Fas/CD95 signaling rather than angiogenesis or proliferative activity is a useful prognostic factor in patients with resected liver metastases from colorectal cancer

Registry of Hepatic Metastases (1988) Resection of the liver for colorectal carcinoma metastases: a multi-institutional study of indications for resection. Surgery 103:278–288 Jatzko GR, Lisborg PH, Stettner HM, Klimpfinger MH (1995) Hepatic resection for metastasis from colorectal carcinoma—a survival analysis. Eur J Cancer 31A:41–46 Yaylor I (1996) Liver metastases from colorectal cancer: lessons from past and present clinical studies. Br J Surg 83:456–460 Stangl R, Annelore AF, Charnley RM, Scheele J (1994) Factors influencing the natural history of colorectal liver metastases. Lancet 343:1405–1410 Sugihara K, Hojo K, Moriya Y, Yamasaki S, Kosuge T, Takayama T (1993) Pattern of recurrence after hepatic resection for colorectal metastases. Br J Surg 80:1032–1035 Scheele J, Stangl R, Annelore AF, Gall FP (1991) Indications of prognosis after hepatic resection for colorectal secondaries. Surgery 110:13–29 Pinston CW, Wright JK, Chapman WC, Garrard CL, Blair TK, Sawyers JL (1996) Repeat hepatic surgery for colorectal cancer metastasis to the liver. Ann Surg 226:765–776 Gayowski TJ, Iwatsuki S, Madariaga JR, Selby R, Todo S, Irish W et al (1994) Experience in hepatic resection for metastatic colorectal cancer: analysis of clinical and pathologic risk factors. Surgery 116:703–711 Doci R, Gennari L, Bignami P, Montalto F, Morabito A, Bozzetti F (1991) One hundred patients with hepatic metastases from colorectal cancer treated by resection: analysis of prognostic determinants. Br J Surg 78:797–801 Fortner JG, Silva JS, Golbey RB, Cox EB, Maclean BJ (1984) Multivariate analysis of a personal series of 247 consecutive patients with liver metastases from colorectal cancer. Ann Surg 199:306–316 Steel G, Bleday R, Mayer RJ, Lindblad A, Petrelli N, Weaver D (1991) A prospective evaluation of hepatic resection for colorectal carcinoma metastases to the liver: gastrointestinal tumor study group protocol 6584. J Clin Oncol 9:1105–1112 Adson MA, van Heerden JA, Adson MH, Wagner JS, Ilstrup DM (1984) Resection of hepatic metastases from colorectal cancer. Arch Surg 119:647–651 Kokudo N, Miki Y, Sugai S, Yanagisawa A, Kato Y, Sakamoto Y et al (2002) Genetic and histological assessment of surgical margins in resected liver metastases from colorectal carcinoma: minimum surgical margins for successful resection. Arch Surg 137:833–840 Choti MA, Sitzmann JV, Tiburi MF, Sumetchotimetha W, Rangsin R, Schulick RD et al (2002) Trends in long-term survival following liver resection for hepatic colorectal metastases. Ann Surg 235:759–766 Saw RP, Koorey D, Painter D, Gallagher PJ, Solomon MJ (2002) p53, DCC and thymidylate synthase as predictors of survival after resection of hepatic metastases from colorectal cancer. Br J Surg 89:1409–1415 Welin S, Youker J, Spratt JS Jr (1963) The rates and patterns of the large intestine and rectum observed serially by double contrast enema study (Malmo technique). Am J Roentgenol Radium Ther Nucl Med 90:673–687 Bolin S, Nilsson E, Sjodahl R (1983) Carcinoma of the colon and rectum: growth rate. Ann Surg 198:151–158 Staah HJ, Anderer FA, Stumph E, Fisher R (1978) Slope analysis of the postoperative CEA time course and its possible application as an aid in diagnosis of disease progression in gastrointestinal cancer. Am J Surg 136:324–327 Maetani S, Onodera H, Nishikawa T, Morimoto H, Ida K, Kitamura O et al (1998) The significance of local recurrence of rectal cancer as a local or disseminated disease. Br J Surg 85:521–525 Onodera H, Maetani H, Kawamoto K, Kan H, Kondo S, Imamura M (2000) Pathologic significance of tumor progression in locally recurrent rectal cancer: different nature from primary cancer. Dis Colon Rectum 43:775–781 Bosari S, Lee AK, DeLellis RA, Wiley BD, Heatley GJ, Silverman ML (1992) Microvessel quantitation and prognosis in invasive breast carcinoma. Hum Pathol 23:755–761 Portera CA, Berman RS, Ellis LM (1998) Molecular determinants of colon cancer metastasis. Surg Oncol 7:183–195 Berney CR, Fisher RJ, Yang J-L, Fisher RJ, Russell PJ, Crowe PJ (1998) Overexpression of nm23 protein assessed by color video image analysis in metastatic colorectal cancer: correlation with reduced