Fecal microbiota transplantation in puppies with canine parvovirus infection

Journal of Veterinary Internal Medicine - Tập 32 Số 2 - Trang 707-711 - 2018
Giorgio Queiroz Pereira1, Lucas Alécio Gomes1, Iago S. Santos1, Alice Fernandes Alfieri2, J. Scott Weese3, Márcio Paulino Costa4
1Department of Clinical Studies, Universidade Estadual de Londrina, Londrina, Paraná, Brazil
2Department of Preventive Veterinary Medicine, Universidade Estadual de Londrina, Londrina, Paraná, Brazil
3Department of Clinical Studies, Ontario Veterinary College, University of Guelph, Guelph, Ontario, Canada
4Departement of Veterinary Biomedicine, Faculté de Médecine Vétérinaire Université de Montréal Saint‐Hyacinthe Quebec Canada

Tóm tắt

BackgroundDiarrhea associated with parvovirus infection is common in dogs. Supportive care is the mainstay of treatment, but recovery may be prolonged and mortality rate can be high. Modification of the intestinal bacterial microbiota has been promising in human and veterinary medicine as an adjunctive treatment of various enteric diseases.ObjectivesTo investigate the safety and efficacy of fecal microbiota transplantation (FMT) on the clinical recovery of puppies with acute hemorrhagic diarrhea syndrome.AnimalsSixty‐six puppies with parvovirus infection were evaluated at 2 veterinary hospitals.MethodsRandomized clinical trial. Puppies were randomly distributed into 2 groups: standard treatment (STD) and standard treatment + FMT (STD + FMT). The STD puppies (n = 33) received only treatment with IV fluids and antimicrobials and the STD + FMT puppies (n = 33) received FMT in addition to standard treatment. For FMT, 10 g of feces from a healthy dog diluted in 10 mL of saline were administered rectally 6‐12 hours post‐admission.ResultsAmong survivors, treatment with FMT was associated with faster resolution of diarrhea (P < .001) and shorter hospitalization time (P = .001; median, 3 days in STD + FMT; median, 6 days in STD) compared to standard treatment. Mortality in STD was 36.4% (12/33) as compared to 21.2% (7/33) in puppies treated with FMT, but there was no statistical difference between groups (P = .174). Polymerase chain reaction indicated that all animals carried canine parvovirus, strain CPV‐2b.ConclusionsFecal microbiota transplantation in parvovirus‐infected puppies was associated with faster resolution of diarrhea.

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Thông tin xuất bản

Journal of Veterinary Internal Medicine

Tập 32 Số 2

707-711

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