Female sex steroid hormones: from receptors to networks to performance—actions on the sensorimotor system

Asso, 1982, Changes with the menstrual cycle in psychophysiological and self-report measures of activation, Biol. Psychol., 15, 95, 10.1016/0301-0511(82)90034-5

Backstrom, 1976, Epileptic seizures in women related to plasma estrogen and progesterone during the menstrual cycle, Acta neurol. scand., 54, 321, 10.1111/j.1600-0404.1976.tb04363.x

Backstrom, 1974, Estrogen and progesterone in plasma in relation to premenstrual tension, J. Steroid Biochem., 5, 257, 10.1016/0022-4731(74)90139-3

Backstrom, 1983, Mood, sexuality, hormones and the menstrual cycle. I, II. Hormone levels and their relationship to the premenstrual syndrome, Psychsom. Med., 45, 503, 10.1097/00006842-198312000-00004

Backstrom, 1984, Effects of intravenous progesterone infusions on the epileptic discharge frequency in women with partial epilepsy, Acta neurol. scand., 69, 240, 10.1111/j.1600-0404.1984.tb07807.x

Barber, 1976, Recurrent hormone-dependent chorea: Effects of estrogens and progesterone, Clin. Endocr., 5, 291, 10.1111/j.1365-2265.1976.tb01956.x

Barnes, 1990, Expression of steroid metabolizing enzymes by aggregating fetal brain cells in culture: A model for developmental regulation of the progesterone 5α-reductase pathway, Endocrinology, 127, 500, 10.1210/endo-127-1-500

Beatty, 1979, Gonadal hormones and sex differences in non-reproductive behaviors in rodents: Organizational and activational influences, Horm. Behav., 12, 112, 10.1016/0018-506X(79)90017-5

Becker, 1990, Direct effect of 17β-estradiol on striatum: Sex differences in dopamine release, Synapse, 5, 157, 10.1002/syn.890050211

Becker, 1990, Estrogen rapidly potentiates amphetamine-induced striatal dopamine release and rotational behavior during microdialysis, Neurosci. Lett., 118, 169, 10.1016/0304-3940(90)90618-J

Becker, 1986, The influence of estrogen on nigrostriatal dopamine activity: Behavioral and neurochemical evidence for both pre- and postsynaptic components, Behav. Brain Res., 19, 27, 10.1016/0166-4328(86)90044-6

Becker, 1981, Sex differences in the amphetamine stimulated release of catecholamines from rat striatal tissue in vitro, Brain Res., 204, 361, 10.1016/0006-8993(81)90595-3

Becker, 1982, Changes in physiological, EEG and psychological parameters in women during the spontaneous menstrual cycle and following oral contraceptives, Psychoneuroendocrinology, 7, 75, 10.1016/0306-4530(82)90057-9

Becker, 1987, The influence of estrous cycle and intrastriatal estradiol on sensorimotor performance in the female rat, Pharmac. Biochem. Behav., 27, 53, 10.1016/0091-3057(87)90476-X

Bereiter, 1980, Hormone-induced enlargement of receptive fields in trigeminal mechanoreceptive neurons. I. Time course, hormone, sex and modality specificity, Brain Res., 184, 395, 10.1016/0006-8993(80)90808-2

Bergqvist, 1990, The prefrontal cortex and sensorimotor behavior: Effects of hormonal and circadian cycles, Prog. Soc. Neurosci., Vol. 16, 503

Birke, 1984, Effects of estradiol and progesterone on scent-marking behavior of female rats, Horm. Behav., 18, 95, 10.1016/0018-506X(84)90054-0

Birke, 1979, Distractibility changes during the estrous cycle of the rat, Anim. Behav., 18, 95

Bitran, 1991, Anxiolytic effects of 3α-hydroxy-5α[β]-pregnan-20-one: Endogenous metabolites of progesterone that are active at the GABAA receptor, Brain Res., 561, 157, 10.1016/0006-8993(91)90761-J

Bitran, 1993, The anxiolytic effect of progesterone is associated with increases in cortical allopregnanolone and GABAA receptor function, Pharmac. Biochem. Behav., 45, 423, 10.1016/0091-3057(93)90260-Z

Bixo, 1990, Regional distribution of progesterone and 5α-pregnane-3,20-dione in rat brain during progesterone-induced ‘anesthesia’, Psychoneuroendocrinology, 15, 159, 10.1016/0306-4530(90)90025-5

Blizard, 1975, Sex differences in open-field behavior in the rat: The inductive and activational role of gonadal hormones, Physiol. Behav., 14, 601, 10.1016/0031-9384(75)90188-2

Brann, 1992, Excitatory amino acid regulation of gonadotropin secretion: Modulation by steroid hormones, J. Steroid Biochem. Molec. Biol., 41, 847, 10.1016/0960-0760(92)90436-M

Brann, 1990, γ-Aminobutyric-A receptors mediate 3α-hydroxy-5α-pregnan-20-one-induced gonadotropin secretion, Endocrinology, 126, 1854, 10.1210/endo-126-4-1854

Broverman, 1968, Roles of activation and inhibition in sex differences in cognitive abilities, Psychol. Rev., 75, 23, 10.1037/h0025293

Bueno, 1976, Single unit recording in hypothalamus and preoptic area of estrogen-treated and untreated ovariectomized female rats, Brain Res., 101, 67, 10.1016/0006-8993(76)90988-4

Bureau, 1990, Multiple distinct subunits of the γ-aminobutyric acid-A receptor protein show different ligand binding affinities, Molec. Pharmac., 37, 497

Buterbaugh, 1987, Postictal events in amygdala-kindled female rats with and without estradiol replacement, Expl Neurol., 95, 697, 10.1016/0014-4886(87)90310-4

