Extracellular vesicles as an emerging mechanism of cell-to-cell communication

Endocrine - Tập 44 Số 1 - Trang 11-19 - 2013
Ciro Tetta1, Ezio Ghigo2, Lorenzo Silengo2, Maria Chiara Deregibus2, Giovanni Camussi3
1Department of Molecular Biotechnology and Health Science, Translational Center for Regenerative Medicine, University of Torino, Via Nizza 52, Turin, Italy.
2Department of Molecular Biotechnology and Health Science and Department of Medical Sciences and Fresenius Medical Care, Translational Center for Regenerative Medicine, University of Torino, Turin, Italy
3Translational Center for Regenerative Medicine, University of Torino

Tóm tắt

Từ khóa


Tài liệu tham khảo

G. Camussi, M.C. Deregibus, S. Bruno, V. Cantaluppi, L. Biancone, Exosomes/microvesicles as a mechanism of cell-to-cell communication. Kidney Int. 78, 838–848 (2010)

A. Michael, S.D. Bajracharya, P.S. Yuen, H. Zhou, R.A. Star, G.G. Illei, I. Alevizos, Exosomes from human saliva as a source of microRNA biomarkers. Oral Dis. 16, 34–38 (2010)

A. Lakkaraju, E. Rodriguez-Boulan, Itinerant exosomes: emerging roles in cell and tissue polarity. Trends Cell Biol. 18, 199–209 (2008)

N. Kosaka, H. Izumi, K. Sekine, T. Ochiya, microRNA as a new immune-regulatory agent in breast milk. Silence 1, 7–14 (2010)

S. Keller, C. Rupp, A. Stoeck, S. Runz, M. Fogel, S. Lugert, H.D. Hager, M.S. Abdel-Bakky, P. Gutwein, P. Altevogt, CD24 is a marker of exosomes secreted into urine and amniotic fluid. Kidney Int. 72, 1095–1102 (2007)

T. Pisitkun, R.F. Shen, M.A. Knepper, Identification and proteomic profiling of exosomes in human urine. Proc. Natl. Acad. Sci. USA 101, 13368–13373 (2004)

J. Nilsson, J. Skog, A. Nordstrand, V. Baranov, L. Mincheva-Nilsson, X.O. Breakefield, A. Widmark, Prostate cancer-derived urine exosomes: a novel approach to biomarkers for prostate cancer. Br. J. Cancer 100, 1603–1607 (2009)

J. Ratajczak, M. Wysoczynski, F. Hayek, A. Janowska-Wieczorek, M.Z. Ratajczak, Membrane-derived microvesicles: important and underappreciated mediators of cell-to-cell communication. Leukemia 20, 1487–1495 (2006)

K. Schara, V. Jansa, V. Sustar, D. Dolinar, J.I. Pavlic, M. Lokar, V. Kralj-Iglic, P. Veranic, A. Iglic, Mechanisms for the formation of membranous nanostructures in cell-to-cell communication. Cell. Mol. Biol. Lett. 14, 636–656 (2009)

F. Bianco, C. Perrotta, L. Novellino, M. Francolini, L. Riganti, E. Menna, L. Saglietti, E.H. Schuchman, R. Furlan, E. Clementi, M. Matteoli, C. Verderio, Acid sphingomyelinase activity triggers microparticle release from glial cells. EMBO J. 28, 1043–1054 (2009)

V. Muralidharan-Chari, J.W. Clancy, A. Sedgwick, C. D’Souza-Schorey, Microvesicles: mediators of extracellular communication during cancer progression. J. Cell Sci. 123, 1603–1611 (2010)

R.L. Williams, S. Urbé, The emerging shape of the ESCRT machinery. Nat. Rev. Mol. Cell Biol. 8, 355–368 (2007)

K. Trajkovic, C. Hsu, S. Chiantia, L. Rajendran, D. Wenzel, F. Wieland, P. Schwille, B. Brügger, M. Simons, Ceramide triggers budding of exosome vesicles into multivesicular endosomes. Science 319, 1244–1247 (2008)

