Fever, Rash, and Systemic Symptoms: Understanding the Role of Virus and HLA in Severe Cutaneous Drug Allergy

Rebecca Pavlos1, S. Mallal1,2, David A. Ostrov3, Y.A. Pompeu3, Elizabeth J. Phillips1,2
1Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia
2Vanderbilt University School of Medicine, Nashville, Tenn
3Department of Pathology, Immunology and Laboratory Medicine, University of Florida, College of Medicine, Gainsville, Fla

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Pirmohamed, 2011, The phenotype standardization project: improving pharmacogenetic studies of serious adverse drug reactions, Clin Pharmacol Ther, 89, 784, 10.1038/clpt.2011.30

Hotz, 2013, Systemic involvement of acute generalized exanthematous pustulosis: a retrospective study on 58 patients, Br J Dermatol, 169, 1223, 10.1111/bjd.12502

Sidoroff, 2001, Acute generalized exanthematous pustulosis (AGEP): a clinical reaction pattern, J Cutan Pathol, 28, 113, 10.1034/j.1600-0560.2001.028003113.x

Speeckaert, 2010, Acute generalized exanthematous pustulosis: an overview of the clinical, immunological and diagnostic concepts, Eur J Dermatol, 20, 425, 10.1684/ejd.2010.0932

Raison-Peyron, 2013, “Cutaneous adverse drug reactions” are not always drug-induced, Eur J Dermatol, 23, 439, 10.1684/ejd.2013.2055

Feio, 1997, Acute generalized exanthematous pustulosis due to Coxsackie B4 virus [in Portuguese], Acta Med Port, 10, 487

Haro-Gabaldon, 1996, Acute generalized exanthematous pustulosis with cytomegalovirus infection, Int J Dermatol, 35, 735, 10.1111/j.1365-4362.1996.tb00653.x

Klein, 2009, Acute generalized exanthematous pustulosis associated with recurrent urinary tract infections [in German with English abstract], Hautarzt, 60, 226, 10.1007/s00105-008-1604-1

Manzano, 2006, Acute generalized exanthematous pustulosis: first case associated with a Chlamydia pneumoniae infection [in French with English abstract ], Arch Pediatr, 13, 1230, 10.1016/j.arcped.2006.06.004

Naides, 1998, Rheumatic manifestations of parvovirus B19 infection, Rheum Dis Clin North Am, 24, 375, 10.1016/S0889-857X(05)70014-4

Bernard, 1995, HLA et prédisposition génétique dans les pustuloses exanthématiques aiguës généralisées (PEAG) et dans les exanthèmes maculo-papuleux (EMP), Ann Dermatol Venereol, 122, S38

Tohyama, 2011, New aspects of drug-induced hypersensitivity syndrome, J Dermatol, 38, 222, 10.1111/j.1346-8138.2010.01176.x

Tohyama, 2007, Association of human herpesvirus 6 reactivation with the flaring and severity of drug-induced hypersensitivity syndrome, Br J Dermatol, 157, 934, 10.1111/j.1365-2133.2007.08167.x

Pavlos, 2012, HLA and pharmacogenetics of drug hypersensitivity, Pharmacogenomics, 13, 1285, 10.2217/pgs.12.108

Martin, 2005, Predisposition to nevirapine hypersensitivity associated with HLA-DRB1*0101 and abrogated by low CD4 T-cell counts, AIDS, 19, 97, 10.1097/00002030-200501030-00014

Phillips EBJ, Sanne I, Lederman M, Hinkle J, Rousseau F, James I, et al. Associations between HLA-DRBA*0102, HLA-B*5801 and hepatotoxicity in patients who initiated nevirapine containing regimens in South Africa. 18th Conference on retroviruses and opportunistic infections. Paper #949. Boston, MA; February 2011.

Yuan, 2011, Toxicogenomics of nevirapine-associated cutaneous and hepatic adverse events among populations of African, Asian, and European descent, AIDS, 25, 1271, 10.1097/QAD.0b013e32834779df

Phillips, 2013, Associations between HLA-DRB1*0102, HLA-B*5801, and hepatotoxicity during initiation of nevirapine-containing regimens in South Africa, J Acquir Immune Defic Syndr, 62, e55, 10.1097/QAI.0b013e31827ca50f

Littera, 2006, HLA-dependent hypersensitivity to nevirapine in Sardinian HIV patients, AIDS, 20, 1621, 10.1097/01.aids.0000238408.82947.09

