People’s Republic of China
2Suzhou National High-tech District Center for Disease Prevention and Control, Suzhou, People’s Republic of China

Tóm tắt

Bệnh lupus ban đỏ hệ thống (SLE) là một bệnh tự miễn. Vị trí chèn gen leukemia bạn bè 1 (Fli-1) thuộc họ yếu tố phiên mã Ets. Những phát hiện gần đây cho thấy biểu hiện của Fli-1 có sự bất thường ở bệnh nhân SLE và chuột lupus. Ngoài ra, phân tích chức năng chỉ ra rằng Fli-1 đóng vai trò quan trọng trong sự phát triển của rối loạn tự miễn dịch phức tạp này. Tại đây, chúng tôi xem xét những bằng chứng được cập nhật cho thấy vai trò của Fli-1 trong bệnh lupus tự miễn. Hy vọng rằng thông tin thu được có thể dẫn đến việc hiểu rõ hơn về sinh bệnh học của bệnh tự miễn hệ thống.

Từ khóa

#lupus tự miễn #Fli-1 #bệnh lupus ban đỏ hệ thống #yếu tố phiên mã #bệnh tự miễn

Tài liệu tham khảo

Xu, W.D., H.F. Pan, Y. Xu, and D.Q. Ye. 2013. Interferon regulatory factor 5 and autoimmune lupus. Expert Reviews in Molecular Medicine 15: e6.

Zhang, L., A. Eddy, Y.T. Teng, M. Fritzler, M. Kluppel, F. Melet, et al. 1995. An immunological renal disease in transgenic mice that overexpress Fli-1, a member of the ets family of transcription factor genes. Molecular and Cellular Biology 15: 6961–6970.

Seth, A., R. Ascione, R.J. Fisher, G.J. Mavrothalassitis, N.K. Bhat, and T.S. Papas. 1992. The ets gene family. Cell Growth and Differentiation 3: 327–334.

Karim, F.D., L.D. Urness, C.S. Thummel, M.J. Klemsz, S.R. McKercher, A. Celada, et al. 1990. The ETS-domain: a new DNA-binding motif that recognizes a purine-rich core DNA sequence. Genes and Development 4: 1451–1453.

Papas, T.S., N.K. Bhat, D.D. Spyropoulos, A.E. Mjaatvedt, J. Vournakis, A. Seth, et al. 1997. Functional relationships among ETS gene family members. Leukemia 11: 557–566.

Sementchenko, V.I., and D.K. Watson. 2000. Ets target genes: past, present and future. Oncogene 19: 6533–6548.

Hsu, T., M. Trojanowska, and D.K. Watson. 2004. Ets proteins in biological control and cancer. Journal of Cellular Biochemistry 91: 896–903.

Ho, H.H., and L.B. Ivashkiv. 2010. Downregulation of Friend leukemia virus integration 1 as a feedback mechanism that restrains lipopolysaccharide induction of matrix metalloproteases and interleukin-10 in human macrophages. Journal of Interferon and Cytokine Research 30: 893–900.

Smeets, M.F., D.L. Wiest, and D.J. Izon. 2014. Fli-1 regulates the DN2 to DN3 thymocyte transition and promotes γδ T-cell commitment by enhancing TCR signal strength. European Journal of Immunology 44: 2617–2624.

Smeets, M.F., A.C. Chan, S. Dagger, C.K. Bradley, A. Wei, and D.J. Izon. 2013. Fli-1 overexpression in hematopoietic progenitors deregulates T cell development and induces pre-T cell lymphoblastic leukaemia/lymphoma. PLoS One 8: e62346.

Spyropoulos, D.D., P.N. Pharr, K.R. Lavenburg, P. Jackers, T.S. Papas, M. Ogawa, et al. 2000. Hemorrhage, impaired hematopoiesis, and lethality in mouse embryos carrying a targeted disruption of the Fli1 transcription factor. Molecular and Cellular Biology 20: 5643–5652.

Richard, E.M., T. Thiyagarajan, M.A. Bunni, F. Basher, P.O. Roddy, L.J. Siskind, et al. 2013. Reducing FLI1 levels in the MRL/lpr lupus mouse model impacts T cell function by modulating glycosphingolipid metabolism. PLoS One 8: e75175.

Rao, V.N., T. Ohno, D.D. Prasad, G. Bhattacharya, and E.S. Reddy. 1993. Analysis of the DNA-binding and transcriptional activation functions of human Fli-1 protein. Oncogene 8: 2167–2173.

Zhang, X.K., O. Moussa, A. LaRue, S. Bradshaw, I. Molano, D.D. Spyropoulos, et al. 2008. The transcription factor Fli-1 modulates marginal zone and follicular B cell development in mice. Journal of Immunology 181: 1644–1654.

