Fibroblast Growth Factor 23 and Risk of Heart Failure Subtype: The CRIC (Chronic Renal Insufficiency Cohort) Study

Kottgen, 2007, Reduced kidney function as a risk factor for incident heart failure: the atherosclerosis risk in communities (ARIC) study, J Am Soc Nephrol, 18, 1307, 10.1681/ASN.2006101159 Saran, 2020, US Renal Data System 2019 Annual Data Report: epidemiology of kidney disease in the United States, Am J Kidney Dis, 75, S1 Kociol, 2010, Generalizability and longitudinal outcomes of a national heart failure clinical registry: Comparison of Acute Decompensated Heart Failure National Registry (ADHERE) and non-ADHERE Medicare beneficiaries, Am Heart J, 160, 885, 10.1016/j.ahj.2010.07.020 Go, 2004, Chronic kidney disease and the risks of death, cardiovascular events, and hospitalization, N Engl J Med, 351, 1296, 10.1056/NEJMoa041031 Davis, 2008, Heart failure with preserved and reduced left ventricular ejection fraction in the antihypertensive and lipid-lowering treatment to prevent heart attack trial, Circulation, 118, 2259, 10.1161/CIRCULATIONAHA.107.762229 Fukumoto, 2007, FGF23 is a hormone-regulating phosphate metabolism--unique biological characteristics of FGF23, Bone, 40, 1190, 10.1016/j.bone.2006.12.062 Mirza, 2009, Serum intact FGF23 associate with left ventricular mass, hypertrophy and geometry in an elderly population, Atherosclerosis, 207, 546, 10.1016/j.atherosclerosis.2009.05.013 Kestenbaum, 2014, Fibroblast growth factor-23 and cardiovascular disease in the general population: the Multi-Ethnic Study of Atherosclerosis, Circ Heart Fail, 7, 409, 10.1161/CIRCHEARTFAILURE.113.000952 Souma, 2016, Fibroblast growth factor 23 and cause-specific mortality in the general population: the Northern Manhattan study, J Clin Endocrinol Metab, 101, 3779, 10.1210/jc.2016-2215 Mehta, 2016, Association of fibroblast growth factor 23 with atrial fibrillation in chronic kidney disease, from the Chronic Renal Insufficiency Cohort study, JAMA Cardiol, 1, 548, 10.1001/jamacardio.2016.1445 Paulus, 2013, A novel paradigm for heart failure with preserved ejection fraction: comorbidities drive myocardial dysfunction and remodeling through coronary microvascular endothelial inflammation, J Am Coll Cardiol, 62, 263, 10.1016/j.jacc.2013.02.092 Jimbo, 2014, Fibroblast growth factor 23 accelerates phosphate-induced vascular calcification in the absence of Klotho deficiency, Kidney Int, 85, 1103, 10.1038/ki.2013.332 Andrukhova, 2014, FGF23 regulates renal sodium handling and blood pressure, EMBO Mol Med, 6, 744, 10.1002/emmm.201303716 Bae, 2011, Preventing progression of cardiac hypertrophy and development of heart failure by paricalcitol therapy in rats, Cardiovasc Res, 91, 632, 10.1093/cvr/cvr133 Wu, 1996, 1,25(OH)2 vitamin D3, and retinoic acid antagonize endothelin-stimulated hypertrophy of neonatal rat cardiac myocytes, J Clin Invest, 97, 1577, 10.1172/JCI118582 Hu, 2015, Klotho and phosphate are modulators of pathologic uremic cardiac remodeling, J Am Soc Nephrol, 26, 1290, 10.1681/ASN.2014050465 Lee, 2009, Relation of disease pathogenesis and risk factors to heart failure with preserved or reduced ejection fraction: insights from the Framingham Heart Study of the National Heart, Lung, and Blood Institute, Circulation, 119, 3070, 10.1161/CIRCULATIONAHA.108.815944 LaMonte, 2005, Coronary artery calcium score and coronary heart disease events in a large cohort of asymptomatic men and women, Am J Epidemiol, 162, 421, 10.1093/aje/kwi228 Munoz Mendoza, 2012, Fibroblast growth factor 23 and inflammation in CKD, Clin J Am Soc Nephrol, 7, 1155, 10.2215/CJN.13281211 Czaya, 2019, The role of fibroblast growth factor 23 in inflammation and anemia, Int J Mol Sci, 20, 10.3390/ijms20174195 Xie, 2015, Soluble klotho protects against uremic cardiomyopathy independently of fibroblast growth factor 23 and phosphate, J Am Soc Nephrol, 26, 1150, 10.1681/ASN.2014040325 Heinzel, 2015, Myocardial hypertrophy and its role in heart failure with preserved ejection fraction, J Appl Physiol (1985), 119, 1233, 10.1152/japplphysiol.00374.2015 Feldman, 2003, The chronic renal insufficiency cohort (CRIC) study: design and methods, J Am Soc Nephrol, 14, S148, 10.1097/01.ASN.0000070149.78399.CE Isakova, 