FEVER IN THE NEUTROPENIC HOST

American Society of Clinical Oncology, 1994, American Society of Clinical Oncology recommendations for the use of hematopoietic colony-stimulating factors: Evidence-based clinical practice guidelines, J Clin Oncol, 12, 2471, 10.1200/JCO.1994.12.11.2471 Anaissie, 1996, Randomized comparison between antibiotics alone and antibiotics plus granulocyte-macrophage colony-stimulating factor (Escherichia coli –derived) in cancer patients with fever and neutropenia, Am J Med, 100, 17, 10.1016/S0002-9343(96)90006-6 Archimbaud, 1991, Perfloxacin and vancomycin vs gentamicin, colistin sulphate, and vancomycin for prevention of infections in granulocytopenic patients: A randomized double-blind study, Eur J Cancer, 27, 174, 10.1016/0277-5379(91)90481-R Barloon, 1991, High-resolution ultrafast chest CT in the clinical management of febrile bone marrow transplant patients with normal or nonspecific chest roentgenograms, Chest, 99, 928, 10.1378/chest.99.4.928 Bensinger, 1993, The effects of daily recombinant human granulocyte colony-stimulating factor administration on normal granulocyte donors undergoing leukapheresis, Blood, 81, 1883, 10.1182/blood.V81.7.1883.1883 Berenguer, 1995, Pathogenesis of pulmonary aspergillosis: Granulocytopenia versus cyclosporine and methylprednisolonone-induced immunosuppression, Am J Respir Crit Care Med, 152, 1079, 10.1164/ajrccm.152.3.7663787 Bingold, 1979, Necrotizing enterocolitis associated with invasion by Clostridium septicum complicating cyclic neutropenia, Aust NZ J Med, 9, 426, 10.1111/j.1445-5994.1979.tb04173.x Bochud, 1994, Bacteremia due to viridans streptococcus in neutropenic patients with cancer: Clinical spectrum and risk factors, Clin Infect Dis, 18, 25, 10.1093/clinids/18.1.25 Bodey, 1966, Quantitative relationships between circulating leukocytes and infections in patients with acute leukemia, Ann Intern Med, 64, 328, 10.7326/0003-4819-64-2-328 Boogaerts, 1995, Granulocyte growth factors: Achieving a consensus, Ann Oncol, 6, 237, 10.1093/oxfordjournals.annonc.a059152 Bow, 1988, Comparison of norfloxacin with clotrimazole for infection prophylaxis in acute leukemia, Am J Med, 84, 847, 10.1016/0002-9343(88)90062-9 Buchanan, 1993, Approach to the treatment of the febrile cancer patient with low-risk neutropenia, Hematol Oncol Clin North Am, 7, 919, 10.1016/S0889-8588(18)30212-0 Centers for Disease Control and Prevention, 1993, Recommendations for preventing the spread of vancomycin resistance, MMWR Morb Mortal Wkly Rep, 44, 1 Chanock, 1993, Evolving risk factors for infectious complications of cancer therapy, Hematol Oncol Clin North Am, 7, 771, 10.1016/S0889-8588(18)30221-1 Chanock, 1996, Granulocyte transfusions: Time for a second look, Infect Dis Clin North Am, 10, 327, 10.1016/S0891-5520(05)70301-9 Chen, 1994, Identification of a granulocytotropic Ehrlichia species as the etiologic agent of human disease, J Clin Microbiol, 32, 589, 10.1128/JCM.32.3.589-595.1994 Chow, 1991, Enterobacter bacteremia: Clinical features and emergence of antibiotic resistance during therapy, Ann Intern Med, 115, 585, 10.7326/0003-4819-115-8-585 Christensen, 1980, Exhaustion of mature marrow neutrophils in neonates with sepsis, J Pediatr, 96, 316, 10.1016/S0022-3476(80)80837-7 Christensen, 1980, Neutropenia and bone marrow exhaustion in human and experimental neonatal sepsis, Pediatr Res, 14, 806, 10.1203/00006450-198006000-00006 Cockerill, 1985, Open-lung biopsy in immunocompromised patients, Arch Intern Med, 145, 1398, 10.1001/archinte.145.8.1398 Collata, 1992, Modulation of granulocyte survival and programmed cell death by cytokines and bacterial products, Blood, 80, 2012, 10.1182/blood.V80.8.2012.2012 Cotton D, Marshall D, Gress J, et al: Pathogen-specific vs broad-spectrum