Experimental therapies
Tài liệu tham khảo
Aboody, 2000, Neural stem cells display extensive tropism for pathology in adult brain: evidence from intracranial gliomas, Proc Natl Acad Sci U S A, 97, 12846, 10.1073/pnas.97.23.12846
Aghi, 2008, Oncolytic herpes virus with defective ICP6 specifically replicates in quiescent cells with homozygous genetic mutations in p16, Oncogene, 27, 4249, 10.1038/onc.2008.53
Aguilar, 2015, Phase II multicenter study of gene mediated cytotoxic immunotherapy as adjuvant to surgical resection for newly diagnosed malignant glioma, J Clin Oncol, 33
Ahmed, 2010, Bone marrow mesenchymal stem cells loaded with an oncolytic adenovirus suppress the anti-adenoviral immune response in the cotton rat model, Mol Ther, 18, 1846, 10.1038/mt.2010.131
Allen, 2013, Oncolytic measles virus strains have significant antitumor activity against glioma stem cells, Gene Ther, 20, 444, 10.1038/gt.2012.62
Alvarez-Breckenridge, 2012, NK cells impede glioblastoma virotherapy through NKp30 and NKp46 natural cytotoxicity receptors, Nat Med, 18, 1827, 10.1038/nm.3013
Assi, 2012, Gene therapy for brain tumors: basic developments and clinical implementation, Neurosci Lett, 527, 71, 10.1016/j.neulet.2012.08.003
Atsarkin, 2009, Solution to the bioheat equation for hyperthermia with La(1-x)Ag(y)MnO(3-delta) nanoparticles: the effect of temperature autostabilization, Int J Hyperthermia, 25, 240, 10.1080/02656730802713565
Bao, 2006, Glioma stem cells promote radioresistance by preferential activation of the DNA damage response, Nature, 444, 756, 10.1038/nature05236
Benedetti, 2000, Gene therapy of experimental brain tumors using neural progenitor cells, Nat Med, 6, 447, 10.1038/74710
Bexell, 2009, Bone marrow multipotent mesenchymal stroma cells act as pericyte-like migratory vehicles in experimental gliomas, Mol Ther, 17, 183, 10.1038/mt.2008.229
Bexell, 2012, Rat multipotent mesenchymal stromal cells lack long-distance tropism to 3 different rat glioma models, Neurosurgery, 70, 731, 10.1227/NEU.0b013e318232dedd
Bexell, 2013, Stem cell-based therapy for malignant glioma, Cancer Treat Rev, 39, 358, 10.1016/j.ctrv.2012.06.006
Boveri, 1914, 1
Burgess, 2011, Targeted delivery of neural stem cells to the brain using MRI-guided focused ultrasound to disrupt the blood–brain barrier, PLoS One, 6, 10.1371/journal.pone.0027877
Chan, 2005, MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells, Cancer Res, 65, 6029, 10.1158/0008-5472.CAN-05-0137
Cheema, 2013, Multifaceted oncolytic virus therapy for glioblastoma in an immunocompetent cancer stem cell model, Proc Natl Acad Sci U S A, 110, 12006, 10.1073/pnas.1307935110
Chertok, 2008, Iron oxide nanoparticles as a drug delivery vehicle for MRI monitored magnetic targeting of brain tumors, Biomaterials, 29, 487, 10.1016/j.biomaterials.2007.08.050
Chinot, 2014, Bevacizumab plus radiotherapy-temozolomide for newly diagnosed glioblastoma, N Engl J Med, 370, 709, 10.1056/NEJMoa1308345
Chiocca, 2010, The many functions of microRNAs in glioblastoma, World Neurosurg, 73, 598, 10.1016/j.wneu.2010.06.047
Chiocca, 2014, Oncolytic viruses and their application to cancer immunotherapy, Cancer Immunol Res, 2, 295, 10.1158/2326-6066.CIR-14-0015
Chiocca, 2004, A phase I open-label, dose-escalation, multi-institutional trial of injection with an E1B-Attenuated adenovirus, ONYX-015, into the peritumoral region of recurrent malignant gliomas, in the adjuvant setting, Mol Ther, 10, 958, 10.1016/j.ymthe.2004.07.021
