Expression and regulation of brain metallothionein

Neurochemistry International - Tập 27 Số 1 - Trang 1-22 - 1995
Manuchair Ebadi1,2, Patrick L. Iversen1, Ruyi Hao2, D. Roselyn Cerutis1, Patricia Rojas1, H K Happe1, L. Charles Murrin1,2, Ronald F. Pfeiffer1,2
1Department of Pharmacology, University of Nebraska College of Medicine, 600 South 42nd Street, Omaha, NE 68198-6260, U.S.A.
2Section of Neurology, University of Nebraska College of Medicine, 600 South 42nd Street, Omaha, NE 68198-6260, U.S.A.

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Aloisi, 1992, Production of hemolymphopoietic cytokines (IL-6, IL-8, colony-stimulating factors) by normal human astrocytes in response to IL-1 β and tumor necrosis factor-α, J. Immun., 149, 2358, 10.4049/jimmunol.149.7.2358

Andersen, 1989, Occurrence of various forms of metallothionein in the rat after a short-term cadmium injection regimen, Comp. Biochem. Physiol., 93C, 367

Andrews, 1987, Regulation of the ontogeny of rat liver metallothionein mRNA by zinc, Eur. J. Biochem., 166, 527, 10.1111/j.1432-1033.1987.tb13545.x

Arvidson, 1986, Distribution of 109Cd in the nervous system of rats after intravenous injection, Acta Neuropath., 69, 111, 10.1007/BF00687046

Awad, 1989, Presence of metallothionein-like protein in the bovine pineal gland, J. Neurol. Transm., 76, 129, 10.1007/BF01578753

Beaulieu, 1992, Enrichment of glutamate in zinc-containing terminals of the cat visual cortex, Neuroreport, 3, 861, 10.1097/00001756-199210000-00010

Benveniste, 1993, Astrocyte-microglia interactions, 399

Berg, 1990, Zinc finger domains: Hypotheses and current knowledge, Ann. Rev. Biophys. Chem., 19, 405, 10.1146/annurev.bb.19.060190.002201

Blaauwgeers, 1993, Distribution of metallothionein in the human central nervous system, Glia, 8, 62, 10.1002/glia.440080108

Blaauwgeers, 1994, Localization of metallothionein in the mammalian central nervous system, Biol. Signals, 3, 181, 10.1159/000109543

Blaylock, 1988, Metallothionein gene expression in rats: Tissue-specific regulation by dietary copper and zinc, J. Nutr., 188, 222, 10.1093/jn/118.2.222

Bremner, 1987, Nutritional and physiological significance of metallothionein, Experientia (Suppl.), 52, 81, 10.1007/978-3-0348-6784-9_5

Bremner, 1990, Metallothionein and the trace minerals, Ann. Rev. Nuir., 10, 63, 10.1146/annurev.nu.10.070190.000431

Brenneman, 1992, Cytokine regulation of neuronal survival, J. Neurochem., 59, 454, 10.1111/j.1471-4159.1992.tb09743.x

Celentano, 1991, Negative modulation of the γ-aminobutyric acid response by extracellular zinc, Molec. Pharmac., 40, 766

Chomczynski, 1987, Single-step method of RNA isolation by acid guanidium thiocyanate-phenol - chloroform extraction, Analyt. Biochem., 162, 156, 10.1016/0003-2697(87)90021-2

Choudhuri, 1993, Differential expression of the metallothionein gene in liver and brain of mice and rats, Toxic appl. Pharmac., 119, 1, 10.1006/taap.1993.1037

Christensen, 1992, Retrograde tracing of zinc-containing neurons by selenide ions: A survey of seven selenium compounds, J. Histochem. Cytochem., 541, 2

Churchich, 1988, Modulation of the catalytic activity of pyridoxal kinase by metallothionein. Biochem, Biochem. Int., 17, 395

Cousins, 1985, Absorption, transport, and hepatic metabolism of copper and zinc: Special reference to metallothionein and ceruloplasmin, Physiol. Rev., 65, 239, 10.1152/physrev.1985.65.2.238

Dang, 1991, c-myc oncoprotein function, Biochim. Biophys. Acta, 1072, 103

De, 1990, Endotoxin induction of murine metallothionein gene expression, J. biol. Chem., 265, 15,267, 10.1016/S0021-9258(18)77251-7

