First-Dose mRNA COVID-19 Vaccine Allergic Reactions: Limited Role for Excipient Skin Testing

Gee, 2021, First month of COVID-19 vaccine safety monitoring - United States, December 14, 2020-January 13, 2021, MMWR Morb Mortal Wkly Rep, 70, 283, 10.15585/mmwr.mm7008e3

2021, Allergic reactions including anaphylaxis after receipt of the first dose of Pfizer-BioNTech COVID-19 vaccine - United States, December 14-23, 2020, MMWR Morb Mortal Wkly Rep, 70, 46, 10.15585/mmwr.mm7002e1

Shimabukuro, 2021, Reports of anaphylaxis after receipt of mRNA COVID-19 vaccines in the US-December 14, 2020-January 18, 2021, JAMA, 325, 1101, 10.1001/jama.2021.1967

Blumenthal, 2021, Acute allergic reactions to mRNA COVID-19 vaccines, JAMA, 325, 1562, 10.1001/jama.2021.3976

Castells, 2021, Maintaining safety with SARS-CoV-2 vaccines, N Engl J Med, 384, 643, 10.1056/NEJMra2035343

Sellaturay, 2021, Polyethylene glycol (PEG) is a cause of anaphylaxis to the Pfizer/BioNTech mRNA COVID-19 vaccine, Clin Exp Allergy, 51, 861, 10.1111/cea.13874

Stone, 2019, Immediate hypersensitivity to polyethylene glycols and polysorbates: more common than we have recognized, J Allergy Clin Immunol Pract, 7, 1533, 10.1016/j.jaip.2018.12.003

Pitlick, 2021, Polyethylene glycol and polysorbate skin testing in the evaluation of coronavirus disease 2019 vaccine reactions: early report, Ann Allergy Asthma Immunol, 126, 735, 10.1016/j.anai.2021.03.012

Banerji, 2021, mRNA vaccines to prevent COVID-19 disease and reported allergic reactions: current evidence and suggested approach, J Allergy Clin Immunol Pract, 9, 1423, 10.1016/j.jaip.2020.12.047

Broyles, 2020, Practical guidance for the evaluation and management of drug hypersensitivity: specific drugs, J Allergy Clin Immunol Pract, 8, S16, 10.1016/j.jaip.2020.08.006

Marcelino, 2021, Non-irritant concentrations for skin testing with SARS-CoV-2 mRNA Vaccine, J Allergy Clin Immunol Pract, 9, 2476, 10.1016/j.jaip.2021.03.022

Bianchi, 2021, Skin tests in urticaria/angioedema and flushing to Pfizer-BioNTech SARS-CoV-2 vaccine: limits of intradermal testing, Allergy, 76, 2605, 10.1111/all.14839

Kelso, 2012, Adverse reactions to vaccines practice parameter 2012 update, J Allergy Clin Immunol, 130, 25, 10.1016/j.jaci.2012.04.003

Mustafa, 2021, Administration of a second dose of the Moderna COVID-19 vaccine after an immediate hypersensitivity reaction with the first dose: two case reports, Ann Intern Med, 174, 1177, 10.7326/L21-0104

Harris, 2019, The REDCap consortium: building an international community of software platform partners, J Biomed Inform, 95, 103208, 10.1016/j.jbi.2019.103208

Harris, 2009, Research electronic data capture (REDCap)—A metadata-driven methodology and workflow process for providing translational research informatics support, J Biomed Inform, 42, 377, 10.1016/j.jbi.2008.08.010

Ring, 1977, Incidence and severity of anaphylactoid reactions to colloid volume substitutes, Lancet, 1, 466, 10.1016/S0140-6736(77)91953-5

Iammatteo, 2017, Identifying allergic drug reactions through placebo-controlled graded challenges, J Allergy Clin Immunol Pract, 5, 711, 10.1016/j.jaip.2016.09.041

Sampath, 2021, Vaccines and allergic reactions: the past, the current COVID-19 pandemic, and future perspectives, Allergy, 76, 1640, 10.1111/all.14840

Kelso, 2021, Misdiagnosis of systemic allergic reactions to mRNA COVID-19 vaccines, Ann Allergy Asthma Immunol, 127, 133, 10.1016/j.anai.2021.03.024

Deepak

Turk, 2021, Anaphylaxis associated with the mRNA COVID-19 vaccines: approach to allergy investigation, Clin Immunol, 227, 108748, 10.1016/j.clim.2021.108748

Robinson, 2019, Allergic symptoms after mRNA COVID-19 vaccination and risk of incomplete vaccination, J Allergy Clin Immunol Pract, 9, 3200, 10.1016/j.jaip.2021.05.031

Greenhawt, 2021, The COVID-19 pandemic in 2021: avoiding overdiagnosis of anaphylaxis risk while safely vaccinating the world, J Allergy Clin Immunol Pract, 9, 1438, 10.1016/j.jaip.2021.01.022

Hause, 2021, Anxiety-related adverse event clusters after Janssen COVID-19 vaccination - five U.S. mass vaccination sites, April 2021, MMWR Morb Mortal Wkly Rep, 70, 685, 10.15585/mmwr.mm7018e3

Blumenthal, 2018, Multiple drug intolerance syndrome and multiple drug allergy syndrome: epidemiology and associations with anxiety and depression, Allergy, 73, 2012, 10.1111/all.13440

Shaker, 2021, The importance of a timely second dose of the 2021 COVID-19 mRNA vaccine depends on the protection afforded by a first dose and subsequent risk of anaphylaxis, J Allergy Clin Immunol Pract, 9, 2556, 10.1016/j.jaip.2021.04.015

Banerji, 2021, mRNA vaccines to prevent COVID-19 disease and reported allergic reactions: current evidence and suggested approach, J Allergy Clin Immunol Pract, 9, 1423, 10.1016/j.jaip.2020.12.047

Ring, 1977, Incidence and severity of anaphylactoid reactions to colloid volume substitutes, Lancet, 1, 466, 10.1016/S0140-6736(77)91953-5