Failsafe program escape and EMT: A deleterious partnership

Bartkova, 2005, DNA damage response as a candidate anti-cancer barrier in early human tumorigenesis, Nature, 434, 864, 10.1038/nature03482 Braig, 2005, Oncogene-induced senescence as an initial barrier in lymphoma development, Nature, 436, 660, 10.1038/nature03841 Collado, 2005, Tumour biology: senescence in premalignant tumours, Nature, 436, 642, 10.1038/436642a Chen, 2005, Crucial role of p53-dependent cellular senescence in suppression of Pten-deficient tumorigenesis, Nature, 436, 725, 10.1038/nature03918 Gorgoulis, 2005, Activation of the DNA damage checkpoint and genomic instability in human precancerous lesions, Nature, 434, 907, 10.1038/nature03485 Bartkova, 2006, Oncogene-induced senescence is part of the tumorigenesis barrier imposed by DNA damage checkpoints, Nature, 444, 633, 10.1038/nature05268 Peinado, 2007, Snail, Zeb and bHLH factors in tumour progression: an alliance against the epithelial phenotype?, Nat Rev Cancer, 7, 415, 10.1038/nrc2131 Thiery, 2009, Epithelial–mesenchymal transitions in development and disease, Cell, 139, 871, 10.1016/j.cell.2009.11.007 Tribulo, 2004, A balance between the anti-apoptotic activity of Slug and the apoptotic activity of msx1 is required for the proper development of the neural crest, Dev Biol, 275, 325, 10.1016/j.ydbio.2004.07.041 Vega, 2004, Snail blocks the cell cycle and confers resistance to cell death, Genes Dev, 8, 1131, 10.1101/gad.294104 Wu, 2005, Slug antagonizes p53-mediated apoptosis of hematopoietic progenitors by repressing puma, Cell, 123, 641, 10.1016/j.cell.2005.09.029 Rodriguez-Aznar, 2011, Repression of Puma by Scratch2 is required for neuronal survival during embryonic development, Cell Death Differ, 18, 1196, 10.1038/cdd.2010.190 Ansieau, 2010, TWISTing an embryonic transcription factor into an oncoprotein, Oncogene, 29, 3173, 10.1038/onc.2010.92 Yang, 2004, Twist, a master regulator of morphogenesis, plays an essential role in tumor metastasis, Cell, 117, 927, 10.1016/j.cell.2004.06.006 Trimboli, 2008, Direct evidence for epithelial–mesenchymal transitions in breast cancer, Cancer Res, 68, 937, 10.1158/0008-5472.CAN-07-2148 Brabletz, 1998, Nuclear overexpression of the oncoprotein beta-catenin in colorectal cancer is localized predominantly at the invasion front, Pathol Res Pract, 194, 701, 10.1016/S0344-0338(98)80129-5 Mani, 2008, The epithelial–mesenchymal transition generates cells with properties of stem cells, Cell, 133, 704, 10.1016/j.cell.2008.03.027 Morel, 2008, Generation of breast cancer stem cells through epithelial–mesenchymal transition, PLoS One, 3, e2888, 10.1371/journal.pone.0002888 Vesuna, 2009, Twist modulates breast cancer stem cells by transcriptional regulation of CD24 expression, Neoplasia, 11, 1318, 10.1593/neo.91084 Gupta, 2009, Cancer stem cells: mirage or reality?, Nat Med, 15, 1010, 10.1038/nm0909-1010 Ansieau, 2011, From where do cancer-initiating cells originate?, Cancer Stem Cells Theories and Practice (InTech), 34–46, 10.5772/14903 Maestro, 1999, Twist is a potential oncogene that inhibits apoptosis, Genes Dev, 13, 2207, 10.1101/gad.13.17.2207 Valsesia-Wittmann, 2004, Oncogenic cooperation between H-Twist and N-Myc overrides failsafe programs in cancer cells, Cancer Cell, 6, 625, 10.1016/j.ccr.2004.09.033 Lee, 2009, Blocking of p53-Snail binding, promoted by oncogenic K-Ras, recovers p53 expression and function, Neoplasia, 11, 22, 10.1593/neo.81006 Sayan, 2009, SIP1 protein protects cells from DNA damage-induced apoptosis and has independent prognostic value in bladder cancer, Proc Natl Acad Sci USA, 106, 14884, 10.1073/pnas.0902042106 Perez-Caro, 2008, Transcriptomal profiling of the cellular response to DNA damage mediated by Slug (Snai2), Br J Cancer, 98, 480, 10.1038/sj.bjc.6604084 Ansieau, 2008, Induction of EMT by twist proteins as a collateral effect of tumor-promoting inactivation of premature senescence, Cancer Cell, 14, 79, 10.1016/j.ccr.2008.06.005 Ohashi, 2010, Epidermal growth factor receptor and mutant p53 expand an esophageal cellular subpopulation capable of epithelial-to-mesenchymal transition through ZEB transcription factors, Cancer Res, 70, 4174, 10.1158/0008-5472.CAN-09-4614 Liu, 2008, Zeb1 links epithelial–mesenchymal transition and cellular senescence, Development, 135, 579, 10.1242/dev.007047 Lee, 2010, Oncogenic KRas suppresses inflammation-associated senescence of pancreatic ductal cells, Cancer Cell, 18, 448, 10.1016/j.ccr.2010.10.020 Felsher, 2008, Oncogene addiction versus