Denner, 1985, Two forms of rat brain glutamic acid decarboxylase differ in their dependence on free pyridoxal phosphate, J. Neurochem., 44, 957, 10.1111/j.1471-4159.1985.tb12910.x

Dolnick, 1990, Antisense agents in pharmacology, Biochem. Pharmac., 40, 671, 10.1016/0006-2952(90)90300-A

Durnam, 1981, Transcriptional regulation of the mouse metallothionein—I gene by heavy metals, J. biol. Chem., 256, 5712, 10.1016/S0021-9258(19)69264-1

Ebadi, 1984, The presence of metallothionein-like protein (MLT) in rat brain, 43, 3317

Ebadi, 1986, Characterization of a metallothionein-like protein in rat brain, Biol. Trace Elem. Res., 11, 101, 10.1007/BF02795528

Ebadi, 1986, Biochemical alteration of a metallothionein-like protein in developing rat brain, Biol. Trace Elem. Res., 11, 117, 10.1007/BF02795529

Ebadi, 1991, Metallothionein and other zinc-binding proteins in brain, Meth. Enzym., 205, 363, 10.1016/0076-6879(91)05119-G

Ebadi, 1989, The amino acid composition of zinc-induced metallothionein isoforms in rat brain, Neurochem. Res., 14, 69, 10.1007/BF00969760

Ebadi, 1978, The synthesis of pyridoxal phosphate in rat brain regions, Int. J. Biochem., 9, 606, 10.1016/0020-711X(78)90122-2

Ebadi, 1986, Zinc binding proteins in the brain, Adv. exp. Med. Biol., 203, 557, 10.1007/978-1-4684-7971-3_43

Ebadi, 1984, Zinc in neurological disorders and in experimentally-induced epileptic seizures, Neurol. Neurobiol., 11B, 307

Ebadi, 1987, Characterization of metallothionein-like protein in rat brain, Experientia (Suppl.), 52, 289, 10.1007/978-3-0348-6784-9_24

Ebadi, 1981, The role of Zn++ in pyridoxal phosphate mediated regulation of glutamic acid decarboxylase in brain, Int. J. Biochem., 13, 1107, 10.1016/0020-711X(81)90174-9

Ebadi, 1984, The presence and functions of zinc binding proteins in developing and mature brains, Neurol. Neurobiol., 11A, 39

Ebadi, 1989, Zinc metallothionein in mammalian brain, 98, 257

Ebadi, 1989, The stimulation of metallothionein synthesis in neuroblastoma IMR-32 by zinc and cadmium but not by dexamethasone, Biol. Trace Elem. Res., 22, 233, 10.1007/BF02916611

Ebadi, 1992, Differential stimulation of hepatic and brain metallothionein by ethanol, Neurochem. Int., 21, 555, 10.1016/0197-0186(92)90088-9

Ebadi, 1993, Actions and regulation of protein kinase C in brain, Neuroendocrin. Lett., 15, 69

Ebadi, 1994, The importance of zinc and metallothionein in the brain, Biol. Signals, 3, 123, 10.1159/000109535

Ebadi, 1994, Zinc, metal lothionein, zinc fingers, and neurotrophic activity in neuroimmunoendocrine system, 11

Evans, 1988, Zinc fingers: Guilt by association, Cell, 52, 1, 10.1016/0092-8674(88)90522-3

Frederickson, 1990, Neurobiology of zinc and zinccontaining neurons, Int. Rev. Neurobiol., 31, 145, 10.1016/S0074-7742(08)60279-2

Frederickson, 1988, Hippocampal zinc, the storage granule pool: Localization, physicchemistry and possible function, 289

Frederickson, 1990, Zinc-containing neurons in the hippocampus and related CNS systems, Prog. Brain Res., 83, 71, 10.1016/S0079-6123(08)61242-X

Frederickson, 1994, Zinc containing neurons, Biol. Signals, 3, 127, 10.1159/000109536

Frederickson, 1992, Distribution of histochemically reactive zinc in the forebrain of the rat, J. Chem. Neuroanat., 5, 521, 10.1016/0891-0618(92)90007-D

Frei, 1989, On the cellular source and function of interleukin 6 produced in the central nervous system in viral disease, Eur. J. Immun., 19, 689, 10.1002/eji.1830190418

