FKBP51 and FKBP52 in signaling and disease

Trends in Endocrinology & Metabolism - Tập 22 Số 12 - Trang 481-490 - 2011
Cheryl L. Storer1, Chad A. Dickey, Mario D. Galigniana, Theo Rein, Marc B. Cox
1The Border Biomedical Research Center and Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968, USA.

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Sanchez, 1990, Hsp56: a novel heat shock protein associated with untransformed steroid receptor complexes, J. Biol. Chem., 265, 22067, 10.1016/S0021-9258(18)45667-0

Smith, 1990, Purification of unactivated progesterone receptor and identification of novel receptor-associated proteins, J. Biol. Chem., 265, 3996, 10.1016/S0021-9258(19)39693-0

Pirkl, 2001, Functional analysis of the Hsp90-associated human peptidyl prolyl cis/trans isomerases FKBP51, FKBP52 and Cyp40, J. Mol. Biol., 308, 795, 10.1006/jmbi.2001.4595

Cheung-Flynn, 2007, FKBP co-chaperones in steroid receptor complexes, 281

Riggs, 2003, The Hsp90-binding peptidylprolyl isomerase FKBP52 potentiates glucocorticoid signaling in vivo, EMBO J., 22, 1158, 10.1093/emboj/cdg108

Tranguch, 2005, Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation, Proc. Natl. Acad. Sci. U.S.A., 102, 14326, 10.1073/pnas.0505775102

Cheung-Flynn, 2005, Physiological role for the cochaperone FKBP52 in androgen receptor signaling, Mol. Endocrinol., 19, 1654, 10.1210/me.2005-0071

Cox, 2006, Functions of the Hsp90-binding FKBP immunophilins, 13

Riggs, 2007, Noncatalytic role of the FKBP52 peptidyl-prolyl isomerase domain in the regulation of steroid hormone signaling, Mol. Cell Biol., 27, 8658, 10.1128/MCB.00985-07

Sinars, 2003, Structure of the large FK506-binding protein FKBP51, an Hsp90-binding protein and a component of steroid receptor complexes, Proc. Natl. Acad. Sci. U.S.A., 100, 868, 10.1073/pnas.0231020100

Miyata, 1997, Phosphorylation of the immunosuppressant FK506-binding protein FKBP52 by casein kinase II: regulation of HSP90-binding activity of FKBP52, Proc. Natl. Acad. Sci. U.S.A., 94, 14500, 10.1073/pnas.94.26.14500

Cox, 2007, FK506-binding protein 52 phosphorylation: a potential mechanism for regulating steroid hormone receptor activity, Mol. Endocrinol., 21, 2956, 10.1210/me.2006-0547

Barent, 1998, Analysis of FKBP51/FKBP52 chimeras and mutants for Hsp90 binding and association with progesterone receptor complexes, Mol. Endocrinol., 12, 342, 10.1210/me.12.3.342

Silverstein, 1999, Different regions of the immunophilin FKBP52 determine its association with the glucocorticoid receptor, hsp90, and cytoplasmic dynein, J. Biol. Chem., 274, 36980, 10.1074/jbc.274.52.36980

Banerjee, 2008, Control of glucocorticoid and progesterone receptor subcellular localization by the ligand-binding domain is mediated by distinct interactions with tetratricopeptide repeat proteins, Biochemistry, 47, 10471, 10.1021/bi8011862

Witchel, 2006, Mechanisms of disease: regulation of glucocorticoid and receptor levels – impact on the metabolic syndrome, Nat. Clin. Pract. Endocrinol. Metab., 2, 621, 10.1038/ncpendmet0323

Galigniana, 2010, Role of molecular chaperones and TPR-domain proteins in the cytoplasmic transport of steroid receptors and their passage through the nuclear pore, Nucleus, 1, 299, 10.4161/nucl.1.4.11743

Galigniana, 2001, Evidence that the peptidylprolyl isomerase domain of the hsp90-binding immunophilin FKBP52 is involved in both dynein interaction and glucocorticoid receptor movement to the nucleus, J. Biol. Chem., 276, 14884, 10.1074/jbc.M010809200