Gatanaga, 2007, HLA-Cw8 primarily associated with hypersensitivity to nevirapine, AIDS, 21, 264, 10.1097/QAD.0b013e32801199d9

Gao, 2011, HLA-dependent hypersensitivity reaction to nevirapine in chinese han hiv-infected patients, AIDS Res Hum Retroviruses, 28, 540, 10.1089/aid.2011.0107

Carr, 2013, Association of human leukocyte antigen alleles and nevirapine hypersensitivity in a Malawian HIV-infected population, Clin Infect Dis, 56, 1330, 10.1093/cid/cit021

Cutrell, 2004, Updated clinical risk factor analysis of suspected hypersensitivity reactions to abacavir, Ann Pharmacother, 38, 2171, 10.1345/aph.1E202

Symonds, 2002, Risk factor analysis of hypersensitivity reactions to abacavir, Clin Ther, 24, 565, 10.1016/S0149-2918(02)85132-3

Hetherington, 2002, Genetic variations in HLA-B region and hypersensitivity reactions to abacavir, Lancet, 359, 1121, 10.1016/S0140-6736(02)08158-8

Mallal, 2002, Association between presence of HLA-B*5701, HLA-DR7, and HLA-DQ3 and hypersensitivity to HIV-1 reverse-transcriptase inhibitor abacavir, Lancet, 359, 727, 10.1016/S0140-6736(02)07873-X

Phillips, 2005, Clinical and immunogenetic correlates of abacavir hypersensitivity, AIDS, 19, 979, 10.1097/01.aids.0000171414.99409.fb

Mallal, 2008, HLA-B*5701 screening for hypersensitivity to abacavir, N Engl J Med, 358, 568, 10.1056/NEJMoa0706135

Phillips ESS, Arribas J, Fitch N, Givens N. Characteristics of abacavir hypersensitivity diagnoses according to HLA-B*5701 status and subsequent abacavir patch test result. 11th European AIDS Conference. Madrid, Spain. 2007:P9.7/04.

Saag, 2008, High sensitivity of human leukocyte antigen-b*5701 as a marker for immunologically confirmed abacavir hypersensitivity in white and black patients, Clin Infect Dis, 46, 1111, 10.1086/529382

Martin, 2012, Clinical pharmacogenetics implementation consortium guidelines for HLA-B genotype and abacavir dosing, Clin Pharmacol Ther, 91, 734, 10.1038/clpt.2011.355

Hughes, 2004, Cost-effectiveness analysis of HLA B*5701 genotyping in preventing abacavir hypersensitivity, Pharmacogenetics, 14, 335, 10.1097/00008571-200406000-00002

Schackman, 2008, The cost-effectiveness of HLA-B*5701 genetic screening to guide initial antiretroviral therapy for HIV, AIDS, 22, 2025, 10.1097/QAD.0b013e3283103ce6

Phillips, 2002, Utility of patch testing in patients with hypersensitivity syndromes associated with abacavir, AIDS, 16, 2223, 10.1097/00002030-200211080-00017

Almeida, 2008, Cytokine profiling in abacavir hypersensitivity patients, Antivir Ther, 13, 281, 10.1177/135965350801300202

Martin, 2007, Immune responses to abacavir in antigen-presenting cells from hypersensitive patients, AIDS, 21, 1233, 10.1097/QAD.0b013e3280119579

Chessman, 2008, Human leukocyte antigen class I-restricted activation of CD8+ T cells provides the immunogenetic basis of a systemic drug hypersensitivity, Immunity, 28, 822, 10.1016/j.immuni.2008.04.020

Chung, 2004, Medical genetics: a marker for Stevens-Johnson syndrome, Nature, 428, 486, 10.1038/428486a

Hung, 2006, Genetic susceptibility to carbamazepine-induced cutaneous adverse drug reactions, Pharmacogenet Genomics, 16, 297, 10.1097/01.fpc.0000199500.46842.4a

Kulkantrakorn, 2011, HLA-B*1502 Strongly predicts carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Thai patients with neuropathic pain, Pain Pract, 12, 202, 10.1111/j.1533-2500.2011.00479.x

Likanonsakul, 2009, HLA-Cw*04 allele associated with nevirapine-induced rash in HIV-infected Thai patients, AIDS Res Ther, 6, 22, 10.1186/1742-6405-6-22

Mehta, 2009, Association of HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome among Indians, Indian J Dermatol Venereol Leprol, 75, 579, 10.4103/0378-6323.57718

Tassaneeyakul, 2010, Association between HLA-B*1502 and carbamazepine-induced severe cutaneous adverse drug reactions in a Thai population, Epilepsia, 51, 926, 10.1111/j.1528-1167.2010.02533.x