Gadient, 1990, Interleukin-1β and tumor necrosis factor-α synergistically stimulate nerve growth factor (NGF) release from cultured rat astrocytes, Neurosci. Lett., 117, 335, 10.1016/0304-3940(90)90687-5

Garg, 1989, Interaction of a positive regulatory factor(s) with a 106base pair upstream region controls transcription of metallothionein-I gene in the liver, J. biol. Chem., 264, 2134, 10.1016/S0021-9258(18)94151-7

Goetzl, 1990, Neuroimmunology, Adv. Immun., 48, 161, 10.1016/S0065-2776(08)60754-3

Gupta, 1993, Deletion within the metallothionein locus of cadmium-tolerant Synechococcus PCC 6301 involving a highly iterated palindrome (HIPI), Molec. Microbial., 7/2, 189, 10.1111/j.1365-2958.1993.tb01110.x

Hao, 1993, Purification of characterization of metallothionein and its activation of pyridoxal phosphokinase in trout brain, Comp. Biochem. Physiol., 104, 293, 10.1016/0305-0491(93)90371-B

Hao, 1994, Distribution of zinc metallothionein I mRNA in rat brain by in situ hybridization, Neurochem. Res., 19, 761, 10.1007/BF00967717

Hamer, 1986, Metallothionein, Ann. Rev. Biochem., 55, 913, 10.1146/annurev.bi.55.070186.004405

Harrison, 1994, Zn2+ : an endogenous modulator of ligand- and voltage-gated ion channels, Neuropharmacology, 33, 935, 10.1016/0028-3908(94)90152-X

Haug, 1971, Timm's sulphide silver reaction for zinc during experimental anterograde degeneration of hippocampal mossy fibers, J. comp. Neural., 142, 23, 10.1002/cne.901420103

Heilmaier, 1985, Metallothionein content and zinc status in various tissues of rats treated with iodoacetic acid and zinc, Archs Toxic., 56, 247, 10.1007/BF00295162

Hidalgo, 1991, Metallothionein-I induction by stress in specific brain areas, Neurochem. Res., 16, 1145, 10.1007/BF00966593

Hiramatsu, 1994, An ESR study of 6-hydroxydopamine-generated hydroxyl radicals and superoxide anions in brain, Neuroscience, 20, 129

Howell, 1984, Electrical stimulation facilitates zinc turnover in hippocampal slices, Vol. A, 141

Howell, 1989, A retrograde transport method for mapping zinc-containing fiber systems in the brain, Brain Res., 515, 277, 10.1016/0006-8993(90)90607-D

Howell, 1991, Zinc containing projections to the bed nucleus of the stria terminalis, Brain Res., 562, 181, 10.1016/0006-8993(91)90620-B

Huber, 1993, Metallothionein expression in rat bone marrow is dependent on dietary zinc but not dependent on interleukin-I or interleukin-6, J. Nutr., 123, 642, 10.1093/jn/123.4.642

Huckle, 1993, Isolation of a prokaryotic metallothionein locus and analysis of transcriptional control by trace metal ions, Molec. Microbial., 7, 177, 10.1111/j.1365-2958.1993.tb01109.x

Huibregtse, 1989, Copper-induced binding of cellular factors to yeast metallothionein upstream activation sequences, 86, 65

Ingvarsson, 1988, Structure and expression of B-myc, anew member of the myc gene family, Molec. Cell. Biol., 8, 3168, 10.1128/MCB.8.8.3168

Itano, 1991, Bacterial endotoxin-induced expression of metallothionein genes in rat brain, as revealed by in situ hybridization, Neurosci. Lett., 124, 13, 10.1016/0304-3940(91)90811-7

Itoh, 1982, The selective inhibition of hippocampal glutamic acid decarboxylase in zinc-treated epileptic seizures, Neurochem. Res., 7, 1287, 10.1007/BF00965899

Itoh, 1983, The presence of zinc binding proteins in brain, J. Neurochem., 41, 823, 10.1111/j.1471-4159.1983.tb04814.x

Iversen, 1992, Antisense oligonucleotidemediated inhibition of metallothionein protein synthesis in neuroblastoma IMR 32 and Chang liver cells in culture, Biol. Signals, 1, 57, 10.1159/000109311