Bradshaw, S., W.J. Zheng, L.C. Tsoi, G. Gilkeson, and X.K. Zhang. 2008. A role for Fli-1 in B cell proliferation: implications for SLE pathogenesis. Clinical Immunology 129: 19–30.

Suzuki, E., S. Williams, S. Sato, G. Gilkeson, D.K. Watson, and X.K. Zhang. 2013. The transcription factor Fli-1 regulates monocyte, macrophage and dendritic cell development in mice. Immunology 139: 318–327.

Sato, S., and X.K. Zhang. 2014. The Friend leukaemia virus integration 1 (Fli-1) transcription factor affects lupus nephritis development by regulating inflammatory cell infiltration into the kidney. Clinical and Experimental Immunology 177: 102–109.

Zhang, X.K., S. Gallant, I. Molano, O.M. Moussa, P. Ruiz, D.D. Spyropoulos, et al. 2004. Decreased expression of the Ets family transcription factor Fli-1 markedly prolongs survival and significantly reduces renal disease in MRL/lpr mice. Journal of Immunology 173: 6481–6489.

Molano, I., J. Mathenia, P. Ruiz, G.S. Gilkeson, and X.K. Zhang. 2010. Decreased expression of Fli-1 in bone marrow-derived haematopoietic cells significantly affects disease development in Murphy Roths Large/lymphoproliferation (MRL/lpr) mice. Clinical and Experimental Immunology 160: 275–282.

Mathenia, J., E. Reyes-Cortes, S. Williams, I. Molano, P. Ruiz, D.K. Watson, et al. 2010. Impact of Fli-1 transcription factor on autoantibody and lupus nephritis in NZM2410 mice. Clinical and Experimental Immunology 162: 362–371.

Castiglione, A., A. Bucci, G. Fellin, G. d'Amico, and R.C. Atkins. 1988. The relationship of infiltrating renal leucocytes to disease activity in lupus and cryoglobulinaemic glomerulonephritis. Nephron 50: 14–23.

Nowling, T.K., and G.S. Gilkeson. 2011. Mechanisms of tissue injury in lupus nephritis. Arthritis Research and Therapy 13: 250.

Apostolidis, S.A., L.A. Lieberman, K. Kis-Toth, J.C. Crispín, and G.C. Tsokos. 2011. The dysregulation of cytokine networks in systemic lupus erythematosus. Journal of Interferon and Cytokine Research 31: 769–779.

Sato, S., M. Richard, D. Brandon Lennard, J.N. Buie, J.C. Jones, G.S. Gilkeson Oates, et al. 2014. A critical role of the transcription factor fli-1 in murine lupus development by regulation of interleukin-6 expression. Arthritis Rheumatology 66: 3436–3444.

Lennard Richard, M.L., S. Sato, E. Suzuki, S. Williams, T.K. Nowling, and X.K. Zhang. 2014. The Fli-1 transcription factor regulates the expression of CCL5/RANTES. Journal of Immunology 193: 2661–2668.

Suzuki, E., E. Karam, S. Williams, D.K. Watson, G. Gilkeson, and X.K. Zhang. 2012. Development by regulating expression of monocyte Fli-1 transcription factor affects glomerulonephritis development by regulating expression of monocyte chemoattractant protein-1 in endothelial cells in the kidney. Clinical Immunology 145: 201–208.

Rupprecht, H.D., G. Hoffer, E. de Heer, R.B. Sterzel, G. Faller, and H.O. Schoecklmann. 1997. Expression of the transcriptional regulator Egr-1 in experimental glomerulonephritis: requirement for mesangial cell proliferation. Kidney international 51: 694–702.

Carl, M., Y. Akagi, S. Weidner, Y. Isaka, E. Imai, and H.D. Rupprecht. 2003. Specific inhibition of Egr-1 prevents mesangial cell hypercellularity in experimental nephritis. Kidney international 63: 1302–1312.

Buschiazzo, E., and N.J. Gemmell. 2006. The rise, fall and renaissance of microsatellites in eukaryotic genomes. Bioessays 28: 1040–1050.

Morris, E.E., M.Y. Amria, E. Kistner-Griffin, J.L. Svenson, D.L. Kamen, G.S. Gilkeson, et al. 2010. A GA microsatellite in the Fli1 promoter modulates gene expression and is associated with systemic lupus erythematosus patients without nephritis. Arthritis Research and Therapy 12: R212.

Georgiou, P., I. Maroulakou, J. Green, P. Dantis, V. Romanospica, S. Kottaridis, et al. 1996. Expression of ets family of genes in systemic lupus erythematosus and Sjogren’s syndrome. International Journal of Oncology 9: 9–18.