Factor H inhibits complement activation induced by liposomal and micellar drugs and the therapeutic antibody rituximab in vitro

Nanomedicine: Nanotechnology, Biology and Medicine - Tập 12 - Trang 1023-1031 - 2016
Tamás Mészáros1,2, Ádám I. Csincsi3, Barbara Uzonyi4, Mario Hebecker5, Tamás G. Fülöp1,2, Anna Erdei4,6, János Szebeni1,2, Mihály Józsi3
1Nanomedicine Research and Education Center, Semmelweis University, Budapest, Hungary
2Seroscience Ltd, Budapest, Hungary
3MTA-ELTE “Lendület” Complement Research Group, Department of Immunology, Eötvös Loránd University, Budapest, Hungary
4MTA-ELTE Immunology Research Group, Department of Immunology, Eötvös Loránd University, Budapest, Hungary
5Junior Research Group for Cellular Immunobiology, Leibniz Institute for Natural Product Research and Infection Biology, Jena, Germany
6Department of Immunology, Eötvös Loránd University, Budapest, Hungary

Tài liệu tham khảo

Adkinson, 2002, Task force report: future research needs for the prevention and management of immune-mediated drug hypersensitivity reactions, J Allergy Clin Immunol, 109, S461, 10.1067/mai.2002.122214 Demoly, 1999, Predictive capacity of histamine release for the diagnosis of drug allergy, Allergy, 54, 500, 10.1034/j.1398-9995.1999.00020.x Szebeni, 2014, Complement activation-related pseudoallergy: a stress reaction in blood triggered by nanomedicines and biologicals, Mol Immunol, 61, 163, 10.1016/j.molimm.2014.06.038 Lasser, 1979, Complement and contrast material reactors, J Allergy Clin Immunol, 64, 105, 10.1016/0091-6749(79)90043-5 Lenz, 2007, Management and preparedness for infusion and hypersensitivity reactions, Oncologist, 12, 601, 10.1634/theoncologist.12-5-601 Cheifetz, 2005, Monoclonal antibodies, immunogenicity, and associated infusion reactions, Mt Sinai J Med, 72, 250 Szebeni, 2001, Complement activation-related pseudoallergy caused by liposomes, micellar carriers of intravenous drugs, and radiocontrast agents, Crit Rev Ther Drug Carrier Syst, 18, 567, 10.1615/CritRevTherDrugCarrierSyst.v18.i6.50 Ricklin, 2010, Complement: a key system for immune surveillance and homeostasis, Nat Immunol, 11, 785, 10.1038/ni.1923 Rodríguez de Córdoba, 2004, The human complement factor H: functional roles, genetic variations and disease associations, Mol Immunol, 41, 355, 10.1016/j.molimm.2004.02.005 Ferreira, 2010, Complement control protein factor H: the good, the bad, and the inadequate, Mol Immunol, 47, 2187, 10.1016/j.molimm.2010.05.007 Kopp, 2012, Factor H: a complement regulator in health and disease, and a mediator of cellular interactions, Biomolecules, 2, 46, 10.3390/biom2010046 Szebeni, 1998, Complement activation by Cremophor EL as a possible contributor to hypersensitivity to paclitaxel: an in vitro study, J Natl Cancer Inst, 90, 300, 10.1093/jnci/90.4.300 Szebeni, 2012, Liposome-induced complement activation and related cardiopulmonary distress in pigs: factors promoting reactogenicity of Doxil and Am Bisome, Nanomedicine, 8, 176, 10.1016/j.nano.2011.06.003 Castiblanco-Valencia, 2012, Leptospiral immunoglobulin-like proteins interact with human complement regulators factor H, FHL-1, FHR-1, and C4BP, J Infect Dis, 205, 995, 10.1093/infdis/jir875 Hebecker, 2013, An engineered construct combining complement regulatory and surface-recognition domains represents a minimal-size functional factor H, J Immunol, 191, 912, 10.4049/jimmunol.1300269 van den Hoven, 2013, Complement activation by PEGylated liposomes containing prednisolone, Eur J Pharm Sci, 49, 265, 10.1016/j.ejps.2013.03.007 Józsi, 2002, Complement receptor type 1 (CD35) mediates inhibitory signals in human B lymphocytes, J Immunol, 168, 2782, 10.4049/jimmunol.168.6.2782 Wu, 2009, Structure of complement fragment C3b-factor H and implications for host protection by complement regulators, Nat Immunol, 10, 728, 10.1038/ni.1755 Józsi, 2007, The C-terminus of complement factor H is essential for host cell protection, Mol Immunol, 44, 2697, 10.1016/j.molimm.2006.12.001 Kajander, 2011, Dual