Extremely acute exacerbation of interstitial pneumonia after interferon-alpha treatment for metastatic renal cell carcinoma
Tóm tắt
We report the case of a 62-year-old Japanese man who presented with right renal cell carcinoma and multiple metastases. The patient had a past medical history of idiopathic interstitial pneumonia 6 years previously. He had received pulse corticosteroid therapy and oral prednisolone, which resulted in marked clinical improvement. He had been followed up for the interstitial pneumonia, without medication, for 5 years and the idiopathic interstitial pneumonia was inactive when the metastatic renal cell carcinoma was diagnosed. However, the patient presented with extremely acute exacerbation of the interstitial pneumonia that occurred after only three intramuscular injections of standard-dose interferon-alpha. Urologists should be aware of this complication in the treatment of renal cell carcinoma patients who have a prior history of interstitial pneumonia.
Tài liệu tham khảo
Tokita H, Fukui H, Tanaka A, et al. (2003) Circulating KL-6 level at baseline is a predictive indicator for the occurrence of interstitial pneumonia during interferon treatment for chronic hepatitis C. Hepatol Res 26:91–97
Midturi J, Sierra-Hoffman M, Hurley D, et al. (2004) Spectrum of pulmonary toxicity associated with the use of interferon therapy for hepatitis C: case report and review of the literature. Clin Infect Dis 39:1724–1729
Hyzy R, Huang S, Myers J, et al. (2007) Acute exacerbation of idiopathic pulmonary fibrosis. Chest 132:1652–1658
Steegmann JL, Requena MJ, Martin-Regueira P, et al. (2003) High incidence of autoimmune alterations in chronic myeloid leukemia patients treated with interferon-α. Am J Hematol 72:170–176
Shind M, Di Bisceglie AM, Hoofnagle JH (1992) Acute exacerbation of lung disease during interferon alpha therapy for chronic hepatitis C. Gastroenterology 102:1406–1408