Flavourings significantly affect inhalation toxicity of aerosol generated from electronic nicotine delivery systems (ENDS)

Tobacco Control - Tập 25 Số Suppl 2 - Trang ii81-ii87 - 2016
Noel J. Leigh1, Ralph Lawton1, Pamela A. Hershberger2, Maciej Ł. Goniewicz3
1Department of Health Behavior, Roswell Park Cancer Institute, Buffalo, New York, USA
2Department of Pharmacology and Therapeutics, Roswell Park Cancer Institute, Buffalo, New York, USA
3Division of Cancer Prevention and Population Sciences, Department of Health Behavior, Roswell Park Cancer Institute, Elm and Carlton Streets, Carlton House A320, Buffalo, NY 14263, USA

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Tài liệu tham khảo

Grana, 2014, E-cigarettes a scientific review, Circulation, 129, 1972, 10.1161/CIRCULATIONAHA.114.007667

Goniewicz, 2014, Levels of selected carcinogens and toxicants in vapour from electronic cigarettes, Tob Control, 23, 133, 10.1136/tobaccocontrol-2012-050859

Kosmider, 2016, Cherry-flavoured electronic cigarettes expose users to the inhalation irritant, benzaldehyde, Thorax, 71, 376, 10.1136/thoraxjnl-2015-207895

McGill, 2013, Research on e-cigarettes examining health effects: regulations due, Nations Health, 43, 1

Benowitz, 2013, The regulatory challenge of electronic cigarettes, JAMA, 310, 685, 10.1001/jama.2013.109501

CDC. Notes from the field: Electronic Cigarette Use Among Middle and High School Students—United States, 2011–2012. 2013. http://www.cdc.gov/mmwr/preview/mmwrhtml/mm6235a6.htm (accessed 26 May 2016).

Wasowicz, 2015, E-Cigarette use among children and young people: the need for regulation, Expert Rev Respir Med, 9, 507, 10.1586/17476348.2015.1077120

Yingst, 2015, Factors associated with electronic cigarette users’ device preferences and transition from first generation to advanced generation devices, Nicotine Tob Res, 17, 1242, 10.1093/ntr/ntv052

Hutzler, 2014, Chemical hazards present in liquids and vapors of electronic cigarettes, Arch Toxicol, 88, 1295, 10.1007/s00204-014-1294-7

Tierney, 2016, Flavour chemicals in electronic cigarette fluids, Tob Control, 25, e10, 10.1136/tobaccocontrol-2014-052175

Farsalinos, 2013, Comparison of the cytotoxic potential of cigarette smoke and electronic cigarette vapour extract on cultured myocardial cells, Int J Environ Res Public Health, 10, 5146, 10.3390/ijerph10105146

Barrington-Trimis, 2014, Flavorings in electronic cigarettes. An unrecognized respiratory health hazard?, JAMA, 312, 2493, 10.1001/jama.2014.14830

Lerner, 2015, Vapors produced by electronic cigarettes and e-juices with flavorings induce toxicity, oxidative stress, and inflammatory response in lung epithelial cells and in mouse lung, PLoS One, 10, e0116732, 10.1371/journal.pone.0116732

Misra, 2014, Comparative in vitro toxicity profile of electronic and tobacco cigarettes, smokeless tobacco and nicotine replacement therapy products: e-liquids, extracts and collected aerosols, Int J Environ Res Public Health, 11, 11325, 10.3390/ijerph111111325

Shen Y , Wolkowicz MJ , Kotova T , et al. Transcriptome sequencing reveals e-cigarette vapor and mainstream-smoke from tobacco cigarettes activate different gene expression profiles in human bronchial epithelial cells. Sci Rep 2016;6:23984. doi:10.1038/srep23984

Scheffler, 2015, Evaluation of e-cigarette liquid vapor and mainstream cigarette smoke after direct exposure of primary human bronchial epithelial cells, Int J Environ Res Public Health, 12, 3915, 10.3390/ijerph120403915

Scheffler, 2016, Response to Polosa et al. Comments on Scheffler et al. Cytotoxic evaluation of e-liquid aerosol using different lung derived cell models. Int. J. Environ. Res. Public Health, 2015, 12, 12466–12474, Int J Environ Res Public Health, 13, pii: E109, 10.3390/ijerph13010109

Hom, 2016, Electronic cigarettes modulate platelet inflammatory, adhesion, activation and aggregation responses, FASEB J, 30, 722.5

Hwang, 2016, Electronic cigarette inhalation promotes inflammatory cytokines within the airways and systemic inflammation in mice, Am J Respir Crit Care Med, 193, A4844

Behar, 2014, Identification of toxicants in cinnamon-flavored electronic cigarette refill fluids, Toxicol In Vitro, 28, 198, 10.1016/j.tiv.2013.10.006

Hayes, 2010, Inhalation toxicology, Molecular, clinical and environmental toxicology, 461, 10.1007/978-3-7643-8338-1_13

Hayes, 2014, Toxicological perspectives of inhaled therapeutics and nanoparticles, Expert Opin Drug Metab Toxicol, 10, 933, 10.1517/17425255.2014.916276

Aufderheide, 2005, Direct exposure methods for testing native atmospheres, Exp Toxicol Pathol, 57, 213, 10.1016/j.etp.2005.05.019

Goniewicz, 2013, Nicotine levels in electronic cigarettes, Nicotine Tob Res, 15, 158, 10.1093/ntr/nts103

Goniewicz, 2015, Nicotine levels in electronic cigarette refill solutions: a comparative analysis of products from the US, Korea, and Poland, Int J Drug Policy, 26, 583, 10.1016/j.drugpo.2015.01.020

Health Canada. Official Method T-115, Determination of “tar”, nicotine and carbon monoxide in mainstream tobacco smoke, prepared by the Department of Health, 1-7, dated 31 December 1999. http://www.hc-sc.gc.ca/hl-vs/alt_formats/hecs-sesc/pdf/tobac-tabac/legislation/reg/indust/method/main-principal/nicotine/nicotine_e.pdf (accessed 20 May 2016).

Kalayciyan, 2007, Nicotine and biochanin A, but not cigarette smoke, induce anti-inflammatory effects on keratinocytes and endothelial cells in patients with Behcet's disease, J Invest Dermatol, 127, 81, 10.1038/sj.jid.5700492