Expression of IGF-1 receptor and GH receptor in hepatic tissue of patients with nonalcoholic fatty liver disease and nonalcoholic steatohepatitis

Bellentani, 2010, Epidemiology of non-alcoholic fatty liver disease, Dig. Dis., 28, 155, 10.1159/000282080 Wree, 2013, From NAFLD to NASH to cirrhosis-new insights into disease mechanisms, Nat. Rev. Gastroenterol. Hepatol., 10, 627, 10.1038/nrgastro.2013.149 Chalasani, 2012, The diagnosis and management of non-alcoholic fatty liver disease: practice guideline by the American Association for the Study of Liver Diseases, American College of Gastroenterology, and the American Gastroenterological Association, Am. J. Gastroenterol., 107, 811, 10.1038/ajg.2012.128 Charlton, 2008, Cirrhosis and liver failure in nonalcoholic fatty liver disease: molehill or mountain?, Hepatology., 47, 1431, 10.1002/hep.22246 Utz, 2008, Growth hormone deficiency by growth hormone releasing hormone-arginine testing criteria predicts increased cardiovascular risk markers in normal young overweight and obese women, J. Clin. Endocrinol. Metab., 93, 2507, 10.1210/jc.2008-0169 Chaves, 2013, The metabolic effects of growth hormone in adipose tissue, Endocrine., 44, 293, 10.1007/s12020-013-9904-3 Giustina, 2008, Growth hormone, insulin-like growth factors, and the skeleton, Endocr. Rev., 29, 535, 10.1210/er.2007-0036 Gleeson, 2005, Insulin-like growth factor-I response to a single bolus of growth hormone is increased in obesity, J. Clin. Endocrinol. Metab., 90, 1061, 10.1210/jc.2004-0501 Nishizawa, 2012, GH-independent IGF-I action is essential to prevent the development of nonalcoholic steatohepatitis in a GH-deficient rat model, Biochem. Biophys. Res. Commun., 423, 295, 10.1016/j.bbrc.2012.05.115 Sos, 2011, Abrogation of growth hormone secretion rescues fatty liver in mice with hepatocyte-specific deletion of JAK2, J. Clin. Invest., 121, 1412, 10.1172/JCI42894 Cordoba-Chacon, 2015, Growth hormone inhibits hepatic de novo lipogenesis in adult mice, Diabetes, 64, 3093, 10.2337/db15-0370 Nordstrom, 2013, Disruption of JAK2 in adipocytes impairs lipolysis and improves fatty liver in mice with elevated GH, Mol. Endocrinol., 27, 1333, 10.1210/me.2013-1110 Fan, 2009, Liver-specific deletion of the growth hormone receptor reveals essential role of growth hormone signaling in hepatic lipid metabolism, J. Biol. Chem., 284, 19937, 10.1074/jbc.M109.014308 Barclay, 2011, GH-dependent STAT5 signaling plays an important role in hepatic lipid metabolism, Endocrinology., 152, 181, 10.1210/en.2010-0537 Collin de l’Hortet, 2014, GH administration rescues fatty liver regeneration impairment by restoring GH/EGFR pathway deficiency, Endocrinology., 155, 2545, 10.1210/en.2014-1010 Matsumoto, 2014, Long-term effects of growth hormone replacement therapy on liver function in adult patients with growth hormone deficiency, Growth Hormon. IGF Res., 24, 174, 10.1016/j.ghir.2014.07.002 Nishizawa, 2012, Nonalcoholic fatty liver disease in adult hypopituitary patients with GH deficiency and the impact of GH replacement therapy, Eur.J. Endocrinol./ Eur. Fed. Endocrine Soc., 167, 67, 10.1530/EJE-12-0252 Takahashi, 2007, Growth hormone reverses nonalcoholic steatohepatitis in a patient with adult growth hormone deficiency, Gastroenterology., 132, 938, 10.1053/j.gastro.2006.12.024 Beauregard, 2008, Growth hormone decreases visceral fat and improves cardiovascular risk markers in women with hypopituitarism: a randomized, placebo-controlled study, J. Clin. Endocrinol. Metab., 93, 2063, 10.1210/jc.2007-2371 Snel, 1995, Magnetic resonance imaging-assessed adipose tissue and serum lipid and insulin concentrations in growth hormone-deficient adults. Effect of growth hormone replacement, Arterioscler. Thromb. Vasc. Biol., 15, 1543, 10.1161/01.ATV.15.10.1543 Bengtsson, 1992, Effects of growth hormone on fat mass and fat distribution, Acta Paediatr. Suppl., 383, 62 Bredella, 2012, Effects of GH in women with abdominal adiposity: a 6-month randomized, double-blind, placebo-controlled trial, Eur. J. Endocrinol., 166, 601, 10.1530/EJE-11-1068 Bredella, 2013, Effects of GH on body composition and cardiovascular risk