Feeding liquid, non-ionic surfactant and cyclodextrin affect the properties of insulin-loaded poly(lactide-co-glycolide) microspheres prepared by spray-drying

Crotts, 1998, Protein delivery from poly(lactic-co-glycolic acid) biodegradable microspheres: release kinetics and stability issues, J. Microencapsul., 15, 699, 10.3109/02652049809008253

Kissel, 1996, Injectable biodegradable microspheres for vaccine delivery, 51

van de Weert, 2000, Protein instability in poly(lactic-co-glycolic acid) microparticles, Pharm. Res., 17, 1159, 10.1023/A:1026498209874

Schwendeman, 1996, Stability of proteins and their delivery from biodegradable polymer microspheres, 1

O’Hara, 2000, Respirable PLGA microspheres containing rifampicin for the treatment of tuberculosis: manufacture and characterization, Pharm. Res., 17, 955, 10.1023/A:1007527204887

Bittner, 1998, Recombinant human erythropoietin (rhEPO) loaded poly(lactide-co-glycolide) microspheres: influence of the encapsulation technique and polymer purity on microsphere characteristics, Eur. J. Pharm. Biopharm., 45, 295, 10.1016/S0939-6411(98)00012-5

Giunchedi, 1998, PDLLA microspheres containing steroids: spray-drying, o/w and w/o/w emulsifications as preparation methods, J. Microencapsul., 15, 185, 10.3109/02652049809006848

Witschi, 1998, Peptide degradation during preparation and in vitro release testing of poly(l-lactic acid) and poly(d,l-lactic-co-glycolic acid) microparticles, Int. J. Pharm., 171, 1, 10.1016/S0378-5173(98)00155-0

Ip, 1995, Stability of recombinant consensus interferon to air-jet and ultrasonic nebulization, J. Pharm. Sci., 84, 1210, 10.1002/jps.2600841013

Broadhead, 1994, The effect of process and formulation variables on the properties of spray-dried beta-galactosidase, J. Pharm. Pharmacol., 46, 458, 10.1111/j.2042-7158.1994.tb03828.x

Maa, 1998, Spray-drying of air-liquid interface sensitive recombinant human growth hormone, J. Pharm. Sci., 87, 152, 10.1021/js970308x

Brange, 1992, Chemical stability of insulin. 3. Influence of excipients, formulation and pH, Acta Pharm. Nord., 4, 149

Oliva, 1996, Influence of temperature and shaking on stability of insulin preparations: degradation kinetics, Int. J. Pharm., 143, 163, 10.1016/S0378-5173(96)04700-X

Brange, 1997, Toward understanding insulin fibrillation, J. Pharm. Sci., 86, 517, 10.1021/js960297s

De Rosa, 2000, Influence of the co-encapsulation of different non-ionic surfactants on the properties of PLGA insulin-loaded microspheres, J. Control. Release, 69, 283, 10.1016/S0168-3659(00)00315-1

Chawla, 1985, Aggregation of insulin, containing surfactant, in contact with different materials, Diabetes, 34, 420, 10.2337/diabetes.34.5.420

Irie, 1999, Cyclodextrins in peptide and protein delivery, Adv. Drug Deliv. Rev., 36, 101, 10.1016/S0169-409X(98)00057-X

Tokihiro, 1997, Varying effects of cyclodextrin derivatives on aggregation and thermal behavior of insulin in aqueous solution, Chem. Pharm. Bull., 45, 525, 10.1248/cpb.45.525

Katakam, 1995, Aggregation of insulin and its prevention by carbohydrate excipients, PDA, J. Pharm. Sci. Technol., 49, 160

Banga, 1993, Minimization of shaking-induced formation of insoluble aggregates of insulin by cyclodextrins, J. Drug Target., 1, 341, 10.3109/10611869308996093

Oliva, 2000, Development of two high-performance liquid chromatographic methods for the analysis and characterization of insulin and its degradation products in pharmaceutical preparations, J. Chromatogr. B, 749, 25, 10.1016/S0378-4347(00)00374-1

Kwon, 2001, In situ study of insulin aggregation induced by water-organic solvent interface, Pharm. Res., 18, 1754, 10.1023/A:1013334916162

Pocker, 1980, Conformational dynamics of insulin in solution. Circular dichroic studies, Biochemistry, 19, 5043, 10.1021/bi00563a017

Brange, 1988, Monomeric insulins obtained by protein engineering and their medical implications, Nature, 333, 679, 10.1038/333679a0

Sato, 1983, Prevention of insulin self-association and surface adsorption, J. Pharm. Sci., 72, 228, 10.1002/jps.2600720307

Kang, 1991, Subcutaneous insulin absorption explained by insulin’s physicochemical properties. Evidence from absorption studies of soluble human insulin and insulin analogues in humans, Diabetes Care, 14, 942, 10.2337/diacare.14.11.942

Nielsen, 2001, Probing the mechanism of insulin fibril formation with insulin mutants, Biochemistry, 40, 8397, 10.1021/bi0105983

Oliva, 1997, Analysis of peptides and proteins: evaluation of purity, stability and structural characterization of insulin, Drug Dev. Ind. Pharm., 23, 915, 10.3109/03639049709148696

Ettinger, 1971, On the nature of the circular dichroism bands, Biochemistry, 10, 824, 10.1021/bi00781a015

Melberg, 1990, Changes in the secondary structure follow the dissociation of human insulin hexamers: a circular dichroism study, Proteins, 8, 280, 10.1002/prot.340080309

Blanco-Prieto, 2000, In vitro and in vivo evaluation of a somatostatin analogue released from PLGA microspheres, J. Control. Release, 67, 19, 10.1016/S0168-3659(99)00289-8

Bittner, 1998, Bovine serum albumin loaded poly(lactide-co-glycolide) microspheres: the influence of polymer purity on particle characteristics, J. Microencapsul., 15, 495, 10.3109/02652049809006876

Rojas, 1999, A polysorbate-based non-ionic surfactant can modulate loading and release of beta-lactoglobulin entrapped in multiphase poly(dl-lactide-co-glycolide) microspheres, Pharm. Res., 16, 255, 10.1023/A:1018880409254

Blanco, 1998, Protein encapsulation and release from poly(lactide-co-glycolide) microspheres: effect of the protein and polymer properties and of the co-encapsulation of surfactants, Eur. J. Pharm. Biopharm., 45, 285, 10.1016/S0939-6411(98)00011-3

Quaglia, 2001, Modulation of drug release from hydrogels by using cyclodextrins: the case of nicardipine/β-cyclodextrin system in crosslinked polyethylenglycol, J. Control. Release, 71, 329, 10.1016/S0168-3659(01)00242-5