Filling in the mechanistic details: two-variable experiments as tests for constitutive relevance
Tóm tắt
Từ khóa
Tài liệu tham khảo
Baetu, T. M. (2012a). Chance, Reproducibility and Irregular Mechanisms.
Baetu, T. M. (2012b), Holistic Confirmation and Extrapolative Hypotheses in Molecular Biology.
Baetu, T. M., Kwon, H., Sharma, S., Grandveaux, N., & Hiscott, J. (2001). Disruption of NF-kB signalling reveals a novel role for NF-kB in the regulation of TNF-related apoptosis-inducing ligand expression. Journal of Immunology, 167, 3164–3173.
Barnes, C. (1979). Memory deficits associated with senescence: a neurophysiological and behavioral study in the rat. Journal of Comparative and Physiological Psychology, 93(1), 74–104.
Bechtel, W. (2006). Discovering cell mechanisms: The creation of modern cell biology. Cambridge: Cambridge University Press.
Bechtel, W. (2008). Mental mechanisms: Philosophical perspectives on cognitive neuroscience. New York: Routledge.
Bechtel, W., & Abrahamsen, A. (2005). Explanation: a mechanist alternative. Studies in History and Philosophy of Biological and Biomedical Sciences, 36, 421–441.
Bechtel, W., & Richardson, R. (2010). Discovering complexity: Decomposition and localization as strategies in scientific research. Cambridge: MIT Press.
Craver, C. (2007). Explaining the brain: Mechanisms and the mosaic unity of neuroscience. Oxford: Clarendon.
Darden, L. (1991). Theory change in science: Strategies from Mendelian Genetics. New York: Oxford University Press.
Darden, L. (2006). Reasoning in biological discoveries: Essays on mechanisms, interfield relations, and anomaly resolution. Cambridge: Cambridge University Press.
Huxford, T., Huang, D.-B., Malek, S., & Ghosh, G. (1998). The crystal structure of the I κB /NF-κ B complex reveals mechanisms of NF- κB inactivation. Cell, 95, 759–770.
Kwon, H., Pelletier, N., DeLuca, C., Genin, P., Cisternas, S., Lin, R., Wainberg, M. A., & Hiscott, J. (1998). Inducible expression of IκBα repressor mutants interferes with NF-κB Activity and HIV-1 replication in Jurkat T cells. Journal of Biological Chemistry, 273, 7431–7440.
Leuridan, B. (2011). Three Problems for the mutual manipulability account of constitutive relevance in mechanisms. British Journal for the Philosophy of Science, doi: 10.1093/bjps/axr036 .
Lynch, G., & Baudry, M. (1984). The biochemistry of memory: a new and specific hypothesis. Science, 224(4653), 1057–1063.
Machamer, P., Darden, L., & Craver, C. (2000). Thinking about mechanisms. Philosophy of Science, 67, 1–25.
McHugh, T., Blum, K., Tsien, J., Tonegawa, S., & Wilson, M. (1996). Impaired hippocampal representation of space in CA1-specific NMDAR1 knockout mice. Cell, 87(7), 1339–1349.
McKay, P., & Williamson, J. (2011). What is a mechanism? Thinking about mechanisms across the sciences. European Journal for Philosophy of Science.
Miura, Y., Misawa, N., Maeda, N., Inagaki, Y., Tanaka, Y., Ito, M., Kayagaki, N., Yamamoto, N., Yagita, H., & Mizusawa, H. (2001). Critical contribution of Tumor Necrosis Factor-related Apoptosis- inducing Ligand (TRAIL) to apoptosis of human CD4(+) T cells in HIV-1- infected hu-PBL-NOD-SCID mice. The Journal of Experimental Medicine, 193, 651–660.
Morris, R. G. M. (1981). Spatial localization does not require the presence of local cues. Learning and Motivation, 12(2), 239–260.
Morris, R., Anderson, E., Lynch, G., & Baudry, M. (1986). Selective impairment of learning and blockade of long-term potentiation by an N-methyl-D-aspartate receptor antagonist, AP5. Nature, 319(6056), 774–776.
Pahl, H. L. (1999). Activators and target genes of Rel/NF-κB transcription factors. Oncogene, 18, 6853–6866.
Scaffidi, C., Fulda, S., Srinivasan, A., Friesen, C., Li, F., Tomaselli, K. J., Debatin, K. M., Krammer, P. H., & Peter, M. E. (1998). Two CD95 (APO-1/Fas) signaling pathways. EMBO Journal, 17, 1675–1687.
Sen, R., & Baltimore, D. (1986). Inducibility of the κ immunoglobulin enhancer-binding protein NF-κB by a post-transcriptional mechanism. Cell, 47, 921–928.
Sun, S.-C., Ganchi, P. A., Ballard, D. W., & Greene, W. C. (1993). NF-κB controls expression of inhibitor I κB α: evidence for an inducible autoregulatory pathway. Science, 259, 1912–1915.
Wiley, S. R., Schooley, K., Smolak, P. J., Din, W. S., Huang, C. P., Nicholl, J. K., Sutherland, G. R., Smith, T. D., Rauch, C., & Smith, C. A. (1995). Identification and characterization of a new member of the TNF family that induces apoptosis. Immunity, 3, 673–682.
Wimsatt, W. C. (1976). Reductive explanation: a functional account. In A. C. Michalos (Ed.), Boston studies in the philosophy of science (pp. 671–710). Dordrecht: Reidel.
Woodward, J. (2003). Making things happen: A theory of causal explanation. Oxford: Oxford University Press.