Expression of Activated Epidermal Growth Factor Receptors, Ras-Guanosine Triphosphate, and Mitogen-activated Protein Kinase in Human Glioblastoma Multiforme Specimens

Neurosurgery - Tập 45 Số 6 - Trang 1442-1453 - 1999
Matthias M. Feldkamp1, Prateek Lala2, Nelson Lau2, Luba Roncari2, Abhijit Guha2
1Samuel Lunenfeld Research Institute, Mount Sinai Hospital, University of Toronto, Ontario, Canada
2Samuel Lunenfeld Research Institute, Mount Sinai Hospital

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1998, Recombinant humanized anti-HER2 antibody (Herceptin) enhances the antitumor activity of paclitaxel and doxorubicin against HER2/neu-overexpressing human breast cancer xenografts, Cancer Res, 58, 2825

1996, Phase II study of weekly intravenous recombinant humanized anti-p185HER2 monoclonal antibody in patients with HER2/neu-overexpressing metastatic breast cancer, J Clin Oncol, 14, 737, 10.1200/JCO.1996.14.3.737

1988, Gene amplification in malignant human gliomas: Clinical and histopathologic aspects, J Neuropathol Exp Neurol, 47, 191, 10.1097/00005072-198805000-00001

1990, Characterization of the epidermal growth factor receptor in human glioma cell lines and xenografts, Cancer Res, 50, 8017

1989, Ras oncogenes in human cancers: A review, Cancer Res, 49, 4682

1994, JNK1: A protein kinase stimulated by UV light and Ha-Ras that binds and phosphorylates the c-Jun activation domain, Cell, 76, 1025, 10.1016/0092-8674(94)90380-8

1994, Functional characterization of an EGF receptor with a truncated extracellular domain expressed in glioblastomas with EGFR gene amplification, Oncogene, 9, 2313

1998, Tandem duplication of the epidermal growth factor receptor tyrosine kinase and calcium internalization domains in A-172 glioma cells, Oncogene, 16, 3435, 10.1038/sj.onc.1202156

1993, Expression of mutated epidermal growth factor receptor by non-small cell lung carcinomas, Cancer Res, 53, 3217

1995, Expression of PDGF and PDGF receptors in human astrocytoma operative specimens supports the existence of an autocrine loop, Int J Cancer, 60, 168, 10.1002/ijc.2910600206

1997, Proliferation of human malignant astrocytomas is dependent on Ras activation, Oncogene, 15, 2755, 10.1038/sj.onc.1201455

1995, Expression of platelet derived growth factor and platelet derived growth factor receptor mRNA in a glioblastoma from a patient with Li-Fraumeni syndrome, J Neurol Neurosurg Psychiatry, 58, 711, 10.1136/jnnp.58.6.711

1996, Ras-GTP levels are elevated in human NF1 peripheral nerve tumours, Oncogene, 12, 507

1996, Tyrphostin AG 1478 preferentially inhibits human glioma cells expressing truncated rather than wild-type epidermal growth factor receptors, Cancer Res, 56, 3859

1995, Specific targeting of a mutant, activated EGF receptor found in glioblastoma using a monoclonal antibody, Int J Cancer, 63, 537, 10.1002/ijc.2910630414

1997, The enhanced tumorigenic activity of a mutant epidermal growth factor receptor common in human cancers is mediated by threshold levels of constitutive tyrosine phosphorylation and unattenuated signaling, J Biol Chem, 272, 2927, 10.1074/jbc.272.5.2927

1990, Anti-synthetic peptide antibody reacting at the fusion junction of deletion-mutant epidermal growth factor receptors in human glioblastoma, Proc Natl Acad Sci U S A, 87, 4207, 10.1073/pnas.87.11.4207

1991, Histological Typing of Tumors of the Nervous System

1997, PTEN: A putative protein tyrosine phosphatase gene mutated in human brain, breast, and prostate cancer, Science, 275, 1943, 10.1126/science.275.5308.1943

1984, Expression of epidermal growth factor receptors in human brain tumors, Cancer Res, 44, 753

1994, The p53 gene and protein in human brain tumors, J Neuropathol Exp Neurol, 53, 11, 10.1097/00005072-199401000-00002

1995, A tiger behind many doors: Multiple genetic pathways to malignant glioma, Trends Genet, 11, 412, 10.1016/S0168-9525(00)89125-8

1995, Specificity of receptor tyrosine kinase signaling: Transient versus sustained extracellular signal-regulated kinase activation, Cell, 80, 179, 10.1016/0092-8674(95)90401-8

1997, DMBT1, a new member of the SRCR superfamily, on chromosome 10q25.3–26.1 is deleted in malignant brain tumours, Nat Genet, 17, 32, 10.1038/ng0997-32

1995, Differential modulation of mitogen-activated protein (MAP) kinase/extracellular signal-related kinase kinase and MAP kinase activities by a mutant epidermal growth factor receptor, J Biol Chem, 270, 30562, 10.1074/jbc.270.51.30562

1995, Frequent expression of a mutant epidermal growth factor receptor in multiple human tumors, Cancer Res, 55, 5536

1996, Transformational and altered signal transduction by a naturally occurring mutant EGF receptor, Oncogene, 13, 85

1997, A naturally occurring mutant human epidermal growth factor receptor as a target for peptide vaccine immunotherapy of tumors, Cancer Res, 57, 1419