G. van Niel, S. Charrin, S. Simoes, M. Romao, L. Rochin, P. Saftig, M.S. Marks, E. Rubinstein, G. Raposo, The tetraspanin CD63 regulates ESCRT-independent and -dependent endosomal sorting during melanogenesis. Dev. Cell 21, 708–721 (2011)

F.J. Verweij, M.A. van Eijndhoven, E.S. Hopmans, T. Vendrig, T. Wurdinger, E. Cahir-McFarland, E. Kieff, D. Geerts, R. van der Kant, J. Neefjes, J.M. Middeldorp, D.M. Pegtel, LMP1 association with CD63 in endosomes and secretion via exosomes limits constitutive NF-κB activation. EMBO J. 30, 2115–2129 (2011)

Y. Fang, N. Wu, X. Gan, W. Yan, J.C. Morrell, S.J. Gould, Higher-order oligomerization targets plasma membrane proteins and HIV gag to exosomes. PLoS Biol. 5, e158 (2007)

E. Cocucci, G. Racchetti, J. Meldolesi, Shedding microvesicles: artefacts no more. Trends Cell Biol. 19, 43–51 (2008)

B.J. Quah, V.P. Barlow, V. McPhun, K.I. Matthaei, M.D. Hulett, C.R. Parish, Bystander B cells rapidly acquire antigen receptors from activated B cells by membrane transfer. Proc. Natl. Acad. Sci. USA 105, 4259–4264 (2008)

J.W. Kim, E. Wieckowski, D.D. Taylor, T.E. Reichert, S. Watkins, T.L. Whiteside, Fas ligand-positive membranous vesicles isolated from sera of patients with oral cancer induce apoptosis of activated T lymphocytes. Clin. Cancer Res. 11, 1010–1020 (2005)

J. Yu, L. May, C. Milsom, G.M. Anderson, J.I. Weitz, J.P. Luyendyk, G. Broze, N. Mackman, J. Rak, Contribution of host-derived tissue factor to tumor neovascularization. Arterioscler. Thromb. Vasc. Biol. 28, 1975–1981 (2008)

K. Al-Nedawi, B. Meehan, R.S. Kerbel, A.C. Allison, J. Rak, Endothelial expression of autocrine VEGF upon the uptake of tumor-derived microvesicles containing oncogenic EGFR. Proc. Natl. Acad. Sci. USA 106, 3794–3799 (2009)

A. Sarkar, S. Mitra, S. Mehta, R. Raices, M.D. Wewers, Monocyte derived microvesicles deliver a cell death message via encapsulated caspase-1. PLoS ONE 4, e7140 (2009)

H. Sheldon, E. Heikamp, H. Turley, R. Dragovic, P. Thomas, C.E. Oon, R. Leek, M. Edelmann, B. Kessler, R.C. Sainson, I. Sargent, J.L. Li, A.L. Harris, New mechanism for notch signaling to endothelium at a distance by Delta-like 4 incorporation into exosomes. Blood 116, 2385–2394 (2010)

C. Frühbeis, D. Fröhlich, E.M. Krämer-Albers, Emerging roles of exosomes in neuron-glia communication. Front. Physiol. 3, 119 (2012)

L.J. Vella, D.L. Greenwood, R. Cappai, J.P. Scheerlinck, A.F. Hill, Enrichment of prion protein in exosomes derived from ovine cerebral spinal fluid. Vet. Immunol. Immunopathol. 124, 385–393 (2008)

K. Al-Nedawi, B. Meehan, J. Micallef, V. Lhotak, L. May, A. Guha, J. Rak, Intercellular transfer of the oncogenic receptor EGFRvIII by microvesicles derived from tumour cells. Nat. Cell Biol. 10, 619–624 (2008)

A. Schneider, M. Simons, Exosomes: vesicular carriers for intercellular communication in neurodegenerative disorders. Cell Tissue Res. (2012) DOI: 10.1007/s00441-012-1428-2

B. Fevrier, D. Vilette, F. Archer, D. Loew, W. Faigle, M. Vidal, H. Laude, G. Raposo, Cells release prions in association with exosomes. Proc. Natl. Acad. Sci. USA 101, 9683–9688 (2004)