Chiocca, 2008, A phase I trial of Ad.hIFN-beta gene therapy for glioma, Mol Ther, 16, 618, 10.1038/sj.mt.6300396
Chiocca, 2011, Phase IB study of gene-mediated cytotoxic immunotherapy adjuvant to up-front surgery and intensive timing radiation for malignant glioma, J Clin Oncol, 29, 3611, 10.1200/JCO.2011.35.5222
Colombo, 2005, Combined HSV-TK/IL-2 gene therapy in patients with recurrent glioblastoma multiforme: biological and clinical results, Cancer Gene Ther, 12, 835, 10.1038/sj.cgt.7700851
Cornetta, 2006, A pilot study of dose-intensified procarbazine, CCNU, vincristine for poor prognosis brain tumors utilizing fibronectin-assisted, retroviral-mediated modification of CD34+ peripheral blood cells with O6-methylguanine DNA methyltransferase, Cancer Gene Ther, 13, 886, 10.1038/sj.cgt.7700963
Corsten, 2007, MicroRNA-21 knockdown disrupts glioma growth in vivo and displays synergistic cytotoxicity with neural precursor cell delivered S-TRAIL in human gliomas, Cancer Res, 67, 8994, 10.1158/0008-5472.CAN-07-1045
Dmitrieva, 2011, Chondroitinase ABC I-mediated enhancement of oncolytic virus spread and antitumor efficacy, Clin Cancer Res, 17, 1362, 10.1158/1078-0432.CCR-10-2213
Duarte, 2012, Suicide gene therapy in cancer: where do we stand now?, Cancer Lett, 324, 160, 10.1016/j.canlet.2012.05.023
Ebert, 2012, Roles for microRNAs in conferring robustness to biological processes, Cell, 149, 515, 10.1016/j.cell.2012.04.005
Emerich, 1999, Biocompatibility of poly (DL-lactide-co-glycolide) microspheres implanted into the brain, Cell Transplant, 8, 47, 10.1177/096368979900800114
Eriksson, 1998, Neurogenesis in the adult human hippocampus, Nat Med, 4, 1313, 10.1038/3305
Ezzeddine, 1991, Selective killing of glioma cells in culture and in vivo by retrovirus transfer of the herpes simplex virus thymidine kinase gene, New Biol, 3, 608
Feng, 2004, Nanoparticles of biodegradable polymers for clinical administration of paclitaxel, Curr Med Chem, 11, 413, 10.2174/0929867043455909
Ferrantini, 1993, Alpha 1-interferon gene transfer into metastatic Friend leukemia cells abrogated tumorigenicity in immunocompetent mice: antitumor therapy by means of interferon-producing cells, Cancer Res, 53, 1107
Ferrantini, 1994, IFN-alpha 1 gene expression into a metastatic murine adenocarcinoma (TS/A) results in CD8+ T cell-mediated tumor rejection and development of antitumor immunity. Comparative studies with IFN-gamma-producing TS/A cells, J Immunol, 153, 4604, 10.4049/jimmunol.153.10.4604
Ferrari, 2005, Cancer nanotechnology: opportunities and challenges, Nat Rev Cancer, 5, 161, 10.1038/nrc1566
Forsyth, 2008, A phase I trial of intratumoral administration of reovirus in patients with histologically confirmed recurrent malignant gliomas, Mol Ther, 16, 627, 10.1038/sj.mt.6300403
Freeman, 2006, Phase I/II trial of intravenous NDV-HUJ oncolytic virus in recurrent glioblastoma multiforme, Mol Ther, 13, 221, 10.1016/j.ymthe.2005.08.016
Friedmann, 1972, Gene therapy for human genetic disease?, Science, 175, 949, 10.1126/science.175.4025.949
Gabriely, 2008, MicroRNA 21 promotes glioma invasion by targeting matrix metalloproteinase regulators, Mol Cell Biol, 28, 5369, 10.1128/MCB.00479-08
Gan, 2010, Transferrin-conjugated nanoparticles of poly(lactide)-D-alpha-tocopheryl polyethylene glycol succinate diblock copolymer for targeted drug delivery across the blood-brain barrier, Biomaterials, 31, 7748, 10.1016/j.biomaterials.2010.06.053