antibiotics for granulocytopenic cancer patients with proven infection. In Program and Abstracts of the 24th Interscience Conference on Antimicrobial Agents and Chemotherapy, Washington, DC, 1984, [abstract 158]. Crawford, 1991, Reduction by granulocyte colony-stimulating factor of fever and neutropenia induced by chemotherapy in patients with small-cell lung cancer, N Engl J Med, 325, 164, 10.1056/NEJM199107183250305 Dale, 1979, Chronic neutropenia, Medicine, 58, 128, 10.1097/00005792-197903000-00002 De Pauw, 1994, Ceftazidime compared with piperacillin and tobramycin for the empiric treatment of fever in neutropenic patients with cancer, Am J Med, 120, 834 Doebbeling, 1992, Comparative efficacy of alternative handwashing agents in reducing nosocomial infections in intensive care units, N Engl J Med, 327, 88, 10.1056/NEJM199207093270205 Dumler, 1993, Human ehrlichiosis: Hematopathology and immunohistologic detection of Erhlichia chaffeensis., Hum Pathol, 24, 391, 10.1016/0046-8177(93)90087-W Dybedal, 1989, Respiratory insufficiency in acute leukemia following treatment with cytosine arabinoside and septicemia with streptococcus viridans, Eur J Haematol, 42, 405 EORTC, 1987, Ceftazidime combined with a short or long course of amikacin for empiric therapy of gram-negative bacteremia in cancer patients with granulocytopenia, N Engl J Med, 317, 1692, 10.1056/NEJM198712313172703 EORTC, 1989, Empiric antifungal therapy in febrile, granulocytopenic patients, Am J Med, 86, 668, 10.1016/0002-9343(89)90441-5 EORTC International Antimicrobial Therapy Cooperative Group, 1990, Gram-positive bacteremia in granulocytopenic cancer patients, Eur J Cancer, 26, 569, 10.1016/0277-5379(90)90079-9 EORTC and National Cancer Institute of Canada, 1991, Vancomycin added to empiric combination antibiotic therapy for fever and granulocytopenic cancer patients, J Infect Dis, 163, 951, 10.1093/infdis/163.5.951 Felitti, 1970, Primary invasion by Clostridium sphenoides in a patient with periodic neutropenia, West J Med, 113, 76 Feusner, 1988, Use of routine chest radiography in the evaluation of fever in neutropenic pediatric oncology patients, J Clin Oncol, 6, 1699, 10.1200/JCO.1988.6.11.1699 Fishbein, 1994, Human ehrlichiosis in the United States, 1985–1990, Ann Intern Med, 120, 736, 10.7326/0003-4819-120-9-199405010-00003 Freifeld, 1995, Monotherapy for fever and neutropenia in cancer patients: A randomized comparison of ceftazidime versus imipenem, J Clin Oncol, 13, 165, 10.1200/JCO.1995.13.1.165 Gibson, 1994, Trends in bacterial infections in febrile neutropenic patients: 1986–1992, Aust NZ J Med, 24, 374, 10.1111/j.1445-5994.1994.tb01464.x Glenn, 1988, Anorectal infections in patients with malignant diseases, Rev Infect Dis, 10, 42, 10.1093/clinids/10.1.42 Goldman, 1992, Handwashing and nosocomial infections, N Engl J Med, 327, 120, 10.1056/NEJM199207093270211 Goodman, 1992, A controlled trial of fluconazole to prevent fungal infections in patients undergoing bone marrow transplantation, N Engl J Med, 326, 845, 10.1056/NEJM199203263261301 Gordon-Smith, 1989, Aplastic anemia-aetiology and clinical features, Baillieres Clin Haematol, 2, 1, 10.1016/S0950-3536(89)80004-6 Groopman, 1990, Management of hematologic complications of human immunodeficiency virus infection, Rev Infect Dis, 12, 931, 10.1093/clinids/12.5.931 Groopman, 1989, Hematopoietic growth factors. Biology and clinical applications, N Engl J Med, 321, 1449, 10.1056/NEJM198911233212106 Gurwith, 1979, A prospective controlled investigation of prophylactic trimethoprim-sulfamethoxazole in hospitalized granulocytopenic patients, Am J Med, 66, 248, 10.1016/0002-9343(79)90539-4 Hiemenz, 1993, Special considerations for the patient undergoing allogeneic or autologous bone marrow