X. Chen, H. Liang, J. Zhang, K. Zen, C.Y. Zhang, Secreted microRNAs: a new form of intercellular communication. Trends Cell Biol. 22, 125–132 (2012)

J. Krol, I. Loedige, W. Filipowicz, The widespread regulation of microRNA biogenesis, function and decay. Nat. Rev. Genet. 11, 597–610 (2010)

M.C. Deregibus, V. Cantaluppi, R. Calogero, M. Lo Iacono, C. Tetta, L. Biancone, S. Bruno, B. Bussolati, G. Camussi, Endothelial progenitor cell derived microvesicles activate an angiogenic program in endothelial cells by a horizontal transfer of mRNA. Blood 110, 2440–2448 (2007)

J.M. Aliotta, M. Pereira, K.W. Johnson, N. de Paz, M.S. Dooner, N. Puente, C. Ayala, K. Brilliant, D. Berz, D. Lee, B. Ramratnam, P.N. McMillan, D.C. Hixson, D. Josic, P.J. Quesenberry, Microvesicle entry into marrow cells mediates tissue-specific changes in mRNA by direct delivery of mRNA and induction of transcription. Exp. Hematol. 38, 233–245 (2010)

S. Bruno, C. Grange, M.C. Deregibus, R.A. Calogero, S. Saviozzi, F. Collino, L. Morando, A. Busca, M. Falda, B. Bussolati, C. Tetta, G. Camussi, Mesenchymal stem cell-derived microvesicles protect against acute tubular injury. J. Am. Soc. Nephrol. 20, 1053–1067 (2009)

H. Valadi, K. Ekström, A. Bossios, M. Sjöstrand, J.J. Lee, J.O. Lötvall, Exosome-mediated transfer of mRNAs and microRNAs is a novel mechanism of genetic exchange between cells. Nat. Cell Biol. 9, 654–659 (2007)

A. Yuan, E.L. Farber, A.L. Rapoport, D. Tejada, R. Deniskin, N.B. Akhmedov, D.B. Farber, Transfer of microRNAs by embryonic stem cell microvesicles. PLoS ONE 4, e4722 (2009)

F. Collino, M.C. Deregibus, S. Bruno, L. Sterpone, G. Aghemo, L. Viltono, C. Tetta, G. Camussi, Microvesicles derived from adult human bone marrow and tissue specific mesenchymal stem cells shuttle selected pattern of miRNAs. PLoS ONE 5, e11803 (2010)

V. Fonsato, F. Collino, M.B. Herrera, C. Cavallari, M.C. Deregibus, B. Cisterna, S. Bruno, R. Romagnoli, M. Salizzoni, C. Tetta, G. Camussi, Human liver stem cell-derived microvesicles inhibit hepatoma growth in SCID mice by delivering antitumor microRNAs. Stem Cells 30, 1985–1998 (2012)

A. Waldenström, N. Gennebäck, U. Hellman, G. Ronquist, Cardiomyocyte microvesicles contain DNA/RNA and convey biological messages to target cells. PLoS ONE 7, e34653 (2012)

K.G. Ronquist, G. Ronquist, L. Carlsson, A. Larsson, Human prostasomes contain chromosomal DNA. Prostate 69, 737–743 (2009)

M. Guescini, S. Genedani, V. Stocchi, L.F. Agnati, Astrocytes and Glioblastoma cells release exosomes carrying mtDNA. J. Neural Transm. 117, 1–4 (2010)

R.M. O’Connell, D.S. Rao, A.A. Chaudhuri, D. Baltimore, Physiological and pathological roles for microRNAs in the immune system. Nat. Rev. Immunol. 10, 111–122 (2010)

G. Raposo, H.W. Nijman, W. Stoorvogel, R. Liejendekker, C.V. Harding, C.J. Melief, H.J. Geuze, B lymphocytes secrete antigen-presenting vesicles. J. Exp. Med. 183, 1161–1172 (1996)