Germano, 2003, Adenovirus/herpes simplex-thymidine kinase/ganciclovir complex: preliminary results of a phase I trial in patients with recurrent malignant gliomas, J Neurooncol, 65, 279, 10.1023/B:NEON.0000003657.95085.56
Gilbert, 2014, A randomized trial of bevacizumab for newly diagnosed glioblastoma, N Engl J Med, 370, 699, 10.1056/NEJMoa1308573
Godlewski, 2008, Targeting of the Bmi-1 oncogene/stem cell renewal factor by microRNA-128 inhibits glioma proliferation and self-renewal, Cancer Res, 68, 9125, 10.1158/0008-5472.CAN-08-2629
Godlewski, 2010, MicroRNA-451 regulates LKB1/AMPK signaling and allows adaptation to metabolic stress in glioma cells, Mol Cell, 37, 620, 10.1016/j.molcel.2010.02.018
Goldstein, 2003, Summary, conclusions and recommendations: adverse temperature levels in the human body, Int J Hyperthermia, 19, 373, 10.1080/0265673031000090701
Gomez-Manzano, 2004, A novel E1A-E1B mutant adenovirus induces glioma regression in vivo, Oncogene, 23, 1821, 10.1038/sj.onc.1207321
Goppert, 2005, Polysorbate-stabilized solid lipid nanoparticles as colloidal carriers for intravenous targeting of drugs to the brain: comparison of plasma protein adsorption patterns, J Drug Target, 13, 179, 10.1080/10611860500071292
Halloran, 1998, Irreversible G2-M arrest and cytoskeletal reorganization induced by cytotoxic nucleoside analogues, Cancer Res, 58, 3855
Harrow, 2004, HSV1716 injection into the brain adjacent to tumour following surgical resection of high-grade glioma: safety data and long-term survival, Gene Ther, 11, 1648, 10.1038/sj.gt.3302289
Herrlinger, 2000, Neural precursor cells for delivery of replication-conditional HSV-1 vectors to intracerebral gliomas, Mol Ther, 1, 347, 10.1006/mthe.2000.0046
Hoffart, 2002, Low molecular weight heparin-loaded polymeric nanoparticles: formulation, characterization, and release characteristics, Drug Dev Ind Pharm, 28, 1091, 10.1081/DDC-120014576
Holgado, 2008, Synthesis of lidocaine-loaded PLGA microparticles by flow focusing. Effects on drug loading and release properties, Int J Pharm, 358, 27, 10.1016/j.ijpharm.2008.02.012
Huang, 2007, Gold nanoparticles: interesting optical properties and recent applications in cancer diagnostics and therapy, Nanomedicine (Lond), 2, 681, 10.2217/17435889.2.5.681
Huang, 2015, Intravenous administration of retroviral replicating vector, Toca 511, demonstrates therapeutic efficacy in orthotopic immune-competent mouse glioma model, Hum Gene Ther, 26, 82, 10.1089/hum.2014.100
Huber, 2005, Synthesis, properties, and applications of iron nanoparticles, Small, 1, 482, 10.1002/smll.200500006
Huber, 1994, Metabolism of 5-fluorocytosine to 5-fluorouracil in human colorectal tumor cells transduced with the cytosine deaminase gene: significant antitumor effects when only a small percentage of tumor cells express cytosine deaminase, Proc Natl Acad Sci U S A, 91, 8302, 10.1073/pnas.91.17.8302
Huse, 2009, The PTEN-regulating microRNA miR-26a is amplified in high-grade glioma and facilitates gliomagenesis in vivo, Genes Dev, 23, 1327, 10.1101/gad.1777409
Ikeda, 1999, Oncolytic virus therapy of multiple tumors in the brain requires suppression of innate and elicited antiviral responses, Nat Med, 5, 881, 10.1038/11320
Immonen, 2004, AdvHSV-tk gene therapy with intravenous ganciclovir improves survival in human malignant glioma: a randomised, controlled study, Mol Ther, 10, 967, 10.1016/j.ymthe.2004.08.002