Iversen, 1992, Synthetic antisense oligonucleotide probes the essentiality of metallothionein gene, Biol. Signals, 1, 293, 10.1159/000109334

Jakobovits, 1985, Expression of N-myc in tetratocarcinoma stem cells and mouse embryos, Nature, 318, 188, 10.1038/318188a0

Kägi, 1989, Mammalian metallothionein, Biol. Trace Elem. Res., 21, 111, 10.1007/BF02917243

Kägi, 1987, Chemistry and biochemistry of metallothionein, Experientia (Suppl.), 52, 25, 10.1007/978-3-0348-6784-9_3

Kägi, 1988, Biochemistry of metallothionein, Biochemistry, 27, 8509, 10.1021/bi00423a001

Kaji, 1992, Possible mechanism for zinc protection against cadmium cytotoxicology in cultured vascular endothelial cells, Toxicology, 76, 257, 10.1016/0300-483X(92)90194-J

Karin, 1982, Human metallothionein genes—Primary structure of the metallothionein-II gene and a related processed gene, Nature, 299, 797, 10.1038/299797a0

Karin, 1984, Human metallothionein genes are clustered on chromosome 16, 81, 5494

Kasahara, 1990, IL-I induces proliferation and IL6 mRNA expression in a human astrocytoma cell line—Positive and negative modulation by cholera toxin and cAMP, Biochem. biophys. Res. Commun., 167, 1242, 10.1016/0006-291X(90)90657-9

Kasarskis, 1993, Trace metals in human neurodegenerative diseases, Prog. clin. Biol. Res., 380, 299

Katsuura, 1989, Interleukin-1 beta increases prostaglandin E2 in rat astrocyte cultures: Modulatory effect of neuropeptides, Endocrinology, 124, 3125, 10.1210/endo-124-6-3125

Kay, 1991, Naturally occurring and recombinant metallothioneins : Structure, immunoreactivity and metal-binding functions, Int. J. Biochem., 23, 1, 10.1016/0020-711X(91)90002-5

Kelly, 1988, Overexpression of metallothionein confers resistance to anticancer drugs, Science, 241, 1813, 10.1126/science.3175622

Kikuchi, 1992, Identification of metallothionein in cultured cells by immunoblotting and immunofluorescence using a new monoclonal antibody, Hybridoma, 11, 295, 10.1089/hyb.1992.11.295

Kikuchi, 1993, Induction of metallothionein in a human astrocytoma cell line by interleukin-1 and heavy metals, FEBS Lett., 317, 22, 10.1016/0014-5793(93)81483-G

Kille, 1991, Elucidation of cDNA sequences for metallothioneins from rainbow trout, stone loach and pike liver using the polymerase chain reaction, Biochim. Biophys. Acta, 1089, 407, 10.1016/0167-4781(91)90187-Q

Kissfng, 1977, Primary structure of human hepatic metallothionein, FEBS Lett., 82, 247, 10.1016/0014-5793(77)80594-2

Kobayashi, 1993, Molecular cloning of rat growth inhibitory factor cDNA and the expression in the central nervous system, Molec. Brain Res., 19, 188, 10.1016/0169-328X(93)90025-K

van der Krol, 1988, Modulation of eukaryotic gene expression by complementary RNA or DNA sequences, Biol. Tech., 6, 958

Lee, 1993, Induction of nitric oxide synthase activity in human astrocytes by interleukin-1β and interferon-γ, J. Neuroimmun., 46, 19, 10.1016/0165-5728(93)90229-R

Lee, 1993, Cytokine production by human fetal microglia and astrocytes: Differential induction by lipopolysaccharide and IL-1β, J. Immun., 150, 2659, 10.4049/jimmunol.150.7.2659

Mandava, 1993, Zinc-containing neuronal innervation of the septal nuclei, Brain Res., 608, 115, 10.1016/0006-8993(93)90781-H

Margoshes, 1957, A cadmium protein from equine kidney cortex, J. Am. Chem. Soc., 79, 4813, 10.1021/ja01574a064

Maret, 1994, Oxidative metal release from metallothionein via zinc-thiol/disulfide interchange, 91, 237

Masters, 1994, Metallothionein III is expressed in neurons that sequester zinc in synaptic vesicles, J. Neurosci., 14, 5844, 10.1523/JNEUROSCI.14-10-05844.1994