L. Zitvogel, A. Regnault, A. Lozier, J. Wolfers, C. Flament, D. Tenza, P. Ricciardi-Castagnoli, G. Raposo, S. Amigorena, Eradication of established murine tumors using a novel cell-free vaccine: dendritic cell-derived exosomes. Nat. Med. 4, 594–600 (1998)

E. Segura, C. Nicco, B. Lombard, P. Veron, G. Raposo, F. Batteux, S. Amigorena, C. Thery, ICAM-1 on exosomes from mature dendritic cells is critical for efficient naive T-cell priming. Blood 106, 216–223 (2005)

M. Baj-Krzyworzeka, J. Baran, K. Weglarczyk, R. Szatanek, A. Szaflarska, M. Siedlar, M. Zembala, Tumour-derived microvesicles (TMV) mimic the effect of tumour cells on monocyte subpopulations. Anticancer Res. 30, 3515–3519 (2010)

A. Bobrie, M. Colombo, G. Raposo, C. Théry, Exosome secretion: molecular mechanisms and roles in immune responses. Traffic 12, 1659–1668 (2011)

M. Mittelbrunn, C. Gutierrez-Vazquez, C. Villarroya-Beltri, S. Gonzalez, F. Sanchez-Cabo, M.A. Gonzalez, A. Bernad, F. Sanchez-Madrid, Unidirectional transfer of microRNA-loaded exosomes from T cells to antigen-presenting cells. Nat. Commun. 2, 282 (2011)

S.I. Buschow, E.N. Nolte-’t Hoen, G. van Niel, M.S. Pols, T. Ten Broeke, M. Lauwen, F. Ossendorp, C.J. Melief, G. Raposo, R. Wubbolts, M.H. Wauben, W. Stoorvogel, MHC II in dendritic cells is targeted to lysosomes or T cell-induced exosomes via distinct multivesicular body pathways. Traffic 10, 1528–1542 (2009)

D. Castellana, C. Kunzelmann, J.M. Freyssinet, Pathophysiologic significance of procoagulant microvesicles in cancer disease and progression. Hamostaseologie 29, 1–57 (2009)

G. Andreola, L. Rivoltini, C. Castelli, V. Huber, P. Perego, P. Deho, P. Squarcina, P. Accornero, F. Lozupone, L. Lugini, A. Stringaro, A. Molinari, G. Arancia, M. Gentile, G. Parmiani, S. Fais, Induction of lymphocyte apoptosis by tumor cell secretion of FasL-bearing microvesicles. J. Exp. Med. 195, 1303–1316 (2002)

D. Castellana, F. Zobairi, M.C. Martinez, M.A. Panaro, V. Mitolo, J.M. Freyssinet, C. Kunzelmann, Membrane microvesicles as actors in the establishment of a favorable prostatic tumoral niche: a role for activated fibroblasts and CX3CL1-CX3CR1 axis. Cancer Res. 69, 69785–69793 (2009)

M. Baj-Krzyworzeka, K. Weglarczyk, B. Mytar, R. Szatanek, J. Baran, M. Zembala, Tumour-derived microvesicles contain interleukin-8 and modulate production of chemokines by human monocytes. Anticancer Res. 31, 1329–1335 (2011)

M.A. Antonyak, B. Li, L.K. Boroughs, J.L. Johnson, J.E. Druso, K.L. Bryant, D.A. Holowka, R.A. Cerione, Cancer cell-derived microvesicles induce transformation by transferring tissue transglutaminase and fibronectin to recipient cells. Proc. Natl. Acad. Sci. USA 108, 4852–4857 (2011)

M. Baj-Krzyworzeka, R. Szatanek, K. Weglarczyk, J. Baran, B. Urbanowicz, P. Brański, M.Z. Ratajczak, M. Zembala, Tumour-derived microvesicles carry several surface determinants and mRNA of tumour cells and transfer some of these determinants to monocytes. Cancer Immunol. Immunother. 55, 808–818 (2006)

J. Skog, T. Würdinger, S. van Rijn, D.H. Meijer, L. Gainche, M. Sena-Esteves, W.T. Jr Curry, B.S. Carter, A.M. Krichevsky, X.O. Breakefield, Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers. Nat. Cell Biol. 10, 1470–1476 (2008)