Jiang, 2014, Delta-24-RGD oncolytic adenovirus elicits anti-glioma immunity in an immunocompetent mouse model, PLoS One, 9
Jin, 2007, Nanoparticle-mediated drug delivery and gene therapy, Biotechnol Prog, 23, 32, 10.1021/bp060348j
Jordan, 2006, The effect of thermotherapy using magnetic nanoparticles on rat malignant glioma, J Neurooncol, 78, 7, 10.1007/s11060-005-9059-z
Kaido, 1995, IFN-alpha 1 gene transfection completely abolishes the tumorigenicity of murine B16 melanoma cells in allogeneic DBA/2 mice and decreases their tumorigenicity in syngeneic C57BL/6 mice, Int J Cancer, 60, 221, 10.1002/ijc.2910600216
Kaman, 2009, Silica encapsulated manganese perovskite nanoparticles for magnetically induced hyperthermia without the risk of overheating, Nanotechnology, 20, 275610, 10.1088/0957-4484/20/27/275610
Kante, 1982, Toxicity of polyalkylcyanoacrylate nanoparticles I: free nanoparticles, J Pharm Sci, 71, 786, 10.1002/jps.2600710716
Karnoub, 2007, Mesenchymal stem cells within tumour stroma promote breast cancer metastasis, Nature, 449, 557, 10.1038/nature06188
Kaul, 2005, Tumor-targeted gene delivery using poly(ethylene glycol)-modified gelatin nanoparticles: in vitro and in vivo studies, Pharm Res, 22, 951, 10.1007/s11095-005-4590-3
Kefas, 2008, microRNA-7 inhibits the epidermal growth factor receptor and the Akt pathway and is down-regulated in glioblastoma, Cancer Res, 68, 3566, 10.1158/0008-5472.CAN-07-6639
Kefas, 2009, The neuronal microRNA miR-326 acts in a feedback loop with notch and has therapeutic potential against brain tumors, J Neurosci, 29, 15161, 10.1523/JNEUROSCI.4966-09.2009
Klatzmann, 1998, A phase I/II study of herpes simplex virus type 1 thymidine kinase “suicide” gene therapy for recurrent glioblastoma. Study Group on Gene Therapy for Glioblastoma, Hum Gene Ther, 9, 2595, 10.1089/hum.1998.9.17-2595
Kneuer, 2000, A nonviral DNA delivery system based on surface modified silica-nanoparticles can efficiently transfect cells in vitro, Bioconjug Chem, 11, 926, 10.1021/bc0000637
Kreuter, 2001, Nanoparticulate systems for brain delivery of drugs, Adv Drug Deliv Rev, 47, 65, 10.1016/S0169-409X(00)00122-8
Krol, 2010, The widespread regulation of microRNA biogenesis, function and decay, Nat Rev Genet, 11, 597, 10.1038/nrg2843
Kuriyama, 2000, Pretreatment with protease is a useful experimental strategy for enhancing adenovirus-mediated cancer gene therapy, Hum Gene Ther, 11, 2219, 10.1089/104303400750035744
Lang, 2003, Phase I trial of adenovirus-mediated p53 gene therapy for recurrent glioma: biological and clinical results, J Clin Oncol, 21, 2508, 10.1200/JCO.2003.11.138
Lawler, 2006, Genetic strategies for brain tumor therapy, Cancer Gene Ther, 13, 225, 10.1038/sj.cgt.7700886
Lee, 1993, The C. elegans heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14, Cell, 75, 843, 10.1016/0092-8674(93)90529-Y
Li, 2004, CNS gene transfer mediated by a novel controlled release system based on DNA complexes of degradable polycation PPE-EA: a comparison with polyethylenimine/DNA complexes, Gene Ther, 11, 109, 10.1038/sj.gt.3302135
Louis, 2007, The 2007 WHO classification of tumours of the central nervous system, Acta Neuropathol, 114, 97, 10.1007/s00401-007-0243-4
Maier-Hauff, 2007, Intracranial thermotherapy using magnetic nanoparticles combined with external beam radiotherapy: results of a feasibility study on patients with glioblastoma multiforme, J Neurooncol, 81, 53, 10.1007/s11060-006-9195-0