Campbell, 1990, Characterization of the purified pituitary cytosolic NADPH: 5α-Dihydroprogesterone 3α-hydroxysteroid oxidoreductase, J. Steroid Biochem. Molec. Biol., 37, 535, 10.1016/0960-0760(90)90398-5

Canonaco, 1989, GABAA receptor level changes in female hamster forebrain following in vivo estrogen, progesterone and benzodiazepine treatment: A quantitative autoradiography analysis, Expl Brain Res., 75, 644, 10.1007/BF00249916

Canonaco, 1989, Longer term progesterone treatment induced changes of GABAA receptor levels in forebrain sites in the female hamster: Quantitative autoradiography study, Expl Brain Res., 77, 407, 10.1007/BF00274998

Carl, 1990, Pregnanolone emulsion, 45, 189

Carter Little, 1983, Physiological and psychological effects of progesterone in men, J. nerv. ment. Dis., 159, 256, 10.1097/00005053-197410000-00004

Cavallotti, 1983, Stimulatory effect of β-estradiol treatment on GABA-degradative enzymes within rat cerebellar cortex, Neurosci. Lett., 39, 205, 10.1016/0304-3940(83)90078-2

Chiodo, 1983, Substantia nigra dopamine neurons: Alterations in basal discharge rates and autoreceptor sensitivity induced by estrogen, Neuropharmacology, 22, 593, 10.1016/0028-3908(83)90150-8

Cohen, 1992, Ventromedial hypothalamic neurons in the mediation of long-lasting effects of estrogen on lordosis behavior, Prog. Neurobiol., 38, 423, 10.1016/0301-0082(92)90045-G

Colvin, 1969, Induction of running activity by intracerebral implants of estrogen in ovariectomized rats, Neuroendocrinology, 4, 309, 10.1159/000121762

Craig, 1966, Anticonvulsant activity of steroids: Separability of anticonvulsant from hormonal effects, J. Pharmac. exp. Ther., 153, 337

Dehertogh, 1971, Equilibrium concentration of [6,7-H3]oestrone and [6,7-H3]17β-oestradiol metabolites in female rat tissues, during long-term intravenous infusions, Acta Endocr., 66, 401

De Marchi, 1972, Menstrual, diurnal and activation effects on the resolution of temporally paired flashes, Psychophys., 9, 362, 10.1111/j.1469-8986.1972.tb03220.x

Dennerstein, 1985, Progesterone and the premenstrual syndrome: A double blind crossover trial, Br. med. J., 290, 1617, 10.1136/bmj.290.6482.1617

Diamond, 1972, Visual sensitivity and sexual arousal levels during the menstrual cycle, J. nerv. ment. Dis., 155, 170, 10.1097/00005053-197209000-00003

Di Paolo, 1982, Effects of estradiol on intact and denervated striatal dopamine receptors and on dopamine levels: A biochemical and behavioral study, Can. J. Physiol. Pharmac., 60, 350, 10.1139/y82-050

Di Paolo, 1985, 17β-Estradiol at a physiological dose acutely increases dopamine turnover in rat brain, Eur. J. Pharmac., 117, 197, 10.1016/0014-2999(85)90604-1

Di Paolo, 1986, A physiological dose of progesterone affects rat striatum biogenic amine metabolism, Eur. J. Pharmac., 125, 11, 10.1016/0014-2999(86)90077-4

Dluzen, 1987, Intermittent infusion of progesterone potentiates whereas continuous infusion reduces amphetamine-stimulated dopamine release from ovariectomized estrogen-primed rat striatal fragments superfused in vitro, Brain Res., 406, 1, 10.1016/0006-8993(87)90762-1

Dluzen, 1989, Progesterone enhances l-dopa-stimulated dopamine release from the caudate nucleus of freely behaving ovariectomized-estrogen-primed rats, Brain Res., 494, 12, 10.1016/0006-8993(89)90150-9

Dluzen, 1990, In vitro progesterone modulation of amphetamine-stimulated dopamine release from the corpus striatum of ovariectomized estrogen-treated female rats: Response characteristics, Brain Res., 517, 117, 10.1016/0006-8993(90)91016-A

Dufy, 1976, Effect of estrogen on the electrical activity of identified and unidentified hypothalamic units, Neuroendocrinology, 22, 38, 10.1159/000122610

Ebner, 1987, New Concepts in Cerebellar Neurobiology, 371

Eccles, 1967, The Cerebellum as a Neuronal Machine, 336

Farrant, 1990, Molecular and cellular mechanisms of GABA/Benzodiazepine-receptor regulation: Electrophysiological and biochemical studies, Neurochem. Res., 15, 175, 10.1007/BF00972208

ffrench-Mullen, 1991, Neurosteroids block Ca++ channel current in freshly isolated hippocampal CA1 neurons, Eur. J. Pharmac., 202, 269, 10.1016/0014-2999(91)90303-8

ffrench-Mullen, 1994, Neurosteroids modulate calcium currents in hippocampal CA1 neurons via a pertussis toxin-sensitive G-protein-coupled mechanism, J. Neurosci., 14, 1963, 10.1523/JNEUROSCI.14-04-01963.1994

Finn, 1993, The influence of the estrous cycle on neurosteroid potency at the gamma-aminobutyric acid A receptor complex, J. Pharmac. exp. Ther., 265, 1374

Fishman, 1981, Biological actions of catechol estrogens, J. Endocr., 89, 59P

Fleischmann, 1990, Ovarian steroids increase veratridine-induced release of amino acid neurotransmitters in preoptic area synaptosomes, Brain Res., 507, 161, 10.1016/0006-8993(90)90538-M