transplantation, Hematol Oncol Clin North Am, 7, 961, 10.1016/S0889-8588(18)30214-4 Hopkins, 1983, Clostridial species in the pathogenesis of necrotizing enterocolitis in patients with neutropenia, Am J Hematol, 14, 289, 10.1002/ajh.2830140311 Howard, 1977, Infections in patients with neutropenia, Am J Dis Child, 131, 788 Hughes, 1990, Guidelines for the use of antimicrobial agents in neutropenic patients with unexplained fever, J Infect Dis, 161, 381, 10.1093/infdis/161.3.381 Ingram, 1991, Complications of indwelling venous access lines in the pediatric hematology patient: A prospective comparison of external venous catheters and subcutaneous ports, Am J Pediatr Hematol Oncol, 13, 130, 10.1097/00043426-199122000-00003 Jacob, 1978, Granulocyte-complement interaction, Arch Intern Med, 138, 461, 10.1001/archinte.138.3.461 Karp, 1986, Empiric use of vancomycin during prolonged treatment-induced granulocytopenia, Am J Med, 81, 237, 10.1016/0002-9343(86)90257-3 Klastersky, 1986, Concept of empiric therapy with antibiotic combinations: Indications and limits, Am J Med, 80, 2 Kramer, 1982, Role of serial microbiologic surveillance and clinical evaluation in the management of cancer patients with fever and neutropenia, Am J Med, 72, 561, 10.1016/0002-9343(82)90449-1 Kyle, 1980, Natural history of chronic idiopathic neutropenia, N Engl J Med, 302, 908, 10.1056/NEJM198004173021608 Liang, 1990, Ofloxacin versus co-trimoaxazole for prevention of infection in neutropenic patients following cytotoxic chemotherapy, Antimicrob Agents Chemother, 34, 215, 10.1128/AAC.34.2.215 Liang, 1990, Ceftazidime versus imipenem-cilastatin as initial monotherapy for febrile neutropenic patients, Antimicrob Agents Chemother, 34, 1336, 10.1128/AAC.34.7.1336 Lieschke, 1992, Granulocyte colony-stimulating factor and granulocyte-macrophage colony-stimulating factor, N Engl J Med, 327, 28, 10.1056/NEJM199207023270106 Linder, 1987, Cytopathology of opportunistic infection in bronchoalveolar lavage, Am J Clin Pathol, 88, 421, 10.1093/ajcp/88.4.421 Maeda, 1987, Human infection with Ehrlichia canis, a leukocytic rickettsia, N Engl J Med, 316, 853, 10.1056/NEJM198704023161406 Maher, 1994, Filgastrim in patients with chemotherapy-induced febrile neutropenia. A double-blind, placebo-controlled trial, Ann Intern Med, 121, 492, 10.7326/0003-4819-121-7-199410010-00004 Malik, 1995, Feasibility of outpatient management of fever in cancer patients with low-risk neutropenia: Results of a prospective randomized trial, Am J Med, 98, 224, 10.1016/S0002-9343(99)80367-2 McWhinney, 1993, Activities of potential therapeutic and prophylactic antibiotics against blood culture isolates of viridans group streptococci from neutropenic patients receiving ciprofloxacin, Antimicrob Agents Chemother, 37, 2493, 10.1128/AAC.37.11.2493 Mueller, 1994, Hematologic problems and their management in children with HIV infection, 591 Mullen, 1990, Early hospital discharge of children with cancer treated for fever and neutropenia: Identification and management of the low-risk patient, J Clin Oncol, 8, 1998, 10.1200/JCO.1990.8.12.1998 Munroe, 1977, The differential leukocyte count in the assessment and outcome of early-onset group B streptococcal disease, Pediatr Res, 91, 428 Murdock, 1972, Hematologic aspects of systemic disease: Infection, Clin Hematol, 1, 619 Nemunaitis, 1991, Phase I trial of recombinant macrophage colony-stimulating factor in patients with invasive fungal infections, Blood, 78, 907, 10.1182/blood.V78.4.907.907 Oppenheim, 1989, Outbreak of coagulase-negative staphylococcus highly resistant to ciprofloxacin in a leukemia unit, BMJ, 299, 294, 10.1136/bmj.299.6694.294 Peterson, 1987, Microbiology of acute periodontal infection in myelosuppressed cancer patients, J Clin Oncol, 5, 1461, 