Extracellular vesicles in allograft rejection and tolerance

Andaloussi S, 2013, Extracellular vesicles: biology and emerging therapeutic opportunities, Nat. Rev. Drug Discovery, 12, 347, 10.1038/nrd3978 Liu, 2016, Donor dendritic cell-derived exosomes promote allograft-targeting immune response, J. Clin. Invest., 126, 2805, 10.1172/JCI84577 Marino, 2016, Donor exosomes rather than passenger leukocytes initiate alloreactive T cell responses after transplantation, Sci. Immunol., 1, 1, 10.1126/sciimmunol.aaf8759 Auchincloss, 1996, Antigen processing and presentation in transplantation, Curr. Opin. Immunol., 8, 681, 10.1016/S0952-7915(96)80086-0 Benichou, 1999, Contributions of direct and indirect T cell alloreactivity during allograft rejection in mice, J. Immunol., 162, 352, 10.4049/jimmunol.162.1.352 Sayegh, 1994, Mechanisms of T cell recognition of alloantigen, role pept. Transplant., 57, 1295 Marino, 2016, Allorecognition by T lymphocytes and allograft rejection, Front. Immunol., 7, 582, 10.3389/fimmu.2016.00582 Poggio, 2004, Alloreactivity in renal transplant recipients with and without chronic allograft nephropathy, J. Am. Soc. Nephrol.: JASN, 15, 1952, 10.1097/01.ASN.0000129980.83334.79 Vella, 1997, Indirect allorecognition of major histocompatibility complex allopeptides in human renal transplant recipients with chronic graft dysfunction, Transplantation, 64, 795, 10.1097/00007890-199709270-00001 Ciubotariu, 1998, Persistent allopeptide reactivity and epitope spreading in chronic rejection of organ allografts, J. Clin. Invest., 101, 398, 10.1172/JCI1117 Lee, 2001, Indirect recognition of allopeptides promotes the development of cardiac allograft vasculopathy, Proc. Natl. Acad. Sci. U S A, 98, 3276, 10.1073/pnas.051584498 Wood, 2003, Regulatory T cells in transplantation tolerance, Nat. Rev. Immunol., 3, 199, 10.1038/nri1027 Waldmann, 2004, Regulatory T cells and organ transplantation, Semin. Immunol., 16, 119, 10.1016/j.smim.2003.12.007 Herrera, 2004, A novel pathway of alloantigen presentation by dendritic cells, J. Immunol., 173, 4828, 10.4049/jimmunol.173.8.4828 Brown, 2008, Extensive and bidirectional transfer of major histocompatibility complex class II molecules between donor and recipient cells in vivo following solid organ transplantation, FASEB journal: official publication of the Federation of American Societies for Experimental Biology, 22, 3776, 10.1096/fj.08-107441 Burlingham, 2017, Cross-Dressing Becomes Fashionable Among Transplant Recipients, Am. J. Transpl., 17, 5, 10.1111/ajt.14032 Robbins, 2014, Regulation of immune responses by extracellular vesicles, Nat. Rev. Immunol., 14, 195, 10.1038/nri3622 Larsen, 1990, Migration of dendritic leukocytes from cardiac allografts into host spleens. A novel pathway for initiation of rejection, J. Exp. Med., 171, 307, 10.1084/jem.171.1.307 Hudson, 1976, Specific adsorption of IgM antibody onto H-2-activated mouse T lymphocytes, J. Exp. Med., 143, 444, 10.1084/jem.143.2.444 Bona, 1973, Transfer of antigen from macrophages to lymphocytes. II. Immunological significance of the transfer of lipopolysaccharide, Immunology, 24, 831 Brown, 2010, Intercellular exchange of surface molecules and its physiological relevance, Archivum immunologiae et therapiae experimentalis, 58, 263, 10.1007/s00005-010-0085-y Frelinger, 1974, Evidence for the expression of Ia (H-2-associated) antigens on thymus-derived lymphocytes, J. Exp. Med., 140, 1273, 10.1084/jem.140.5.1273 Dolan, 