Fleischmann, 1991, Effects of non-competitive NMDA receptor antagonists on reproductive and motor behaviors in female rats, Brain Res., 568, 138, 10.1016/0006-8993(91)91389-I

Flood, 1992, Memory-enhancing effects in male mice of pregnenolene and steroids derived from it, 89, 1567

Fraile, 1988, Comparative effects of progesterone and alphaxalone on aggressive, reproductive and locomotor behaviors, Pharmac. Biochem. Behav., 30, 729, 10.1016/0091-3057(88)90091-3

Frankfurt, 1990, Gonadal steroids modify dendritic spine density in ventromedial hypothalamic neurons: A Golgi study in the adult rat, Neuroendocrinology, 51, 530, 10.1159/000125387

Freedman, 1975, A quantitative microiontophoretic analysis of the responses of central neurones to noradrenaline; Iontophoresis with cobalt, manganese, verapamil, and dichloroisoprenaline, Br. J. Pharmac., 54, 529, 10.1111/j.1476-5381.1975.tb07601.x

Friedman, 1982

Friedman, 1993, γ-Aminobutyric AcidA receptor regulation: Chronic treatment with pregnanolone uncouples allosteric interactions between steroid and benzodiazepine recognition sites, Molec. Pharmac., 44, 191

Frye, 1993, 3α-OH-DHP and 5α-THDOC implants to the VTA facilitate sexual receptivity in hamsters after progesterone priming to the VMH, Brain Res., 612, 130, 10.1016/0006-8993(93)91653-A

Frye, 1992, Evidence for a non-genomic action of progestins on sexual receptivity in hamster ventral tegmental area but not hypothalamus, Brain Res., 578, 87, 10.1016/0006-8993(92)90233-Y

Gallo, 1993, Progesterone withdrawal decreases latency and increases duration of electrified prod burial: A possible rat model of PMS anxiety, Pharmac. Biochem. Behav., 46, 897, 10.1016/0091-3057(93)90219-J

Gee, 1988, Steroid modulation of the GABA/benzodiazepine receptor-linked chloride ionophore, Molec. Neurobiol., 2, 291, 10.1007/BF02935636

Gee, 1991, Gamma-aminobutyric acid-A receptor complexes in rat frontal cortex and spinal cord show differential responses to steroid modulation, Molec. Pharmac., 40, 995

Gee, 1987, GABA-dependent modulation of the Cl− ionophore by steroids in rat brain, Eur. J. Pharmac., 136, 419, 10.1016/0014-2999(87)90317-7

Gellman, 1983, Somatosensory properties of the inferior olive of the cat, J. comp. Neurol., 215, 228, 10.1002/cne.902150210

Gellman, 1985, Inferior olivary neurons in the awake cat: Detection of contact and passive body displacement, J. Neurophysiol., 54, 40, 10.1152/jn.1985.54.1.40

Gentry, 1975, Sex differences in sensitivity of food intake, body weight, and running-wheel activity to ovarian steroids in rats, J. comp. physiol. Psychol., 90, 747, 10.1037/h0077246

Glick, 1972, Psychiatric effects of progesterone and oral contraceptives, 295

Gould, 1990, Gonadal steroids regulate dendritic spine density in hippocampal pyramidal cells in adulthood, J. Neurosci., 10, 1286, 10.1523/JNEUROSCI.10-04-01286.1990

Gray, 1992, Preliminary study of a pregnanolone emulsion (Kabi 2213) for i.v. induction of general anaesthesia, Br. J. Anaesth., 68, 272, 10.1093/bja/68.3.272

Hales, 1992, Immortalized hypothalamic GT1-7 neurons express functional gamma-aminobutyric acid type A receptors, Molec. Pharmac., 42, 197

Hales, 1994, GABA has excitatory actions on GnRH-secreting immortalized hypothalamic (GT1-7) neurons, Neuroendocrinology, 59, 297, 10.1159/000126671

Hampson, 1988, Reciprocal effects of hormonal fluctuations on human motor and perceptual-spatial skills, Behav. Neurosci., 102, 456, 10.1037/0735-7044.102.3.456

Hanukoglu, 1977, Progesterone metabolism in the pineal, brain stem, thalamus and corpus callosum of the female rat, Brain Res., 125, 313, 10.1016/0006-8993(77)90624-2

Harrison, 1984, Modulation of the GABA receptor complex by a steroid anaesthetic, Brain Res., 323, 287, 10.1016/0006-8993(84)90299-3

Harrison, 1987, Structure-activity relationships for steroid interaction with a γ-aminobutyric acidA receptor complex, J. Pharmac. exp. Ther., 241, 346

Havens, 1988, Estrogen-dependent and estrogen-independent effects of progesterone on the electrophysiological excitability of dorsal midbrain neurons in golden hamsters, Neuroendocrinology, 48, 120, 10.1159/000124999

Henkin, 1974, Sensory changes during the menstrual cycle, 277

Heritage, 1978, 3H-estradiol in catecholamine neurons of rat brainstem: Combined localization by autoradiography and formaldehyde-induced fluorescence, J. comp. Neurol., 176, 607, 10.1002/cne.901760410

Herrmann, 1978, The psychotropic properties of progestins, 11, 164

Hitchcock, 1925, Studies in vigor, Am. J. Physiol., 75, 205, 10.1152/ajplegacy.1925.75.1.205

Holmes, 1984, The effect of progesterone on kindling: A developmental study, Devl Brain Res., 16, 45, 10.1016/0165-3806(84)90061-0

Holzbauer, 1976, Physiological aspects of steroids with anesthetic properties, Med. Biol., 54, 227

Holzbauer, 1985, In vivo secretion of 3α-hydroxy-5α-pregnan-20-one, a potent anaesthetic steroid, by the adrenal gland of the rat, J. Steroid Biochem., 22, 97, 10.1016/0022-4731(85)90147-5