10.1200/JCO.1987.5.9.1461 Pettengell, 1992, Granulocyte colony-stimulating factor to prevent dose-limiting neutropenia in non-Hodgkin's lymphoma: A randomized controlled trial, Blood, 80, 1430, 10.1182/blood.V80.6.1430.1430 Pizzo, 1983, Antibiotic prophylaxis in the immunosuppressed patient with cancer, 153 Pizzo, 1984, Granulocytopenia and cancer therapy: Past problems, current solutions, future challenges, Cancer, 54, 2649, 10.1002/1097-0142(19841201)54:2+<2649::AID-CNCR2820541409>3.0.CO;2-6 Pizzo, 1984, Approaching the controversies in antibacterial management of cancer patients, Am J Med, 76, 436, 10.1016/0002-9343(84)90663-6 Pizzo, 1978, Increasing incidence of gram-positive sepsis in cancer patients, Med Pediatr Oncol, 5, 241, 10.1002/mpo.2950050133 Pizzo, 1978, Alpha-hemolytic streptococci—clinical significance in cancer patients, Med Pediatr Oncol, 4, 367, 10.1002/mpo.2950040414 Pizzo, 1983, Oral antibiotic prophylaxis in patients with cancer: A double-blind randomized placebo-controlled trial, J Pediatr, 102, 125, 10.1016/S0022-3476(83)80310-2 Pizzo, 1985, New beta-lactam antibiotics in granulocytopenic patients: New options and new questions, Am J Med, 79, 75, 10.1016/0002-9343(85)90265-7 Pizzo, 1987, After empiric therapy: What to do until the granulocyte comes back, Rev Infect Dis, 9, 214, 10.1093/clinids/9.1.214 Pizzo, 1989, Considerations for the prevention of infectious complications in patients with cancer, Rev Infect Dis, 11, S1551, 10.1093/clinids/11.Supplement_7.S1551 Pizzo, 1989, Evaluation of fever in the patient with cancer, Eur J Cancer Clin Oncol, 25, S9 Pizzo, 1993, Management of fever in patients with cancer and treatment-induced neutropenia, N Engl J Med, 328, 1323, 10.1056/NEJM199305063281808 Pizzo, 1986, A randomized trial comparing ceftazidime alone with combination antibiotic therapy in cancer patients with fever and neutropenia, N Engl J Med, 315, 552, 10.1056/NEJM198608283150905 Pizzo, 1982, Empiric antibiotic and antifungal therapy for cancer patients with prolonged fever and granulocytopenia, Am J Med, 72, 101, 10.1016/0002-9343(82)90594-0 Pizzo, 1982, Fever in the pediatric and young adult patient with cancer. A prospective study of 1001 episodes, Medicine, 61, 153, 10.1097/00005792-198205000-00003 Rabinowe, 1993, Long-term follow-up of a phase III study of recombinant human granulocyte-macrophage colony-stimulating factor after autologous bone marrow transplantation for lymphoid malignancies, Blood, 81, 1903, 10.1182/blood.V81.7.1903.1903 Ramphal, 1992, Vancomycin is not an essential component of the initial empiric treatment regimen for febrile neutropenic patients receiving ceftazidime: A randomized prospective study, Antimicrob Agents Chemother, 36, 1062, 10.1128/AAC.36.5.1062 Rockoff, 1996, Predicting the risk of bacteremia in children with fever and neutropenia, J Clin Oncol, 14, 919, 10.1200/JCO.1996.14.3.919 Roilides, 1993, Biologicals and hematopoietic cytokines in prevention or treatment of infections in immunocompromised hosts, Hematol Oncol Clin North Am, 7, 841, 10.1016/S0889-8588(18)30224-7 Roilides, 1992, Neutrophil oxidative burst in response to blastoconidia and pseudohyphae of Candida albicans: augmentation by granulocyte colony-stimulating factor and interferon-gamma, J Infect Dis, 166, 668, 10.1093/infdis/166.3.668 Roilides, 1991, Granulocyte colony-stimulating factor enhances the phagocytic and bactericidal activity of normal and defective human neutrophils, J Infect Dis, 163, 579, 10.1093/infdis/163.3.579 Rubenstein, 1993, Outpatient treatment of febrile episodes in low-risk neutropenic patients with cancer, Cancer, 71, 3640, 10.1002/1097-0142(19930601)71:11<3640::AID-CNCR2820711128>3.0.CO;2-H Rubin, 1988, Gram-positive infections and the use of vancomycin in 550 