Fatty Acids Activate the Transcriptional Coactivator YAP1 to Promote Liver Fibrosis via p38 Mitogen-Activated Protein Kinase

Williams, 2011, Prevalence of nonalcoholic fatty liver disease and nonalcoholic steatohepatitis among a largely middle-aged population utilizing ultrasound and liver biopsy: a prospective study, Gastroenterology, 140, 124, 10.1053/j.gastro.2010.09.038 Diehl, 2017, Cause, pathogenesis, and treatment of nonalcoholic steatohepatitis, N Engl J Med, 377, 2063, 10.1056/NEJMra1503519 Kim, 2019, OPTN/SRTR 2017 Annual Data Report: liver, Am J Transplant, 19, 184, 10.1111/ajt.15276 Estes, 2018, Modeling the epidemic of nonalcoholic fatty liver disease demonstrates an exponential increase in burden of disease, Hepatology, 67, 123, 10.1002/hep.29466 Machado, 2015, Accumulation of duct cells with activated YAP parallels fibrosis progression in non-alcoholic fatty liver disease, J Hepatol, 63, 962, 10.1016/j.jhep.2015.05.031 Wang, 2016, Hepatocyte TAZ/WWTR1 promotes inflammation and fibrosis in nonalcoholic steatohepatitis, Cell Metab, 24, 848, 10.1016/j.cmet.2016.09.016 Zhao, 2007, Inactivation of YAP oncoprotein by the Hippo pathway is involved in cell contact inhibition and tissue growth control, Genes Dev, 21, 2747, 10.1101/gad.1602907 Mooring, 2019, Hepatocyte stress increases expression of yes-associated protein and transcriptional coactivator with PDZ-binding motif in hepatocytes to promote parenchymal inflammation and fibrosis, Hepatology, 0, 1 Friedman, 2018, Mechanisms of NAFLD development and therapeutic strategies, Nat Med, 24, 908, 10.1038/s41591-018-0104-9 McPherson, 2015, Evidence of NAFLD progression from steatosis to fibrosing-steatohepatitis using paired biopsies: Implications for prognosis and clinical management, J Hepatol, 62, 1148, 10.1016/j.jhep.2014.11.034 Nasr, 2018, Natural history of nonalcoholic fatty liver disease: A prospective follow-up study with serial biopsies, Hepatol Commun, 2, 199, 10.1002/hep4.1134 Collins, 2006, p38 mitogen-activated protein kinase mediates free fatty acid-induced gluconeogenesis in hepatocytes, J Biol Chem, 281, 24336, 10.1074/jbc.M602177200 Liu, 2007, Prolonged treatment of primary hepatocytes with oleate induces insulin resistance through p38 mitogen-activated protein kinase, J Biol Chem, 282, 14205, 10.1074/jbc.M609701200 Lei, 2008, TAZ promotes cell proliferation and epithelial-mesenchymal transition and is inhibited by the hippo pathway, Mol Cell Biol, 28, 2426, 10.1128/MCB.01874-07 Oh, 2008, In vivo regulation of Yorkie phosphorylation and localization, Development, 135, 1081, 10.1242/dev.015255 Farrell, 2019, Mouse models of nonalcoholic steatohepatitis: toward optimization of their relevance to human nonalcoholic steatohepatitis, Hepatology, 69, 2241, 10.1002/hep.30333 Neuschwander-Tetri, 2010, Hepatic lipotoxicity and the pathogenesis of nonalcoholic steatohepatitis: the central role of nontriglyceride fatty acid metabolites, Hepatology, 52, 774, 10.1002/hep.23719 Tsuchida, 2017, Mechanisms of hepatic stellate cell activation, Nat Rev Gastroenterol Hepatol, 14, 397, 10.1038/nrgastro.2017.38 Zhang, 2010, The Merlin/NF2 tumor suppressor functions through the YAP oncoprotein to regulate tissue homeostasis in mammals, Dev Cell, 19, 27, 10.1016/j.devcel.2010.06.015 González-Terán, 2016, p38γ and p38δ reprogram liver metabolism by modulating neutrophil infiltration, EMBO J, 35, 536, 10.15252/embj.201591857 Johnson, 2002, Mitogen-Activated Protein Kinase Pathways Mediated by ERK, JNK, and p38 Protein Kinases, Science, 298, 1911, 10.1126/science.1072682 Bian, 2013, CCN1 expression in hepatocytes contributes to macrophage infiltration in nonalcoholic fatty liver disease in mice, J Lipid Res, 54, 44, 10.1194/jlr.M026013 Huang, 2016, Regulation of Hippo signalling by p38 signalling, J Mol Cell Biol, 8, 328 Yimlamai, 2014, Hippo pathway activity influences liver cell fate, Cell, 157, 1324, 10.1016/j.cell.2014.03.060 Mannaerts, 2015, The Hippo pathway effector YAP controls mouse hepatic stellate cell activation, J Hepatol, 63, 679, 10.1016/j.jhep.2015.04.011 Song, 2020, Yes-associated protein in Kupffer cells enhances the production of proinflammatory cytokines and promotes the development of nonalcoholic steatohepatitis, Hepatology, 0, 1 Almpanis, 2016, Evaluation of liver fibrosis: “something old, something new….”, Ann Gastroenterol, 29, 445 Kitani, 2011, A Simple and efficient method to isolate macrophages from mixed primary cultures of adult liver cells, J Vis Exp, 1 Foty, 2011, A simple hanging drop cell culture protocol for generation of 3D spheroids, J Vis Exp, 20, 4 Salloum, 2016, Exposure to human immunodeficiency virus/hepatitis C virus in hepatic and stellate cell lines reveals cooperative profibrotic transcriptional activation between viruses and cell types, Hepatology, 64, 1951, 10.1002/hep.28766