Davies, 2002, A new first step in activation of steroid receptors: hormone-induced switching of FKBP51 and FKBP52 immunophilins, J. Biol. Chem., 277, 4597, 10.1074/jbc.C100531200

Wochnik, 2005, FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells, J. Biol. Chem., 280, 4609, 10.1074/jbc.M407498200

Piwien Pilipuk, 2007, Evidence for NL1-independent nuclear translocation of the mineralocorticoid receptor, Biochemistry, 46, 1389, 10.1021/bi0621819

Gallo, 2007, Differential recruitment of tetratricorpeptide repeat domain immunophilins to the mineralocorticoid receptor influences both heat-shock protein 90-dependent retrotransport and hormone-dependent transcriptional activity, Biochemistry, 46, 14044, 10.1021/bi701372c

Galigniana, 2010, The hsp90–FKBP52 complex links the mineralocorticoid receptor to motor proteins and persists bound to the receptor in early nuclear events, Mol. Cell Biol., 30, 1285, 10.1128/MCB.01190-09

Harrell, 2004, Evidence for glucocorticoid receptor transport on microtubules by dynein, J. Biol. Chem., 279, 54647, 10.1074/jbc.M406863200

Galigniana, 2002, Binding of hsp90-associated immunophilins to cytoplasmic dynein: direct binding and in vivo evidence that the peptidylprolyl isomerase domain is a dynein interaction domain, Biochemistry, 41, 13602, 10.1021/bi020399z

Galigniana, 2004, Retrograde transport of the glucocorticoid receptor in neurites requires dynamic assembly of complexes with the protein chaperone hsp90 and is linked to the CHIP component of the machinery for proteasomal degradation, Brain Res. Mol. Brain Res., 123, 27, 10.1016/j.molbrainres.2003.12.015

Galigniana, 2004, Hsp90-binding immunophilins link p53 to dynein during p53 transport to the nucleus, J. Biol. Chem., 279, 22483, 10.1074/jbc.M402223200

Pratt, 1987, Transformation of glucocorticoid and progesterone receptors to the DNA-binding state, J. Cell. Biochem., 35, 51, 10.1002/jcb.240350105

Schaaf, 2003, Molecular determinants of glucocorticoid receptor mobility in living cells: the importance of ligand affinity, Mol. Cell. Biol., 23, 1922, 10.1128/MCB.23.6.1922-1934.2003

Echeverria, 2009, Nuclear import of the glucocorticoid receptor-hsp90 complex through the nuclear pore complex is mediated by its interaction with Nup62 and importin beta, Mol. Cell. Biol., 29, 4788, 10.1128/MCB.00649-09

Yong, 2007, Essential role for co-chaperone Fkbp52 but not Fkbp51 in androgen receptor-mediated signaling and physiology, J. Biol. Chem., 282, 5026, 10.1074/jbc.M609360200

Hong, 2007, Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity, Reproduction, 133, 395, 10.1530/REP-06-0180

Tranguch, 2007, FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific, J. Clin. Invest., 117, 1824, 10.1172/JCI31622

Yang, 2006, FK506-binding protein 52 is essential to uterine reproductive physiology controlled by the progesterone receptor A isoform, Mol. Endocrinol., 20, 2682, 10.1210/me.2006-0024

Hirota, 2010, Uterine FK506-binding protein 52 (FKBP52)–peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress, Proc. Natl. Acad. Sci. U.S.A., 107, 15577, 10.1073/pnas.1009324107

Hirota, 2008, Deficiency of immunophilin FKBP52 promotes endometriosis, Am. J. Pathol., 173, 1747, 10.2353/ajpath.2008.080527

Chambraud, 2010, A role for FKBP52 in Tau protein function, Proc. Natl. Acad. Sci. U.S.A., 107, 2658, 10.1073/pnas.0914957107

Jinwal, 2010, The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules, J. Neurosci., 30, 591, 10.1523/JNEUROSCI.4815-09.2010

Stechschulte, 2011, FKBP51 – a selective modulator of glucocorticoid and androgen sensitivity, Curr. Opin. Pharmacol., 11, 332, 10.1016/j.coph.2011.04.012

