Fabrication, characterization, and implementation of engineered hydrogels for controlling breast cancer cell phenotype and dormancy

Gomis, 2017, Tumor cell dormancy, Mol. Oncol., 11, 62, 10.1016/j.molonc.2016.09.009 Aguirre-Ghiso, 2007, Models, mechanisms and clinical evidence for cancer dormancy, Nat. Rev. Cancer, 7, 834, 10.1038/nrc2256 Pradhan, 2018, Engineered in vitro models of tumor dormancy and reactivation, J. Biol. Eng., 12, 37, 10.1186/s13036-018-0120-9 Barkan, 2010, Extracellular matrix: a gatekeeper in the transition from dormancy to metastatic growth, Eur. J. Cancer, 46, 1181, 10.1016/j.ejca.2010.02.027 Grzelak, 2017, Metastasis “systems” biology: how are macro-environmental signals transmitted into microenvironmental cues for disseminated tumor cells?, Curr. Opin. Cell Biol., 48, 79, 10.1016/j.ceb.2017.06.002 Rao, 2019, Bioengineered models to study tumor dormancy, J. Biol. Eng., 13, 3, 10.1186/s13036-018-0137-0 Pradhan, 2019, Tunable hydrogels for controlling phenotypic cancer cell states to model breast cancer dormancy and reactivation, Biomaterials, 215, 10.1016/j.biomaterials.2019.04.022 Pradhan, 2019, Datasets describing hydrogel properties and cellular metrics for modeling of tumor dormancy, Data Brief, 25, 10.1016/j.dib.2019.104128 Culver, 2012, Three-dimensional biomimetic patterning in hydrogels to guide cellular organization, Adv. Mater., 24, 2344, 10.1002/adma.201200395 Heintz, 2016, Fabrication of 3D biomimetic microfluidic networks in hydrogels, Adv. Healthc. Mater., 5, 2153, 10.1002/adhm.201600351 Banda, 2019, Reference-free traction force microscopy platform fabricated via two-photon laser scanning lithography enables facile measurement of cell-generated forces, ACS Appl. Mater. Interfaces, 11, 18233, 10.1021/acsami.9b04362 Fairbanks, 2009, Photoinitiated polymerization of PEG-diacrylate with lithium phenyl-2,4,6-trimethylbenzoylphosphinate: polymerization rate and cytocompatibility, Biomaterials, 30, 6702, 10.1016/j.biomaterials.2009.08.055 Turturro, 2013, Effective tuning of ligand incorporation and mechanical properties in visible light photopolymerized poly(ethylene glycol) diacrylate hydrogels dictates cell adhesion and proliferation, Biomed. Mater., 8, 10.1088/1748-6041/8/2/025001 Pradhan, 2017, PEG-fibrinogen hydrogels for three-dimensional breast cancer cell culture, J. Biomed. Mater. Res. A, 105, 236, 10.1002/jbm.a.35899