1996, A common mutant epidermal growth factor receptor confers enhanced tumorigenicity on human glioblastoma cells by increasing proliferation and reducing apoptosis, Cancer Res, 56, 5079

1995, Loss of P16INK4 expression is frequent in high grade gliomas, Cancer Res, 55, 1941

1994, A mutant epidermal growth factor receptor common in human gliomas confers enhanced tumorigenicity, Proc Natl Acad Sci U S A, 91, 7727, 10.1073/pnas.91.16.7727

1996, Monoclonal antibody against the fusion junction of a deletion-mutant epidermal growth factor receptor, Br J Cancer, 73, 1366, 10.1038/bjc.1996.260

1998, Gene amplification as a prognostic factor in primary brain tumors, Clin Cancer Res, 4, 215

1998, Inhibition of a naturally occurring EGFR oncoprotein by the p185neu ectodomain: Implications for subdomain contributions to receptor assembly, Oncogene, 16, 1197, 10.1038/sj.onc.1201635

1998, Phase II study of receptor-enhanced chemosensitivity using recombinant humanized anti-p185HER2/neu monoclonal antibody plus cisplatin in patients with HER2/neu-overexpressing metastatic breast cancer refractory to chemotherapy treatment, J Clin Oncol, 16, 2659, 10.1200/JCO.1998.16.8.2659

1992, Vascular endothelial growth factor is a potential tumour angiogenesis factor in human gliomas in vivo, Nature, 359, 845, 10.1038/359845a0

1993, Her-2/neu expression in node-negative breast cancer: Direct tissue quantitation by computerized image analysis and association of overexpression with increased risk of recurrent disease, Cancer Res, 53, 4960

1996, Enhanced tumorigenic behavior of glioblastoma cells expressing a truncated epidermal growth factor receptor is mediated through the Ras-Shc-Grb2 pathway, J Biol Chem, 271, 25639, 10.1074/jbc.271.41.25639

1997, Expression of a variant epidermal growth factor receptor in Barrett's esophagus and gastric adenocarcinoma, Proc Am Assoc Cancer Res, 38, 277

1993, Amplification and overexpression of the MDM2 gene in a subset of human malignant gliomas without p53 mutations, Cancer Res, 53, 2736

1997, Improved targeting of an anti-epidermal growth factor receptor variant III monoclonal antibody in tumor xenografts after labeling using N-succinimidyl 5-iodo-3-pyridinecarboxylate, Cancer Res, 57, 1510

1997, In vitro and in vivo behavior of radiolabeled chimeric anti-EGFRvIII monoclonal antibody: Comparison with its murine parent, Nucl Med Biol, 24, 639, 10.1016/S0969-8051(97)00080-2

1994, Phosphatidylinositol-3-OH kinase as a direct target of Ras, Nature, 370, 527, 10.1038/370527a0

1994, Determination of absolute amounts of Ras-GDP and GTP bound to Ras in mammalian cells: Comparison of parental and Ras-overproducing NIH 3T3 fibroblasts, Proc Natl Acad Sci U S A, 92, 1097

1998, Expression of an oncogenic mutant EGF receptor markedly increases the sensitivity of cells to an EGF receptor-specific antibody-toxin, Int J Cancer, 75, 878, 10.1002/(SICI)1097-0215(19980316)75:6<878::AID-IJC10>3.0.CO;2-#

1993, Dominant-negative mutants of platelet-derived growth factor revert the transformed phenotype of human astrocytoma cells, Mol Cell Biol, 13, 7203, 10.1128/MCB.13.12.7203

1987, Human breast cancer: Correlation of relapse and survival with amplification of the HER-2/neu oncogene, Science, 235, 177, 10.1126/science.3798106

1988, Expression of an altered epidermal growth factor receptor by human glioblastoma cells, Cancer Res, 48, 5433

1997, Identification of a candidate tumour suppressor gene, MMAC1, at chromosome 10q23.3 that is mutated in multiple advanced cancers, Nat Genet, 15, 356, 10.1038/ng0497-356

1990, Identical splicing of aberrant epidermal growth factor receptor transcripts from amplified rearranged genes in human glioblastomas, Proc Natl Acad Sci U S A, 87, 8602, 10.1073/pnas.87.21.8602

1992, Loss of tumorigenicity of rat glioblastoma directed by episome-based antisense cDNA transcription of insulin-like growth factor I, Proc Natl Acad Sci U S A, 89, 4874, 10.1073/pnas.89.11.4874

1991, Expression of growth factor receptors in human brain tumours, Br J Cancer, 63, 227, 10.1038/bjc.1991.54

1991, Retinoblastoma gene deletions in human glioblastomas, Oncogene, 6, 445

1998, Activation of the Ras/mitogen-activated protein kinase pathway by kinase-defective epidermal growth factor receptors results in cell survival but not proliferation, Mol Cell Biol, 18, 7192, 10.1128/MCB.18.12.7192

1995, Monoclonal antibodies against EGFRvIII are tumor specific and react with breast and lung carcinomas and malignant gliomas, Cancer Res, 55, 3140

1992, Structural alterations of the epidermal growth factor receptor gene in human gliomas, Proc Natl Acad Sci U S A, 89, 2965, 10.1073/pnas.89.7.2965

1988, Amplification of the structurally and functionally altered epidermal growth factor receptor gene (c-erbB) in human brain tumors, Mol Cell Biol, 8, 1816, 10.1128/MCB.8.4.1816