2006, Dendritic cells cross-dressed with peptide MHC class I complexes prime CD8+ T cells, J. Immunol., 177, 6018, 10.4049/jimmunol.177.9.6018 Smyth, 2006, A novel pathway of antigen presentation by dendritic and endothelial cells: Implications for allorecognition and infectious diseases, Transplantation, 82, S15, 10.1097/01.tp.0000231347.06149.ca Russo, 2000, Acquisition of intact allogeneic human leukocyte antigen molecules by human dendritic cells, Blood, 95, 3473, 10.1182/blood.V95.11.3473 Harper, 2015, CD8 T-cell recognition of acquired alloantigen promotes acute allograft rejection, Proc. Natl. Acad. Sci. U S A, 112, 12788, 10.1073/pnas.1513533112 Markey, 2014, Cross-dressing by donor dendritic cells after allogeneic bone marrow transplantation contributes to formation of the immunological synapse and maximizes responses to indirectly presented antigen, J. Immunol., 192, 5426, 10.4049/jimmunol.1302490 Smyth, 2017, Continuous Acquisition of MHC: peptide complexes by recipient cells contributes to the generation of anti-graft CD8+ T Cell immunity, Am. J. Transplant., 17, 60, 10.1111/ajt.13996 Dieude, 2015, The 20S proteasome core, active within apoptotic exosome-like vesicles, induces autoantibody production and accelerates rejection, Sci. Transl. Med, 7, 318ra200, 10.1126/scitranslmed.aac9816 van Niel, 2001, Intestinal epithelial cells secrete exosome-like vesicles, Gastroenterology, 121, 337, 10.1053/gast.2001.26263 Karlsson, 2001, “Tolerosomes” are produced by intestinal epithelial cells, Eur. J. Immunol., 31, 2892, 10.1002/1521-4141(2001010)31:10<2892::AID-IMMU2892>3.0.CO;2-I Frangsmyr, 2005, Cytoplasmic microvesicular form of Fas ligand in human early placenta: switching the tissue immune privilege hypothesis from cellular to vesicular level, Mol. Hum. Reprod., 11, 35, 10.1093/molehr/gah129 LeMaoult, 2007, Immune regulation by pretenders: cell-to-cell transfers of HLA-G make effector T cells act as regulatory cells, Blood, 109, 2040, 10.1182/blood-2006-05-024547 Brown, 2012, CD86+ or HLA-G+ can be transferred via trogocytosis from myeloma cells to T cells and are associated with poor prognosis, Blood, 120, 2055, 10.1182/blood-2012-03-416792 Caumartin, 2007, Trogocytosis-based generation of suppressive NK cells, EMBO j., 26, 1423, 10.1038/sj.emboj.7601570 HoWangYin, 2011, Proper regrafting of Ig-like transcript 2 after trogocytosis allows a functional cell-cell transfer of sensitivity, J. Immunol., 186, 2210, 10.4049/jimmunol.1000547 Tilburgs, 2015, The HLA-G cycle provides for both NK tolerance and immunity at the maternal-fetal interface, Proc. Natl. Acad. Sci. U S A, 112, 13312, 10.1073/pnas.1517724112 Peche, 2006, Induction of tolerance by exosomes and short-term immunosuppression in a fully MHC-mismatched rat cardiac allograft model, Am. J. Transplant., 6, 1541, 10.1111/j.1600-6143.2006.01344.x Agarwal, 2014, Regulatory T cell-derived exosomes: possible therapeutic and diagnostic tools in transplantation, Front. Immunol., 5, 555, 10.3389/fimmu.2014.00555 Yu, 2013, CD4+CD25+ regulatory T cells-derived exosomes prolonged kidney allograft survival in a rat model, Cell. Immunol., 285, 62, 10.1016/j.cellimm.2013.06.010 Aiello, 2017, Extracellular vesicles derived from T regulatory cells suppress T cell proliferation and prolong allograft survival, Sci. Rep., 7, 11518, 10.1038/s41598-017-08617-3 Okoye, 2014, MicroRNA-containing T-regulatory-cell-derived exosomes suppress pathogenic T helper 1 cells, Immunity, 41, 89, 