markers in young men with abdominal obesity, J. Clin. Endocrinol. Metab., 98, 3864, 10.1210/jc.2013-2063 Massague, 1982, The subunit structures of two distinct receptors for insulin-like growth factors I and II and their relationship to the insulin receptor, J. Biol. Chem., 257, 5038, 10.1016/S0021-9258(18)34631-3 Caro, 1998, Insulin-like growth factor I binding in hepatocytes from human liver, human hepatoma, and normal, regenerating, and fetal rat liver, J. Clin. Invest., 81, 976, 10.1172/JCI113451 Stefano, 2006, Increased hepatic expression of insulin-like growth factor-I receptor in chronic hepatitis C, World J. Gastroenterol., 12, 3821, 10.3748/wjg.v12.i24.3821 Alisi, 2018, Expression of insulin-like growth factor I and its receptor in the liver of children with biopsy-proven NAFLD, PLoS One, 13, 10.1371/journal.pone.0201566 Kleiner, 2005, Design and validation of a histological scoring system for nonalcoholic fatty liver disease, Hepatology., 41, 1313, 10.1002/hep.20701 Subudhi, 2021, Distinct hepatic gene-expression patterns of NAFLD in patients with obesity, Hepatol Commun., 6, 77, 10.1002/hep4.1789 Bartoszek, 2015, The new statistics with R: an introduction for biologists. — by Andy Hector, Syst. Biol., 64, 1125, 10.1093/sysbio/syv049 McCarthy, 2012, Differential expression analysis of multifactor RNA-Seq experiments with respect to biological variation, Nucleic Acids Res., 40, 4288, 10.1093/nar/gks042 Dichtel, 2017, The association between IGF-1 levels and the histologic severity of nonalcoholic fatty liver disease, Clin. Transl. Gastroenterol., 8, 10.1038/ctg.2016.72 Bennett, 1996, Differential regulation of the growth hormone receptor gene: effects of dexamethasone and estradiol, Endocrinology., 137, 3891, 10.1210/endo.137.9.8756562 Maes, 1983, Ontogeny of liver somatotropic and lactogenic binding sites in male and female rats, Endocrinology., 113, 1325, 10.1210/endo-113-4-1325 Baxter, 1980, Somatogenic receptors of rat liver: regulation by insulin, Endocrinology., 107, 1176, 10.1210/endo-107-4-1176 Leung, 2004, Estrogen regulation of growth hormone action, Endocr. Rev., 25, 693, 10.1210/er.2003-0035 Span, 2000, Gender difference in insulin-like growth factor I response to growth hormone (GH) treatment in GH-deficient adults: role of sex hormone replacement, J. Clin. Endocrinol. Metab., 85, 1121, 10.1210/jcem.85.3.6463 Balakrishnan, 2021, Women have a lower risk of nonalcoholic fatty liver disease but a higher risk of progression vs men: a systematic review and meta-analysis, Clin. Gastroenterol. Hepatol., 19, 61, 10.1016/j.cgh.2020.04.067 Gutierrez-Grobe, 2010, Prevalence of non alcoholic fatty liver disease in premenopausal, posmenopausal and polycystic ovary syndrome women. The role of estrogens, Ann. Hepatol., 9, 402, 10.1016/S1665-2681(19)31616-3 Klair, 2016, A longer duration of estrogen deficiency increases fibrosis risk among postmenopausal women with nonalcoholic fatty liver disease, Hepatology., 64, 85, 10.1002/hep.28514 Matsuo, 2016, Surgical menopause and increased risk of nonalcoholic fatty liver disease in endometrial cancer, Menopause., 23, 189, 10.1097/GME.0000000000000500 Schneider, 1979, Increased estrogen production in obese men, J. Clin. Endocrinol. Metab., 48, 633, 10.1210/jcem-48-4-633 Sarmento-Cabral, 2021, GH directly inhibits steatosis and liver injury in a sex-dependent and IGF1-independent manner, J. Endocrinol., 248, 31, 10.1530/JOE-20-0326 Sanz, 2005, Expression of insulin-like growth factor I by activated hepatic stellate cells reduces fibrogenesis and enhances regeneration after liver injury, Gut, 54, 134, 10.1136/gut.2003.024505 Desbois-Mouthon, 2006, Hepatocyte proliferation during liver regeneration is impaired in mice with liver-specific IGF-1R knockout, FASEB J., 20, 773, 10.1096/fj.05-4704fje Eslam, 2020, A new definition for metabolic dysfunction-associated fatty liver disease: an international expert consensus statement, J. Hepatol., 73, 202, 10.1016/j.jhep.2020.03.039 Eslam, 2020, MAFLD: a consensus-driven proposed nomenclature for metabolic associated fatty liver disease, Gastroenterology., 158, 1999, 10.1053/j.gastro.2019.11.312