Malam, 2009, Liposomes and nanoparticles: nanosized vehicles for drug delivery in cancer, Trends Pharmacol Sci, 30, 592, 10.1016/j.tips.2009.08.004
Manjunath, 2006, Pharmacokinetics, tissue distribution and bioavailability of nitrendipine solid lipid nanoparticles after intravenous and intraduodenal administration, J Drug Target, 14, 632, 10.1080/10611860600888850
Markert, 2000, Conditionally replicating herpes simplex virus mutant, G207 for the treatment of malignant glioma: results of a phase I trial, Gene Ther, 7, 867, 10.1038/sj.gt.3301205
Markert, 2009, Phase Ib trial of mutant herpes simplex virus G207 inoculated pre-and post-tumor resection for recurrent GBM, Mol Ther, 17, 199, 10.1038/mt.2008.228
Martuza, 1991, Experimental therapy of human glioma by means of a genetically engineered virus mutant, Science, 252, 854, 10.1126/science.1851332
McLean, 2011, Human ovarian carcinoma-associated mesenchymal stem cells regulate cancer stem cells and tumorigenesis via altered BMP production, J Clin Invest, 121, 3206, 10.1172/JCI45273
Menei, 1993, Biodegradation and brain tissue reaction to poly(D, L-lactide-co-glycolide) microspheres, Biomaterials, 14, 470, 10.1016/0142-9612(93)90151-Q
Merrill, 2004, Poliovirus receptor CD155-targeted oncolysis of glioma, Neuro Oncol, 6, 208, 10.1215/S1152851703000577
Moolten, 1986, Tumor chemosensitivity conferred by inserted herpes thymidine kinase genes: paradigm for a prospective cancer control strategy, Cancer Res, 46, 5276
Nakamizo, 2005, Human bone marrow-derived mesenchymal stem cells in the treatment of gliomas, Cancer Res, 65, 3307, 10.1158/0008-5472.CAN-04-1874
Nakamura, 2004, Antitumor effect of genetically engineered mesenchymal stem cells in a rat glioma model, Gene Ther, 11, 1155, 10.1038/sj.gt.3302276
Nakashima, 2014, Switching a replication-defective adenoviral vector into a replication-competent, oncolytic adenovirus, J Virol, 88, 345, 10.1128/JVI.02668-13
Nestler, 2004, The combination of adenoviral HSV TK gene therapy and radiation is effective in athymic mouse glioblastoma xenografts without increasing toxic side effects, J Neurooncol, 67, 177, 10.1023/B:NEON.0000021897.53969.ca
Nunes, 2003, Identification and isolation of multipotential neural progenitor cells from the subcortical white matter of the adult human brain, Nat Med, 9, 439, 10.1038/nm837
Olivier, 1999, Indirect evidence that drug brain targeting using polysorbate 80-coated polybutylcyanoacrylate nanoparticles is related to toxicity, Pharm Res, 16, 1836, 10.1023/A:1018947208597
Onishi, 2003, Antitumor properties of irinotecan-containing nanoparticles prepared using poly(DL-lactic acid) and poly(ethylene glycol)-block-poly(propylene glycol)-block-poly(ethylene glycol), Biol Pharm Bull, 26, 116, 10.1248/bpb.26.116
Packer, 2000, Treatment of progressive or recurrent pediatric malignant supratentorial brain tumors with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration, J Neurosurg, 92, 249, 10.3171/jns.2000.92.2.0249
Palu, 1999, Gene therapy of glioblastoma multiforme via combined expression of suicide and cytokine genes: a pilot study in humans, Gene Ther, 6, 330, 10.1038/sj.gt.3300805
Papagiannakopoulos, 2008, MicroRNA-21 targets a network of key tumor-suppressive pathways in glioblastoma cells, Cancer Res, 68, 8164, 10.1158/0008-5472.CAN-08-1305