Houk, 1987, Sensorimotor processing in the cerebellum, 387

Hruska, 1980, Increased dopamine receptor sensitivity after estrogen treatment using the rat rotation model, Science, 208, 1466, 10.1126/science.7189902

Jacobsohn, 1988, Oxidation of 2-hydroxyestradiol and its incorporation into melanin by mushroom tyrosinase, J. Steroid Biochem., 31, 377, 10.1016/0022-4731(88)90305-6

Johnson, 1983, Comparative effects of estradiol steroisomers on Pimozide-induced catalepsy, locomotor activity and body-weight in the rat, Pharmac. Biochem. Behav., 19, 801, 10.1016/0091-3057(83)90084-9

Jones, 1992, Enhancement of γ-aminobutyric acid-activated Cl− currents in cultured rat hippocampal neurones by three volatile anesthetics, J. Physiol., 449, 279, 10.1113/jphysiol.1992.sp019086

Joyce, 1984, Behaviors induced by intrastriatal dopamine vary independently across the estrous cycle, Pharmac. Biochem. Behav., 20, 551, 10.1016/0091-3057(84)90304-6

Karavolas, 1991, Metabolism of progesterone and related steroids by neural and neuroendocrine structures, Vol. 8, 135

Karavolas, 1979, In vivo uptake of [3H]progesterone and [3H]-5α-dihydroprogesterone by rat brain and pituitary and effects of estradiol and time: Tissue concentration of progesterone itself or specific metabolites?, Endocrinology, 104, 1418, 10.1210/endo-104-5-1418

Karavolas, 1984, Progesterone processing by neuroendocrine structures, Vol. 13, 149

Ke, 1990, Binding of progesterone to nerve cell membranes of rat brain using progesterone conjugated to 125-I bovine serum albumin as a ligand, J. Neurochem., 54, 467, 10.1111/j.1471-4159.1990.tb01895.x

Kelly, 1977, The effects of microelectrophoretically applied estrogen, cortisol and acetylcholine on medial preoptic septal unit activity throughout the estrous cycle, Expl Brain Res., 30, 53, 10.1007/BF00237858

Kelly, 1980, Hyperpolarization of hypothalamic parvocellular neurons by 17β-estradiol and their identification through intracellular staining with procion yellow, Expl Brain Res., 40, 440, 10.1007/BF00236152

Kelly, 1992, Estrogen suppresses μ-Opioid- and GABAB-mediated hyperpolarization of hypothalamic arcuate neurons, J. Neurosci., 12, 2745, 10.1523/JNEUROSCI.12-07-02745.1992

Kenshalo, 1966, Changes in the cool threshold associated with phases of the menstrual cycle, J. appl. Physiol., 21, 1031, 10.1152/jappl.1966.21.3.1031

Klaiber, 1974, Rhythms in plasma MAO activity, EEG and behavior during the menstrual cycle, 124

Klaiber, 1979, Estrogen therapy for severe persistent depressions in women, Archs gen. Psychiat., 36, 550, 10.1001/archpsyc.1979.01780050060006

Knox, 1974, Cross-correlation functions for a neuronal model, Biophys. J., 14, 567, 10.1016/S0006-3495(74)85936-9

Kokka, 1993, Sex differences in sensitivity to pentylene tetrazol but not GABAA receptor binding, Pharmac. Biochem. Behav., 43, 441, 10.1016/0091-3057(92)90174-E

Kolb, 1974, Dissociation of the effects of lesions of the orbital or medial aspect of the prefrontal cortex of the rat with respect to activity, Behav. Biol., 10, 329, 10.1016/S0091-6773(74)91924-5

Kopell, 1969, Variations in some measures of arousal during the menstrual cycle, J. nerv. ment. Dis., 148, 180, 10.1097/00005053-196902000-00009

Kow, 1983, Effects of estrogen treatment on the size of receptive field and response threshold of pudendal nerve in the female rat, Neuroendocrinology, 13, 299, 10.1159/000122214

Kow, 1985, Estrogen effects on neuronal responsiveness to electrical and neurotransmitter stimulation: An in vitro study on the ventromedial nucleus of the hypothalamus, Brain Res., 347, 1, 10.1016/0006-8993(85)90883-2

Krieger, 1989, Nonneuronal localization for steroid converting enzyme: 3α-Hydroxysteroid oxidoreductase in olfactory tubercle of rat brain, J. Neurochem., 52, 1866, 10.1111/j.1471-4159.1989.tb07269.x

Laidlaw, 1956, Catamenial epilepsy, Lancet, 2, 1235, 10.1016/S0140-6736(56)90003-4

Lambert, 1987, Actions of synthetic and endogenous steroids on the GABAA receptor, Trends Pharmac. Sci., 8, 224, 10.1016/0165-6147(87)90067-8

Lambert, 1990, Steroid modulation of the GABAA receptor complex: Electrophysiological studies, 56

Lan, 1991, Differential responses of expressed recombinant human γ-aminobutyric acidA receptors to neurosteroids, J. Neurochem., 57, 1818, 10.1111/j.1471-4159.1991.tb06388.x

Landgren, 1991, Pregnanolone (3α-hydroxy-5α-pregnane-20-one), a progesterone metabolite facilitates inhibition of synaptic transmission in the Schaffer collateral pathway of the guinea pig hippocamus in vitro, Epilepsy Res., 10, 156, 10.1016/0920-1211(91)90008-4

Landgren, 1978, The effect of progesterone on the spontaneous interictal spike evoked by the application of penicillin to the cat's cerebral cortex, J. Neurol. Sci., 36, 119, 10.1016/0022-510X(78)90166-1

Landgren, 1987, The effect of progesterone and its metabolites on the interictal epileptiform discharge in the cat's cerebral cortex, Acta physiol. scand., 131, 33, 10.1111/j.1748-1716.1987.tb08202.x

Landgren, S. O. E. Interaction between short latency estradiol and pregnanolone effects in CA1 of the guinea pig hippocampus in vitro, in press.