oncogene amnesia: perhaps more than just a bad habit?, Cancer Res, 68, 3081, 10.1158/0008-5472.CAN-07-5832 Wang, 2010, Critical role for transcriptional repressor Snail2 in transformation by oncogenic RAS in colorectal carcinoma cells, Oncogene, 29, 4658, 10.1038/onc.2010.218 Arima, 2008, Rb depletion results in deregulation of E-cadherin and induction of cellular phenotypic changes that are characteristic of the epithelial-to-mesenchymal transition, Cancer Res, 68, 5104, 10.1158/0008-5472.CAN-07-5680 Liu, 2009, Mouse fibroblasts lacking RB1 function form spheres and undergo reprogramming to a cancer stem cell phenotype, Cell Stem Cell, 4, 336, 10.1016/j.stem.2009.02.015 Liu, 2010, Tumor initiation via loss of cell contact inhibition versus Ras mutation: do all roads lead to EMT?, Cell Cycle, 9, 897, 10.4161/cc.9.5.10933 Wellner, 2009, The EMT-activator ZEB1 promotes tumorigenicity by repressing stemness-inhibiting microRNAs, Nat Cell Biol, 11, 1487, 10.1038/ncb1998 Chang, 2011, p53 regulates epithelial–mesenchymal transition and stem cell properties through modulating miRNAs, Nat Cell Biol, 13, 317, 10.1038/ncb2173 Elenbaas, 2001, Human breast cancer cells generated by oncogenic transformation of primary mammary epithelial cells, Genes Dev, 15, 50, 10.1101/gad.828901 Kogan-Sakin, 2011, Mutant p53(R175H) upregulates Twist1 expression and promotes epithelial–mesenchymal transition in immortalized prostate cells, Cell Death Differ, 18, 271, 10.1038/cdd.2010.94 Wang, 2009, p53 controls cancer cell invasion by inducing the MDM2-mediated degradation of Slug, Nat Cell Biol, 11, 694, 10.1038/ncb1875 Blick, 2010, Epithelial mesenchymal transition traits in human breast cancer cell lines parallel the CD44(hi/)CD24 (lo/-) stem cell phenotype in human breast cancer, J Mammary Gland Biol Neoplasia, 15, 235, 10.1007/s10911-010-9175-z Bearss, 2002, Differential effects of p21(WAF1/CIP1) deficiency on MMTV-ras and MMTV-myc mammary tumor properties, Cancer Res, 62, 2077 Liu, 2009, p21CIP1 attenuates Ras- and c-Myc-dependent breast tumor epithelial mesenchymal transition and cancer stem cell-like gene expression in vivo, Proc Natl Acad Sci USA, 106, 19035, 10.1073/pnas.0910009106 Libusova, 2010, N-cadherin can structurally substitute for E-cadherin during intestinal development but leads to polyp formation, Development, 137, 2297, 10.1242/dev.048488 Yang, 2010, Bmi1 is essential in Twist1-induced epithelial–mesenchymal transition, Nat Cell Biol, 12, 982, 10.1038/ncb2099 Onder, 2008, Loss of E-cadherin promotes metastasis via multiple downstream transcriptional pathways, Cancer Res, 68, 3645, 10.1158/0008-5472.CAN-07-2938 Derksen, 2011, Mammary-specific inactivation of E-cadherin and p53 impairs functional gland development and leads to pleomorphic invasive lobular carcinoma in mice, Dis Model Mech, 4, 347, 10.1242/dmm.006395 Kwok, 2007, Role of p14ARF in TWIST-mediated senescence in prostate epithelial cells, Carcinogenesis, 28, 2467, 10.1093/carcin/bgm185 Husemann, 2008, Systemic spread is an early step in breast cancer, Cancer Cell, 13, 58, 10.1016/j.ccr.2007.12.003 Kwok, 2005, Up-regulation of TWIST in prostate cancer and its implication as a therapeutic target, Cancer Res, 65, 5153, 10.1158/0008-5472.CAN-04-3785 Ohuchida, 2007, Twist, a novel oncogene, is upregulated in pancreatic cancer: clinical implication of Twist expression in pancreatic juice, Int J Cancer, 120, 1634, 10.1002/ijc.22295 Zhang, 2007, Significance of TWIST expression and its association with E-cadherin in bladder cancer, Hum Pathol, 38, 598, 10.1016/j.humpath.2006.10.004 Singh, 2009, A gene expression signature associated with “K-Ras addiction” reveals regulators of EMT and tumor cell survival, Cancer Cell, 15, 489, 10.1016/j.ccr.2009.03.022 Hong, 2009, Suppression of induced pluripotent stem cell generation by the p53-p21 pathway, Nature, 460, 1132, 10.1038/nature08235 Kawamura, 2009, Linking the p53 tumour suppressor pathway to somatic cell reprogramming, Nature, 460, 1140, 10.1038/nature08311 Li, 2009, The Ink4/Arf locus is a barrier for iPS cell reprogramming, Nature, 460, 1136, 10.1038/nature08290 Utikal, 2009, Immortalization eliminates a roadblock during cellular reprogramming into iPS cells, Nature, 460, 1145, 10.1038/nature08285 Schickel, 2010, miR-200c regulates induction of apoptosis through CD95 by targeting FAP-1, Mol Cell, 38, 908, 10.1016/j.molcel.2010.05.018 Brabletz, 2011, The ZEB1/miR-200 feedback loop controls Notch signalling in cancer cells, EMBO J, 30, 770, 10.1038/emboj.2010.349