O’Malley, 2009, The expression of androgen-responsive genes is up-regulated in the epithelia of benign prostatic hyperplasia, Prostate, 69, 1716, 10.1002/pros.21034

Periyasamy, 2007, The immunophilin ligands cyclosporin A and FK506 suppress prostate cancer cell growth by androgen receptor-dependent and -independent mechanisms, Endocrinology, 148, 4716, 10.1210/en.2007-0145

Ni, 2010, FKBP51 promotes assembly of the Hsp90 chaperone complex and regulates androgen receptor signaling in prostate cancer cells, Mol. Cell. Biol., 30, 1243, 10.1128/MCB.01891-08

Periyasamy, 2010, FKBP51 and Cyp40 are positive regulators of androgen-dependent prostate cancer cell growth and the targets of FK506 and cyclosporin A, Oncogene, 29, 1691, 10.1038/onc.2009.458

Schålke, 2010, Differential impact of tetratricopeptide repeat proteins on the steroid hormone receptors, PLoS ONE, 5, e11717, 10.1371/journal.pone.0011717

Mukaide, 2008, FKBP51 expressed by both normal epithelial cells and adenocarcinoma of colon suppresses proliferation of colorectal adenocarcinoma, Cancer Invest., 26, 385, 10.1080/07357900701799228

Rees-Unwin, 2007, Proteomic evaluation of pathways associated with dexamethasone-mediated apoptosis and resistance in multiple myeloma, Br. J. Haematol., 139, 559, 10.1111/j.1365-2141.2007.06837.x

Avellino, 2005, Rapamycin stimulates apoptosis of childhood acute lymphoblastic leukemia cells, Blood, 106, 1400, 10.1182/blood-2005-03-0929

Romano, 2010, FK506 binding proteins as targets in anticancer therapy, Anticancer Agents Med. Chem., 10, 651, 10.2174/187152010794479816

Pei, 2009, FKBP51 affects cancer cell response to chemotherapy by negatively regulating Akt, Cancer Cell, 16, 259, 10.1016/j.ccr.2009.07.016

Warrier, 2010, Susceptibility to diet-induced hepatic steatosis and glucocorticoid resistance in FK506-binding protein 52-deficient mice, Endocrinology, 151, 3225, 10.1210/en.2009-1158

Lin, 2007, Identification of candidate prostate cancer biomarkers in prostate needle biopsy specimens using proteomic analysis, Int. J. Cancer, 121, 2596, 10.1002/ijc.23016

De Leon, 2011, Targeting the regulation of androgen receptor signaling by the heat shock protein 90 cochaperone FKBP52 in prostate cancer cells, Proc. Natl. Acad. Sci. U.S.A., 108, 11878, 10.1073/pnas.1105160108

Sivils, 2011, Regulation of steroid hormone receptor function by the 52-kDa FK506-binding protein (FKBP52), Curr. Opin. Pharmacol., 11, 314, 10.1016/j.coph.2011.03.010

De Kloet, 2005, Stress and the brain: from adaptation to disease, Nat. Rev. Neurosci., 6, 463, 10.1038/nrn1683

Holsboer, 2000, The corticosteroid receptor hypothesis of depression, Neuropsychopharmacology, 23, 477, 10.1016/S0893-133X(00)00159-7

Binder, 2004, Polymorphisms in FKBP5 are associated with increased recurrence of depressive episodes and rapid response to antidepressant treatment, Nat. Genet., 36, 1319, 10.1038/ng1479

Kirchheiner, 2008, Genetic variants in FKBP5 affecting response to antidepressant drug treatment, Pharmacogenomics, 9, 841, 10.2217/14622416.9.7.841

Laje, 2009, Pharmacogenetics studies in STAR*D: strengths, limitations, and results, Psychiatr. Serv., 60, 1446, 10.1176/appi.ps.60.11.1446

Lekman, 2008, The FKBP5 gene in depression and treatment response – an association study in the Sequenced Treatment Alternatives to Relieve Depression (STAR*D) cohort, Biol. Psychiatry, 63, 1103, 10.1016/j.biopsych.2007.10.026