B.S. Hong, J.H. Cho, H. Kim, E.J. Choi, S. Rho, J. Kim, J.H. Kim, D.S. Choi, Y.K. Kim, D. Hwang, Y.S. Gho, Colorectal cancer cell-derived microvesicles are enriched in cell cycle-related mRNAs that promote proliferation of endothelial cells. BMC Genomics 10, 556–568 (2009)

M. Del Tatto, T. Ng, J.M. Aliotta, G.A. Colvin, M.S. Dooner, D. Berz, G.J. Dooner, E.F. Papa, D.C. Hixson, B. Ramratnam, B.I. Aswad, E.H. Sears, J. Reagan, P.J. Quesenberry, Marrow cell genetic phenotype change induced by human lung cancer cells. Exp. Hematol. 39, 1072–1080 (2011)

J.F. Renzulli II, M. Del Tatto, G. Dooner, J. Aliotta, L. Goldstein, M. Dooner, G. Colvin, D. Chatterjee, P. Quesenberry, Microvesicle induction of prostate specific gene expression in normal human bone marrow cells. J. Urol. 184, 2165–2171 (2010)

C. Grange, M. Tapparo, F. Collino, L. Vitillo, C. Damasco, M.C. Deregibus, C. Tetta, B. Bussolati, G. Camussi, Microvesicles released from human renal cancer stem cells stimulate angiogenesis and formation of lung premetastatic niche. Cancer Res. 71, 5346–5356 (2011)

J. Ratajczak, K. Miekus, M. Kucia, J. Zhang, R. Reca, P. Dvorak, M.Z. Ratajczak, Embryonic stem cell-derived microvesicles reprogram hematopoietic progenitors: evidence for horizontal transfer of mRNA and protein delivery. Leukemia 20, 847–856 (2006)

V. Cantaluppi, S. Gatti, D. Medica, F. Figliolini, S. Bruno, M.C. Deregibus, A. Sordi, L. Biancone, C. Tetta, G. Camussi, Microvesicles derived from endothelial progenitor cells protect the kidney from ischemia-reperfusion injury by microRNA-dependent reprogramming of resident renal cells. Kidney Int. 82, 412–427 (2012)

P.J. Quesenberry, M.S. Dooner, J.M. Aliotta, Stem cell plasticity revisited: the continuum marrow model and phenotypic changes mediated by microvesicles. Exp. Hematol. 38, 581–592 (2010)

G. Müller, Microvesicles/exosomes as potential novel biomarkers of metabolic diseases. Diabetes Metab. Syndr. Obes. 5, 247–282 (2012)

C. Cipolletta, K.E. Ryan, E.V. Hanna, E.R. Trimble, Activation of peripheral blood CD14+monocytes occurs in diabetes. Diabetes 54, 2779–2786 (2005)

F. Sabatier, P. Darmon, B. Hugel, V. Combes, M. Sanmarco, J.G. Velut, D. Arnoux, P. Charpiot, J.M. Freyssinet, C. Oliver, J. Sampol, F. Dignat-George, Type 1 and type 2 diabetic patients display different patterns of cellular microparticles. Diabetes 51, 2840–2845 (2002)

K.T. Tan, M.H. Tayebjee, H.S. Lim, G.Y. Lip, Clinically apparent atherosclerotic disease in diabetes is associated with an increase in platelet microparticle levels. Diabet. Med. 22, 1657–1662 (2005)

H. Koga, S. Sugiyama, K. Kugiyama, H. Fukushima, K. Watanabe, T. Sakamoto, M. Yoshimura, H. Jinnouchi, H. Ogawa, Elevated levels of remnant lipoproteins are associated with plasma platelet microparticles in patients with type-2 diabetes mellitus without obstructive coronary artery disease. Eur. Heart J. 27, 817–823 (2006)

A.L. Sun, J.T. Deng, G.J. Guan, S.H. Chen, Y.T. Liu, J. Cheng, Z.W. Li, X.H. Zhuang, F.D. Sun, H.P. Deng, Dipeptidyl peptidase-IV is a potential molecular biomarker in diabetic kidney disease. Diab. Vasc. Dis. Res. 9, 301–308 (2012)