Then, 2011, Frequency of the HLA-B*1502 allele contributing to carbamazepine-induced hypersensitivity reactions in a cohort of Malaysian epilepsy patients, Asian Pac J Allergy Immunol, 29, 290

Kim, 2011, Carbamazepine-induced severe cutaneous adverse reactions and HLA genotypes in Koreans, Epilepsy Res, 97, 190, 10.1016/j.eplepsyres.2011.08.010

Chen, 2011, Carbamazepine-induced toxic effects and HLA-B*1502 screening in Taiwan, N Engl J Med, 364, 1126, 10.1056/NEJMoa1009717

Amstutz, 2013, HLA-A 31:01 and HLA-B 15:02 as genetic markers for carbamazepine hypersensitivity in children, Clin Pharmacol Ther, 94, 142, 10.1038/clpt.2013.55

McCormack, 2011, HLA-A*3101 and carbamazepine-induced hypersensitivity reactions in Europeans, N Engl J Med, 364, 1134, 10.1056/NEJMoa1013297

Ozeki, 2011, Genome-wide association study identifies HLA-A*3101 allele as a genetic risk factor for carbamazepine-induced cutaneous adverse drug reactions in a Japanese population, Hum Mol Genet, 20, 1034, 10.1093/hmg/ddq537

Ko, 2011, Shared and restricted T-cell receptor use is crucial for carbamazepine-induced Stevens-Johnson syndrome, J Allergy Clin Immunol, 128, 1266, 10.1016/j.jaci.2011.08.013

Park, 2001, Metabolic activation in drug allergies, Toxicology, 158, 11, 10.1016/S0300-483X(00)00397-8

Pichler, 2006, Pharmacological interaction of drugs with immune receptors: the p-i concept, Allergol Int, 55, 17, 10.2332/allergolint.55.17

Illing, 2012, Immune self-reactivity triggered by drug-modified HLA-peptide repertoire, Nature, 486, 554, 10.1038/nature11147

Ostrov, 2012, Drug hypersensitivity caused by alteration of the MHC-presented self-peptide repertoire, Proc Natl Acad Sci U S A, 109, 9959, 10.1073/pnas.1207934109

Norcross, 2012, Abacavir induces loading of novel self-peptides into HLA-B*57: 01: an autoimmune model for HLA-associated drug hypersensitivity, AIDS, 26, F21, 10.1097/QAD.0b013e328355fe8f

Wei, 2012, Direct interaction between HLA-B and carbamazepine activates T cells in patients with Stevens-Johnson syndrome, J Allergy Clin Immunol, 129, 1562, 10.1016/j.jaci.2011.12.990

Kano, 2004, Association between anticonvulsant hypersensitivity syndrome and human herpesvirus 6 reactivation and hypogammaglobulinemia, Arch Dermatol, 140, 183, 10.1001/archderm.140.2.183

Descamps, 2001, Association of human herpesvirus 6 infection with drug reaction with eosinophilia and systemic symptoms, Arch Dermatol, 137, 301

Kano, 2006, Several herpesviruses can reactivate in a severe drug-induced multiorgan reaction in the same sequential order as in graft-versus-host disease, Br J Dermatol, 155, 301, 10.1111/j.1365-2133.2006.07238.x

Seishima, 2006, Reactivation of human herpesvirus (HHV) family members other than HHV-6 in drug-induced hypersensitivity syndrome, Br J Dermatol, 155, 344, 10.1111/j.1365-2133.2006.07332.x

Shiohara, 2006, Drug-induced hypersensitivity syndrome (DIHS): a reaction induced by a complex interplay among herpesviruses and antiviral and antidrug immune responses, Allergol Int, 55, 1, 10.2332/allergolint.55.1

Picard, 2010, Drug reaction with eosinophilia and systemic symptoms (DRESS): a multiorgan antiviral T cell response, Sci Transl Med, 2, 10.1126/scitranslmed.3001116

Ushigome, 2013, Short- and long-term outcomes of 34 patients with drug-induced hypersensitivity syndrome in a single institution, J Am Acad Dermatol, 68, 721, 10.1016/j.jaad.2012.10.017

Aihara, 2001, Anticonvulsant hypersensitivity syndrome associated with reactivation of cytomegalovirus, Br J Dermatol, 144, 1231, 10.1046/j.1365-2133.2001.04239.x