Zou, 2010, Meta-analysis of FKBP5 gene polymorphisms association with treatment response in patients with mood disorders, Neurosci. Lett., 484, 56, 10.1016/j.neulet.2010.08.019

Velders, 2011, Genetics of cortisol secretion and depressive symptoms: a candidate gene and genome wide association approach, Psychoneuroendocrinology, 36, 1053, 10.1016/j.psyneuen.2011.01.003

Willour, 2008, Family-based association of FKBP5 in bipolar disorder, Mol. Psychiatry, 14, 261, 10.1038/sj.mp.4002141

Lavebratt, 2010, Variations in FKBP5 and BDNF genes are suggestively associated with depression in a Swedish population-based cohort, J. Affect. Disord., 125, 249, 10.1016/j.jad.2010.02.113

Brent, 2010, Association of FKBP5 polymorphisms with suicidal events in the Treatment of Resistant Depression in Adolescents (TORDIA) study, Am. J. Psychiatry, 167, 190, 10.1176/appi.ajp.2009.09040576

Roy, 2010, Interaction of FKBP5, a stress-related gene, with childhood trauma increases the risk for attempting suicide, Neuropsychopharmacology, 35, 1674, 10.1038/npp.2009.236

Supriyanto, 2011, Association of FKBP5 gene haplotypes with completed suicide in the Japanese population, Prog. Neuropsychopharmacol. Biol. Psychiatry, 35, 252, 10.1016/j.pnpbp.2010.11.019

Shibuya, 2010, Association study between a functional polymorphism of FK506-binding protein 51 (FKBP5) gene and personality traits in healthy subjects, Neurosci. Lett., 485, 194, 10.1016/j.neulet.2010.09.010

Ising, 2008, Polymorphisms in the FKBP5 gene region modulate recovery from psychosocial stress in healthy controls, Eur. J. Neurosci., 28, 389, 10.1111/j.1460-9568.2008.06332.x

Koenen, 2005, Polymorphisms in FKBP5 are associated with peritraumatic dissociation in medically injured children, Mol .Psychiatry, 10, 1058, 10.1038/sj.mp.4001727

Ozer, 2003, Predictors of posttraumatic stress disorder and symptoms in adults: a meta-analysis, Psychol. Bull., 129, 52, 10.1037/0033-2909.129.1.52

Yehuda, 2009, Gene expression patterns associated with posttraumatic stress disorder following exposure to the World Trade Center attacks, Biol. Psychiatry, 66, 708, 10.1016/j.biopsych.2009.02.034

Binder, 2008, Association of FKBP5 polymorphisms and childhood abuse with risk of posttraumatic stress disorder symptoms in adults, J. Am. Med. Assoc., 299, 1291, 10.1001/jama.299.11.1291

Koenen, 2010, FKBP5 polymorphisms modify the effects of childhood trauma, Neuropsychopharmacology, 35, 1623, 10.1038/npp.2010.60

Xie, 2010, Interaction of FKBP5 with childhood adversity on risk for post-traumatic stress disorder, Neuropsychopharmacology, 35, 1684, 10.1038/npp.2010.37

Zimmermann, P., et al. Interaction of variants in the FKBP5 gene and adverse life events in predicting the first depression onset: results from a ten-year prospective community study. Am. J. Psychiatry, in press

Lee, 2010, Chronic corticosterone exposure increases expression and decreases deoxyribonucleic acid methylation of Fkbp5 in mice, Endocrinology, 151, 4332, 10.1210/en.2010-0225

Matsushita, 2010, Enhanced expression of mRNA for FK506-binding protein 5 in bone marrow CD34 positive cells in patients with rheumatoid arthritis, Clin. Exp. Rheumatol., 28, 87

Jiang, 2008, FK506 binding protein mediates glioma cell growth and sensitivity to rapamycin treatment by regulating NF-kappaB signaling pathway, Neoplasia, 10, 235, 10.1593/neo.07929

