Fabrication and characterization of hyaluronic acid microneedles to enhance delivery of magnesium ascorbyl phosphate into skin

S.M. Bal, A.C. Kruithof, R. Zwier, E. Dietz, J.A. Bouwstra, J. Lademann, M.C. Meinke, Influence of microneedle shape on the transport of a fluorescent dye into human skin in vivo. J. Control. Release 147, 218–224 (2010)

M. Campos, Histopathological, morphometric and stereological studies of ascorbic acid and magnesium ascorbyl phosphate in a skin care formulation. Int. J. Cosmet. Sci. 22, 169–179 (2000)

M. Chen, V. Gupta, A.C. Anselmo, J.A. Muraski, S. Mitragotri, Topical delivery of hyaluronic acid into skin using SPACE-peptide carriers. J. Control. Release 173, 67–74 (2014)

M. Dangol, S. Kim, C.G. Li, S.F. Lahiji, M. Jang, Y. Ma, I. Huh, H. Jung, Anti-obesity effect of a novel caffeine-loaded dissolving microneedle patch in high-fat diet-induced obese C57BL/6J mice. J. Control. Release265, 41–47 (2017)

P.C. DeMuth, A.V. Li, P. Abbink, J. Liu, H. Li, K.A. Stanley, K.M. Smith, C.L. Lavine, M.S. Seaman, J.A. Kramer, Vaccine delivery with microneedle skin patches in nonhuman primates. Nat. Biotechnol. 31, 1082 (2013)

R.F. Donnelly, R. Majithiya, T.R.R. Singh, D.I. Morrow, M.J. Garland, Y.K. Demir, K. Migalska, E. Ryan, D. Gillen, C.J. Scott, Design, optimization and characterisation of polymeric microneedle arrays prepared by a novel laser-based micromoulding technique. Pharm. Res. 28, 41–57 (2011)

R.F. Donnelly, D.I. Morrow, T.R. Singh, K. Migalska, P.A. McCarron, C. O'Mahony, A.D. Woolfson, Processing difficulties and instability of carbohydrate microneedle arrays. Drug Dev. Ind. Pharm. 35, 1242–1254 (2009)

R.F. Donnelly, T.R.R. Singh, M.J. Garland, K. Migalska, R. Majithiya, C.M. McCrudden, P.L. Kole, T.M.T. Mahmood, H.O. McCarthy, A.D. Woolfson, Hydrogel-forming microneedle arrays for enhanced transdermal drug delivery. Adv. Funct. Mater. 22, 4879–4890 (2012)

J.C. Geesin, J.S. Gordon, R.A. Berg, Regulation of collagen synthesis in human dermal fibroblasts by the sodium and magnesium salts of ascorbyl-2-phosphate. Skin Pharmacol. Physiol. 6, 65–71 (1993)

H.S. Gill, M.R. Prausnitz, Coating formulations for microneedles. Pharm. Res. 24, 1369–1380 (2007)

S.D. Gittard, A. Ovsianikov, B.N. Chichkov, A. Doraiswamy, R.J. Narayan, Two-photon polymerization of microneedles for transdermal drug delivery. Expert Opin. Drug Deliv. 7, 513–533 (2010)

M. Han, D.K. Kim, S.H. Kang, H.-R. Yoon, B.-Y. Kim, S.S. Lee, K.D. Kim, H.G. Lee, Improvement in antigen-delivery using fabrication of a grooves-embedded microneedle array. Sensors Actuators B Chem. 137, 274–280 (2009)

M. Haq, E. Smith, D.N. John, M. Kalavala, C. Edwards, A. Anstey, A. Morrissey, J.C. Birchall, Clinical administration of microneedles: skin puncture, pain and sensation. Biomed. Microdevices 11, 35–47 (2009)

S. Henry, D.V. McAllister, M.G. Allen, M.R. Prausnitz, Microfabricated microneedles: a novel approach to transdermal drug delivery. J. Pharm. Sci. 87, 922–925 (1998)

S. Hirobe, H. Azukizawa, T. Hanafusa, K. Matsuo, Y.S. Quan, F. Kamiyama, I. Katayama, N. Okada, S. Nakagawa, Clinical study and stability assessment of a novel transcutaneous influenza vaccination using a dissolving microneedle patch. Biomaterials 57, 50–58 (2015)

W.W.-Y. Kao, J.G. Flaks, D.J. Prockop, Primary and secondary effects of ascorbate on procollagen synthesis and protein synthesis by primary cultures of tendon fibroblasts. Arch. Biochem. Biophys. 173, 638–648 (1976)

Y.C. Kim, J.H. Park, M.R. Prausnitz, Microneedles for drug and vaccine delivery. Adv. Drug Deliv. Rev. 64, 1547–1568 (2012)

S. Lau, J. Fei, H. Liu, W. Chen, R. Liu, Multilayered pyramidal dissolving microneedle patches with flexible pedestals for improving effective drug delivery. J. Control. Release 265, 113–119 (2017)

J.W. Lee, J.H. Park, M.R. Prausnitz, Dissolving microneedles for transdermal drug delivery. Biomaterials 29, 2113–2124 (2008)

W.-R. Lee, S.-C. Shen, K.-H. Wang, C.-H. Hu, J.-Y. Fang, Lasers and microdermabrasion enhance and control topical delivery of vitamin C. J. Investig. Dermatol. 121, 1118–1125 (2003)

W. Li, R.N. Terry, J. Tang, M.R. Feng, S.P. Schwendeman, M.R. Prausnitz, Rapidly separable microneedle patch for the sustained release of a contraceptive. Nat. Biomed. Eng. 3, 220–229 (2019)