Descamps, 2003, Drug-induced hypersensitivity syndrome associated with Epstein-Barr virus infection, Br J Dermatol, 148, 1032, 10.1046/j.1365-2133.2003.05330.x

Harding, 2012, Severe drug-induced hypersensitivity syndrome with a shared HLA-B allele, Med J Aust, 197, 411, 10.5694/mja12.10477

Aota, 2009, Systemic lupus erythematosus presenting with Kikuchi-Fujimoto's disease as a long-term sequela of drug-induced hypersensitivity syndrome. A possible role of Epstein-Barr virus reactivation, Dermatology, 218, 275, 10.1159/000187619

Chiou, 2006, Fulminant type 1 diabetes mellitus caused by drug hypersensitivity syndrome with human herpesvirus 6 infection, J Am Acad Dermatol, 54, S14, 10.1016/j.jaad.2005.03.057

Kano, 2007, Sclerodermoid graft-versus-host disease-like lesions occurring after drug-induced hypersensitivity syndrome, Br J Dermatol, 156, 1061, 10.1111/j.1365-2133.2007.07784.x

Sekine, 2001, Rapid loss of insulin secretion in a patient with fulminant type 1 diabetes mellitus and carbamazepine hypersensitivity syndrome, JAMA, 285, 1153, 10.1001/jama.285.9.1153

Takahashi, 2009, Defective regulatory T cells in patients with severe drug eruptions: timing of the dysfunction is associated with the pathological phenotype and outcome, J Immunol, 182, 8071, 10.4049/jimmunol.0804002

Chen, 2013, Long-term sequelae of drug reaction with eosinophilia and systemic symptoms: a retrospective cohort study from Taiwan, J Am Acad Dermatol, 68, 459, 10.1016/j.jaad.2012.08.009

Burrows, 1994, An alloresponse in humans is dominated by cytotoxic T lymphocytes (CTL) cross-reactive with a single Epstein-Barr virus CTL epitope: implications for graft-versus-host disease, J Exp Med, 179, 1155, 10.1084/jem.179.4.1155

Gamadia, 2004, Cross-reactivity of cytomegalovirus-specific CD8+ T cells to allo-major histocompatibility complex class I molecules, Transplantation, 77, 1879, 10.1097/01.TP.0000131158.81346.64

Koelle, 2002, Herpes simplex virus type 2-specific CD8 cytotoxic T lymphocyte cross-reactivity against prevalent HLA class I alleles, Blood, 99, 3844, 10.1182/blood.V99.10.3844

Landais, 2006, EBV-specific CD4+ T cell clones exhibit vigorous allogeneic responses, J Immunol, 177, 1427, 10.4049/jimmunol.177.3.1427

Amir, 2010, Allo-HLA reactivity of virus-specific memory T cells is common, Blood, 115, 3146, 10.1182/blood-2009-07-234906

D'Orsogna, 2011, Screening of viral specific T-cell lines for HLA alloreactivity prior to adoptive immunotherapy may prevent GvHD, Transpl Immunol, 24, 141, 10.1016/j.trim.2010.12.001

Morice, 2010, Cross-reactivity of herpesvirus-specific CD8 T cell lines toward allogeneic class I MHC molecules, PLoS One, 5, e12120, 10.1371/journal.pone.0012120

Amir, 2011, Allo-HLA-reactive T cells inducing graft-versus-host disease are single peptide specific, Blood, 118, 6733, 10.1182/blood-2011-05-354787

Deckers, 1998, Epithelial- and endothelial-cell specificity of renal graft infiltrating T cells, Clin Transplant, 12, 285

Yard, 1994, Recognition of a tissue-specific polymorphism by graft infiltrating T-cell clones isolated from a renal allograft with acute rejection, Nephrol Dial Transplant, 9, 805

Deckers, 1997, Tissue-specific characteristics of cytotoxic graft-infiltrating T cells during renal allograft rejection, Transplantation, 64, 178, 10.1097/00007890-199707150-00034

D'Orsogna, 2011, Tissue specificity of cross-reactive allogeneic responses by EBV EBNA3A-specific memory T cells, Transplantation, 91, 494, 10.1097/TP.0b013e318207944c

Schnyder, 2013, HLA-B*57:01(+) abacavir-naive individuals have specific T cells but no patch test reactivity, J Allergy Clin Immunol, 132, 756, 10.1016/j.jaci.2013.04.013

Mackay, 2012, Maintenance of T cell function in the face of chronic antigen stimulation and repeated reactivation for a latent virus infection, J Immunol, 188, 2173, 10.4049/jimmunol.1102719