G. Müller, S. Wied, E.A. Dearey, G. Biemer-Daub, Glycosylphosphatidylinositol-anchored proteins coordinate lipolysis inhibition between large and small adipocytes. Metabolism 60, 1021–1037 (2011)

F.F. van Doormaal, A. Kleinjan, M. Di Nisio, H.R. Büller, R. Nieuwland, Cell-derived microvesicles and cancer. Neth. J. Med. 67, 266–273 (2009)

M. Logozzi, A. De Milito, L. Lugini, M. Borghi, L. Calabrò, M. Spada, M. Perdicchio, M.L. Marino, C. Federici, E. Iessi, D. Brambilla, G. Venturi, F. Lozupone, M. Santinami, V. Huber, M. Maio, L. Rivoltini, S. Fais, High levels of exosomes expressing CD63 and caveolin-1 in plasma of melanoma patients. PLoS ONE 4, e5219 (2009)

J. Baran, M. Baj-Krzyworzeka, K. Weglarczyk, R. Szatanek, M. Zembala, J. Barbasz, A. Czupryna, A. Szczepanik, M. Zembala, Circulating tumour-derived microvesicles in plasma of gastric cancer patients. Cancer Immunol. Immunother. 59, 841–850 (2010)

A.M. Friel, C. Corcoran, J. Crown, L. O’Driscoll, Relevance of circulating tumor cells, extracellular nucleic acids, and exosomes in breast cancer. Breast Cancer Res. Treat. 123, 613–625 (2010)

N. Kosaka, H. Iguchi, T. Ochiya, Circulating microRNA in body fluid: a new potential biomarker for cancer diagnosis and prognosis. Cancer Sci. 101, 2087–2092 (2010)

D.D. Taylor, C. Gercel-Taylor, MicroRNA signatures of tumor-derived exosomes as diagnostic biomarkers of ovarian cancer. Gynecol. Oncol. 110, 13–21 (2008)

G. Rabinowits, C. Gerçel-Taylor, J.M. Day, D.D. Taylor, G.H. Kloecker, Exosomal microRNA: a diagnostic marker for lung cancer. Clin. Lung Cancer 10, 42–46 (2009)

A.V. Vlassov, S. Magdaleno, R. Setterquist, R. Conrad, Exosomes: current knowledge of their composition, biological functions, and diagnostic and therapeutic potentials. Biochim. Biophys. Acta 1820, 940–948 (2012)

L. Biancone, S. Bruno, M.C. Deregibus, C. Tetta, G. Camussi, Therapeutic potential of mesenchymal stem cell-derived microvesicles. Nephrol. Dial. Transplant. 27, 3037–3042 (2012)

S. Bruno, C. Grange, F. Collino, M.C. Deregibus, V. Cantaluppi, L. Biancone, C. Tetta, G. Camussi, Microvesicles derived from mesenchymal stem cells enhance survival in a lethal model of acute kidney injury. PLoS ONE 7, e33115 (2012)

A. Ranghino, V. Cantaluppi, C. Grange, L. Vitillo, F. Fop, L. Biancone, M.C. Deregibus, C. Tetta, G.P. Segoloni, G. Camussi, Endothelial progenitor cell-derived microvesicles improve neovascularization in a murine model of hindlimb ischemia. Int. J. Immunopathol. Pharmacol. 25, 75–85 (2012)

R.C. Lai, T.S. Chen, S.K. Lim, Mesenchymal stem cell exosome: a novel stem cell-based therapy for cardiovascular disease. Regen. Med. 6, 481–492 (2011)

M.B. Herrera, V. Fonsato, S. Gatti, M.C. Deregibus, A. Sordi, D. Cantarella, R. Calogero, B. Bussolati, C. Tetta, G. Camussi, Human liver stem cell-derived microvesicles accelerate hepatic regeneration in hepatectomized rats. J. Cell Mol. Med. 14, 1605–1618 (2010)