Fate and Transport of Antibiotic Residues and Antibiotic Resistance Genes following Land Application of Manure Waste
Tóm tắt
Antibiotics are used in animal livestock production for therapeutic treatment of disease and at subtherapeutic levels for growth promotion and improvement of feed efficiency. It is estimated that approximately 75% of antibiotics are not absorbed by animals and are excreted in waste. Antibiotic resistance selection occurs among gastrointestinal bacteria, which are also excreted in manure and stored in waste holding systems. Land application of animal waste is a common disposal method used in the United States and is a means for environmental entry of both antibiotics and genetic resistance determinants. Concerns for bacterial resistance gene selection and dissemination of resistance genes have prompted interest about the concentrations and biological activity of drug residues and break‐down metabolites, and their fate and transport. Fecal bacteria can survive for weeks to months in the environment, depending on species and temperature, however, genetic elements can persist regardless of cell viability. Phylogenetic analyses indicate antibiotic resistance genes have evolved, although some genes have been maintained in bacteria before the modern antibiotic era. Quantitative measurements of drug residues and levels of resistance genes are needed, in addition to understanding the environmental mechanisms of genetic selection, gene acquisition, and the spatiotemporal dynamics of these resistance genes and their bacterial hosts. This review article discusses an accumulation of findings that address aspects of the fate, transport, and persistence of antibiotics and antibiotic resistance genes in natural environments, with emphasis on mechanisms pertaining to soil environments following land application of animal waste effluent.
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Tài liệu tham khảo
AHI, 2001, Survey shows decline in antibiotic use in animals
Andremont A., 2003, Commensal flora may play key role in spreading antibiotic resistance, ASM News, 69, 601
Azadpour‐Keeley A., 2003, Movement and longevity of viruses in the subsurface
Bauer B., 1996, Genetic transformation in freshwater: Escherichia coli is able to develop natural competence, Appl. Environ. Microbiol., 62, 3673, 10.1128/aem.62.10.3673-3678.1996
Beegle D., 1997, Using composted dairy manure, Adv. Dairy Technol., 9, 67
Bennett P.M., 2008, Plasmid encoded antibiotic resitance: Acquisition and tranfer of antibiotic resistance genes in bacteria, Br. J. Pharmacol., 153, 5347, 10.1038/sj.bjp.0707607
Bitton G., 1992, Environmental microbiology, 103
Chakrabarty A.N., 1990, ‘DNA’ as contaminants in antibiotics and its capacity to transform bacteria to drug resistance, Indian J. Exp. Biol., 28, 58
Chandler D., 1981, Persistence and distribution of pollution indicator bacteria on land used for disposal of piggery effluent, Appl. Environ. Microbiol., 42, 453, 10.1128/aem.42.3.453-460.1981
Chen I., 2004, DNA uptake during bacterial transformation, Nat. Rev., 2, 241
Cherry J.A., 2007, Contaminant transport through aquitards: A state‐of‐the‐science review
Cromwell G.L., 2001, Swine nutrition, 401
Di Giovanni G., 1996, Gene transfer of Alcaligenes eutrophus JMP134 plasmid pJP4 to indigenous soil recipients, Appl. Environ. Microbiol., 62, 2521, 10.1128/aem.62.7.2521-2526.1996
Donohoe A.L., 1984, Biochemical studies on the fate of monensin in animals and in the environment, J. Anim. Sci., 58, 1528, 10.2527/jas1984.5861528x
Feinman S.E., 1978, Bureau of Veterinary Medicine
Fulhage C.D. andPost D.Swine manure management systems in Missouri. Available at (verified 16 Feb. 2009).. Available athttp://www.muextension.missouri.edu/xplor/envqual/eq0350.htm(verified 16 Feb. 2009).2005
Gattinger A., 2006, Structure and function of archaeal communities in natural and agriculturally used soil ecosystems, 06426
Gerba C.P., 1984, Groundwater pollution microbiology, 65
Goyal S.M., 1983, Viral pollution of the environment, 211
Hanzawa Y., 1984, Antibiotic‐resistant coliforms in the waste of piggeries and dairy farms, Japan. J. Vet. Sci., 46, 363, 10.1292/jvms1939.46.363
Harwood C., 2008, The uncharted microbial world: Microbes and their activities in the environment