Lang, 2009, Inflation and long-term maintenance of CD8 T cells responding to a latent herpesvirus depend upon establishment of latency and presence of viral antigens, J Immunol, 183, 8077, 10.4049/jimmunol.0801117

Lang, 2011, Functional CD8 T cell memory responding to persistent latent infection is maintained for life, J Immunol, 187, 3759, 10.4049/jimmunol.1100666

Allam, 2009, The CD8+ memory T-cell state of readiness is actively maintained and reversible, Blood, 114, 2121, 10.1182/blood-2009-05-220087

Brehm, 2002, T cell immunodominance and maintenance of memory regulated by unexpectedly cross-reactive pathogens, Nat Immunol, 3, 627, 10.1038/ni806

Gray, 1991, T cell memory is short-lived in the absence of antigen, J Exp Med, 174, 969, 10.1084/jem.174.5.969

Genin, 2011, Genome-wide association study of Stevens-Johnson syndrome and toxic epidermal necrolysis in Europe, Orphanet J Rare Dis, 6, 52, 10.1186/1750-1172-6-52

Hung, 2005, HLA-B*5801 allele as a genetic marker for severe cutaneous adverse reactions caused by allopurinol, Proc Natl Acad Sci U S A, 102, 4134, 10.1073/pnas.0409500102

Lonjou, 2008, A European study of HLA-B in Stevens-Johnson syndrome and toxic epidermal necrolysis related to five high-risk drugs, Pharmacogenet Genomics, 18, 99, 10.1097/FPC.0b013e3282f3ef9c

Somkrua, 2011, Association of HLA-B*5801 allele and allopurinol-induced Stevens Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis, BMC Med Genet, 12, 118, 10.1186/1471-2350-12-118

Tassaneeyakul, 2009, Strong association between HLA-B*5801 and allopurinol-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in a Thai population, Pharmacogenet Genomics, 19, 704, 10.1097/FPC.0b013e328330a3b8

Cristallo, 2011, A study of HLA class I and class II 4-digit allele level in Stevens-Johnson syndrome and toxic epidermal necrolysis, Int J Immunogenet, 38, 303, 10.1111/j.1744-313X.2011.01011.x

Kang, 2011, Positive and negative associations of HLA class I alleles with allopurinol-induced SCARs in Koreans, Pharmacogenet Genomics, 21, 303, 10.1097/FPC.0b013e32834282b8

Ramasamy, 2013, Allopurinol hypersensitivity: a systematic review of all published cases, 1950-2012, Drug Saf, 36, 953, 10.1007/s40264-013-0084-0

Goncalo, 2013, HLA-B*58:01 is a risk factor for allopurinol-induced DRESS and Stevens-Johnson syndrome/toxic epidermal necrolysis in a Portuguese population, Br J Dermatol, 169, 660, 10.1111/bjd.12389

Locharernkul, 2008, Carbamazepine and phenytoin induced Stevens-Johnson syndrome is associated with HLA-B*1502 allele in Thai population, Epilepsia, 49, 2087, 10.1111/j.1528-1167.2008.01719.x

Man, 2007, Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese, Epilepsia, 48, 1015, 10.1111/j.1528-1167.2007.01022.x

Wang, 2011, Association between HLA-B*1502 allele and carbamazepine-induced severe cutaneous adverse reactions in Han people of southern China mainland, Seizure, 20, 446, 10.1016/j.seizure.2011.02.003

Wu, 2010, Association between carbamazepine-induced cutaneous adverse drug reactions and the HLA-B*1502 allele among patients in central China, Epilepsy Behav, 19, 405, 10.1016/j.yebeh.2010.08.007

Zhang, 2011, Strong association between HLA-B*1502 and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in mainland Han Chinese patients, Eur J Clin Pharmacol, 67, 885, 10.1007/s00228-011-1009-4

Chang, 2011, Association of HLA-B*1502 allele with carbamazepine-induced toxic epidermal necrolysis and Stevens-Johnson syndrome in the multi-ethnic Malaysian population, Int J Dermatol, 50, 221, 10.1111/j.1365-4632.2010.04745.x

Tangamornsuksan, 2013, Relationship between the HLA-B*1502 allele and carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis: a systematic review and meta-analysis, JAMA Dermatol, 149, 1025, 10.1001/jamadermatol.2013.4114

Cheung, 2013, HLA-B alleles associated with severe cutaneous reactions to antiepileptic drugs in Han Chinese, Epilepsia, 54, 1307, 10.1111/epi.12217

