Fatal primary dengue-induced Haemophagocytic Lymphohistiocytosis (HLH) in a returning traveller from India treated with anakinra for the first time

Fardet, 2014, Development and validation of the hscore, a score for the diagnosis of reactive hemophagocytic syndrome, Arthritis Rheumatol, 66, 2613, 10.1002/art.38690 Tricou, 2011, Kinetics of viremia and NS1 antigenemia are shaped by immune status and virus serotype in adults with dengue, PLoS Negl Trop Dis, 10.1371/journal.pntd.0001309 Bhatt, 2013, The global distribution and burden of dengue, Nature, 496, 504, 10.1038/nature12060 World Health Organization. Dengue and severe dengue key facts. 2018; February: 1–7. http://www.who.int/news-room/fact-sheets/detail/dengue-and-severe-dengue. Jacobs, 1991, Dengue haemorrhagic fever: A risk of returning home, Br Med J, 10.1136/bmj.302.6780.828 Kan, 2019, Dengue infection complicated by hemophagocytic lymphohistiocytosis: Experiences from 180 patients with severe dengue, Clin Infect Dis, 1 Giang, 2018, Dengue hemophagocytic syndrome: A systematic review and meta-analysis on epidemiology, clinical signs, outcomes, and risk factors, Rev Med Virol, 28, 1, 10.1002/rmv.2005 Carter, 2019, Macrophage activation syndrome in adults: Recent advances in pathophysiology, diagnosis and treatment, Rheumatol (United Kingdom), 58, 5 Brisse, 2016, Advances in the pathogenesis of primary and secondary haemophagocytic lymphohistiocytosis: Differences and similarities, Br J Haematol, 174, 203, 10.1111/bjh.14147 Shabbir, 2019, THU0051 off-licence use of anakinra in critically ill adults with suspected haemophagocytosis – a single centre experience, Ann Rheum Dis, 78 Katzelnick, 2017, Antibody-dependent enhancement of severe dengue disease in humans, Science (80-.), 10.1126/science.aan6836