Expression analysis of cadherins in the songbird brain: Relationship to vocal system development

Journal of Comparative Neurology - Tập 508 Số 2 - Trang 329-342 - 2008
Eiji Matsunaga1,2, Kazuo Okanoya2
1Japan Society for the Promotion of Science, Tokyo, Japan
2Laboratory for Biolinguistics, RIKEN Brain Science Institute, Wako, Japan

Tóm tắt

AbstractSongbirds learn their songs as juveniles. The brains of songbirds have a series of nuclei and neural circuits called the song system, which is indispensable for vocal learning and production. In the present study we analyzed the expression patterns of cell adhesion molecules, cadherins, in the Bengalese finch (Lonchura striata var. domestica) to investigate their potential involvement in song nuclei and neural circuit formation. We found that cadherin‐6B was expressed in many song nuclei of the juvenile and adult brain, while R‐cadherin was complementarily expressed in surrounding areas. On the other hand, cadherin‐7 was expressed in the robust nucleus of the arcopallium (RA) in the sensory learning stage, and its expression was downregulated during the sensorimotor learning stage. This downregulation of cadherin‐7 was sexually dimorphic, suggesting its involvement in song development. Other cadherins, including cadherin‐9, ‐10, and ‐12, showed different song‐nuclei‐related expression profiles. These patterns of song nuclei related expression suggest the possibility that cadherins are involved in the formation and maintenance of the song nuclei or neural pathways of the song system. J. Comp. Neurol. 508:329–342, 2008. © 2008 Wiley‐Liss, Inc.

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Tài liệu tham khảo

10.1038/nn1212

10.1016/S0896-6273(01)00388-9

10.1002/(SICI)1096-9861(19960923)373:3<373::AID-CNE5>3.0.CO;2-#

10.1002/(SICI)1096-9861(19981123)401:3<367::AID-CNE5>3.0.CO;2-S

10.1016/0896-6273(94)90026-4

10.1016/S0306-4522(02)00375-5

10.1038/nrn1904

10.1002/(SICI)1096-9861(20000501)420:2<244::AID-CNE7>3.0.CO;2-M

10.1016/j.mcn.2004.08.008

10.1038/417351a

10.1098/rspb.1996.0239

10.1126/science.3283939

10.1159/000047263

10.1002/(SICI)1097-0177(199707)209:3<269::AID-AJA3>3.0.CO;2-G

10.1002/1096-9861(20001016)426:2<182::AID-CNE2>3.0.CO;2-M

10.1196/annals.1298.025

Gahr M, 1999, The sexually dimorphic expression of androgen receptors in the song nucleus hyperstriatalis ventrale pars caudale of the zebra finch develops independently of gonadal steroids, J Neurosci, 19, 2628, 10.1523/JNEUROSCI.19-07-02628.1999

10.1038/84001

10.1146/annurev.neuro.26.010302.081139

10.1002/(SICI)1097-0177(199804)211:4<338::AID-AJA5>3.0.CO;2-I

10.1242/dev.128.4.561

10.1196/annals.1298.038

10.1038/nrn1606

10.1002/cne.903260309

10.1016/S0165-3806(00)00052-3

10.1016/j.neuroscience.2004.06.063

10.1002/cne.11033

10.1038/315145a0

10.1002/(SICI)1096-9861(19990503)407:2<228::AID-CNE6>3.0.CO;2-2

10.1016/S0003-3472(05)80047-8

Marler P, 2004, Nature's music. The science of birdsong

10.1523/JNEUROSCI.4556-05.2006

Matsunaga E, 2008, Comparative analysis of gene expressions among avian brains: a molecular approach to the evolution of vocal learning, Brain Res Bull, 10.1016/j.brainresbull.2007.10.045

10.1006/dbio.1995.8029

Mooney R, 1994, Waiting periods versus early innervation: the development of axonal connections in the zebra finch song system, J Comp Neurol, 14, 6532

10.1242/dev.121.5.1321

10.1242/dev.125.15.2963

10.1002/cne.901650405

10.1002/cne.902070406

10.1196/annals.1298.026

10.1006/dbio.1996.0315

10.1002/cne.903330307

10.1002/(SICI)1096-9861(20000612)421:4<481::AID-CNE3>3.0.CO;2-H

10.1002/cne.1315

10.1002/cne.20118

Shimoyama Y, 2000, Identification of three human type‐II cadherins and frequent heterophilic interations between different subclasses of type‐II classic cadherins, Biochem J, 349, 159, 10.1042/bj3490159

10.1006/mcne.1997.0626

10.1523/JNEUROSCI.0243-07.2007

10.1016/0955-0674(95)80102-2

10.1038/nrn2043

10.1126/science.274.5290.1123

10.1016/S0896-6273(02)00748-1

10.1083/jcb.135.3.767

10.1002/(SICI)1096-9861(19970407)380:2<275::AID-CNE9>3.0.CO;2-0

10.1196/annals.1298.015

10.1002/cne.903490403

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Journal of Comparative Neurology

Tập 508 Số 2

329-342

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