Kaniwa, 2010, HLA-B*1511 is a risk factor for carbamazepine-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients, Epilepsia, 51, 2461, 10.1111/j.1528-1167.2010.02766.x

Ikeda, 2010, HLA class I markers in Japanese patients with carbamazepine-induced cutaneous adverse reactions, Epilepsia, 51, 297, 10.1111/j.1528-1167.2009.02269.x

Niihara, 2011, HLA-A31 strongly associates with carbamazepine-induced adverse drug reactions but not with carbamazepine-induced lymphocyte proliferation in a Japanese population, J Dermatol, 39, 594, 10.1111/j.1346-8138.2011.01457.x

Hung, 2010, Common risk allele in aromatic antiepileptic-drug induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Han Chinese, Pharmacogenomics, 11, 349, 10.2217/pgs.09.162

An, 2010, Association study of lamotrigine-induced cutaneous adverse reactions and HLA-B*1502 in a Han Chinese population, Epilepsy Res, 92, 226, 10.1016/j.eplepsyres.2010.10.006

Shi, 2011, Hla-B alleles and lamotrigine-induced cutaneous adverse drug reactions in the Han Chinese population, Basic Clin Pharmacol Toxicol, 109, 42, 10.1111/j.1742-7843.2011.00681.x

Kaniwa, 2013, Specific HLA types are associated with antiepileptic drug-induced Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese subjects, Pharmacogenomics, 14, 1821, 10.2217/pgs.13.180

Roujeau, 1987, Genetic susceptibility to toxic epidermal necrolysis, Arch Dermatol, 123, 1171, 10.1001/archderm.1987.01660330082014

Lee, 2009, Strontium ranelate-induced toxic epidermal necrolysis in a patient with post-menopausal osteoporosis, Osteoporos Int, 20, 161, 10.1007/s00198-008-0677-0

Musette, 2010, Treatment of osteoporosis: recognizing and managing cutaneous adverse reactions and drug-induced hypersensitivity, Osteoporos Int, 21, 723, 10.1007/s00198-009-1097-5

Kaniwa, 2008, HLA-B locus in Japanese patients with anti-epileptics and allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis, Pharmacogenomics, 9, 1617, 10.2217/14622416.9.11.1617

Tohkin, 2011, A whole-genome association study of major determinants for allopurinol-related Stevens-Johnson syndrome and toxic epidermal necrolysis in Japanese patients, Pharmacogenomics J, 13, 60, 10.1038/tpj.2011.41

Chiu, 2012, Association between HLA-B*58:01 allele and severe cutaneous adverse reactions with allopurinol in Han Chinese in Hong Kong, Br J Dermatol, 167, 44, 10.1111/j.1365-2133.2012.10894.x

Phillips E, Keane N, Blyth C, Lucas A, Pavlos R, Lucas M, et al. Both HLA Class I restricted CD8+ and class II restricted CD4+ T cells are implicated in the pathogenesis of nevirapine hypersensitivity. 51st ICAAC. Chicago, Ill; September 2011:H1-1399c.

Alfirevic, 2006, HLA-B locus in Caucasian patients with carbamazepine hypersensitivity, Pharmacogenomics, 7, 813, 10.2217/14622416.7.6.813

Pirmohamed, 2001, TNF alpha promoter region gene polymorphisms in carbamazepine-hypersensitive patients, Neurology, 56, 890, 10.1212/WNL.56.7.890

Jonville-Bera, 2009, Strontium ranelate-induced DRESS syndrome: first two case reports, Allergy, 64, 658, 10.1111/j.1398-9995.2009.01940.x

Zhang, 2013, HLA-B*13:01 and the dapsone hypersensitivity syndrome, N Engl J Med, 369, 1620, 10.1056/NEJMoa1213096

Vitezica, 2008, HLA-DRB1*01 associated with cutaneous hypersensitivity induced by nevirapine and efavirenz, AIDS, 22, 540, 10.1097/QAD.0b013e3282f37812

Chantarangsu, 2009, HLA-B*3505 allele is a strong predictor for nevirapine-induced skin adverse drug reactions in HIV-infected Thai patients, Pharmacogenet Genomics, 19, 139, 10.1097/FPC.0b013e32831d0faf

Chantarangsu, 2011, Genome-wide association study identifies variations in 6p21.3 associated with nevirapine-induced rash, Clin Infect Dis, 53, 341, 10.1093/cid/cir403

Romano, 1998, Delayed hypersensitivity to aminopenicillins is related to major histocompatibility complex genes, Ann Allergy Asthma Immunol, 80, 433, 10.1016/S1081-1206(10)62997-3