Papanastassiou, 2002, The potential for efficacy of the modified (ICP 34.5(–)) herpes simplex virus HSV1716 following intratumoural injection into human malignant glioma: a proof of principle study, Gene Ther, 9, 398, 10.1038/sj.gt.3301664
Perez, 2012, Design and selection of Toca 511 for clinical use: modified retroviral replicating vector with improved stability and gene expression, Mol Ther, 20, 1689, 10.1038/mt.2012.83
Phillips, 2006, Molecular subclasses of high-grade glioma predict prognosis, delineate a pattern of disease progression, and resemble stages in neurogenesis, Cancer Cell, 9, 157, 10.1016/j.ccr.2006.02.019
Pradhan, 2007, Comparative evaluation of heating ability and biocompatibility of different ferrite-based magnetic fluids for hyperthermia application, J Biomed Mater Res B Appl Biomater, 81, 12, 10.1002/jbm.b.30630
Prados, 2003, Treatment of progressive or recurrent glioblastoma multiforme in adults with herpes simplex virus thymidine kinase gene vector-producer cells followed by intravenous ganciclovir administration: a phase I/II multi-institutional trial, J Neurooncol, 65, 269, 10.1023/B:NEON.0000003588.18644.9c
Pulkkanen, 2005, Gene therapy for malignant glioma: current clinical status, Mol Ther, 12, 585, 10.1016/j.ymthe.2005.07.357
Qin, 1998, Interferon-beta gene therapy inhibits tumor formation and causes regression of established tumors in immune-deficient mice, Proc Natl Acad Sci U S A, 95, 14411, 10.1073/pnas.95.24.14411
Qin, 2001, Human and mouse IFN-beta gene therapy exhibits different anti-tumor mechanisms in mouse models, Mol Ther, 4, 356, 10.1006/mthe.2001.0464
Rainov, 2000, A phase III clinical evaluation of herpes simplex virus type 1 thymidine kinase and ganciclovir gene therapy as an adjuvant to surgical resection and radiation in adults with previously untreated glioblastoma multiforme, Hum Gene Ther, 11, 2389, 10.1089/104303400750038499
Ram, 1997, Therapy of malignant brain tumors by intratumoral implantation of retroviral vector-producing cells, Nat Med, 3, 1354, 10.1038/nm1297-1354
Rampling, 2000, Toxicity evaluation of replication-competent herpes simplex virus (ICP 34.5 null mutant 1716) in patients with recurrent malignant glioma, Gene Ther, 7, 859, 10.1038/sj.gt.3301184
Russell, 2012, Oncolytic virotherapy, Nat Biotechnol, 30, 658, 10.1038/nbt.2287
Sanai, 2004, Unique astrocyte ribbon in adult human brain contains neural stem cells but lacks chain migration, Nature, 427, 740, 10.1038/nature02301
Sandmair, 2000, Thymidine kinase gene therapy for human malignant glioma, using replication-deficient retroviruses or adenoviruses, Hum Gene Ther, 11, 2197, 10.1089/104303400750035726
Shackleton, 2009, Heterogeneity in cancer: cancer stem cells versus clonal evolution, Cell, 138, 822, 10.1016/j.cell.2009.08.017
Shand, 1999, A phase 1-2 clinical trial of gene therapy for recurrent glioblastoma multiforme by tumor transduction with the herpes simplex thymidine kinase gene followed by ganciclovir. GLI328 European-Canadian Study Group, Hum Gene Ther, 10, 2325, 10.1089/10430349950016979
Shive, 1997, Biodegradation and biocompatibility of PLA and PLGA microspheres, Adv Drug Deliv Rev, 28, 5, 10.1016/S0169-409X(97)00048-3
Silber, 2008, miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells, BMC Med, 6, 14, 10.1186/1741-7015-6-14
Singh, 2004, Identification of human brain tumour initiating cells, Nature, 432, 396, 10.1038/nature03128
