Fibronectin fragments cause release and degradation of collagen-binding molecules from equine explant cultures

Joosten, 1999, IL-1 alpha beta blockade prevents cartilage and bone destruction in murine type II collagen-induced arthritis, whereas TNF-alpha blockade only ameliorates joint inflammation, J Immunol, 163, 5049, 10.4049/jimmunol.163.9.5049 Andreakos, 2002, Cytokines and anti-cytokine biologicals in autoimmunity: present and future, Cytokine Growth Factor Rev, 13, 299, 10.1016/S1359-6101(02)00018-7 Feldmann, 2001, Anti-TNF alpha therapy of rheumatoid arthritis: what have we learned, Annu Rev Immunol, 19, 163, 10.1146/annurev.immunol.19.1.163 den Broeder, 2002, Long term anti-tumour necrosis factor alpha monotherapy in rheumatoid arthritis: effect on radiological course and prognostic value of markers of cartilage turnover and endothelial activation, Ann Rheum Dis, 61, 311, 10.1136/ard.61.4.311 Saxne, 1988, Synovial fluid concentrations of interleukin-1 beta and proteoglycans are inversely related, J Autoimmun, 1, 373, 10.1016/0896-8411(88)90007-8 Saxne, 1988, Detection of tumor necrosis factor alpha but not tumor necrosis factor beta in rheumatoid arthritis synovial fluid and serum, Arthritis Rheum, 31, 1041, 10.1002/art.1780310816 Bingham, 2002, The pathogenesis of rheumatoid arthritis: pivotal cytokines involved in bone degradation and inflammation, J Rheumatol, 65, 3 Williams, 1998, Autoantibodies in rheumatoid arthritis, 9.1 Hill Gaston, 1998, Cellular immunity in RA, 10.1 Hynes RO. Fibronectins. New York, Berlin: Springer V-lg; 1990. Ruoslahti, 1981, Alignment of biologically active domains in the fibronectin molecule, J Biol Chem, 256, 7277, 10.1016/S0021-9258(19)68958-1 Woods, 1986, Adhesion and cytoskeletal organisation of fibroblasts in response to fibronectin fragments, EMBO J, 5, 665, 10.1002/j.1460-2075.1986.tb04265.x Homandberg, 1999, Potential regulation of cartilage metabolism in osteoarthritis by fibronectin fragments, Front Biosci, 4, D713, 10.2741/Homandberg Homandberg, 1992, Fibronectinfragments cause chondrolysis of bovine articular cartilage slices in culture, J Biol Chem, 267, 3597, 10.1016/S0021-9258(19)50566-X Caterson, 2000, Mechanisms involved in cartilage proteoglycan catabolism, Matrix Biol, 19, 333, 10.1016/S0945-053X(00)00078-0 Goldberg RL, Spirito D, Doughty JR, Ganu V,Heinegård D. Time-dependent release of matrix components from bovine cartilage after Il-1 treatment and the relative inhibition by matrix metalloprotease inhibitors. Transactions of the 41st Annual Meeting of the Orthopaedic Research Society 20, section 1.2-13-1995. Saxne, 1993, Release of cartilage macromolecules into the synovial fluid in patients with acute and prolonged phases of reactive arthritis, Arthritis Rheum, 36, 20, 10.1002/art.1780360105 Heinegård, 2002, Glycosylated Matrix Proteins, 41 Vogel, 1984, Specific inhibition of type I and type II collagen fibrillogenesis by the small proteoglycan of tendon, Biochem J, 223, 587, 10.1042/bj2230587 Bidanset, 1992, Binding of the proteoglycan decorin to collagen type VI, J Biol Chem, 267, 5250, 10.1016/S0021-9258(18)42759-7 Oldberg, 1989, A collagen-binding 59-kd protein (fibromodulin) is structurally related to the small interstitial proteoglycans PG-S1 and PG-S2 (decorin), EMBO J, 8, 2601, 10.1002/j.1460-2075.1989.tb08399.x Eyre, 1987, Collagen type IX: evidence for covalent linkages to type II collagen in cartilage, FEBS Lett, 220, 337, 10.1016/0014-5793(87)80842-6 Camper, 1997, Integrin alpha2beta1 is a receptor for the cartilage matrix protein chondroadherin. J, J Cell Biol, 138, 1159, 10.1083/jcb.138.5.1159 Bengtsson, 2002, The leucine-rich repeat protein PRELP binds perlecan and collagens and may function as a basement anchor, J Biol Chem, 277, 15061, 10.1074/jbc.M108285200 Komoriya, 1991, The minimal essential sequence for a major cell type-specific adhesion site (CS1) within the alternatively spliced type III connecting segment domain of fibronectin is leucine-aspartic acid-valine, J Biol Chem, 266, 15075, 10.1016/S0021-9258(18)98588-1 Mould, 1991, The CS5 peptide is a second site in the IIICS region of fibronectin recognized by the integrin alpha 4 beta 1. Inhibition of alpha 4 beta 1 function by RGD peptide homologues, J Biol Chem, 266, 3579, 10.1016/S0021-9258(19)67834-8 Laemmli, 1970, Cleavage of structural proteins during the assembly of the head of bacteriophage T4, Nature, 227, 680, 10.1038/227680a0 Towbin, 1979, Electrophoretic transfer of proteins from polyacrylamide gels to nitrocellulose sheets: procedure and some applications, Proc Natl Acad Sci USA, 76, 4350, 10.1073/pnas.76.9.4350 Thorpe, 1985, Phenols as enhancers of the chemiluminescent horseradish peroxidase-luminol-hydrogen peroxide reaction: application in luminescence-monitored enzyme immunoassays, Clin Chem, 31, 