Larsson-Backstrom, 1988, Anaesthetic properties of pregnanolone in mice in an emulsion preparation for intravenous administration: A comparison with thiopentone, Pharmac. Toxic., 63, 143, 10.1111/j.1600-0773.1988.tb00929.x

Le Goascogne, 1987, Neurosteroids: Cytochrome P-450scc in rat brain, Science, 237, 1212, 10.1126/science.3306919

Lee, 1984, An empirical study of the structure of the patrol/marking motivational system in the rat, Physiol. Behav., 32, 565, 10.1016/0031-9384(84)90310-X

Lincoln, 1969, Effects of progesterone on the electrical activity of the forebrain, J. Endocr., 45, 585, 10.1677/joe.0.0450585

Logothetis, 1959, The role of oestrogen and catamenial exacerbations of epilepsy, Neurology, 9, 352, 10.1212/WNL.9.5.352

Luntz-Leybman, 1990, 5α-Pregnan-3α-ol-20-one blocks nicotine-induced seizures and enhances paired-pulse inhibition, Eur. J. Pharmac., 185, 239, 10.1016/0014-2999(90)90648-P

MacDonald, 1991, Recurrent secretion of progesterone in large amounts: An endocrine/metabolic disorder unique to young women?, Endo. Rev., 12, 372, 10.1210/edrv-12-4-372

MacLuskey, 1980, Progestin receptors in rat brain, distribution and properties of cytoplasmic progestin-binding sites, Endocrinology, 106, 192, 10.1210/endo-106-1-192

Majewska, 1986, Steroid hormone metabolites are barbiturate-like modulators of the GABA receptor, Science, 232, 1004, 10.1126/science.2422758

Marcus, 1966, Effects of steroids on cerebral electrical activity: Epileptogenic effects of conjugated estrogens and related compounds in the cat and rabbit, Archs Neurol., 15, 521, 10.1001/archneur.1966.00470170075008

Markram, 1991, Calcimycin potentiates responses of rat hippocampal neurons to N-methyl-d-aspartate, Brain Res., 540, 322, 10.1016/0006-8993(91)90529-5

Mattson, 1985, Epilepsy, sex hormones and antiepileptic drugs, Epilepsia, 26, S40, 10.1111/j.1528-1157.1985.tb05723.x

McCarthy, M. M. and Schwartz-Giblin, S. Estradiol modulation of GAD65 and GAD67 mRNA in the midbrain central gray and in the forebrain, unpublished data.

McCarthy, 1991, Ovarian steroid modulation of [3H]muscimol binding in the spinal cord of the rat, Brain Res., 556, 321, 10.1016/0006-8993(91)90323-N

McEwen, 1988, Genomic regulation of sexual behavior, J. Steroid Biochem., 30, 179, 10.1016/0022-4731(88)90091-X

McEwen, 1991, Non-genomic and genomic effects of steroids on neural activity, Trends Pharmac. Sci., 12, 141, 10.1016/0165-6147(91)90531-V

McEwen, 1990, Steroid effects on neuronal activity: When is the genome involved?, 153, 3

McGinnis, 1980, Time course and localization of the effects of estrogen on glutamic acid decarboxylase activity, J. Neurochem., 34, 785, 10.1111/j.1471-4159.1980.tb09648.x

Melcangi, 1990, 5α-Reductase activity in isolated and cultured neuronal and glial cells of the rat, Brain Res., 516, 229, 10.1016/0006-8993(90)90923-Y

Michel, 1978, Affinity labelling of the estrogen binding site of glutamate dehydrogenase with iodoacetyldiethylstilbestrol, Eur. J. Biochem., 84, 267, 10.1111/j.1432-1033.1978.tb12165.x

Mienville, 1989, Pregnenolone sulfate antagonizes GABAA receptor-mediated currents via a reduction of channel opening frequency, Brain Res., 489, 190, 10.1016/0006-8993(89)90024-3

Minami, 1990, 17β-estradiol depolarization of hypothalamic neurons is mediated by cyclic AMP, Brain Res., 519, 301, 10.1016/0006-8993(90)90092-P

Moises, 1979, Interactions of norepinephrine with Purkinje cell responses to putative amino acid neurotransmitters applied by microiontophoresis, Expl Neurol., 64, 493, 10.1016/0014-4886(79)90227-9

Mok, 1990, Evidence that 5α-pregnan-3α-ol-20-one is the metabolite responsible for progesterone anesthesia, Brain Res., 533, 42, 10.1016/0006-8993(90)91792-F

Monaghan, 1986, Distribution of N-methyl-d-aspartate-sensitivel-[3H]glutamate binding sites in rat brain, J. Neurosci., 5, 2909, 10.1523/JNEUROSCI.05-11-02909.1985

Morris, 1970, Variations in pedometer activity during the menstrual cycle, Obstet. Gynec., 35, 199

Morrow, 1990, Characterization of steroid interactions with γ-aminobutyric acid receptor-gated chloride ion channels: Evidence for multiple steroid recognition sites, Molec. Pharmac., 37, 263

Murphy, 1987, Estrogen induction of N-myc and c-myc protooncogene expression in the rat uterus, Endocrinology, 120, 1882, 10.1210/endo-120-5-1882

Nakano, 1987, Novel and potent biological antioxidants on membrane phospholipid peroxidation: 2-Hydroxy estrone and 2-hydroxy estradiol, Biochem. biophys. Res. Commun., 142, 919, 10.1016/0006-291X(87)91501-4