Huang C.‐H., 2001, Proc. of the 2nd Int. Conf. on Pharmaceuticals and Endocrine Disrupting Chemicals in Water, 46
Institute of Medicine, 1989, Human health risks with the subtherapeutic use of penicillin or tetracyclines in animal feed
Isaacson R.E., 2002, The role of antibiotics in agriculture
Khachatourians G.G., 1998, Agricultural use of antibiotics and the evolution and transfer of antibiotic‐resistant bacteria, Can. Med. Assoc. J., 159, 1129
Krapac I.G., 2004, Proc. of the 4th Int. Conf. on Pharmaceuticals and Endocrine Disrupting Chemicals in Water, 158
Lenski R.E., 1997, The cost of antibiotic resistance—From the perspective of a bacterium, Ciba Found. Symp., 207, 131
Lesická‐Hupková M., 1996, Mobilization of antibiotic resistance for transfer in Pseudomonas aeruginosa., J. Chemother., 8, 261, 10.1179/joc.1996.8.4.261
Levy S.B., 1989, Gene transfer in the environment
Livestock and Poultry Environmental Stewardship.Appendix C: Livestock and poultry manure characterization. Available at (verified 16 Feb. 2009).. Available athttp://www.lpes.org/Lessons/Lesson21/21_9_manure_character.pdf(verified 16 Feb. 2009).2005
MacDonald J.M., 2008, Econ. Information Bull. 38
Nasser A.M., 1993, Comparative survival of E. coli, F+ bacteriophages, HAV and poliovirus 1 in wastewater and groundwater, Water Sci. Technol., 27, 401, 10.2166/wst.1993.0381
Nebraska Beef Council, 2007, Beef industry information, State/industry facts
Park N., 1994, CANVAS: A composite analytical‐numerical model for viral and solute transport simulation, version 2.0
Payment P., 1989, Virus removal by drinking water treatment processes, Crit. Rev. Environ. Contr., 19, 15, 10.1080/10643388909388357
Pillai S.D., 1997, Antibiotic resistance profiles of Escherichia coli isolated from rural and urabn environments, J. Environ. Sci. Health A, 32, 1665
Pinck L.A., 1962, Antibiotics in soils: 4. Polypeptides and macrolides, Soil Sci., 94, 121, 10.1097/00010694-196208000-00011
Prescott L.M., 1999, Microbiology, 678
Richert B.T., 1995, J. of Extension
Rotz C.A., 2004, Management to reduce nitrogen losses in animal production, J. Anim. Sci., 82, E119
Scandura J.E., 1997, Viral and bacterial contamination of groundwater from on‐site sewage treatment systems, Water Sci. Technol., 35, 107, 10.2166/wst.1997.0724
Sims J.D.Flow and transport through fractured clay till: A laboratory study. M.S. thesis. Dep. of Earth Sciences Univ. of Waterloo Waterloo ON.1993
Simunek J., 1999, The HYDRUS‐2D software package for simulating the two‐dimensional movement of water, heat, and multiple solutes in variably‐saturated media, Version 2.0
Sobsey M.D. Khatib L.A. Hill V.R. Alocilja E. andPillai S.Pathogens in animal wastes and the impacts of waste management practices on their survival transport and fate.White Paper Summaries. Available online (verified 16 Feb. 2009).2001
Stewart G.J., 1989, Gene transfer in the environment, 139
Timoney J.F., 1978, Heavy‐metal and antibiotic resistance in the bacterial flora of sediments of New York Bight, Appl. Environ. Microbiol., 36, 465, 10.1128/aem.36.3.465-472.1978
Union of Concerned Scientists, 2001, Hogging it: Estimates of antimicrobial abuse in livestock, 109
USDA, 2001, Part I: Reference of swine health and management in the United States, 2000, National Animal Health Monitoring System
USDA, 2001, Part II: Reference of swine health and management in the United States, 2000, National Animal Health Monitoring System
USDA, 2007, Swine 2006, Part II: Reference of swine health and health management practices in the United States, 2006 USDA:APHIS:VS, CEAH
USDA NASS.Statistics of cattle hogs and sheep. Available at (verified 16 Feb. 2009).. Available athttp://www.nass.usda.gov/Publications/Ag_Statistics/2008/Chap07.pdf(verified 16 Feb. 2009).2002
USDA NRCS.Animal manure management. NRCS/RCA issue brief 7 Dec. 1995. Available at (verified 16 Feb. 2009).1995
USGAO, 1999, General Accounting Office
Utah Department of Health.Medication disposal summary report. Available at (verified 16 Feb. 2009).. Available athttp://health.utah.gov/prescription/pdf/NewHampshire_Disposal_technical.pdf(verified 16 Feb. 2009).2007
Wellings F.M., 1974, Virus survival in water and wastewater systems
Wellings F.M., 1975, Demonstration of virus in groundwater after effluent discharge onto soil, Appl. Microbiol., 29, 751, 10.1128/am.29.6.751-757.1975
Yates M.V., 2000, Project 262