Expression of Activated PKC Epsilon (PKC ϵ) Protects the Ischemic Heart, without Attenuating Ischemic H+ Production

Journal of Molecular and Cellular Cardiology - Tập 34 Số 3 - Trang 361-367 - 2002
H. R. Cross1, Elizabeth Murphy, Roberto Bolli, Peipei Ping, Charles Steenbergen
1Department of Pathology, Duke University Medical Center, Durham, NC 27710, USA. [email protected]

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Mochly-Rosen, 1995, Localization of protein kinases by anchoring proteins: a theme in signal transduction, Science, 268, 247, 10.1126/science.7716516

Mitchell, 1995, Preconditioning of isolated rat heart is mediated by protein kinase C, Circ Res, 76, 73, 10.1161/01.RES.76.1.73

Speechly-Dick, 1994, Protein kinase C. Its role in ischemic preconditioning in the rat, Circ Res, 75, 586, 10.1161/01.RES.75.3.586

Ytrehus, 1994, Preconditioning protects ischemic rabbit heart by protein kinase C, Am J Physiol, 266, H1145

Murry, 1990, Ischemic preconditioning slows energy metabolism and delays ultrastructural damage during a sustained ischemic episode, Circ Res, 66, 913, 10.1161/01.RES.66.4.913

Kida, 1991, Ischemic preconditioning preserves creatine phosphate and intracellular pH, Circulation, 84, 2495, 10.1161/01.CIR.84.6.2495

Steenbergen, 1993, Mechanisms of preconditioning: ionic alterations, Circ Res, 72, 112, 10.1161/01.RES.72.1.112

de Albuquerque, 1994, Importance of metabolic inhibition and cellular pH in mediating preconditioning contractile and metabolic effects in rat hearts, Circ Res, 74, 139, 10.1161/01.RES.74.1.139

Ping, 1997, Ischemic preconditioning induces selective translocation of protein kinase C isoforms ϵ and in the heart of conscious rabbits without subcellular redistribution of total protein kinase C activity, Circ Res, 81, 404, 10.1161/01.RES.81.3.404

Gray, 1997, A selective ϵ-protein kinase C antagonist inhibits protection of cardiac myocytes from hypoxia-induce cell death, J Biol Chem, 272, 30945, 10.1074/jbc.272.49.30945

Dorn, 1999, Sustained in vivo cardiac protection by a rationally designed peptide that causes ϵ protein kinase C translocation, Proc Nat Acad Sci USA, 96, 12798, 10.1073/pnas.96.22.12798

Pass, 2001, Enhanced PKCβII translocation and PKCβII-RACK1 interactions in PKCϵ-induced cardiac hypertrophy and failure—a role for RACK1, Am J Physiol, 281, H2500

Cross, 1999, Overexpression of the β2-adrenergic receptor and a βARK1 inhibitor both increase contractility but have differential effects on susceptibility to ischemic injury, Circ Res, 85, 1077, 10.1161/01.RES.85.11.1077

Jennings, 1990, Development of cell injury in sustained acute ischemia, Circulation, 82, II.2

Chen, 1996, Effect of ischemic preconditioning and PKC activation on acidification during ischemia in rat heart, J Mol Cell Cardiol, 28, 871, 10.1006/jmcc.1996.0082

Cave, 1997, Ischemic preconditioning and intracellular pH: a 31P NMR study in the isolated rat heart, Am J Physiol, 272, H544

Pass, 2001, PKC activation induces dichotomous cardiac phenotypes and modulates PKC-RACK interactions and RACK expression, Am J Physiol, 280, H946