Namba, 1984, Acute administration of high doses of estrogen increases glucose utilization throughout brain, Brain Res., 291, 391, 10.1016/0006-8993(84)91276-9

Nausieda, 1979, Chorea induced by oral contraceptives, Neurology, 29, 1605, 10.1212/WNL.29.12.1605

Nicolelis, 1993, Peripheral block of ascending cutaneous information induces immediate spatio-temporal changes in thalamic networks, Nature, 361, 533, 10.1038/361533a0

Nicolelis, 1993, Dynamic distributed properties of many-neuron ensembles in the ventral posterior medial (VPM) thalamus of awake rats, 90, 2212

Norberg, 1987, The anesthetic potency of 3α-hydroxy-5α-pregnan-20-one and 3α-hydroxy-5β-pregnan-20-one determined with an intravenous EEG-threshold method in male rats, Pharmac. Toxic., 61, 42, 10.1111/j.1600-0773.1987.tb01770.x

‘O’Connor, 1988, Regional specificity of gamma-aminobutyric acid receptor regulation by estradiol, Neuroendocrinology, 47, 473, 10.1159/000124958

Olsen, 1990, Discussion, 72

Olsen, 1990, Discussion, 103

Olsen, 1990, Discussion, 221

Olsen, 1990, Discussion, 233

Olsen, 1990, Molecular biology of GABAA receptors, FASEB, 4, 1469, 10.1096/fasebj.4.5.2155149

Paganini-Hill, 1993, Estrogen replacement and Alzheimer's disease in women, Vol. 19

Park, 1987, Pregnanolone, a metabolite of progesterone, stimulates LH-RH release: In vitro and in vivo studies, Brain Res., 437, 245, 10.1016/0006-8993(87)91640-4

Parsons, 1981, Sequential inhibition of sexual receptivity by progesterone is prevented by a protein synthesis inhibitor and is not causally related to decreased levels of hypothalamic progestin receptors in the female rat, J. Neurosci., 5, 527, 10.1523/JNEUROSCI.01-05-00527.1981

Parvizi, 1983, Catecholestrogens in the brain: Neuroendocrine integration, J. Steroid Biochem., 19, 615, 10.1016/0022-4731(83)90226-1

Patkai, 1974, Mood, alertness and sympathetic-adrenal medullary activity during the menstrual cycle, Psychosom. Med., 36, 503, 10.1097/00006842-197411000-00005

Paul, 1992, Neuroactive steroids, FASEB, 6, 2311, 10.1096/fasebj.6.6.1347506

Pepe, 1973, Metabolic clearance rate of progesterone: Comparison between ovariectomized, pregnant, pseudopregnant and deciduoma-bearing pseudopregnant rats, Endocrinology, 93, 1200, 10.1210/endo-93-5-1200

Pfaff, 1980, Estrogen and Brain Function, 281

Pfaff, 1989, Features of a hormone-driven defined neural circuit for a mammalian behavior, 563, 131

Pfaff, 1989, Patterns of steroid hormone effects on electrical and molecular events in hypothalamic neurons, Molec. Neurobiol., 3, 135, 10.1007/BF02935628

Pfaff, 1983, Actions of estrogens and progestins on nerve cells, Science, 219, 808, 10.1126/science.6297008

Phillips, 1992, Effects of estrogen on memory function in surgically menopausal women, Psychoneuroendocrinology, 17, 485, 10.1016/0306-4530(92)90007-T

Phillis, 1985, Estradiol and progesterone potentiate adenosine's depressant action on rat cerebral cortical neurons, Gen. Pharmac., 16, 609, 10.1016/0306-3623(85)90151-X

Pons, 1978, Structural requirements for maximal inhibitory allosteric effect of estrogens and estrogen analogues on glutamate dehydrogenase, Eur. J. Biochem., 84, 257, 10.1111/j.1432-1033.1978.tb12164.x

Puia, 1990, Neurosteroids act on recombinant human GABAA receptors, Neuron, 4, 759, 10.1016/0896-6273(90)90202-Q

Purdy, 1990, Radioimmunoassay of 3α-hydroxy-5α-pregnane-20-one in rat and human plasma, Steroids, 55, 290, 10.1016/0039-128X(90)90031-6

Purdy, 1990, Synthesis, metabolism, and pharmacological activity of 3α-hydroxy steroids which potentiate GABA-receptor-mediated chloride ion uptake in rat cerebral cortical synaptoneurosomes, J. med. Chem., 33, 1572, 10.1021/jm00168a008

Purdy, 1991, Stress-induced elevations of γ-aminobutyric acid type A receptor-active steroids in the rat brain, 88, 4553

Quadagno, 1972, Influence of gonadal hormones in social, sexual, emergence, and open field behavior in the rat, Rattus norvegicus, Anim. Behav., 20, 732, 10.1016/S0003-3472(72)80145-3

Raisingham, 1968, Uptake of intravenously administered progesterone, pregnanedione and pregnanolone by the rat brain, Acta Endocr., 57, 395

Robel, 1985, Neuro-steroids: 3β-hydroxy-delta 5-derivatives in the rodent brain, Neurochem. Int., 7, 953, 10.1016/0197-0186(85)90143-3

Robel, 1987, Neuro-steroids: 3β-hydroxy-delta 5-derivatives in rat and monkey brain, J. Steroid Biochem., 27, 649, 10.1016/0022-4731(87)90133-6

Rodgers-Neame, 1992, Effects of a benz[e]indene on GABA-gated chloride currents in cultured postnatal rat hippocampal neurons, Molec. Pharmac., 42, 952