S. Liu, D. Wu, Y.S. Quan, F. Kamiyama, K. Kusamori, H. Katsumi, T. Sakane, A. Yamamoto, Improvement of transdermal delivery of Exendin-4 using novel tip-loaded microneedle arrays fabricated from hyaluronic acid. Mol. Pharm.13, 272–279 (2016)

P.M.B.G. Maia Campos, F.B. de Camargo Júnior, J.P. de Andrade, L.R. Gaspar, Efficacy of cosmetic formulations containing dispersion of liposome with magnesium ascorbyl phosphate, alpha-lipoic acid and kinetin. Photochem. Photobiol. 88, 748–752 (2012)

W. Martanto, S.P. Davis, N.R. Holiday, J. Wang, H.S. Gill, M.R. Prausnitz, Transdermal delivery of insulin using microneedles in vivo. Pharm. Res. 21, 947–952 (2004)

W. Martanto, J.S. Moore, T. Couse, M.R. Prausnitz, Mechanism of fluid infusion during microneedle insertion and retraction. J. Control. Release112, 357–361 (2006)

D.V. McAllister, P.M. Wang, S.P. Davis, J.H. Park, P.J. Canatella, M.G. Allen, M.R. Prausnitz, Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: fabrication methods and transport studies. Proc. Natl. Acad. Sci. U. S. A. 100, 13755–13760 (2003)

M.G. McGrath, S. Vucen, A. Vrdoljak, A. Kelly, C. O'Mahony, A.M. Crean, A. Moore, Production of dissolvable microneedles using an atomised spray process: effect of microneedle composition on skin penetration. Eur. J. Pharm. Biopharm. 86, 200–211 (2014)

H.X. Nguyen, A.K. Banga, Enhanced skin delivery of vismodegib by microneedle treatment. Drug Deliv. Transl. Res. 5, 407–423 (2015)

H.X. Nguyen, A.K. Banga, Delivery of methotrexate and characterization of skin treated by fabricated PLGA microneedles and fractional ablative laser. Pharm. Res. 35, 68 (2018)

H.X. Nguyen, B.D. Bozorg, Y. Kim, A. Wieber, G. Birk, D. Lubda, A.K. Banga, Poly (vinyl alcohol) microneedles: fabrication, characterization, and application for transdermal drug delivery of doxorubicin. Eur. J. Pharm. Biopharm. 129, 88–103 (2018)

J. Pan, W. Ruan, M. Qin, Y. Long, T. Wan, K. Yu, Y. Zhai, C. Wu, Y. Xu, Intradermal delivery of STAT3 siRNA to treat melanoma via dissolving microneedles. Sci. Rep. 8, 1117 (2018)

E. Papakonstantinou, M. Roth, G. Karakiulakis, Hyaluronic acid: a key molecule in skin aging. Dermato-endocrinology 4, 253–258 (2012)

J.H. Park, M.G. Allen, M.R. Prausnitz, Polymer microneedles for controlled-release drug delivery. Pharm. Res. 23, 1008–1019 (2006)

S.Y. Park, H.U. Lee, Y.C. Lee, G.H. Kim, E.C. Park, S.H. Han, J.G. Lee, S. Choi, N.S. Heo, D.L. Kim, Y.S. Huh, J. Lee, Wound healing potential of antibacterial microneedles loaded with green tea extracts. Materials science & engineering C. Mater. Biol. Appl. 42, 757–762 (2014)

Y. Park, J. Park, G.S. Chu, K.S. Kim, J.H. Sung, B. Kim, Transdermal delivery of cosmetic ingredients using dissolving polymer microneedle arrays. Biotechnol. Bioprocess Eng. 20, 543–549 (2015)

F. Pérennès, B. Marmiroli, M. Matteucci, M. Tormen, L. Vaccari, E.D. Fabrizio, Sharp beveled tip hollow microneedle arrays fabricated by LIGA and 3D soft lithography with polyvinyl alcohol. J. Micromech. Microeng.16, 473–479 (2006)

F. Sammoura, J. Kang, Y.-M. Heo, T. Jung, L. Lin, Polymeric microneedle fabrication using a microinjection molding technique. Microsyst. Technol. 13, 517–522 (2007)

H.P. Tham, K. Xu, W.Q. Lim, H. Chen, M. Zheng, T.G.S. Thng, S.S. Venkatraman, C. Xu, Y. Zhao, Microneedle-assisted topical delivery of photodynamically active mesoporous formulation for combination therapy of deep-seated melanoma. ACS Nano 12, 11936–11948 (2018)

K. van der Maaden, W. Jiskoot, J. Bouwstra, Microneedle technologies for (trans)dermal drug and vaccine delivery. J. Control. Release161, 645–655 (2012)

M. Yang, J.D. Zahn, Microneedle insertion force reduction using vibratory actuation. Biomed. Microdevices 6, 177–182 (2004)

C. Zhang, K. Zhang, J. Zhang, H. Ou, J. Duan, S. Zhang, D. Wang, S. Mitragotri, M. Chen, Skin delivery of hyaluronic acid by the combined use of sponge spicules and flexible liposomes. Biomater. Sci. 7, 1299–1310 (2019)

Z. Zhu, H. Luo, W. Lu, H. Luan, Y. Wu, J. Luo, Y. Wang, J. Pi, C.Y. Lim, H. Wang, Rapidly dissolvable microneedle patches for transdermal delivery of exenatide. Pharm. Res. 31, 3348–3360 (2014)