1335, 10.1093/clinchem/31.8.1335 Larsson, 1991, Cartilage matrix proteins. A basic 36-kDa protein with a restricted distribution to cartilage and bone, J Biol Chem, 266, 20428, 10.1016/S0021-9258(18)54941-3 Hedbom, 1992, Cartilagematrix proteins. An acidic oligomeric protein (COMP) detected only in cartilage, J Biol Chem, 267, 6132, 10.1016/S0021-9258(18)42671-3 Engvall, 1980, Enzyme immunoassay ELISA and EMIT, Methods Enzymol, 70, 419, 10.1016/S0076-6879(80)70067-8 Cherdchutham, 1999, Age-related changes and effect of exercise on the molecular composition of immature equine superficial digital flexor tendons, Equine Vet J, Suppl, 86 Farndale, 1982, A direct spectrophotometric microassay for sulfated glycosaminoglycans in cartilage cultures, Connect Tissue Res, 9, 247, 10.3109/03008208209160269 Gross, 1992, Tetrahydrobiopterin synthesis. An absolute requirement for cytokine-induced nitricoxide generation by vascular smooth muscle, J Biol Chem, 267, 25722, 10.1016/S0021-9258(18)35667-9 Yasuda, 2002, A fibronectin fragment induces type II collagen degradation by collagenase through an interleukin-1-mediated pathway, Arthritis Rheum, 46, 138, 10.1002/1529-0131(200201)46:1<138::AID-ART10051>3.0.CO;2-K Bengtsson, 2000, The amino-terminal part of PRELP binds to heparin and heparan sulfate, J Biol Chem, 275, 40695, 10.1074/jbc.M007917200 Reinholt, 1990, Osteopontin—a possible anchor of osteoclasts to bone, Proc Natl Acad Sci USA, 87, 4473, 10.1073/pnas.87.12.4473 Saxne, 1992, Cartilage oligomeric matrix protein: a novel marker of cartilage turnover detectable in synovial fluid and blood, Br J Rheumatol, 31, 583, 10.1093/rheumatology/31.9.583 Di Cesare, 1996, Increased degradation and altered tissue distribution of cartilage oligomeric matrix protein in human rheumatoid and osteoarthritic cartilage, J Orthop Res, 14, 946, 10.1002/jor.1100140615 Neidhart, 1997, Small fragments of cartilage oligomeric matrix protein in synovial fluid and serum as markers for cartilage degradation, Br J Rheumatol, 36, 1151, 10.1093/rheumatology/36.11.1151 Riessen, 2001, Cartilage oligomeric matrix protein (thrombospondin-5) is expressed by human vascular smooth muscle cells, Arterioscler Thromb Vasc Biol, 21, 47, 10.1161/01.ATV.21.1.47 DiCesare, 1994, Cartilage oligomeric matrix protein (COMP) is an abundant component of tendon, FEBS Lett, 354, 237, 10.1016/0014-5793(94)01134-6 Rosenberg, 1998, Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen, J Biol Chem, 273, 20397, 10.1074/jbc.273.32.20397 Rosenberg, 1998, Cartilage oligomeric matrix protein shows high affinity zinc-dependent interaction with triple helical collagen, J Biol Chem, 273, 20397, 10.1074/jbc.273.32.20397 Shen, 1998, Chondroadherin expression changes in skeletal development, Biochem J, 330, 549, 10.1042/bj3300549 Månsson, 2001, Association of chondroadherin with collagen type II, J Biol Chem, 276, 32883, 10.1074/jbc.M101680200 Charles, 1993, Cloning, characterization, and expression of a cDNA encoding an inducible nitric oxide synthase from the human chondrocyte, Proc Natl Acad Sci USA, 90, 11419, 10.1073/pnas.90.23.11419 Amin, 1998, The role of nitric oxide in articular cartilage breakdown in osteoarthritis, Curr Opin Rheumatol, 10, 263, 10.1097/00002281-199805000-00018 Gemba, 2002, Focal adhesion kinase and mitogen-activated protein kinases are involved in chondrocyte activation by the 29-kDa amino-terminal fibronectin fragment, J Biol Chem, 277, 907, 10.1074/jbc.M109690200 Yasuda, 2003, Involvement of CD44 in induction of matrix metalloproteinases by a COOH-terminal heparin-binding fragment of fibronectin in human articular cartilage in culture, Arthritis Rheum, 48, 1271, 10.1002/art.10951 Homandberg, 2002, Antisense oligonucleotides to the integrin receptor subunit alpha(5) decrease fibronectin fragment mediated cartilage chondrolysis, Osteoarthritis Cartilage, 10, 381, 10.1053/joca.2002.0524 Homandberg, 2002, Fibronectin fragments active in chondrocytic chondrolysis can be chemically cross-linked to the alpha5 integrin receptor subunit, Osteoarthritis Cartilage, 10, 938, 10.1053/joca.2002.0854 Shen, 1995, Distribution and expression of cartilage oligomeric matrix protein and bone sialoprotein show marked changes during rat femoral head development, Matrix Biol, 14, 773, 10.1016/S0945-053X(05)80020-4 Di Cesare, 2002, Matrix–matrix interaction of cartilage oligomeric matrix protein and fibronectin, Matrix Biol, 21, 461, 10.1016/S0945-053X(02)00015-X Durr, 1993, Localization of beta 1-integrins in human cartilage and their role in chondrocyte adhesion to collagen and fibronectin, Exp Cell Res, 207, 235, 10.1006/excr.1993.1189 Holmvall, 1995, Chondrocyte and chondrosarcoma cell integrins with affinity for collagen type II and their response to mechanical stress, Exp Cell Res, 221, 496, 10.1006/excr.1995.1401