Rodriguez-Sierra, 1984, Effect of ovarian hormones on conflict behavior, Psychopharmacology, 9, 293

Rodriguez-Sierra, 1986, Anxiolytic effects of progesterone are sexually dimorphic, Life Sci., 3, 1841, 10.1016/0024-3205(86)90139-6

Rose, 1986, Functional reconfiguration of midbrain neurons by ovarian steroids in behaving hamsters, Physiol. Behav., 37, 633, 10.1016/0031-9384(86)90298-2

Rose, 1990, Brainstem influences on sexual behavior, 407

Rose, 1978, Facilitation by estradiol of midbrain and pontine unit responses to vaginal and somatosensory stimulation in the squirrel monkey, Expl Neurol., 58, 46, 10.1016/0014-4886(78)90119-X

Roy, 1987, Estradiol implants in the rat striatum stimulate locomotor activity in running wheels, Mtg. Neurosci. Soc., 13, 224

Roy, 1990, Estradiol in the striatum: Effects on behavior and dopamine receptors but no evidence for membrane steroid receptors, Brain Res. Bull., 25, 221, 10.1016/0361-9230(90)90064-7

Sapp, 1992, Regional variation in steroid anesthetic modulation of [35s]TBPS binding to gamma-aminobutyric acidA receptors in rat brain, J. Pharmac. exp. Ther., 262, 801

Schumacher, 1990, Behavioral effects of progesterone associated with rapid modulation of oxytocin receptors, Science, 250, 691, 10.1126/science.2173139

Schwartz-Giblin, 1990, Ipsilateral and contralateral effects on cutaneous reflexes in a back muscle of the female rat: Modulation by steroids relevant for reproductive behavior, J. Neurophysiol., 64, 835, 10.1152/jn.1990.64.3.835

Schwartz-Giblin, 1988, Effects of in vivo estradiol and progesterone on tritiated flunitrazepam binding in rat spinal cord, Neuroscience, 25, 249, 10.1016/0306-4522(88)90023-1

Schwartz-Giblin, 1989, Steroid hormone effects on picrotoxin-induced seizures in female and male rats, Brain Res., 476, 240, 10.1016/0006-8993(89)91244-4

Schwartz-Giblin, S. and McCarthy, M. Infusions of the GABA-A modulators diazepam and allogregnanolone into the midbrain central gray facilitate sex-differentiated behaviors, unpublished data.

Selye, 1942, Correlations between the chemical structure and pharmacological actions of the steroids, Endocrinology, 30, 437, 10.1210/endo-30-3-437

Servan-Schreiber, 1990, A network model of catecholamine effects: Gain, signal-to-noise ratio and behavior, Science, 249, 892, 10.1126/science.2392679

Sherwin, 1988, Affective changes with estrogen and androgen replacement therapy in surgically menopausal women, J. Affective Disorders, 14, 177, 10.1016/0165-0327(88)90061-4

Sherwin, 1985, Differential symptom response to parenteral estrogen and/or androgen administration in the surgical menopause, Am. J. Obstet. Gynec., 151, 153, 10.1016/0002-9378(85)90001-8

Shingai, 1991, Effects of subunit types of the cloned GABAA receptor on the response to a neurosteroid, Eur. J. Pharmac., 206, 77, 10.1016/0922-4106(91)90149-C

Simerly, 1990, Distribution of androgen and estrogen receptor mRNA-containing cells in the rat brain: An in situ hybridization study, J. comp. Neurol., 294, 76, 10.1002/cne.902940107

Simmonds, 1984, Interaction of steroids with the GABAA receptor complex, Neuropharmacology, 23, 877, 10.1016/0028-3908(84)90290-9

Smith, 1989, Estrogen produces long-term increases in excitatory neuronal responses to NMDA and quisqualate, Brain Res., 503, 354, 10.1016/0006-8993(89)91691-0

Smith, 1989, Progesterone enhances inhibitory responses of cerebellar Purkinje cells mediated by the GABAA receptor subtype, Brain Res. Bull., 23, 317, 10.1016/0361-9230(89)90215-3

Smith, 1989, Quisqualate and NMDA synergistically excite cerebellar Purkinje cells as a long-term effect, Neurosci. Lett., 107, 63, 10.1016/0304-3940(89)90791-X

Smith, 1990, Discussion, 74

Smith, 1991, Progesterone administration attenuates excitatory amino acid responses of cerebellar Purkinje cells, Neuroscience, 42, 309, 10.1016/0306-4522(91)90377-Z

Smith, 1991, Network properties of the olivo-cerebellar circuitry during spontaneous alterations in limb coordination, Soc. Neurosci. Abstr., 551.7

Smith, 1991, The effects of estrogen and progesterone on GABA and glutamate responses at extrahypothalamic sites, Vol. 8, 87

Smith, 1987, A paradigm for determination of direct drug-induced modulatory alterations in Purkinje cell activity during treadmill locomotion, J. Neurosci. Meth., 21, 335, 10.1016/0165-0270(87)90127-0

Smith, 1987, Estrous cycle-correlated alterations in single unit activity recorded from multiple extra-hypothalamic neurons during locomotion, Soc. Neurosci. Abstr., 244.1

Smith, 1991, GABAB receptor stimulation by baclofen and taurine enhances excitatory amino acid induced phosphatidylinositol turnover in neonatal rat cerebellum, Neurosci. Lett., 132, 59, 10.1016/0304-3940(91)90433-T

Smith, 1984, Can estrogen alter neuronal responsiveness to putative amino acid neurotransmitters?, Vol. 10, 541

Smith, 1987, Progesterone alters GABA and glutamate responsiveness: A possible mechanism for its anxiolytic action, Brain Res., 400, 353, 10.1016/0006-8993(87)90634-2