10.1016/j.immuni.2014.05.019 Bracamonte-Baran, 2017, Modification of host dendritic cells by microchimerism-derived extracellular vesicles generates split tolerance, Proc. Natl. Acad. Sci. U S A, 114, 1099, 10.1073/pnas.1618364114 Dutta, 2009, Tolerance to noninherited maternal antigens in mice and humans, Current opinion in organ transplant., 14, 439, 10.1097/MOT.0b013e32832d6683 Dutta, 2009, Microchimerism is strongly correlated with tolerance to noninherited maternal antigens in mice, Blood, 114, 3578, 10.1182/blood-2009-03-213561 Molitor-Dart, 2008, Tolerance induction or sensitization in mice exposed to noninherited maternal antigens, Am. J. Transplant., 8, 2307, 10.1111/j.1600-6143.2008.02417.x Akiyama, 2011, Transplantation tolerance to a single noninherited MHC class I maternal alloantigen studied in a TCR-transgenic mouse model, J. Immunol., 186, 1442, 10.4049/jimmunol.1003023 Burlingham, 1998, The effect of tolerance to noninherited maternal HLA antigens on the survival of renal transplants from sibling donors, N. Engl. J. med., 339, 1657, 10.1056/NEJM199812033392302 Ono, 2017, Graft-infiltrating PD-L1(hi) cross-dressed dendritic cells regulate antidonor T cell responses in mouse liver transplant tolerance, Hepatology LeGuern, 2019, On the elusive TCR specificity of thymic regulatory T cells, Am. J. Transplant., 19, 15, 10.1111/ajt.15165 Miranda, 2010, Nucleic acids within urinary exosomes/microvesicles are potential biomarkers for renal disease, Kidney Int., 78, 191, 10.1038/ki.2010.106 Schroppel, 2014, Delayed kidney graft function: from mechanism to translation, Kidney Int., 86, 251, 10.1038/ki.2014.18 Wang, 2019, Expression profiling of exosomal miRNAs derived from the peripheral blood of kidney recipients with DGF using high-throughput sequencing, Biomed Res. Int., 2019, 1759697 Alvarez, 2013, Urinary exosomes as a source of kidney dysfunction biomarker in renal transplantation, Transplant Proc, 45, 3719, 10.1016/j.transproceed.2013.08.079 Peake, 2014, A comparison of the ability of levels of urinary biomarker proteins and exosomal mRNA to predict outcomes after renal transplantation, PLoS ONE, 9, 10.1371/journal.pone.0098644 Sigdel, 2014, Perturbations in the urinary exosome in transplant rejection, Front Med (Lausanne), 1, 57 Lim, 2018, Novel urinary exosomal biomarkers of acute T cell-mediated rejection in kidney transplant recipients: A cross-sectional study, Plos One, 13, 10.1371/journal.pone.0204204 Tower, 2017, Plasma C4d+ endothelial microvesicles increase in acute antibody-mediated rejection, Transplantation, 101, 2235, 10.1097/TP.0000000000001572 Zhang, 2017, Plasma exosomes from HLA-sensitized kidney transplant recipients contain mRNA transcripts which predict development of antibody-mediated rejection, Transplantation, 101, 2419, 10.1097/TP.0000000000001834 Kennel, 2018, Serum exosomal protein profiling for the non-invasive detection of cardiac allograft rejection, J. Heart Lung Transplant., 37, 409, 10.1016/j.healun.2017.07.012 Gunasekaran, 2017, Donor-Derived exosomes with lung self-antigens in human lung allograft rejection, Am. J. Transplant., 17, 474, 10.1111/ajt.13915 Gunasekaran, 2018, Circulating exosomes with distinct properties during chronic lung allograft rejection, J. Immunol., 200, 2535, 10.4049/jimmunol.1701587 Vallabhajosyula, 2017, Tissue-specific exosome biomarkers for noninvasively monitoring immunologic rejection of transplanted tissue, J. Clin. Invest., 127, 1375, 10.1172/JCI87993