episodes of fever and neutropenia, Ann Intern Med, 108, 30, 10.7326/0003-4819-108-1-30 Rubin, 1992, 111 Indium-labelled nonspecific immunoglobulin scanning in the detection of focal infection, N Engl J Med, 321, 935, 10.1056/NEJM198910053211404 Sanders, 1992, Ceftazidime monotherapy for empiric treatment of febrile, neutropenic patients: A meta-analysis, J Infect Dis, 164, 907, 10.1093/infdis/164.5.907 Schimpff, 1985, Overview of empiric antibiotic therapy for the febrile, neutropenic patient, Rev Infect Dis, 7, 573, 10.1093/clinids/7.Supplement_4.S734 Schimpff, 1971, Empiric therapy with carbenicillin and gentamicin for febrile patients with cancer and granulocytopenia, N Engl J Med, 284, 1061, 10.1056/NEJM197105132841904 Sickles, 1975, Clinical presentation of infection in granulocytopenic patients, Arch Intern Med, 135, 715, 10.1001/archinte.135.5.715 Slavin, 1995, Efficacy and safety of fluconazole prophylaxis for fungal infections after marrow transplantation—a prospective, randomized, double-blind study, J Infect Dis, 171, 1545, 10.1093/infdis/171.6.1545 Souza, 1986, Recombinant human granulocyte colony-stimulating factor: Effects on normal and leukemic myeloid cells, Science, 232, 61, 10.1126/science.2420009 Strauss, 1994, Granulocyte transfusion therapy, Hematol Oncol Clin North Am, 8, 1159, 10.1016/S0889-8588(18)30127-8 Talcott, 1992, Risk assessment in cancer patients with fever and neutropenia: A prospective, two-center validation of a prediction rule, J Clin Oncol, 10, 316, 10.1200/JCO.1992.10.2.316 Trillet-Lenoir, 1993, Recombinant granulocyte colony-stimulating factor reduces infectious complications of cytotoxic chemotherapy, Eur J Cancer, 29A, 319, 10.1016/0959-8049(93)90376-Q Uttley, 1989, High-level vancomycin-resistance enterococci causing hospital infections, Epidemiol Infect, 103, 173, 10.1017/S0950268800030478 Van der Meer, 1994, Defects in host defense mechanisms, 33 Wade, 1986, Monotherapy for empiric treatment of fever in granulocytopenic cancer patients, Am J Med, 80, 85 Walsh, 1994, Evolving risk factors for invasive fungal infections: All neutropenic patients are not the same, Clin Infect Dis, 18, 793, 10.1093/clinids/18.5.793 Walsh, 1991, Empiric therapy with amphotericin B in febrile granulocytopenic patients, Rev Infect Dis, 13, 496, 10.1093/clinids/13.3.496 Weinberger, 1993, Approach to management of fever and infection in patients with primary bone marrow failure and hemoglobinopathies, Hematol Oncol Clin North Am, 7, 865, 10.1016/S0889-8588(18)30225-9 Weinberger, 1992, Patterns of infections in patients with aplastic anemia and the emergence of aspergillus as a major cause of death, Medicine, 71, 24, 10.1097/00005792-199201000-00003 Winston, 1993, Fluconazole prophylaxis of fungal infections in patients with acute leukemia. Results of a randomized placebo-controlled double-blinded, multicenter trial, Ann Intern Med, 118, 495, 10.7326/0003-4819-118-7-199304010-00003 Winston, 1983, Coagulase-negative staphylococcal bacteremia in patients receiving immunosuppressive therapy, Arch Intern Med, 143, 32, 10.1001/archinte.143.1.32 Winston, 1990, Ofloxacin versus vancomycin/polymyxin for prevention of infections in granulocytopenic patients, Am J Med, 88, 36, 10.1016/0002-9343(90)90125-W Winston, 1991, Beta-lactam antibiotic therapy in febrile, granulocytopenic patients: A randomized trial comparing cefoperazone plus piperacillin, ceftazidime plus piperacillin, and imipenem alone, Ann Intern Med, 115, 849, 10.7326/0003-4819-115-11-849 Wright, 1981, Human cyclic neutropenia: Clinical review and long-term follow-up of patients, Medicine, 60, 1, 10.1097/00005792-198101000-00001 Wright, 1986, Assessing the delivery of neutrophils to tissues in neutropenia, Blood, 67, 1023, 10.1182/blood.V67.4.1023.1023