Park, 2007, Glucocorticoids modulate NF-kappaB-dependent gene expression by up-regulating FKBP51 expression in Newcastle disease virus-infected chickens, Mol. Cell Endocrinol., 278, 7, 10.1016/j.mce.2007.08.002

Baker, 2011, NF-kappaB, inflammation, and metabolic disease, Cell Metab., 13, 11, 10.1016/j.cmet.2010.12.008

Hayden, 2011, NF-kappaB in immunobiology, Cell Res., 21, 223, 10.1038/cr.2011.13

Nakamura, 2006, Isolation and expression profiling of genes upregulated in bone marrow-derived mononuclear cells of rheumatoid arthritis patients, DNA Res., 13, 169, 10.1093/dnares/dsl006

Holownia, 2009, Increased FKBP51 in induced sputum cells of chronic obstructive pulmonary disease patients after therapy, Eur. J. Med. Res., 14, 108, 10.1186/2047-783X-14-S4-108

Imai, 2007, Inhibition of endogenous MHC class II-restricted antigen presentation by tacrolimus (FK506) via FKBP51, Eur. J. Immunol., 37, 1730, 10.1002/eji.200636392

Baughman, 1995, FKBP51, a novel T-cell-specific immunophilin capable of calcineurin inhibition, Mol. Cell. Biol., 15, 4395, 10.1128/MCB.15.8.4395

Weiwad, 2006, Comparative analysis of calcineurin inhibition by complexes of immunosuppressive drugs with human FK506 binding proteins, Biochemistry, 45, 15776, 10.1021/bi061616p

Li, 2002, Calcium- and FK506-independent interaction between the immunophilin FKBP51 and calcineurin 1692, J. Cell. Biochem., 84, 460, 10.1002/jcb.10026

Smith, 1990, Reconstitution of progesterone receptor with heat shock proteins, Mol. Endocrinol., 4, 1704, 10.1210/mend-4-11-1704

Smith, 1993, Dynamics of heat shock protein 90–progesterone receptor binding and the disactivation loop model for steroid receptor complexes, Mol. Endocrinol., 7, 1418, 10.1210/me.7.11.1418

Li, 2011, Mixed Hsp90–cochaperone complexes are important for the progression of the reaction cycle, Nat. Struct. Mol. Biol., 18, 61, 10.1038/nsmb.1965

Hildenbrand, 2011, Hsp90 can accommodate the simultaneous binding of the FKBP52 and HOP proteins, Oncotarget, 2, 45, 10.18632/oncotarget.225

Dickey, 2007, The high-affinity HSP90–CHIP complex recognizes and selectively degrades phosphorylated tau client proteins, J. Clin. Invest., 117, 648, 10.1172/JCI29715

Waza, 2005, 17-AAG, an Hsp90 inhibitor, ameliorates polyglutamine-mediated motor neuron degeneration, Nat. Med., 11, 1088, 10.1038/nm1298

Sittler, 2001, Geldanamycin activates a heat shock response and inhibits huntingtin aggregation in a cell culture model of Huntington's disease, Hum. Mol. Genet., 10, 1307, 10.1093/hmg/10.12.1307

Auluck, 2002, Chaperone suppression of alpha-synuclein toxicity in a Drosophila model for Parkinson's disease, Science, 295, 865, 10.1126/science.1067389

Kraemer, 2006, Molecular pathways that influence human tau-induced pathology in Caenorhabditis elegans, Hum. Mol. Genet., 15, 1483, 10.1093/hmg/ddl067

Chambraud, 2007, The immunophilin FKBP52 specifically binds to tubulin and prevents microtubule formation, FASEB J., 21, 2787, 10.1096/fj.06-7667com

Elbi, 2004, A novel in situ assay for the identification and characterization of soluble nuclear mobility factors, Sci. STKE, 2004, pl10, 10.1126/stke.2382004pl10

Galas, 2006, The peptidylprolyl cis/trans-isomerase Pin1 modulates stress-induced dephosphorylation of Tau in neurons. Implication in a pathological mechanism related to Alzheimer disease, J. Biol. Chem., 281, 19296, 10.1074/jbc.M601849200