Hu, 2011, Pilot association study of oxcarbazepine-induced mild cutaneous adverse reactions with HLA-B*1502 allele in Chinese Han population, Seizure, 20, 160, 10.1016/j.seizure.2010.11.014

Lv, 2013, The association between oxcarbazepine-induced maculopapular eruption and HLA-B alleles in a northern Han Chinese population, BMC Neurol, 13, 75, 10.1186/1471-2377-13-75

Hautekeete, 1999, HLA association of amoxicillin-clavulanate–induced hepatitis, Gastroenterology, 117, 1181, 10.1016/S0016-5085(99)70404-X

Lucena, 2011, Susceptibility to amoxicillin-clavulanate-induced liver injury is influenced by multiple HLA class I and II alleles, Gastroenterology, 141, 338, 10.1053/j.gastro.2011.04.001

O'Donohue, 2000, Co-amoxiclav jaundice: clinical and histological features and HLA class II association, Gut, 47, 717, 10.1136/gut.47.5.717

Singer, 2010, A genome-wide study identifies HLA alleles associated with lumiracoxib-related liver injury, Nat Genet, 42, 711, 10.1038/ng.632

Kindmark, 2008, Genome-wide pharmacogenetic investigation of a hepatic adverse event without clinical signs of immunopathology suggests an underlying immune pathogenesis, Pharmacogenomics J, 8, 186, 10.1038/sj.tpj.6500458

Daly, 2007, Genetic susceptibility to diclofenac-induced hepatotoxicity: contribution of UGT2B7, CYP2C8, and ABCC2 genotypes, Gastroenterology, 132, 272, 10.1053/j.gastro.2006.11.023

Daly, 2009, Genetic association studies in drug-induced liver injury, Semin Liver Dis, 29, 400, 10.1055/s-0029-1240009

Daly, 2012, Genetic association studies in drug-induced liver injury, Drug Metab Rev, 44, 116, 10.3109/03602532.2011.605790

Daly, 2009, HLA-B*5701 genotype is a major determinant of drug-induced liver injury due to flucloxacillin, Nat Genet, 41, 816, 10.1038/ng.379

Spraggs, 2011, HLA-DQA1*02:01 is a major risk factor for lapatinib-induced hepatotoxicity in women with advanced breast cancer, J Clin Oncol, 29, 667, 10.1200/JCO.2010.31.3197

Pellicano, 1994, Genetic susceptibility to fixed drug eruption: evidence for a link with HLA-B22, J Am Acad Dermatol, 30, 52, 10.1016/S0190-9622(94)70007-9

Pellicano, 1997, Fixed drug eruptions with feprazone are linked to HLA-B22, J Am Acad Dermatol, 36, 782, 10.1016/S0190-9622(97)80347-7

Ozkaya-Bayazit, 2001, Fixed drug eruption induced by trimethoprim-sulfamethoxazole: evidence for a link to HLA-A30 B13 Cw6 haplotype, J Am Acad Dermatol, 45, 712, 10.1067/mjd.2001.117854

Lieberman, 1990, HLA-B38, DR4, DQw3 and clozapine-induced agranulocytosis in Jewish patients with schizophrenia, Arch Gen Psychiatry, 47, 945, 10.1001/archpsyc.1990.01810220061007

Valevski, 1998, HLA-B38 and clozapine-induced agranulocytosis in Israeli Jewish schizophrenic patients, Eur J Immunogenet, 25, 11, 10.1046/j.1365-2370.1998.00091.x

Athanasiou, 2011, Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis, J Clin Psychiatry, 72, 458, 10.4088/JCP.09m05527yel

Dettling, 2007, Clozapine-induced agranulocytosis in schizophrenic Caucasians: confirming clues for associations with human leukocyte class I and II antigens, Pharmacogenomics J, 7, 325, 10.1038/sj.tpj.6500423

Diez, 1990, HLA-B27 and agranulocytosis by levamisole, Immunol Today, 11, 270, 10.1016/0167-5699(90)90109-M

Batchelor, 1980, Hydralazine-induced systemic lupus erythematosus: influence of HLA-DR and sex on susceptibility, Lancet, I, 1107, 10.1016/S0140-6736(80)91554-8

Vedove, 2009, Drug-induced lupus erythematosus, Arch Dermatol Res, 301, 99, 10.1007/s00403-008-0895-5

Kim, 2008, Pharmacogenetics of aspirin-intolerant asthma, Pharmacogenomics, 9, 85, 10.2217/14622416.9.1.85

