Feasibility analysis of using a bubble column evaporator as a solvent swap device

Fazlollahi, 2018, Novel solvent exchange distillation column, Chem. Eng. Sci., 184, 216, 10.1016/j.ces.2018.02.025 Papadakis, 2016, Solvent selection methodology for pharmaceutical processes: solvent swap, Chem. Eng. Res. Des., 115, 443, 10.1016/j.cherd.2016.09.004 Hsieh, 2009, Model-based solvent selection during conceptual process design of a new drug manufacturing process, Org. Process Res. Dev., 13, 690, 10.1021/op900058e Elgue, 2006, Optimisation of solvent replacement procedures according to economic and environmental criteria, Chem. Eng. J., 117, 169, 10.1016/j.cej.2005.11.017 Li, 2009, Optimization of solvent chasing in API manufacturing process: constant volume distillation, Org. Process Res. Dev., 13, 73, 10.1021/op800152n Schwartz, 2003, Diafiltration for desalting or buffer exchange, Bioprocess Int. Sheth, 2003, Nanofiltration-based diafiltration process for solvent exchange in pharmaceutical manufacturing, J. Membr. Sci., 211, 251, 10.1016/S0376-7388(02)00423-4 May, 2012, Rapid development and scale-up of a 1H-4-substituted imidazole intermediate enabled by chemistry in continuous plug flow reactors, Org. Process Res. Dev., 16, 982, 10.1021/op200351g Cole, 2017 Roche, 2020, Low-temperature evaporation of continuous pharmaceutical process streams in a bubble column, Chem. Eng. Res. Des. Donnellan, 2014, Absorption of steam bubbles in lithium bromide solution, Chem. Eng. Sci., 119, 10, 10.1016/j.ces.2014.07.060 Donnellan, 2015, Analysis of the velocity and displacement of a condensing bubble in a liquid solution, Chem. Eng. Sci., 130, 56, 10.1016/j.ces.2015.02.041 Cappelli, 2022, CFD analysis of a bubble column evaporator, Int. J. Heat Mass Transf., 188, 122296, 10.1016/j.ijheatmasstransfer.2021.122296 Tyn, 1975, Diffusion coefficients in dilute binary liquid mixtures, J. Chem. Eng. Data, 20, 106, 10.1021/je60064a006 Roche, 2021, Development of a continuous evaporation system for an API solution stream prior to crystallization, AlChE J., 67, e17377, 10.1002/aic.17377 Carsibasi, 2005, Bubble column reactors, Process Biochem., 40, 2263, 10.1016/j.procbio.2004.10.004 Dopazo, 1977, On conditioned averages for intermittent turbulent flows, J. Fluid Mech., 81, 433, 10.1017/S0022112077002158 Rusche, 2002 Versteeg, 1995 Michta, 2011 Pu, 2019, Simulation on direct contact heat transfer in gas-molten salt bubble column for high temperature solar thermal storage, Int. Commun. Heat Mass Transf., 104, 51, 10.1016/j.icheatmasstransfer.2019.02.019 Shaikh, 2007, A review on flow regime transition in bubble columns, Int. J. Chem. Reactor Eng., 5, 1, 10.2202/1542-6580.1368 Mougin, 2002, The generalized kirchhoff equations and their application to the interaction between a rigid body and an arbitrary time-dependent viscous flow, Int. J. Multiph. Flow, 28, 1837, 10.1016/S0301-9322(02)00078-2 Cappelli, 2018, A detailed description of reactingTwoPhaseEulerFoam focussing on the links between mass and heat transfer at the phase interface J. Wilms, T. Harms, On the development of an openfoam solver to model two-phase horizontal flow in a heated pipe, 2014. Ranz, 1952, Evaporation from drops, parts I & II, Chem. Eng. Prog., 48, 141 Lewis, 1924, Principles of gas absorption, Ind. Eng. Chem., 16, 1215, 10.1021/ie50180a002 Renksizbulut, 1991, A mass transfer correlation for droplet evaporation in high-temperature flows, Chem. Eng. Sci., 46, 2351, 10.1016/0009-2509(91)85133-I Gbadago, 2020, CFD simulation of a packed bed industrial absorber with interbed liquid distributors, Int. J. Greenhouse Gas Control, 95, 102983, 10.1016/j.ijggc.2020.102983 Miller, 1974, Scale-up of agitated vessels gas-liquid mass transfer, AlChE J., 20, 445, 10.1002/aic.690200303