Expression of Immediate Early Genes in Sensory Ganglia

Neurochemical Research - 2001
David A. Groneberg1, Silke Wiegand2, Q. Thai Dinh1, Christian Peiser2, Jochen Springer2, Axel Fischer1
1Division of Allergy Research, Biomedical Research Center, Charité Medical School, Humboldt University of Berlin, Berlin, Germany
2Institute of Anatomy and Cell Biology, School of Medicine, Justus-Liebig-University Giessen, Giessen, Germany

Tóm tắt

C-Jun and c-Fos belong to the family of immediate early genes. Apart from their role as transcription factors, a basal expression was shown for them in central nervous system tissues. The expression of c-Jun and c-Fos in sensory ganglia of guinea pig, rat and murine sensory ganglia was examined under normal, unstimulated conditions by quantitative double-immunohistochemistry. 4.6 ± 2.8% of neuron-specific protein gene-product 9.5 -positive cells in nodose ganglia, 51.6 ± 2.1% in jugular ganglia, 46.4 ± 3.0% in trigeminal ganglia and 42.5 ± 1.3% of cervical dorsal root ganglia neurons were positive for c-Jun in the guinea pig (less than 1% for c-Fos). In rat and mouse, less than 1% of the sensory neurons exhibited c-Jun and c-Fos-immunoreactivity. The high basal expression of c-Jun in guinea pig sensory neurons suggests that in this species the presence of c-Jun does not only depend on specific stimulation and is not exclusively associated with neuronal plasticity of gene expression and functional changes.

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