Rodriguez-Perez, 1994, Association of HLA-DR5 with mucocutaneous lesions in patients with rheumatoid arthritis receiving gold sodium thiomalate, J Rheumatol, 21, 41

Speerstra, 1985, HLA associations in aurothioglucose- and D-penicillamine-induced haematotoxic reactions in rheumatoid arthritis, Tissue Antigens, 26, 35, 10.1111/j.1399-0039.1985.tb00932.x

Quiralte, 1999, Association of HLA-DR11 with the anaphylactoid reaction caused by nonsteroidal anti-inflammatory drugs, J Allergy Clin Immunol, 103, 685, 10.1016/S0091-6749(99)70243-5

Garlepp, 1983, HLA antigens and acetylcholine receptor antibodies in penicillamine induced myasthenia gravis, Br Med J (Clin Res Ed), 286, 1442, 10.1136/bmj.286.6375.1442-a

Pachoula-Papasteriades, 1986, HLA-A,-B, and -DR antigens in relation to gold and D-penicillamine toxicity in Greek patients with RA, Dis Markers, 4, 35

Maier, 2003, Influence of MHC class II in susceptibility to beryllium sensitization and chronic beryllium disease, J Immunol, 171, 6910, 10.4049/jimmunol.171.12.6910

Rosenman, 2011, HLA class II DPB1 and DRB1 polymorphisms associated with genetic susceptibility to beryllium toxicity, Occup Environ Med, 68, 487, 10.1136/oem.2010.055046

Morito, 2012, Drug eruption with eosinophilia and systemic syndrome associated with reactivation of human herpesvirus 7, not human herpesvirus 6, J Dermatol, 39, 669, 10.1111/j.1346-8138.2011.01365.x

Descamps, 1997, Human herpesvirus 6 infection associated with anticonvulsant hypersensitivity syndrome and reactive haemophagocytic syndrome, Br J Dermatol, 137, 605, 10.1111/j.1365-2133.1997.tb03795.x

Kawakami, 2009, Drug-induced hypersensitivity syndrome: drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome induced by aspirin treatment of Kawasaki disease, J Am Acad Dermatol, 60, 146, 10.1016/j.jaad.2008.07.044

Hamaguchi, 2010, Intractable genital ulcers from herpes simplex virus reactivation in drug-induced hypersensitivity syndrome caused by allopurinol, Int J Dermatol, 49, 700, 10.1111/j.1365-4632.2009.04441.x

Mardivirin, 2010, Amoxicillin-induced flare in patients with DRESS (drug reaction with eosinophilia and systemic symptoms): report of seven cases and demonstration of a direct effect of amoxicillin on Human Herpesvirus 6 replication in vitro, Eur J Dermatol, 20, 68, 10.1684/ejd.2010.0821

Tamagawa-Mineoka, 2007, DRESS syndrome caused by teicoplanin and vancomycin, associated with reactivation of human herpesvirus-6, Int J Dermatol, 46, 654, 10.1111/j.1365-4632.2007.03255.x

Draz, 2013, Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome secondary to antituberculosis drugs and associated with human herpes virus-7 (HHV-7), BMJ Case Rep. July 31,, 10.1136/bcr-2013-010348

Funck-Brentano, 2011, Auto-immune thyroiditis and drug reaction with eosinophilia and systemic symptoms (DRESS) associated with HHV-6 viral reactivation [in French with English abstract], Ann Dermatol Venereol, 138, 580, 10.1016/j.annder.2011.01.048

Sandouk, 2012, DRESS syndrome and thrombotic thrombocytopaenic purpura: are they related?, BMJ Case Rep. November 14,, 10.1136/bcr-2012-007558

Kinyo, 2011, Strontium ranelate-induced DRESS syndrome with persistent autoimmune hepatitis, Acta Derm Venereol, 91, 205, 10.2340/00015555-1014

Bejia, 2006, DRESS syndrome induced by sulphasalazine in rheumatoid arthritis, Joint Bone Spine, 73, 764, 10.1016/j.jbspin.2006.01.006

Michel, 2005, DRESS syndrome in a patient on sulfasalazine for rheumatoid arthritis, Joint Bone Spine, 72, 82, 10.1016/j.jbspin.2004.06.002

Pinana, 2010, DRESS-syndrome on sulfasalazine and naproxen treatment for juvenile idiopathic arthritis and reactivation of human herpesvirus 6 in an 11-year-old Caucasian boy, J Clin Pharm Ther, 35, 365, 10.1111/j.1365-2710.2009.01081.x