McCormick, 1971, Pyridoxal phosphokinase. I. Assay, distribution, purification and properties, J. biol. Chem., 236, 2076, 10.1016/S0021-9258(18)64132-8

Meister, 1983, Selective modification of glutathione metabolism, Science, 220, 472, 10.1126/science.6836290

Merrill, 1984, Metabolism of vitamin B6 by human liver, J. Nutr., 114, 1664, 10.1093/jn/114.9.1664

Mokdad, 1987, Metallothionein genes in Drosophila melanogaster constitute a dual system, 84, 2658

Moos, 1993, Simultaneous application of Timm's sulphide silver method and immunofluorescence histochemistry, J. Neurosci. Meth., 48, 149, 10.1016/S0165-0270(05)80017-2

Munger, 1985, (Cu, Zn)-Metallothioneins from fetal bovine liver, J. biol. Chem., 260, 10,032, 10.1016/S0021-9258(17)39207-4

Nakajima, 1989, Immunocytochemical studies of metallothionein I in brain, retina, peripheral nerve and paraneuron, J. Trace Elem. Exp. Med., 2, 104

Nakajima, 1991, Detection of metallothionein in brain, Meth. Enzym., 205, 387, 10.1016/0076-6879(91)05120-K

Nishimura, 1990, Metallothionein localization in cadmium-treated rat brain, J. Histochem. Cytochem., 38, 1023

Nishimura, 1992, Localization of metallothionein in the brain of rat and mouse, J. Histochem. Cytochem., 40, 309, 10.1177/40.2.1552172

Nordberg, 1972, Separation of two forms of rabbit metallothionein by isoelectric focusing, Biochem. J., 126, 491, 10.1042/bj1260491

Olafson, 1979, Isolation and chemical characterization of the heavy metal-binding protein metallothionein from marine invertebrates, Comp. Biochem. Physiol., 62, 407, 10.1016/0305-0491(79)90111-1

Paliwal, 1989, Biochemical properties of metallothionein isoforms from bovine hippocampus, Exp. Brain Res., 75, 477, 10.1007/BF00249899

Paliwal, 1990, Regulation of zinc metallothionein II mRNA synthesis in rat brain, Neurochem. Int., 17, 441, 10.1016/0197-0186(90)90026-P

Palmiter, 1987, Molecular biology of metallothionein gene expression, Experientia (Suppl.), 52, 63, 10.1007/978-3-0348-6784-9_4

Palmiter, 1992, MT-III, a brain-specific member of the metallothionein gene family, 89, 6333

Panno, 1993, Expression of the myc photo-oncogene in the rainbow trout, Oncorhynchus mykiss, Comp. Biochem. Physiol., 1046, 649

Pavletich, 1991, Zinc finger-DNA recognition: Crystal structure of a Zif268-DNA complex at 2.1 A, Science, 252, 809, 10.1126/science.2028256

Perez-Clausef, 1986, Release of zinc sulphide accumulations into synaptic clefts after in vivo injection of sodium sulphide, Brain Res., 362, 358, 10.1016/0006-8993(86)90463-4

Peterson, 1988, Differential expression of four linked sheep metallothionein genes, Eur. J. Biochem., 174, 425, 10.1111/j.1432-1033.1988.tb14115.x

Peterson, 1988, The sheep metallothionein gene family: Structure, sequence, and evolutionary relationship of five linked genes, Eur. J. Biochem., 174, 417, 10.1111/j.1432-1033.1988.tb14114.x

Quaife, 1994, Induction of a new metallothionein isoform (MT-IV) occurs during differentiation of stratified squamous epithelia, Biochemistry, 33, 7250, 10.1021/bi00189a029

Richards, 1984, Structural and functional analysis of the human metallothionein-1A gene: Differential induction of metal ions and glucocorticoids, Cell, 37, 273, 10.1016/0092-8674(84)90322-2

Rojas-Castaneda, 1994, Protective effects of zinc and metallothionein in oxygen free radical-mediated oxidative stress in brain, Soc. Neurosci. Abstr., 24, 2

Sadhu, 1988, Regulation of human metallothionein (MT) genes, J. biol. Chem., 263, 2679, 10.1016/S0021-9258(18)69121-5

