FOXP3: Controlador maestro de la generación y función de las células reguladoras naturales

Ochs, 2005, FOXP3 acts as a rheostat of the immune response, Immunol Rev, 203, 156, 10.1111/j.0105-2896.2005.00231.x Hori, 2004, Foxp3: a critical regulator of the development and function of regulatory T cells, Microb Infect, 6, 745, 10.1016/j.micinf.2004.02.020 Coffer, 2004, Forkhead-box transcription factors and their role in the immune system, Nat Rev Immunol, 4, 889, 10.1038/nri1488 Bettelli, 2005, Foxp3 interacts with nuclear factor of activated T cells and NF-κB to repress cytokine gene expression and effector functions of T helper cells, Proc Natl Acad Sci USA, 102, 5138, 10.1073/pnas.0501675102 Fontenot, 2005, A well adapted regulatory contrivance: regulatory T cell development and the forkhead family transcription factor Foxp3, Nat Immunol, 6, 331, 10.1038/ni1179 Hori, 2003, Control of regulatory T cell development by the transcription factor Foxp3, Science, 299, 1057, 10.1126/science.1079490 Yagi, 2004, Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells, Int Immunol, 16, 1643, 10.1093/intimm/dxh165 Russell, 1959, Exceptional inheritance of a sex-linked gene in the mouse explained on the basis that the X/O sex-chromosome constitution is female, Proc Natl Acad Sci USA, 45, 554, 10.1073/pnas.45.4.554 Ramsdell, 2003, Foxp3 and natural regulatory T cells: key to a cell lineage?, Immunity, 19, 165, 10.1016/S1074-7613(03)00207-3 Godfrey, 1991, X-linked lymphoreticular disease in the scurfy (sf) mutant mouse, Am J Pathol, 138, 1379 Sakaguchi, 2004, Naturally arising CD4+ regulatory T cells for immunologic self-tolerance and negative control of immune responses, Annu Rev Immunol, 22, 531, 10.1146/annurev.immunol.21.120601.141122 Bennett, 2001, The immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome (IPEX) is caused by mutations of FOXP3, Nat Genet, 27, 20, 10.1038/83713 Allan, 2005, The role of 2 FOXP3 isoforms in the generation of human CD4+ Tregs, J Clin Invest, 115, 3276, 10.1172/JCI24685 Wildin, 2002, Clinical and molecular features of the immunodysregulation, polyendocrinopathy, enteropathy, X linked (IPEX) syndrome, J Med Gen, 39, 537, 10.1136/jmg.39.8.537 Walker, 2003, Induction of FoxP3 and acquisition of T regulatory activity by stimulated human CD4+CD25− T cells, J Clin Invest, 112, 1437, 10.1172/JCI19441 Park, 2005, Analysis of the Foxp3/scurfin gene in Crohn's disease, Ann N Y Acad Sci, 1051, 218, 10.1196/annals.1361.125 Huan, 2005, Decreased FOXP3 levels in multiple sclerosis patients, J Neurosci Res, 81, 45, 10.1002/jnr.20522 Brunkow, 2001, Disruption of a new forkhead/winged-helix protein, scurfin, results in the fatal lymphoproliferative disorder of the scurfy mouse, Nat Genetics, 27, 68, 10.1038/83784 Albert, 2005, Antigen-dependent suppression of alloresponses by Foxp3-induced regulatory T cells in transplantation, Eur J Immunol, 35, 2598, 10.1002/eji.200526077 Fehervari, 2004, CD4+ Tregs and immune control, J Clin Invest, 114, 1209, 10.1172/JCI200423395 Chang, 2005, The Scurfy mutation of FoxP3 in the thymus stroma leads to defective thymopoiesis, J Exp Med, 202, 1141, 10.1084/jem.20050157 Huehn, 2009, Epigenetic control of FOXP3 expression: the key to a stable regulatory T-cell lineage?, Nat Rev Immunol, 9, 83, 10.1038/nri2474 Rudensky, 2006, FOXP3 and NFAT: partners in tolerance, Cell, 126, 253, 10.1016/j.cell.2006.07.005 Wu, 2006, FOXP3 controls regulatory T cell function through cooperation with NFAT, Cell, 126, 375, 10.1016/j.cell.2006.05.042 Chen, 2003, Conversion of peripheral CD4+CD25− naive T cells to CD4+CD25+ regulatory T cells by TGF-β induction of transcription factor Foxp3, J Exp Med, 198, 1875, 10.1084/jem.20030152 Fantini, 2004, Cutting edge: TGF-β induces a regulatory phenotype in CD4+CD25− T cells through Foxp3 induction and down-regulation of Smad7, J Immunol, 172, 5149, 10.4049/jimmunol.172.9.5149 Csencsits, 2005, Transforming growth factor-β1 gene transfer is associated with the development of regulatory cells, Am J Transplant, 5, 2378, 10.1111/j.1600-6143.2005.01042.x Fontenot, 2005, A function for interleukin 2 in Foxp3-expressing regulatory T cells, Nat Immunol, 6, 1142, 10.1038/ni1263 Polanczyk, 2005, Enhanced FoxP3 expression and Treg cell function in pregnant and estrogen-treated mice, J Neuroimmunol, 170, 85, 10.1016/j.jneuroim.2005.08.023 Baratelli, 2005, Prostaglandin E2 induces FOXP3 gene expression and T regulatory cell function in human CD4+ T cells, J Immunol, 175, 1483, 10.4049/jimmunol.175.3.1483 Sharma, 2005, Tumor cyclooxygenase-2/prostaglandin E2-dependent promotion of FOXP3 expression and CD4+ CD25+ T regulatory cell activities in lung cancer, Cancer Res, 65, 5211, 10.1158/0008-5472.CAN-05-0141 Fontenot, 2005, Developmental regulation of Foxp3 expression during ontogeny, J Exp Med, 202, 901, 10.1084/jem.20050784 Watanabe, 2005, Hassall's corpuscles instruct dendritic cells to induce CD4+CD25+ regulatory T cells in human thymus, Nature, 436, 1181, 10.1038/nature03886 Fontenot, 2005, Regulatory T cell lineage specification by the forkhead transcription factor foxp3, Immunity, 22, 329, 10.1016/j.immuni.2005.01.016 Salomon, 2000, B7/CD28 costimulation is essential for the homeostasis of the CD4+CD25+ immunoregulatory T cells that control autoimmune diabetes, Immunity, 12, 431, 10.1016/S1074-7613(00)80195-8 Tai, 2005, CD28 costimulation of developing thymocytes induces Foxp3 expression and regulatory T cell differentiation independently of interleukin 2, Nat Immunol, 6, 152, 10.1038/ni1160 Baan, 2005, Differential effect of calcineurin inhibitors, anti-CD25 antibodies and rapamycin on the induction of FOXP3 in human T cells, Transplantation, 80, 110, 10.1097/01.TP.0000164142.98167.4B Graca, 2005, New tools to identify regulatory T cells, Eur J Immunol, 35, 1678, 10.1002/eji.200526303 Wan, 2005, Identifying Foxp3-expressing suppressor T cells with a bicistronic reporter, Proc Natl Acad Sci USA, 102, 5126, 10.1073/pnas.0501701102