Expression of the melanin‐concentrating hormone (MCH) receptor mRNA in the rat brain

Journal of Comparative Neurology - Tập 435 Số 1 - Trang 26-40 - 2001
Yumiko Saito1, Michelle Cheng, Frances M. Leslie, Olivier Civelli
1Department of Pharmacology, University of California, Irvine, Irvine, California 92697-4625, USA.

Tóm tắt

AbstractThe melanin‐concentrating hormone (MCH) system is thought to be an important regulator of food intake. Recently the orphan G protein‐coupled receptor SLC‐1 was identified as the MCH receptor (MCHR). Preliminary analyses of MCHR mRNA distribution have supported a role for the MCH system in nutritional homeostasis. We report here a complete anatomical distribution of the MCHR mRNA. We have found high levels of expression of MCHR mRNA in most anatomical areas implicated in control of olfaction, with the exception of the main olfactory bulb. Dense labeling was also detected in the hippocampal formation, subiculum, and basolateral amygdala, all of which are important in learning and memory, and in the shell of the nucleus accumbens, a substrate for motivated behavior and feeding. Within the hypothalamus, MCHR mRNA was moderately expressed in the ventromedial nucleus, arcuate nucleus, and zona incerta, all of which serve key roles in the neuronal circuitry of feeding. In the brainstem, strong expression was observed in the locus coeruleus, which is implicated in arousal, as well as in nuclei that contribute to orofacial function and mastication, including the facial, hypoglossal, motor trigeminal, and dorsal motor vagus nuclei. In most regions there was a good correspondence between MCHR mRNA distribution and that of MCH‐immunoreactive fibers. Taken together, these data suggest that MCH may act at various levels of the brain to integrate various aspects of feeding behavior. However, the extensive MCHR distribution throughout the brain suggests that this receptor may play a role in other functions, most notably reinforcement, arousal, sensorimotor integration, and autonomic control. J. Comp. Neurol. 435:26–40, 2001. © 2001 Wiley‐Liss, Inc.

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Tài liệu tham khảo

Amaral DG, 1995, The rat nervous system, 473

10.1016/S0014-5793(99)01092-3

10.1111/j.1749-6632.1993.tb19690.x

10.1016/0306-4522(91)90151-D

10.1002/cne.903190204

10.1002/cne.903240203

10.1002/cne.903480103

10.1038/22313

10.1016/S0014-5793(98)00524-9

Clark DL, 1999, The brain and the behavior, 146

10.1002/cne.901810202

10.1016/S0092-8674(00)80937-X

10.1152/physrev.1983.63.3.844

10.1016/0306-4522(91)90299-4

10.1016/0196-9781(95)02092-6

10.1159/000127246

10.1016/0306-4522(87)90268-5

Hervieu G, 1996, Similarities in cellular expression and functions of melanin‐concentrating hormone and atrial natriuretic factor in the rat digestive tract, Endocrinology, 137, 561, 10.1210/endo.137.2.8593803

10.1046/j.1460-9568.2000.00008.x

10.1152/ajplegacy.1942.136.4.609

10.1210/en.130.2.1024

Joens EG, 1974, Retrograde axonal transport and the demonstration of non‐specific projections to the cerebral cortex and striatum from thalamic intralaminar nuclei in the rat, cat and monkey, J Comp Neurol, 154, 349, 10.1002/cne.901540402

10.1038/305321a0

10.1016/0031-9384(86)90209-X

10.1126/science.271.5248.512

Knollema S, 1992, Novel hypothalamic and preoptic sites of prepro‐melanin‐concentrating hormone messenger ribonucleic acid and peptide expression in lactating rat, J Endocrinol, 4709

Kolakowski LF, 1996, Characterization of a human gene related to genes encoding somatostatin receptors, FEBS Lett, 398, 255, 10.1016/S0014-5793(96)01160-X

10.1016/0018-506X(90)90019-T

Lakaye B, 1997, Cloning of the rat brain cDNA encoding for the SLC‐1 G protein coupled receptor reveals the presence of an intron in the gene, Biochem Biophys Acta, 1401, 216, 10.1016/S0167-4889(97)00135-3

10.1038/12978

10.1152/ajpendo.1998.274.4.E627

10.1126/science.287.5451.248

10.1016/0196-9781(93)90128-4

10.1016/S0031-9384(99)00117-1

Neave N, 1997, Evidence for the involvement of the mammillary bodies and cingulum bundle in allocentric spatial processing by rats, Eur J Neurosci, 8, 941, 10.1111/j.1460-9568.1997.tb01445.x

Ottersen OP, 1979, Afferent connections to the amygdaloid complex of the rat and cat. I. Projections from the thalamus, J Comp Neurol, 205, 30

10.1126/science.283.5400.401

10.1002/cne.901510204

10.1038/380243a0

10.1016/S0959-4388(96)80077-8

10.1210/endo.138.1.4887

10.1016/S0006-8993(99)01922-8

10.1038/22321

10.1016/S0196-9781(96)00327-0

10.1038/25341

10.1016/0006-8993(87)91508-3

10.1006/bbrc.1999.1104

10.1002/cne.902940107

10.1016/0361-9230(85)90213-8

10.1523/JNEUROSCI.10-09-03106.1990

10.1152/jn.1982.48.2.352

10.1523/JNEUROSCI.17-11-04434.1997

10.1016/S0166-4328(97)00140-X

10.1126/science.49928

Swanson LW, 1979, The connections of the septal region in the rat. J Comp, Neurol, 186, 621

10.1016/S0166-2236(98)01265-X

Travers G, 1995, The rat nervous system, 239

10.1037/0735-7044.106.4.698

10.1016/0031-9384(73)90285-0

Walsh LL, 1975, Loss of feeding to 2‐deoxy‐D‐glucose but not insulin after zona incerta lesions in the rat, Physiol Behav, 15, 481, 10.1016/0031-9384(75)90263-2

10.1016/S1385-299X(98)00043-9

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Journal of Comparative Neurology

Tập 435 Số 1

26-40

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