Saijoh, 1989, Molecular cloning of cDNA for rat brain metallothionein-1I and regulation of its gene expression, Pharmac. Toxic., 64, 464, 10.1111/j.1600-0773.1989.tb00688.x

Saijoh, 1994, Brain metallothionen gene expression and regulation, Biol. Signals, 3, 150, 10.1159/000109538

Sato, 1993, Oxygen free radicals and metal lothionein, Free Rad. Biol. Med., 14, 325, 10.1016/0891-5849(93)90029-T

Sawada, 1993, Production of interleukin-5 by mouse astrocytes and microglia in culture, Neurosci. Lett., 155, 175, 10.1016/0304-3940(93)90701-L

Sawada, 1994, Induction of metallothionein in astrocytes by cytokines and heavy metals, Biol. Signals, 3, 157, 10.1159/000109539

Schroeder, 1990, Interleukin-6 regulates metallothionein gene expression and zinc metabolism in hepatocyte monolayer cultures, 87, 3137

Searle, 1984, Regulation, linkage, and sequence of mouse metallothionein I and II genes, Molec. Cell. Biol., 4, 1221, 10.1128/MCB.4.7.1221

Semsei, 1989, Differential expression of the myc protooncogene family throughout the lifespan of the C57BL/6J mouse strain, Oncogene, 4, 465

Shiraga, 1993, The effects of 6-hydroxydopamine and oxidative stress on the level of brain metallothionein, Neurochem. Int., 23, 561, 10.1016/0197-0186(93)90104-D

Shiraishi, 1989, Elevation in metallothionein messenger RNA in rat tissues after exposure to X-irradiation, Toxic. appl. Pharmac., 8, 501, 10.1016/0041-008X(89)90178-6

Slomianka, 1990, Labeling of the neurons of origin of zinc-containing pathways by intraperitoneal injections of sodium selenite, Neuroscience, 38, 843, 10.1016/0306-4522(90)90076-G

South, 1990, Zinc fingers, Adv. Inorg. Biochem., 8, 199

Spranger, 1990, Regulation of nerve growth factor (NGF) synthesis in the rat central nervous system: Comparison between the effects of interleukin-1 and various growth factors in astrocyte cultures and in vivo, Eur. J. Neurosci., 2, 69, 10.1111/j.1460-9568.1990.tb00382.x

Stein, 1988, Oligodeoxynucleotides as inhibitors of gene expression: A review, Cancer Res., 48, 2659

Sutcliffe, 1988, mRNA in the mammalian central nervous system, Ann. Rev. Neurosci., 11, 157, 10.1146/annurev.ne.11.030188.001105

Suzuki, 1992, Localization of metallothionein in the brain of Macaca fascicularis, Acta Histochem. Cytochem., 25, 609, 10.1267/ahc.25.609

Suzuki, 1992, Metallothionein in the human brain, Acta Histochem. Cytochem., 25, 617, 10.1267/ahc.25.617

Suzuki, 1994, Metallothionein in developing human brain, Biol. Signals, 3, 188, 10.1159/000109544

Takahashi, 1988, Subcellular distribution of zinc and the presence of a metallothioneinlike protein in bovine retina, Neurochem. Int., 13, 525, 10.1016/0197-0186(88)90084-8

Takeda, 1992, Elevation of hepatic levels of metallothionein and zinc in mice bearing experimental tumors, Biochem. biophys. Res. Commun., 189, 645, 10.1016/0006-291X(92)92249-W

Takeda, 1994, Antisense oligonucleotide of c-myc discriminates between zinc- and dexamethasone-induced synthesis of metaliothionein, Pharmacology, 48, 119, 10.1159/000139170

Taplitz, 1986, Alternative inducers of the rat metallothionein I gene cause distinct changes in chromatin structure in the 5′ region of the gene, Molec. Cell. Biol., 6, 2576, 10.1128/MCB.6.7.2576

Touhne, 1988, Antimessenger oligodeoxyribonucleotides : An alternative to antisense RNA for artificial regulation of gene expression. A review, Gene, 72, 51, 10.1016/0378-1119(88)90127-8

Tsuji, 1992, Molecular cloning of human growth inhibitor factor cDNA and its down-regulation in Alzheimer's disease, EMBO J., 11, 4843, 10.1002/j.1460-2075.1992.tb05590.x

