Expression of vitamin D-metabolizing enzymes in human adipose tissue—the effect of obesity and diet-induced weight loss

Parikh SJ, Edelman M, Uwaifo GI, Freedman RJ, Semega-Janneh M, Reynolds J et al. The relationship between obesity and serum 1,25-dihydroxy vitamin D concentrations in healthy adults. J Clin Endocrinol Metab 2004; 89: 1196–1199.

Snijder MB, van Dam RM, Visser M, Deeg DJ, Dekker JM, Bouter LM et al. Adiposity in relation to vitamin D status and parathyroid hormone levels: a population-based study in older men and women. J Clin Endocrinol Metab 2005; 90: 4119–4123.

Vilarrasa N, Maravall J, Estepa A, Sanchez R, Masdevall C, Navarro MA et al. Low 25-hydroxyvitamin D concentrations in obese women: their clinical significance and relationship with anthropometric and body composition variables. J Endocrinol Invest 2007; 30: 653–658.

Carlin AM, Rao DS, Meslemani AM, Genaw JA, Parikh NJ, Levy S et al. Prevalence of vitamin D depletion among morbidly obese patients seeking gastric bypass surgery. Surg Obes Relat Dis 2006; 2: 98–103.

Stein EM, Strain G, Sinha N, Ortiz D, Pomp A, Dakin G et al. Vitamin-D insufficiency prior to bariatric surgery: risk factors and a pilot treatment study. Clin Endocrinol 2009; 71: 176–183.

Earthman CP, Beckman LM, Masodkar K, Sibley SD . The link between obesity and low circulating 25-hydroxyvitamin D concentrations: considerations and implications. Int J Obes 2012; 36: 387–396.

Holick MF . The Vitamin D Epidemic and its Health Consequences. J Nutr 2005; 135: 2739S–2748S.

Holick MF, Binkley NC, Bischoff-Ferrari HA, Gordon CM, Hanley DA, Heaney RP et al. Evaluation, Treatment, and Prevention of Vitamin D Deficiency: an Endocrine Society Clinical Practice Guideline. J Clin Endocrinol Metab 2011; 96: 1911–1930.

Reinehr T, de SG, Alexy U, Kersting M, Andler W . Vitamin D status and parathyroid hormone in obese children before and after weight loss. Eur J Endocrinol 2007; 157: 225–232.

Tzotzas T, Papadopoulou FG, Tziomalos K, Karras S, Gastaris K, Perros P et al. Rising serum 25-hydroxy-vitamin D levels after weight loss in obese women correlate with improvement in insulin resistance. J Clin Endocrinol Metab 2010; 95: 4251–4257.

Villareal DT, Shah K, Banks MR, Sinacore DR, Klein S . Effect of weight loss and exercise therapy on bone metabolism and mass in obese older adults: a one-year randomized controlled trial. J Clin Endocrinol Metab 2008; 93: 2181–2187.

Mason C, Xiao L, Imayama I, Duggan CR, Bain C, Foster-Schubert KE et al. Effects of weight loss on serum vitamin D in postmenopausal women. Am J Clin Nutr 2011; 94: 95–103.

Aasheim ET, Johnson LK, Hofsø D, Bøhmer T, Hjelmesæth J . Vitamin status after gastric bypass and lifestyle intervention: a comparative prospective study. Surg Obes Relat Dis 2011; 8: 169–175.

Lin E, Armstrong-Moore D, Liang Z, Sweeney JF, Torres WE, Ziegler TR et al. Contribution of adipose tissue to plasma 25-hydroxyvitamin d concentrations during weight loss following gastric bypass surgery. Obesity (Silver Spring) 2011; 19: 588–594.

Tsiftsis D, Mylonas P, Mead N, Kalfarentzos F, Alexandrides T . Bone mass decreases in morbidly obese women after long limb-biliopancreatic diversion and marked weight loss without secondary hyperparathyroidism. A physiological adaptation to weight loss? Obes Surg 2009; 19: 1497–1503.

Sinha N, Shieh A, Stein EM, Strain G, Schulman A, Pomp A et al. Increased PTH and 1.25(OH)2D levels associated with increased markers of bone turnover following bariatric surgery. Obesity Res 2011; 19: 2388–2393.

Ruiz-Tovar J, Oller I, Tomas A, Llavero C, Arroyo A, Calero A et al. Mid-term effects of sleeve gastrectomy on calcium metabolism parameters, vitamin D and parathormone (PTH) in morbid obese women. Obes Surg 2011; 22: 797–801.

