Expression of IL-5 receptors on B cells: Role in mucosal B cell responses
Tóm tắt
IL-5 plays an important role in mucosal B cell responses. An in vitro model of IgA B cell differentiation, CH12LX, has been used to demonstrate that IL-5R are expressed on both IgM+ and IgA+ B cells and that IL-5 will enhance secretion of both IgM and IgA by CH12LX B cells, depending on the surface isotype of individual cells. Further, the enhanced secretion of Ig in response to IL-5 is associated with increased steady-state levels of Ig mRNA. Finally, normal Peyer's patch B cells are also capable of expressing IL-5R in response to appropriate stimuli (i.e. anti-IgM- or anti-IgD-dextran). Thus, mucosal B cell responses to IL-5 are brought about by interaction of IL-5 with specific receptors expressed on the surface of those cells.
Từ khóa
Tài liệu tham khảo
Harriman GR, Strober W: The immunobiology of interleukin 5; in Cruse JM, Lewis RE Jr (eds): The Year in Immunology 1988. Immunoregulatory Cytokines and Cell Growth. Year Immunol. Basel, Karger, 1989, vol 5, pp 160–177.
Murray PD, McKenzie DT, Swain SL, Kagnoff MF: Interleukin 5 and interleukin 4 produced by Peyer's patch T cells selectively enhance immunoglobulin A expression. J Immunol 1987;139:2669–2674.
Coffman RL, Shrader B, Carty K, Mosmann TR, Bond MW: A mouse T cell product that preferentially enhances IgA production. I. Biologic characterization. J Immunol 1987;139:3685–3690.
Harriman GR, Kunimoto DY, Elliot JF, Paetkau V, Strober W: The role of IL-5 in IgA B cell differentiation. J Immunol 1988;140:3033–3039.
Beagley KW, Eldridge JH, Kiyono H, Everson MP, Koopman WJ, Honjo T, McGhee JR: Recombinant murine IL-5 induces high rate IgA synthesis in cycling IgA-positive Peyer's patch B cells. J Immunol 1988;141:2035–2042.
Lebman DA, Coffman RL: The effects of IL-4 and IL-5 on the IgA response by murine Peyer's patch B cell subpopulations. J Immunol 1988;141:2050–2056.
Schoenbeck S, McKenzie DT, Kagnoff MF: Interleukin 5 is a differentiation factor for IgA B cells. Eur J Immunol 1989;19:965–969.
Mita S, Harada N, Naomi S, Hitoshi Y, Sakamoto K, Akagi M, Tominaga A, Takatsu K: Receptors for T cell-replacing factor/interleukin 5. Specificity, quantitation, and its implication. J Exp Med 1988;168:863–878.
Mita S, Tominaga A, Hitoshi Y, Sakamota K, Honjo T, Akagi M, Kikuchi Y, Yamaguchi N, Takatsu K: Characterization of high-affinity receptors for interleukin 5 on interleukin 5-dependent cell lines. Proc Natl Acad Sci USA 1989;86:2311–2315.
Rolink AG, Melchers F, Palacios R: Monoclonal antibodies reactive with the mouse interleukin 5 receptor. J Exp Med 1989;169:1693–1701.
Hitoshi Y, Yamaguchi N, Mita S, Sonada E, Takaki S, Tominaga A, Takatsu K: Distribution of IL-5 receptor-positive B cells. Expression of IL-5 receptor on Ly-1 (CD5)+ B cells. J Immunol 1990; 144:4218–4225.
Kunimoto DY, Harriman GR, Strober W: Regulation of IgA differentiation in CH12LX B cells by lymphokines. IL-4 induces membrane IgM-positive CH12LX cells to express membrane IgA and IL-5 induces membrane IgA-positive CH12LX cells to secrete IgA. J Immunol 1988; 141:713–720.
Kunimoto DY, Allison KC, Watson C, Fuerst T, Armstrong GD, Paul W, Strober W: Baculovirus expression of murine IL-5 and its purification. Cytokine, in press.
Schumacher JH, O'Garra A, Shrader B, Van Kimmenade A, Bond MW, Mosmann TR, Coffman RL: The characterization of four monoclonal antibodies specific for mouse IL-5 and development of mouse and human enzyme-linked immunosorbent (sic). J Immunol 1988;141:1576–1581.