patient survival. World J Surg 22:484–490 Berney CR, Fisher RJ, Yang J, Russell PJ, Crowe PJ (1999) Protein markers in colorectal cancer—predictor of liver metastasis. Ann Surg 230:179–184 Sinicrope FA, Hart J, Hsu H-A, Lemoine M, Michelassi F, Stephens LC (1999) Apoptotic and mitotic indices predict survival rates in lymph node-negative colon carcinomas. Clin Cancer Res 5:1793–1804 Tullo A, D’Eerchia AM, Honda K, Mitry RR, Kelley MD, Habib NA et al (1999) Characterization of p53 mutations in colorectal liver metastases and correlation with clinical parameters. Clin Cancer Res 5:3523–3528 Hamelin R, Laurent-Puig P, Olschwang S, Jego N, Asselain B, Remvikos Y et al (1994) Association of p53 with short survival in colorectal cancer. Gastroenterology 106:42–48 Liao G, Zhang Y, Shen M, Jiang H, Yan Z (1997) Significance of proliferating cell nuclear antigen expression in liver metastasis of colorectal cancer. Colon Rectum 40:1489–1493 Belluco C, Guillem JC, Kemeny N, Huang Y, Klimstra D, Berger MF et al (1996) p53 nuclear protein overexpression in colorectal cancer: a dominant predictor of survival in patients with advanced hepatic metastases. J Clin Oncol 14:2696–2701 Seto S, Onodera H, Kaido T, Yoshikawa A, Ishigami S, Arii S et al (2000) Tissue factor expression in human colorectal carcinoma—correlation with hepatic metastasis and impact on prognosis. Cancer 88:297–303 Kawamoto K, Onodera H, Kondo, Kan S, Ikeuchi D, Maetani S et al (1998) Expression of insulin-like growth factor-2 can predict the prognosis of human colorectal cancer patients: correlation with tumor progression, proliferative activity and survival. Oncology 55:242–248 Kawamoto K, Onodera H, Kondo S, Kan S, Ikeuchi D, Maetani S et al (1999) Insulin-like growth factor-2 stimulates cancer cell proliferation in the liver; possible paracrine mechanism in colorectal cancer patients with liver metastasis. Cancer 85:18–25 Tanigawa N, Amaya H, Matsumura M, Lu C, Kitaoka A, Matsuyama K et al (1997) Tumor angiogenesis and mode of metastasis in patients with colorectal cancer. Cancer Res 57:1043–1046 Frank RE, Saclarides TJ, Leurgans S, Speziale NJ, Drab EA, Rubin DB (1995) Tumor angiogenesis as a predictor of recurrence and survival in patients with colorectal cancer. Ann Surg 222:695–699 Kerr JFR, Winterford CM, Harmon BV (1994) Apoptosis: its significance in cancer and cancer therapy. Cancer 73:2013–2026 Lowe SW, Ruley HE, Jacks T, Housman DE (1993) p53-dependent apoptosis modulates the cytotoxicity of anticancer agents. Cell 74:957–967 Sturm I, Kohne CH, Wolff G, Petrowsky H, Hillebrand T, Hauptmann S et al (1999) Analysis of the p53/BAX pathway in colorectal cancer: low bax is a negative prognostic factor in patients with resected liver metastases. J Clin Oncol 17:1364–1374 Heisterkamp J, Bommel J, Hop WCJ, Tilanus HW, Zondervan PE, Ijzermans JNM (1999) P53 overexpression in colorectal metastases confined to the liver and outcome of liver resection. Hepatogastroenterology 46:3109–3114 Wong CW, Lee A, Shientag L, Yu J, Dong Y, Kao G et al (2001) Apoptosis: an early event in metastatic inefficiency. Cancer Res 61:333–338 Oliver L, Cordel S, Barbieux I, LeCabellec MT, Meflah K, Gregoire M et al (2002) Resistance to apoptosis is increased during metastatic dissemination of colon cancer. Clin Exp Metastasis 19:175–180 Folkman J (1997) Angiogenesis and angiogenesis inhibitor: an overview. EXS 79:1–8 O’Reilly MS, Boehm T, Shing Y, Fukai N, Vasios G, Lane WS et al (1997) Endostatin: an endogenous inhibitor of angiogenesis and tumor growth. Cell 88:277–285 Ishigami S, Arii S, Furutani M, Niwano M, Harada T, Mizumoto M et al (1998) Predictive value of vascular endothelial growth factor (VEGF) in metastasis and prognosis of human colorectal cancer. Br J Cancer 78:1379–1384 Kondo Y, Arii S, Furutani M, Ishigami S, Mori A, Onodera H et al (2000) Implication of VEGF and p53 status for angiogenesis in non-invasive colorectal carcinoma. Cancer 88:1820–1827 Gervaz P, Scholl B, Mainguene C, Poitry S, Gillet M, Wexner S (2000) Angiogenesis of liver metastases: role of sinusoidal endothelial cells. Dis Colon Rectum 43:980–986 Willett CG, Boucher Y, di Tomaso E, Duda DG, Munn LL, Tong R et al (2004) Direct evidence that the VEGF-specific antibody bevacizumab has antivascular effects in human rectal cancer. Nat Med 10:145–147