Smith, 1987, Locally applied progesterone metabolites alter neuronal responsiveness to iontophoretically applied glutamate in the cerebellum, Brain Res. Bull., 18, 739, 10.1016/0361-9230(87)90209-7

Smith, 1987, Sex steroid effects on extrahypothalamic CNS I: Estrogen augments neuronal responsiveness to iontophoretically applied glutamate in the cerebellum, Brain Res., 422, 40, 10.1016/0006-8993(87)90538-5

Smith, 1987, Sex steroid effects on extrahypothalamic CNS II: Progesterone, alone and in combination with estrogen, modulates cerebellar response to amino acid neurotransmitters, Brain Res., 422, 52, 10.1016/0006-8993(87)90539-7

Smith, 1988, Locally applied estrogens potentiate glutamate-evoked excitation of cerebellar Purkinje cells, Brain Res., 475, 272, 10.1016/0006-8993(88)90615-4

Smith, 1989, Sex steroids modulate motor-correlated increases in cerebellar discharge, Brain Res., 476, 307, 10.1016/0006-8993(89)91251-1

Sommer, 1973, The effect of menstruation on cognitive and perceptual-motor behavior: A review, Psychosom. Med., 35, 515, 10.1097/00006842-197311000-00007

Spence, 1991, The neurosteroids pregnenolone and pregnenolone-sulfate but not progesterone, block Ca++ currents in acutely isolated hippocampal CA1 neurons, Life Sci., 49, PL235, 10.1016/0024-3205(91)90649-V

Stitt, 1968, The effect of certain progestins and estrogens on the threshold of electrically induced seizure patterns, Neurology, 18, 213, 10.1212/WNL.18.3.213

Su, 1988, Steroid binding at sigma receptors suggests a link between endocrine, nervous, and immune systems, Science, 240, 219, 10.1126/science.2832949

Tam, 1988, Conditional cross-interval correlation analyses with applications to simultaneously recorded cerebellar neurons, J. Neurosci. Meth., 23, 23, 10.1016/0165-0270(88)90018-0

Tapper, 1975, The secretion and metabolic clearance rates of oestradiol in the rat, J. Endocr., 64, 215, 10.1677/joe.0.0640215

Terasawa, 1970, Diurnal variation in the effects of progesterone on multiple unit activity in the rat hypothalamus, Expl Neurol., 27, 359, 10.1016/0014-4886(70)90228-1

Teyler, 1980, Gonadal steroids: Effects on excitability of hippocampal pyramidal cells, Science, 209, 1017, 10.1126/science.7190730

Tischkau, 1993, A specific membrane binding protein for progesterone in rat brain: Sex differences and induction by estrogen, 90, 1285

Turner, 1989, Steroid anesthetics and naturally occurring analogs modulate the γ-aminobutyric acid receptor complex at a site distinct from barbiturates, J. Pharmac. exp. Ther., 248, 960

Twyman, 1992, Neurosteroid regulation of GABAA receptor-single channel kinetic properties of mouse spinal cord neurons in culture, J. Physiol., 456, 215, 10.1113/jphysiol.1992.sp019334

Urbanski, 1990, A role for N-methyl-d-aspartate (NMDA) receptors in the control of LH secretion and initiation of female puberty, Endocrinology, 126, 1774, 10.1210/endo-126-3-1774

Weiland, 1992, Estradiol selectively regulates agonist binding sites on the N-Methyl-d-aspartate receptor complex in the CA1 region of the hippocampus, Endocrinology, 131, 662, 10.1210/en.131.2.662

Weiss, 1990, Inhibition of sensory responses of cat inferior olive neurons produced by stimulation of red nucleus, J. Neurophysiol., 64, 1170, 10.1152/jn.1990.64.4.1170

Wieland, 1991, Anxiolytic activity of the progesterone metabolite 5α-pregnan-3α-ol-20-one, Brain Res., 565, 263, 10.1016/0006-8993(91)91658-N

Williams, 1989, Serotonin binding sites during proestrus and following estradiol treatment, Pharmac. Biochem. Behav., 33, 615, 10.1016/0091-3057(89)90397-3

Wilson, 1992, Influences of gender, gonadectomy, and estrous cycle on GABA/BZ receptors and benzodiazepine responses in rats, Brain Res. Bull., 29, 165, 10.1016/0361-9230(92)90022-P

Winfree, 1992, Analgesic effects of intrathecally-administered 3α-hydroxy-5α-pregnan-20-one in a rat mechanical visceral pain model, Life Sci., 50, 1007, 10.1016/0024-3205(92)90095-7

Wong, 1992, Long-term and short-term electrophysiological effects of estrogen on the synaptic properties of hippocampal CA1 neurons, J. Neurosci., 12, 3217, 10.1523/JNEUROSCI.12-08-03217.1992

Woolley, 1992, Estradiol mediates fluctuation in hippocampal synapse density during the estrous cycle in the adult rat, J. Neurosci., 12, 2549, 10.1523/JNEUROSCI.12-07-02549.1992

Wooley, 1962, The gonad-brain relationship, 70, 196

Wu, 1991, Pregnenolone sulfate: A positive allosteric modulator at the N-methyl-d-aspartate receptor, Molec. Pharmac., 40, 333

Young, 1945, The ovarian hormones and spontaneous running activity in the female rat, Endocrinology, 36, 181, 10.1210/endo-36-3-181

Zemlen, 1975, Lordosis after cerebellar damage in female rats, Horm. Behav., 6, 27, 10.1016/0018-506X(75)90020-3

Zimmerman, 1973, Behavioral changes associated with the menstrual cycle: An experimental investigation, J. appl. Soc. Psychol., 3, 335, 10.1111/j.1559-1816.1973.tb02400.x