Aasheim ET, Björkman S, Søvik TT, Engström M, Hanvold SE, Mala T et al. Vitamin status after bariatric surgery: a randomized study of gastric bypass and duodenal switch. Am J Clin Nutr 2009; 90: 15–22.

Pramyothin P, Biancuzzo RM, Lu Z, Hess DT, Apovian CM, Holick MF . Vitamin D in adipose tissue and serum 25-hydroxyvitamin D after Roux-en-Y gastric bypass. Obesity Res 2011; 19: 2228–2234.

Kull M, Kallikorm R, Lember M . Body mass index determines sunbathing habits: implications on vitamin D levels. Intern Med J 2009; 39: 256–258.

Bell NH, Epstein S, Greene A, Shary J, Oexmann MJ, Shaw S . Evidence for alteration of the vitamin D-endocrine system in obese subjects. J Clin Invest 1985; 76: 370–373.

Wortsman J, Matsuoka LY, Chen TC, Lu Z, Holick MF . Decreased bioavailability of vitamin D in obesity. Am J Clin Nutr 2000; 72: 690–693.

Drincic AT, Armas LAG, Van Diest EE, Heaney RP . Volumetric dilution, rather than sequestration best explains the low vitamin D status of obesity. Obesity 2012; 20: 1444–1448.

Blum M, Dolnikowski G, Seyoum E, Harris SS, Booth SL, Peterson J et al. Vitamin D(3) in fat tissue. Endocr 2008; 33: 90–94.

Heaney RP, Horst RL, Cullen DM, Armas LAG . Vitamin D3 distribution and status in the body. J Am Coll Nutr 2009; 28: 252–256.

Mawer EB, Backhouse J, Holman CA, Lumb GA, Stanbury SW . The distribution and storage of vitamin D and its metabolites in human tissues. Clin Sci 1972; 43: 413–431.

Rosenstreich SJ, Rich C, Volwiler W . Deposition in and release of vitamin D3 from body fat: evidence for a storage site in the rat. J Clin Invest 1971; 50: 679–687.

Cheng JB, Levine MA, Bell NH, Mangelsdorf DJ, Russell DW . Genetic evidence that the human CYP2R1 enzyme is a key vitamin D 25-hydroxylase. Proc Natl Acad Sci USA 2004; 101: 7711–7715.

Shinkyo R, Sakaki T, Kamakura M, Ohta M, Inouye K . Metabolism of vitamin D by human microsomal CYP2R1. Biochem Biophys Res Commun 2004; 324: 451–457.

Gupta RP, Hollis BW, Patel SB, Patrick KS, Bell NH . CYP3A4 is a human microsomal vitamin D 25-hydroxylase. J Bone Miner Res 2004; 19: 680–688.

Usui E, Noshiro M, Ohyama Y, Okuda K . Unique property of liver mitochondrial P450 to catalyze the two physiologically important reactions involved in both cholesterol catabolism and vitamin D activation. FEBS Letters 1990; 274: 175–177.

Aiba I, Yamasaki T, Shinki T, Izumi S, Yamamoto K, Yamada S et al. Characterization of rat and human CYP2J enzymes as Vitamin D 25-hydroxylases. Steroids 2006; 71: 849–856.

Takeyama Ki Kitanaka S, Sato T, Kobori M, Yanagisawa J, Kato S . 25-Hydroxyvitamin D3 1-alpha-hydroxylase and vitamin D synthesis. Science 1997; 277: 1827–1830.

Lawson DE, Fraser DR, Kodicek E, Morris HR, Williams DH . Identification of 1,25-dihydroxycholecalciferol, a new kidney hormone controlling calcium metabolism. Nature 1971; 230: 228–230.

Zehnder D, Bland R, Williams MC, McNinch RW, Howie AJ, Stewart PM et al. Extrarenal expression of 25-hydroxyvitamin d(3)-1 alpha-hydroxylase. J Clin Endocrinol Metab 2001; 86: 888–894.

Beckman MJ, Tadikonda P, Werner E, Prahl J, Yamada S, DeLuca HF . Human 25-hydroxyvitamin D3-24-hydroxylase, a multicatalytic enzyme. Biochemistry 1996; 35: 8465–8472.

Jones G, Prosser DE, Kaufmann M . 25-Hydroxyvitamin D-24-hydroxylase (CYP24A1): Its important role in the degradation of vitamin D. Arch Biochem Biophys 2011; 523: 9–18.

Ellero S, Chakhtoura G, Barreau C, Langouët S, Benelli C, Penicaud L et al. Xenobiotic-Metabolizing Cytochromes P450 in Human White Adipose Tissue: Expression and Induction. Drug Metab Dispos 2010; 38: 679–686.