2011, Fibroblast growth factor 23 is elevated before parathyroid hormone and phosphate in chronic kidney disease, Kidney Int, 79, 1370, 10.1038/ki.2011.47 Faul, 2011, FGF23 induces left ventricular hypertrophy, J Clin Invest, 121, 4393, 10.1172/JCI46122 Mahmood, 2013, The epidemiology of congestive heart failure: the Framingham Heart Study perspective, Glob Hear, 8, 77, 10.1016/j.gheart.2012.12.006 Bansal, 2019, Burden and outcomes of heart failure hospitalizations in adults with chronic kidney disease, J Am Coll Cardiol, 73, 2691, 10.1016/j.jacc.2019.02.071 Bansal, 2018, Evolution of echocardiographic measures of cardiac disease from CKD to ESRD and risk of all-cause mortality: findings from the CRIC study, Am J Kidney Dis, 72, 390, 10.1053/j.ajkd.2018.02.363 Bansal, 2013, A longitudinal study of left ventricular function and structure from CKD to ESRD: the CRIC study, Clin J Am Soc Nephrol, 8, 355, 10.2215/CJN.06020612 Inker, 2021, New creatinine- and cystatin C–based equations to estimate GFR without race, N Engl J Med, 385, 1737, 10.1056/NEJMoa2102953 Karson, 1968, Handbook of methods of applied statistics, J Am Stat Assoc, 63, 392, 10.2307/2283899 Lunn, 1995, Applying Cox regression to competing risks, Biometrics, 51, 524, 10.2307/2532940 Feakins, 2018, Standard and competing risk analysis of the effect of albuminuria on cardiovascular and cancer mortality in patients with type 2 diabetes mellitus, Diagn Progn Res, 2, 13, 10.1186/s41512-018-0035-4 Lim, 2010, Methods of competing risks analysis of end-stage renal disease and mortality among people with diabetes, BMC Med Res Methodol, 10, 97, 10.1186/1471-2288-10-97 Ho, 2013, Predictors of new-onset heart failure: differences in preserved versus reduced ejection fraction, Circ Heart Fail, 6, 279, 10.1161/CIRCHEARTFAILURE.112.972828 Balkan, 2022, Association of perceived stress with incident heart failure, J Card Fail, 28, 1401, 10.1016/j.cardfail.2022.04.013 Almahmoud, 2018, Fibroblast growth factor-23 and heart failure with reduced versus preserved ejection fraction: MESA, J Am Heart Assoc, 7 Kitzman, 2002, Pathophysiological characterization of isolated diastolic heart failure in comparison to systolic heart failure, JAMA, 288, 2144, 10.1001/jama.288.17.2144 Zile, 2011, Prevalence and significance of alterations in cardiac structure and function in patients with heart failure and a preserved ejection fraction, Circulation, 124, 2491, 10.1161/CIRCULATIONAHA.110.011031 Kuro-o, 2019, The klotho proteins in health and disease, Nat Rev Nephrol, 15, 27, 10.1038/s41581-018-0078-3 Böckmann, 2019, FGF23-mediated activation of local raas promotes cardiac hypertrophy and fibrosis, Int J Mol Sci, 20, 10.3390/ijms20184634 Leifheit-Nestler, 2017, Vitamin D treatment attenuates cardiac FGF23/FGFR4 signaling and hypertrophy in uremic rats, Nephrol Dial Transplant, 32, 1493, 10.1093/ndt/gfw454 Willerson, 2004, Inflammation as a cardiovascular risk factor, Circulation, 109, II2 Desjardins, 2012, FGF23 is independently associated with vascular calcification but not bone mineral density in patients at various CKD stages, Osteoporos Int, 23, 2017, 10.1007/s00198-011-1838-0 Reindl, 2017, Fibroblast growth factor 23 as novel biomarker for early risk stratification after ST-elevation myocardial infarction, Heart, 103, 856, 10.1136/heartjnl-2016-310520 Muñoz, 2017, Heart failure labelled patients with missing ejection fraction in primary care: prognosis and determinants, BMC Fam Pract, 18, 38, 10.1186/s12875-017-0612-6 Poppe, 2013, Known and missing left ventricular ejection fraction and survival in patients with heart failure: a MAGGIC meta-analysis report, Eur J Heart Fail, 15, 1220, 10.1093/eurjhf/hft101 Binnenmars, 2022, Fibroblast growth factor 23 and risk of new onset heart failure with preserved or reduced ejection fraction: the PREVEND study, J Am Heart Assoc, 11 Kestenbaum, 2009, Incidence and progression of coronary calcification in chronic kidney disease: the Multi-Ethnic Study of Atherosclerosis, Kidney Int, 76, 991, 10.1038/ki.2009.298 Akwo, 2022, Association of genetically predicted fibroblast growth factor-23 with heart failure: a Mendelian randomization study, Clin J Am Soc Nephrol, 17, 1183, 10.2215/CJN.00960122