Turner, 1993, Construction of Zn2+/Cd2+ hypersensitive cyanobacterial mutants lacking a functional metallothionein locus, J. biol. Chem., 268, 4494, 10.1016/S0021-9258(18)53636-X

Uchida, 1991, The growth inhibitory factor that is deficient in the Alzheimer's disease brain is a 68 amino acid metallothionein-like protein, Neuron, 7, 337, 10.1016/0896-6273(91)90272-2

Vallee, 1988, Zinc: Biochemistry, physiology, toxicology and clinical pathology, Biofactors, 1, 31

Vallee, 1990, Zinc coordination, function, and structure of zinc enzymes and other proteins, Biochemistry, 29, 5647, 10.1021/bi00476a001

Vallee, 1993, The biochemical basis of zinc physiology, Physiol. Rev., 73, 79, 10.1152/physrev.1993.73.1.79

Van Beneden, 1986, Cellular myc (c-myc) in fish (rainbow trout), 83, 3698

Varshney, 1986, Structure, organization and regulation of human metallothionein gene: Differential and cell-type-specific expression in response to heavy metals and glucocorticoids, Molec. Cell. Biol., 6, 26, 10.1128/MCB.6.1.26

Walsh, 1994, Zinc: Health effects and research priorities for the 1990s, Envir. Health Perspect., 102, 5, 10.1289/ehp.941025

Westbrook, 1987, Micromolar concentrations of Zn2+ antagonize NMDA and GABA responses of hippocampal neurons, Nature, 328, 640, 10.1038/328640a0

Wilkinson, 1987, Metallothionein genes MTa and MTb expressed under distinct quantitative and tissue-specific regulation in sea urchin embryos, Molec. Cell. Biol., 7, 48, 10.1128/MCB.7.1.48

Winge, 1984, Structural characterization of the isoforms of neonatal and adult rat liver metallothionein, J. biol. Chem., 259, 11,419, 10.1016/S0021-9258(18)90877-X

Wong, 1979, Isolation and characterization of metallothionein which is highly concentrated in newborn rat liver, J. biol. Chem., 254, 12,399, 10.1016/S0021-9258(19)86328-7

Woodroofe, 1991, Detection of interleukin-1 and interleukin-6 in adult rat brain, following mechanical injury, by in vivo microdialysis: Evidence of a role for microglia in cytokine production, J. Neuroimmun., 33, 227, 10.1016/0165-5728(91)90110-S

Wu, 1987, Zinc in DNA replication and transcription, Ann. Rev. Nutr., 7, 251, 10.1146/annurev.nu.07.070187.001343

Wu, 1974, Properties of brain l-glutamic decarboxylase : Inhibition studies, J. Neurochem., 23, 759, 10.1111/j.1471-4159.1974.tb04401.x

Wu, 1976, Properties of l-glutamate decarboxylase from brains of adult and newborn mice, J. Neurochem., 27, 653, 10.1111/j.1471-4159.1976.tb10390.x

Xie, 1991, A physiological role for endogenous zinc in rat hippocampal synaptic neurotransmission, Nature, 349, 521, 10.1038/349521a0

Yan, 1992, Expression of interleukin (IL)1β, IL-6 and their respective receptors in the normal rat brain and after injury, Eur. J. Immun., 22, 2963, 10.1002/eji.1830221131

Yang, 1994, Human metallothionein isoform gene expression in cisplatin-sensitive and resistant cells, Molec. Pharmac., 45, 453

Yokoyama, 1986, Brief exposure to zinc is toxic to cortical neurons, Neurosci. Letr., 71, 351, 10.1016/0304-3940(86)90646-4

Young, 1994, Glial metallothionein, Biol. Signals, 3, 169, 10.1159/000109540

Young, 1991, Glial immunoreactivity for metallothionein in the rat brain, Glia, 4, 602, 10.1002/glia.440040607

Zheng, 1991, Choroid plexus protects cerebrospinal fluid against toxic metals, FASEB J., 5, 2188, 10.1096/fasebj.5.8.1850706

Zimmerman, 1986, Differential expression of myc family genes during murine development, Nature, 319, 780, 10.1038/319780a0

Zon, 1988, Oligonucleotide analogues as potential chemotherapeutic agents, Pharmac. Res., 5, 539, 10.1023/A:1015985728434