Li J, Byrne ME, Chang E, Jiang Y, Donkin SS, Buhman KK et al. 1alpha,25-Dihydroxyvitamin D hydroxylase in adipocytes. J Steroid Biochem Mol Biol 2008; 112: 122–126.

Haussler MR, Jurutka PW, Mizwicki M, Norman AW . Vitamin D receptor (VDR)-mediated actions of 1,25(OH)2vitamin D3: Genomic and non-genomic mechanisms. Best Pract Res Clin Endocrinol Metab 2011; 25: 543–559.

Kamei Y, Kawada T, Kazuki R, Ono T, Kato S, Sugimoto E . Vitamin D receptor gene expression is up-regulated by 1, 25-dihydroxyvitamin D3 in 3T3-L1 preadipocytes. Biochem Biophys Res Commun 1993; 193: 948–955.

Querfeld U, Hoffmann MM, Klaus G, Eifinger F, Ackerschott M, Michalk D et al. Antagonistic effects of vitamin D and parathyroid hormone on lipoprotein lipase in cultured adipocytes. J Am Soc Nephrol 1999; 10: 2158–2164.

Fisker S, Hansen B, Fuglsang J, Kristensen K, Ovesen P, Orskov H et al. Gene expression of the GH receptor in subcutaneous and intraabdominal fat in healthy females: relationship to GH-binding protein. Eur J Endocrinol 2004; 150: 773–777.

Christiansen T, Paulsen SK, Bruun JM, Overgaard K, Ringgaard S, Pedersen SB et al. Comparable reduction of the visceral adipose tissue depot after a diet-induced weight loss with or without aerobic exercise in obese subjects: a 12-week randomized intervention study. Eur J Endocrinol 2009; 160: 759–767.

Bruun JM, Lihn AS, Pedersen SB, Richelsen Br . Monocyte chemoattractant protein-1 release is higher in visceral than subcutaneous human adipose tissue (AT): implication of macrophages resident in the AT. J Clin Endocrinol Metab 2005; 90: 2282–2289.

Maunsell Z, Wright DJ, Rainbow SJ . Routine isotope-dilution liquid chromatography-tandem mass spectrometry assay for simultaneous measurement of the 25-hydroxy metabolites of vitamins D2 and D3. Clin Chem 2005; 51: 1683–1690.

Hojskov CS, Heickendorff L, Moller HJ . High-throughput liquid-liquid extraction and LCMSMS assay for determination of circulating 25(OH) vitamin D3 and D2 in the routine clinical laboratory. Clin Chim Acta 2010; 411: 114–116.

Mosekilde L, Nielsen LR, Larsen ER, Moosgaard B, Heickendorff L . Vitamin D deficiency. Definition and prevalence in Denmark. Ugeskr Laeger 2005; 167: 29–33.

Botella-Carretero JI, Alvarez-Blasco F, Villafruela JJ, Balsa JA, Vazquez C, Escobar-Morreale HF . Vitamin D deficiency is associated with the metabolic syndrome in morbid obesity. Clin Nutr 2007; 26: 573–580.

de Luis DA, Pacheco D, Izaola O, Terroba MC, Cuellar L, Cabezas G . Micronutrient status in morbidly obese women before bariatric surgery. Surg Obes Relat Dis 2011; e-pub ahead of print 29 October 2011; doi:10.1016/j.soard.2011.09.015.

Fish E, Beverstein G, Olson D, Reinhardt S, Garren M, Gould J . Vitamin D status of morbidly obese bariatric surgery patients. J Surg Res 2010; 164: 198–202.

Buffington C, Walker B, Cowan GS, Scruggs D . Vitamin D deficiency in the morbidly obese. Obes Surg 1993; 3: 421–424.

Geng S, Zhou S, Glowacki J . Effects of 25-hydroxyvitamin D3 on proliferation and osteoblast differentiation of human marrow stromal cells require CYP27B1/1a-hydroxylase. J Bone Miner Res 2011; 26: 1145–1153.

Holick MF . Vitamin D: extraskeletal health. Endocrinol Metab Clin North Am 2010; 39: 381–400.

Lorente-Cebrián S, Eriksson A, Dunlop T, Mejhert N, Dahlman I, Åström G et al. Differential effects of 1,25-dihydroxycholecalciferol on MCP-1 and adiponectin production in human white adipocytes. Eur J Nutr 2012; 51: 335–344.

Sun C, Qi R, Wang L, Yan J, Wang Y . p38 MAPK regulates calcium signal-mediated lipid accumulation through changing VDR expression in primary preadipocytes of mice. Mol Biol Rep 2011; 39: 3179–3184.