Flexible Cationic Nanoparticles with Photosensitizer Cores for Multifunctional Biomedical Applications

Small - Tập 14 Số 22 - 2018
Rui Wu1, Xiaokang Ding1, Qi Yu1, Qiang Zeng2, Yuwei Wu2, Bingran Yu1, Fu‐Jian Xu1
1State Key Laboratory of Chemical Resource Engineering Key Laboratory of Carbon Fiber and Functional Polymers (Beijing University of Chemical Technology) Ministry of Education Beijing Laboratory of Biomedical Materials Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical Technology Beijing 100029 China
2National Engineering Laboratory for Digital and Material Technology of Stomatology Peking University School and Hospital of Stomatology Beijing 10010 China

Tóm tắt

AbstractOne challenge for multimodal therapy is to develop appropriate multifunctional agents to meet the requirements of potential applications. Photodynamic therapy (PDT) is proven to be an effective way to treat cancers. Diverse polycations, such as ethylenediamine‐functionalized poly(glycidyl methacrylate) (PGED) with plentiful primary amines, secondary amines, and hydroxyl groups, demonstrate good gene transfection performances. Herein, a series of multifunctional cationic nanoparticles (PRP) consisting of photosensitizer cores and PGED shells are readily developed through simple dopamine‐involving processes for versatile bioapplications. A series of experiments demonstrates that PRP nanoparticles are able to effectively mediate gene delivery in different cell lines. PRP nanoparticles are further validated to possess remarkable capability of combined PDT and gene therapy for complementary tumor treatment. In addition, because of their high dispersities in biological matrix, the PRP nanoparticles can also be used for in vitro and in vivo imaging with minimal aggregation‐caused quenching. Therefore, such flexible nanoplatforms with photosensitizer cores and polycationic shells are very promising for multimodal tumor therapy with high efficacy.

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Small

Tập 14 Số 22

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