Feto‐maternal consequences of high‐dose glucose infusion during labour

BJOG: An International Journal of Obstetrics and Gynaecology - Tập 89 Số 1 - Trang 27-32 - 1982
Gordon F. Lawrence1, Valerie Brown1, R. J. Parsons1, Ian Cooke1
1University Department of Obstetrics and Gynaecology, Jessop Hospital for Women, Sheffield S3 7RE, UK

Tóm tắt

Summary. The effects on the fetus of high doses of glucose given to the mother in labour to correct maternal ketonuria were investigated. Three groups of patients were compared: one group received 1 litre of 10% (w/v) glucose intravenously over 1 h, the second group received 1 litre of 0.9% sodium chloride solution intravenously over 1 h and the final group had no supplementary infusion. It was observed that whereas glucose administration rapidly corrected maternal ketonaemia, there was a significant fall in pH and a rise in lactate in fetal blood. These effects were not observed in the other two groups. It was concluded that the use of high doses of intravenous glucose in labour should be avoided.

Từ khóa


Tài liệu tham khảo

Anderson G. G., 1970, Hypertonic glucose infusion during labour. Effect on acid‐base status, fetal heart rate and uterine concentrations, Obstet Gynecol, 36, 405

10.1177/000456327501200166

Bergmcyer H. U., 1974, Methods of Enzymatic Analysis, 1205

10.1113/jphysiol.1963.sp007177

10.1113/jphysiol.1963.sp007248

10.1515/jpme.1977.5.2.84

10.1159/000240725

Haynes P. J., 1976, Relationships between plasma glucose, plasma lactate and arterial pH in well oxygenated and hypoxic, chronically catheterized fetal lambs, Br J Obstet Gynaecol, 83, 330

10.1111/j.1471-0528.1971.tb00325.x

10.1016/S0002-9378(16)33949-7

10.1016/B978-0-12-091304-6.50038-0

10.1136/bmj.1.5798.466

10.1016/0009-8981(71)90486-4

10.1016/0002-9378(67)90080-4

10.1016/0002-9378(78)90366-6

10.1016/0002-9378(66)90421-2

Shelley H. J., 1973, Foetal and Neonatal Physiology, 360

10.1093/oxfordjournals.bmb.a071239

10.1016/0002-9378(66)90685-5

Thông tin
Thông tin xuất bản

BJOG: An International Journal of Obstetrics and Gynaecology

Tập 89 Số 1

27-32

Thông tin tác giả