Skog, 2008, Glioblastoma microvesicles transport RNA and proteins that promote tumour growth and provide diagnostic biomarkers, Nat Cell Biol, 10, 1470, 10.1038/ncb1800
Smitt, 2003, Treatment of relapsed malignant glioma with an adenoviral vector containing the herpes simplex thymidine kinase gene followed by ganciclovir, Mol Ther, 7, 851, 10.1016/S1525-0016(03)00100-X
Tabatabai, 2005, Lessons from the bone marrow: how malignant glioma cells attract adult haematopoietic progenitor cells, Brain, 128, 2200, 10.1093/brain/awh563
Tai, 2005, Single-shot, multicycle suicide gene therapy by replication-competent retrovirus vectors achieves long-term survival benefit in experimental glioma, Mol Ther, 12, 842, 10.1016/j.ymthe.2005.03.017
Tamura, 2013, Multimechanistic tumor targeted oncolytic virus overcomes resistance in brain tumors, Mol Ther, 21, 68, 10.1038/mt.2012.175
Tiwari, 2006, A review of nanocarrier-based CNS delivery systems, Curr Drug Deliv, 3, 219, 10.2174/156720106776359230
Tomicic, 2002, Ganciclovir-induced apoptosis in HSV-1 thymidine kinase expressing cells: critical role of DNA breaks, Bcl-2 decline and caspase-9 activation, Oncogene, 21, 2141, 10.1038/sj.onc.1205280
Trask, 2000, Phase I study of adenoviral delivery of the HSV-tk gene and ganciclovir administration in patients with current malignant brain tumors, Mol Ther, 1, 195, 10.1006/mthe.2000.0030
Verhaak, 2010, Integrated genomic analysis identifies clinically relevant subtypes of glioblastoma characterized by abnormalities in PDGFRA, IDH1, EGFR, and NF1, Cancer Cell, 17, 98, 10.1016/j.ccr.2009.12.020
Wei, 1998, S- and G2-phase cell cycle arrests and apoptosis induced by ganciclovir in murine melanoma cells transduced with herpes simplex virus thymidine kinase, Exp Cell Res, 241, 66, 10.1006/excr.1998.4005
Westphal, 2013, Adenovirus-mediated gene therapy with sitimagene ceradenovec followed by intravenous ganciclovir for patients with operable high-grade glioma (ASPECT): a randomised, open-label, phase 3 trial, Lancet Oncol, 14, 823, 10.1016/S1470-2045(13)70274-2
Wurdinger, 2008, miR-296 regulates growth factor receptor overexpression in angiogenic endothelial cells, Cancer Cell, 14, 382, 10.1016/j.ccr.2008.10.005
Wust, 2002, Hyperthermia in combined treatment of cancer, Lancet Oncol, 3, 487, 10.1016/S1470-2045(02)00818-5
Yang, 1999, Body distribution of camptothecin solid lipid nanoparticles after oral administration, Pharm Res, 16, 751, 10.1023/A:1018888927852
Yoo, 2001, Biodegradable polymeric micelles composed of doxorubicin conjugated PLGA-PEG block copolymer, J Control Release, 70, 63, 10.1016/S0168-3659(00)00340-0
Zara, 2002, Intravenous administration to rabbits of non-stealth and stealth doxorubicin-loaded solid lipid nanoparticles at increasing concentrations of stealth agent: pharmacokinetics and distribution of doxorubicin in brain and other tissues, J Drug Target, 10, 327, 10.1080/10611860290031868
Zhang, 2012, Bevacizumab with angiostatin-armed oHSV increases antiangiogenesis and decreases bevacizumab-induced invasion in U87 glioma, Mol Ther, 20, 37, 10.1038/mt.2011.187
Zhang, 2014, Enhanced antitumor efficacy of an oncolytic herpes simplex virus expressing an endostatin-angiostatin fusion gene in human glioblastoma stem cell xenografts, PLoS One, 9
Zhou, 2010, Downregulation of miR-21 inhibits EGFR pathway and suppresses the growth of human glioblastoma cells independent of PTEN status, Lab Invest, 90, 144, 10.1038/labinvest.2009.126