interaction of factor H with C3d and glycosaminoglycans in host–nonhost discrimination by complement, Proc Natl Acad Sci U S A, 108, 2897, 10.1073/pnas.1017087108 Morgan, 2011, Structural basis for engagement by complement factor H of C3b on a self surface, Nat Struct Mol Biol, 18, 463, 10.1038/nsmb.2018 Heinen, 2009, Factor H-related protein 1 (CFHR-1) inhibits complement C5 convertase activity and terminal complex formation, Blood, 114, 2439, 10.1182/blood-2009-02-205641 Timmann, 1991, Two major serum components antigenically related to complement factor H are different glycosylation forms of a single protein with no factor H-like complement regulatory functions, J Immunol, 146, 1265, 10.4049/jimmunol.146.4.1265 Szebeni, 1999, Hemodynamic changes induced by liposomes and liposome-encapsulated hemoglobin in pigs: a model for pseudoallergic cardiopulmonary reactions to liposomes. Role of complement and inhibition by soluble CR1 and anti-C5a antibody, Circulation, 99, 2302, 10.1161/01.CIR.99.17.2302 Smith, 2001, Membrane-targeted complement inhibitors, Mol Immunol, 38, 249, 10.1016/S0161-5890(01)00047-5 Smith, 2002, Targeting anticomplement agents, Biochem Soc Trans, 30, 1037, 10.1042/bst0301037 Ricklin, 2013, Complement in immune and inflammatory disorders: therapeutic interventions, J Immunol, 190, 3839, 10.4049/jimmunol.1203200 Kishore, 2012, Factor H as a regulator of the classical pathway activation, Immunobiology, 217, 162, 10.1016/j.imbio.2011.07.024 Kuznetsova, 2014, Differential binding of plasma proteins by liposomes loaded with lipophilic prodrugs of methotrexate and melphalan in the bilayer, Biochemistry (Mosc), 79, 797, 10.1134/S0006297914080070 Schmidt, 2013, Rational engineering of a minimized immune inhibitor with unique triple-targeting properties, J Immunol, 190, 5712, 10.4049/jimmunol.1203548 Nichols, 2015, An extended mini-complement factor H molecule ameliorates experimental C3 glomerulopathy, Kidney Int, 88, 1314, 10.1038/ki.2015.233 Strobel, 2011, Factor H-related protein 1 neutralizes anti-factor H autoantibodies in autoimmune hemolytic uremic syndrome, Kidney Int, 80, 397, 10.1038/ki.2011.152 Goicoechea de Jorge, 2013, Dimerization of complement factor H-related proteins modulates complement activation in vivo, Proc Natl Acad Sci U S A, 110, 4685, 10.1073/pnas.1219260110 Tortajada, 2013, C3 glomerulopathy-associated CFHR1 mutation alters FHR oligomerization and complement regulation, J Clin Invest, 123, 2434, 10.1172/JCI68280 Józsi, 2015, Factor H-related proteins determine complement-activating surfaces, Trends Immunol, 36, 374, 10.1016/j.it.2015.04.008 Baldo, 2013, Adverse events to monoclonal antibodies used for cancer therapy: focus on hypersensitivity responses, Oncoimmunology, 2, e26333, 10.4161/onci.26333 Kimby, 2005, Tolerability and safety of rituximab (MabThera), Cancer Treat Rev, 31, 456, 10.1016/j.ctrv.2005.05.007 Boross, 2012, Mechanisms of action of CD20 antibodies, Am J Cancer Res, 2, 676 Hörl, 2013, Reduction of complement factor H binding to CLL cells improves the induction of rituximab-mediated complement-dependent cytotoxicity, Leukemia, 27, 2200, 10.1038/leu.2013.169 Hakobyan, 2010, Variant-specific quantification of factor H in plasma identifies null alleles associated with atypical hemolytic uremic syndrome, Kidney Int, 78, 782, 10.1038/ki.2010.275 Harris, 2012, The complotype: dictating risk for inflammation and infection, Trends Immunol, 33, 513, 10.1016/j.it.2012.06.001 Kozma, 2015, Variable association of complement activation by rituximab and paclitaxel in cancer patients in vivo and in their screening serum in vitro with clinical manifestations of hypersensitivity: a pilot study, Eur J Nanomed, 7, 289, 10.1515/ejnm-2015-0026 Fülöp, 2015, The possible role of factor H in complement activation-related pseudoallergy (CARPA): a failed attempt to correlate blood levels of FH with liposome-induced hypersensitivity reactions in patients with autoimmune disease, Eur J Nanomed, 7, 7, 10.1515/ejnm-2015-0004